Register
Medicines reference
Active substance

D-cyphenothrin

Pyrethroid ectoparasiticide. Toxic doses for cat from published sources; they are not treatment doses.

Cat: Toxic
Toxic to cats: the US EPA names it among dog spot-ons that may be fatal to cats.
Source: US EPA, meetings with registrants of pet spot-on products (2017) · UPD ↗
Species safety: cats →
Toxicity

Toxic doses

Single acute ingestion, mg of the substance per kg of body weight. These are toxic doses, not treatment doses.

Species Signs begin Severe Deaths reported Source
Cat
also gels and creams licked off
not established not established not established
Medium confidence
Regulator text naming this substance.

Cat

Signs: Named for pyrethroids in dogs, cats and large animals: salivation, vomiting, hyperexcitability, tremors, seizures, dyspnoea, weakness, prostration and death.

Toxic to cats: do not use on cats. The US EPA lists cyphenothrin among the dog spot-on actives whose label must warn that the product may be fatal to cats. Salivation, vomiting, tremors, seizures, death.

Dose and use

Doses

We have no dose with a cited source for this substance yet.

Before use

Safety information

Known Contraindications

  • Critical (Cat)
    Toxic to cats: do not use on cats. The US EPA lists cyphenothrin among the dog spot-on actives whose label must warn that the product may be fatal to cats. Salivation, vomiting, tremors, seizures, death.
    Sources: MSD Vet Manual
Latin name
D-cyphenothrin
Georgian name
D-ციფენოტრინი
Authorisation status
Authorised veterinary medicine
An authorised veterinary medicine containing this substance exists. Whether a particular use is on-label depends on the species and the indication - see each dose rule.
Registered in Georgia
1 of 1 forms
Products
Controlled in Georgia
Unknown
All forms and registration1

Registration in Georgia and abroad: the register, number, validity and source are behind (i).

RolfClub 3D 5%/5%/2%, Topical (unspecified)

collar 75 cm for large dogs
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
5.4/10
Weak evidence support
vetman assessment

RolfClub 3D

5%/5%/2%, collar 75 cm for large dogs
Assessed clinical scopeDog · Complete dog label: treatment/prevention of flea, lice/biting-lice and ixodid-tick infestation, short-term protection from blood-sucking dipterans and linked babesiosis, borreliosis and dirofilariasis prevention claims · On the skin
Care settingOwner-fitted continuous-wear dog collar after veterinarian/product selection, with fit/skin checks, household-species separation and environmental controls
vetman score 5.4/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 002683 · Verified on 23 Oct 2026

A highly convenient, current locally authorised dog collar whose components are plausible, but whose exact six-month efficacy and vector-borne-disease claims lack a public formulation-specific outcome dossier. Convenience cannot erase the evidence gap, cat-contact pyrethroid risk or aquatic/handling controls, so the complete-label value remains weak.

Regulatory and scientific credibility6.0/10

The exact 75 cm product has a current time-limited Georgian authorisation, an approved manufacturer instruction and a current Russian register-derived identity record. It has no exact EU/GB/US authorisation or public regulator assessment comparable with current long-acting collar controls.

Clinical efficacy4.0/10

The three actives have plausible and partly studied ectoparasite activity, and other formulation-specific collars prove multi-month control is possible. However, no public controlled trial of this exact polymer collar, six-month flea/tick/lice claim, five-day dipteran claim or pathogen-transmission endpoints was found; spot-on studies cannot be transferred.

Safety and tolerability4.5/10

The exact label reports mainly individual erythema/pruritus, but does not provide quantified target-animal safety or continuous-exposure pharmacovigilance. Dog-only cyphenothrin creates potentially severe feline-contact risk; chewing/ingestion, dermatitis, neurologic signs, child contact and aquatic toxicity require explicit controls.

Clinical practicality8.0/10

One continuously worn collar can cover the exact label flea/tick/lice period for up to six months and avoids monthly dosing. A 75 cm presentation is easy to fit and trim for a large dog, but correct 1.0-1.5 cm clearance, growth/skin checks, water precautions, household-cat separation and replacement after loss/damage remain necessary.

Full-course cost-effectiveness-

Current Georgian per-protection-period price was unavailable; price is excluded from the denominator.

Important safety and use flags

  • Complete-scope boundary: this score covers the exact dog collar label—fleas, lice/biting lice, ixodid ticks, blood-sucking dipterans and the linked babesiosis, borreliosis and dirofilariasis claims. Component plausibility does not validate every pest, duration or pathogen endpoint.
  • Evidence ceiling: no public controlled exact RolfClub collar trial or regulator assessment was found. Seresto/Scalibor collar data and fipronil/cyphenothrin spot-on studies use different formulations, release kinetics and doses; do not transfer their quantified efficacy or safety.
  • Duration boundary: the exact instruction claims up to six months for fleas, lice/biting lice and ixodid ticks, but only up to five days for flying blood-sucking insects. Record fitting/replacement date and reassess parasites rather than assuming uniform six-month repellency.
  • Disease-prevention boundary: a flea/tick/insect collar lowers exposure but cannot guarantee prevention of babesiosis, borreliosis or dirofilariasis. The five-day flying-insect claim cannot replace an authorised heartworm preventive, testing and geographic risk plan.
  • Dog only—cat hazard: D-cyphenothrin is a pyrethroid and relevant US EPA dog-product mitigation warns cat exposure may be fatal. Never fit this collar to a cat; prevent licking, chewing and prolonged close contact by household cats and choose a cat-safe household protocol.
  • Fit/physical safety: leave 1.0-1.5 cm between neck and collar, secure and trim excess, then recheck skin and fit as the dog grows or coat/weight changes. Prevent chewing/ingestion and snagging; replace a lost, damaged or excessively loose collar rather than improvising repairs.
  • Stop and remove for important erythema, pruritus, alopecia, salivation, vomiting, weakness, ataxia, twitching, tremor or seizure; wash exposed skin with mild detergent/water and obtain veterinary/poison advice. Do not add another insectoacaricide without a product-specific veterinarian plan.
  • Do not use under 3 months, during infectious disease or convalescence, or with hypersensitivity. Pregnancy/lactation require veterinarian benefit-risk consultation; the exact instruction does not provide a quantified reproductive safety dossier.
  • Aquatic/environmental control: fipronil and pyrethroids are hazardous to aquatic organisms. Keep the dog/collar from watercourses, follow bathing/swimming restrictions or remove as directed, and dispose of the used collar and trimmed pieces safely—not in wastewater or fire.
  • Handler/household control: keep the sealed and fitted collar, offcuts and removed collar away from children, food and feed. Wash hands after fitting or touching it, avoid sleeping/prolonged skin contact with the collar and do not allow small children close contact with the collared dog.
Assessment sources
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Formulation Type
Topical (unspecified)
Administration route
On the skin
Manufacturer
Manufacturer (register)
JSC SPC EKOPROM, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 584, 19 Oct 2026.
Registration
Georgia Yes, veterinary
In force until 12 Apr 2027
Veterinary (National Food Agency)
In the register: როლფკლუბ 3D 5%/5%/2%, 75 სმ საყელო დიდი ძაღლებისთვის
№ 002683
Verified on: 23 Oct 2026
EU No
UK No
US No
Controlled in Georgia
Unknown
Information not fully verified Dog only. Fit one 75 cm collar continuously with 1.0-1.5 cm clearance and trim the excess. The exact instruction claims up to 6 months against fleas, lice/biting lice and ixodid ticks, but only up to 5 days against blood-sucking flying insects. No public exact-product controlled efficacy dossier was found; vector-borne-disease prevention is not equivalent to guaranteed pathogen protection.

All of this shows in vetman as you prescribe

The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.