Register
Medicines reference
Active substance

Molnupiravir

Nucleoside analogue antiviral. No registration in force in Georgia. Forms: capsule.

Dose and use

Doses

Each dose comes with its source. Check the label of the product you use.

Active substance Molnupiravir
Before use

Safety information

Known Contraindications

  • Critical (Dog)
    Dog: no treatment dose exists, and the cat dose must not be transferred. In the safety studies, bone marrow toxicity affecting all blood cell lines appeared at 17 mg/kg a day or more (no-effect level 6 mg/kg a day), with thrombocytopenia and haemorrhage; recovery was partial or full depending on the dose. The usual cat dose is 20-40 mg/kg a day.
    Source: EMA Sources: Lagevrio SmPC · FDA · EMA · PubMed
  • Warning
    Do not use in pregnant or lactating animals or animals intended for breeding. In the human label, embryo-fetal death and malformations (eye, kidney, axial skeleton) occurred in rats at 8 times the human exposure, and reduced fetal weight in rabbits; the active metabolite reached nursing pups.
    Sources: Lagevrio SmPC · FDA
  • Warning
    Young animals: in young rats it thickened growth cartilage and impaired its change into bone at 500 mg/kg a day or more (5-6 times the human exposure). No such effect was seen in dogs; the meaning for kittens is not known.
    Source: EMA Sources: Lagevrio SmPC · FDA · EMA
  • Warning
    Handling: wear gloves; pregnant people should not handle it. The human label says not to open the capsule; cat doses need the powder divided or compounded (off-label). Bacterial mutation tests were positive and one animal test equivocal, while the other animal tests were negative; the human label's low-risk statement refers to a 5-day course, and cat courses run 84 days.
    Sources: Lagevrio SmPC · FDA
  • Warning (Cat)
    Cat (off-label): raised liver enzymes (ALT) and gastrointestinal signs are the most reported. Neutropenia and occasional anaemia occur at higher doses, with severe leukopenia reported above 23 mg/kg; folded ears and hair or whisker loss are also reported. Guidelines advise caution above 15 mg/kg every 12 hours and keep it second-line to GS-441524.
Latin name
Molnupiravir
Georgian name
მოლნუპირავირი
Authorisation status
Human medicine, cascade use
No veterinary authorisation was found in any register checked. Veterinary use is off-label, under the prescribing cascade.
Registered in Georgia
0 of 2 forms
Controlled in Georgia
Unknown
All forms and registration2

Registration in Georgia and abroad: the register, number, validity and source are behind (i).

All of this shows in vetman as you prescribe

The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.