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Molnupiravir
Nucleoside analogue antiviral. No registration in force in Georgia. Forms: capsule.
Doses
Each dose comes with its source. Check the label of the product you use.
| Dose | Species | Indication | Route | Frequency | Source |
|---|---|---|---|---|---|
|
10–15 mg/kg
off-label |
Cat | Feline Infectious Peritonitis, effusive | By mouth | 2 times daily |
JVIM 2024 (10 cats)
Scientific article A study or review published in a scientific journal. Its findings apply to the animals and conditions it studied. Journal of Veterinary Internal Medicine 38:3087-3094, 2024 |
|
15 mg/kg
off-label |
Cat | Feline Infectious Peritonitis, non-effusive | By mouth | 2 times daily |
JVIM 2023 (18 cats)
Scientific article A study or review published in a scientific journal. Its findings apply to the animals and conditions it studied. Journal of Veterinary Internal Medicine 37:1876-1880, 2023 |
|
15–20 mg/kg
off-label |
Cat | Feline Infectious Peritonitis, ocular; Feline Infectious Peritonitis, neurological | By mouth | 2 times daily |
JVIM 2023 (18 cats)
Scientific article A study or review published in a scientific journal. Its findings apply to the animals and conditions it studied. Journal of Veterinary Internal Medicine 37:1876-1880, 2023 |
Safety information
Known Contraindications
-
Critical
(Dog) Dog: no treatment dose exists, and the cat dose must not be transferred. In the safety studies, bone marrow toxicity affecting all blood cell lines appeared at 17 mg/kg a day or more (no-effect level 6 mg/kg a day), with thrombocytopenia and haemorrhage; recovery was partial or full depending on the dose. The usual cat dose is 20-40 mg/kg a day.Source: EMA Sources: Lagevrio SmPC · FDA · EMA · PubMed
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Warning
Do not use in pregnant or lactating animals or animals intended for breeding. In the human label, embryo-fetal death and malformations (eye, kidney, axial skeleton) occurred in rats at 8 times the human exposure, and reduced fetal weight in rabbits; the active metabolite reached nursing pups.Sources: Lagevrio SmPC · FDA
-
Warning
Young animals: in young rats it thickened growth cartilage and impaired its change into bone at 500 mg/kg a day or more (5-6 times the human exposure). No such effect was seen in dogs; the meaning for kittens is not known.Source: EMA Sources: Lagevrio SmPC · FDA · EMA
-
Warning
Handling: wear gloves; pregnant people should not handle it. The human label says not to open the capsule; cat doses need the powder divided or compounded (off-label). Bacterial mutation tests were positive and one animal test equivocal, while the other animal tests were negative; the human label's low-risk statement refers to a 5-day course, and cat courses run 84 days.Sources: Lagevrio SmPC · FDA
-
Warning
(Cat) Cat (off-label): raised liver enzymes (ALT) and gastrointestinal signs are the most reported. Neutropenia and occasional anaemia occur at higher doses, with severe leukopenia reported above 23 mg/kg; folded ears and hair or whisker loss are also reported. Guidelines advise caution above 15 mg/kg every 12 hours and keep it second-line to GS-441524.
All forms and registration2
Registration in Georgia and abroad: the register, number, validity and source are behind (i).
Molnupiravir Alvils 200 mg, Capsule
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