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Atipamezole · Orion Corporation

1 form: solution. In force in Georgia: 1 of 1 (veterinary register).

Forms and doses1 of 1 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Dose Frequency Georgia
Solution · Cat Cat 0.04 ml/kg
0.04 ml/kg is the label example (0.2 ml per 5 kg after dexmedetomidine 40 micrograms/kg). The real volume is half the volume of Dexdomitor 0.5 mg/ml or Domitor 1 mg/ml that was given (one tenth of dexmedetomidine 0.1 mg/ml). Into a muscle, once; not within 30-40 minutes of ketamine.
 · once		 once Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ანტისედანი
Verified on: 18 Oct 2026
Solution · Dog Dog 0.04 ml/kg
0.04 ml/kg is the label example (0.4 ml per 10 kg after dexmedetomidine 20 micrograms/kg). The real volume equals the volume of Dexdomitor 0.5 mg/ml or Domitor 1 mg/ml that was given (one fifth of dexmedetomidine 0.1 mg/ml). Into a muscle, once; not to reverse a combination that included ketamine.
 · once		 once Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ანტისედანი
Verified on: 18 Oct 2026
Details: pack, label wording, sources, registration

Antisedan, Solution

Atipamezole hydrochloride 5 mg/ml, solution for injection for dogs and cats
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Full canine label: reversal of the sedative, analgesic, cardiovascular and respiratory effects of medetomidine or dexmedetomidine, including labelled postoperative recovery protocols
8.6/10
Very good
vetman assessment

Antisedan

Atipamezole hydrochloride 5 mg/ml, solution for injection for dogs and cats
Assessed clinical scopeDog · Full canine label: reversal of the sedative, analgesic, cardiovascular and respiratory effects of medetomidine or dexmedetomidine, including labelled postoperative recovery protocols · Intramuscular
Care settingMonitored veterinary recovery after medetomidine or dexmedetomidine, with the preceding protocol and dose known
vetman score 8.6/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · Verified on 18 Oct 2026

A well documented and highly practical specific reversal agent for canine medetomidine or dexmedetomidine protocols. It reliably accelerates arousal, but the patient remains an anaesthesia-recovery patient until cardiovascular function and the risk of resedation are reassessed.

Regulatory and scientific credibility9.0/10

The exact product is registered in Georgia and has a current detailed VMD SPC with explicit species-specific dose ratios, timing, adverse events and interaction limits.

Clinical efficacy8.5/10

Controlled dose-response evidence and long clinical use support rapid reversal, but modern haemodynamic work shows that awakening does not guarantee immediate restoration of heart rate or cardiac index and resedation can occur.

Safety and tolerability8.0/10

Adverse events are very rare in the label, but transient hypotension, tachycardia, hyperactivity, gastrointestinal signs and incomplete cardiovascular recovery require continued observation.

Clinical practicality9.0/10

A single IM injection with a simple volume relationship to the preceding alpha-2 agonist and typical rapid arousal is highly practical when the original drug, concentration and dose are known.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use in hypersensitivity. Do not use atipamezole to reverse a canine protocol that included ketamine with medetomidine or dexmedetomidine, with or without butorphanol.
  • The microgram dose is five times the preceding medetomidine dose or ten times the dexmedetomidine dose; verify the original drug, concentration and administered dose before calculating volume.
  • Allow recovery in a maximally quiet place. Continue cardiovascular observation: transient hypotension may occur in the first ten minutes and awakening may precede full haemodynamic recovery or be followed by resedation.
  • Concurrent use of other CNS-active drugs is not recommended except for combinations specifically described in the SPC.
  • Safety during pregnancy and lactation is not established; use is not recommended.
  • Very rare events include behavioural change, hyperactivity, tachycardia, vomiting, diarrhoea, hypersalivation and panting; overdose may cause transient over-alertness and tachycardia.
  • Atipamezole reverses medetomidine or dexmedetomidine; it is not a general antidote for unrelated sedatives or anaesthetics.
Assessment sources
  1. VMD SPC 20252025
  2. Dog atipamezole dose-response trial1990
  3. Dog atipamezole haemodynamic trial2019
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Full feline label: reversal of the sedative, analgesic, cardiovascular and respiratory effects of medetomidine or dexmedetomidine, including recovery after labelled ketamine combinations
8.4/10
Very good
vetman assessment

Antisedan

Atipamezole hydrochloride 5 mg/ml, solution for injection for dogs and cats
Assessed clinical scopeCat · Full feline label: reversal of the sedative, analgesic, cardiovascular and respiratory effects of medetomidine or dexmedetomidine, including recovery after labelled ketamine combinations · Intramuscular
Care settingMonitored veterinary recovery after medetomidine or dexmedetomidine, with active warming and strict ketamine timing
vetman score 8.4/10 Very good
Evidence confidence: Medium Georgia: Yes, veterinary · Verified on 18 Oct 2026

A strong specific reversal option for feline alpha-2 protocols with direct randomized clinical support. Its excellent practical value depends on exact dose-ratio calculation, temperature support and never reversing a ketamine-containing protocol too early.

Regulatory and scientific credibility9.0/10

The exact product is registered in Georgia and has a current detailed VMD SPC with explicit feline dose ratios, a maximum ratio, ketamine timing and adverse-event guidance.

Clinical efficacy8.5/10

A blinded randomized multicentre trial in 120 cats found complete reversal of sedation and analgesia with recovery of heart rate and prevention of further respiratory-rate and temperature decline; evidence outside that principal protocol is thinner.

Safety and tolerability7.5/10

Labelled adverse events are very rare, but hypothermia can persist after partial reversal and administration before ketamine has cleared can precipitate convulsions; tachycardia or over-alertness can follow overdose.

Clinical practicality8.5/10

A single IM injection and rapid arousal are practical, but the half-volume calculation, dose-ratio ceiling, active warming and mandatory 30-40 minute delay after ketamine add clinically important checks.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use in hypersensitivity. After a ketamine-containing protocol, do not administer atipamezole until at least 30-40 minutes after ketamine; earlier alpha-2 reversal can precipitate convulsions.
  • The microgram dose is 2.5 times the preceding medetomidine dose or five times the dexmedetomidine dose and must not exceed four or eight times respectively; verify the original concentration and dose.
  • Allow recovery in a maximally quiet place and continue active temperature monitoring and warming; hypothermia can persist even after low-dose partial reversal has awakened the cat.
  • Concurrent use of other CNS-active drugs is not recommended except for combinations specifically described in the SPC.
  • Safety during pregnancy and lactation is not established; use is not recommended.
  • Very rare events include behavioural change, hyperactivity, tachycardia, vomiting, diarrhoea, hypersalivation and panting; overdose may cause transient over-alertness and tachycardia.
  • Atipamezole reverses medetomidine or dexmedetomidine; it is not a general antidote for unrelated sedatives or anaesthetics.
Assessment sources
  1. VMD SPC 20252025
  2. Feline dexmedetomidine-atipamezole trial2006
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Atipamezole5 mg/ml
Formulation Type
Solution
Administration route
Intramuscular
Manufacturer
Orion Corporation · Finland
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ანტისედანი
Verified on: 18 Oct 2026
 EU Yes, veterinary
Verified on: 18 Oct 2026
 UK Yes, veterinary
№ Vm 06043/4004
Verified on: 18 Oct 2026
 US Yes, veterinary
№ NADA 141-033
Verified on: 18 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 18 Oct 2026
DoseSpeciesWeightRouteFrequencySource
0.04 ml/kg
0.04 ml/kg is the label example (0.2 ml per 5 kg after dexmedetomidine 40 micrograms/kg). The real volume is half the volume of Dexdomitor 0.5 mg/ml or Domitor 1 mg/ml that was given (one tenth of dexmedetomidine 0.1 mg/ml). Into a muscle, once; not within 30-40 minutes of ketamine.
 Cat Any weight Intramuscular once
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Antisedan 5 mg/ml solution for injection - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
0.04 ml/kg
0.04 ml/kg is the label example (0.4 ml per 10 kg after dexmedetomidine 20 micrograms/kg). The real volume equals the volume of Dexdomitor 0.5 mg/ml or Domitor 1 mg/ml that was given (one fifth of dexmedetomidine 0.1 mg/ml). Into a muscle, once; not to reverse a combination that included ketamine.
 Dog Any weight Intramuscular once
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Antisedan 5 mg/ml solution for injection - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025

Known Contraindications

  • Critical
    Do not use in animals hypersensitive to atipamezole or to the excipients (methyl parahydroxybenzoate).
  • Warning
    Safety in pregnancy and lactation has not been established; use is not recommended.
  • Warning
    Safety in pregnancy and lactation has not been established; use is not recommended.
  • Caution
    Ketamine: in dogs do not use atipamezole to reverse a combination that included ketamine; in cats do not give it within 30-40 minutes of ketamine, as the remaining ketamine effect may cause convulsions. Let the animal recover somewhere quiet; dogs may have transient low blood pressure in the first 10 minutes.

Products are connected by name, active ingredients, or therapeutic group. They are not direct substitutes for one another.

Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

For veterinary professionals only. It does not replace clinical judgement or the product label; check the dose in the official label (SPC). vetman is not liable for harm caused by using this information.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 18 Oct 2026

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The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

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