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Vanguard Plus 5-CVL

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Canine distemper virus + Canine adenovirus + Canine parainfluenza virus + Canine parvovirus + Canine coronavirus + Leptospira canicola + Leptospira icterohaemorrhagiae · Zoetis Inc.

1 form: suspension. In force in Georgia: 1 of 1 (veterinary register).

Forms and doses1 of 1 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Form Species Dose Frequency Georgia
Suspension · Dog Dog 1 ml (1 ml)
Reconstitute the lyophilisate with the entire liquid-vaccine component and inject the full 1 ml dose subcutaneously or intramuscularly. For primary immunisation from 6 weeks of age, give three doses at three-week intervals, then one dose annually. Vaccinate healthy dogs only. Do not vaccinate pregnant bitches. Individual dogs may develop an allergic reaction; administer epinephrine and supportive treatment as indicated. Use aseptic technique; do not chemically disinfect syringes or needles. Use immediately after opening/reconstitution. Contains penicillin and streptomycin. Infection incubation, malnutrition, parasites, transport/environmental stress, immunosuppression or deviation from the label may cause vaccination failure. Store at 2-8 C, do not freeze or expose to prolonged heat.
 · 3 doses 3 weeks apart from 6 weeks of age; then annually		 3 doses 3 weeks apart from 6 weeks of age; then annually Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ვანგარდ პლუს 5/CVL - ძაღლის ჭირის-ადენოვირუსის ტიპი-2-კორონავირუსის-პარაგრიპის-პარვოვირუსის ვაქცინა - ლეპტოსპირა კანიკოლა-იქტეროჰემორაგიული ბაქტერიები. (მოდიფიცირებული ცოცხალი და მკვდარი ვირუს ვაქცინა
№ 285-11
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Vanguard Plus 5-CVL, Suspension

lyophilisate and liquid vaccine, 1 ml dose for dogs
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
7.5/10
Good
vetman assessment

Vanguard Plus 5-CVL

lyophilisate and liquid vaccine, 1 ml dose for dogs
Assessed clinical scopeDog · Full dog label from 6 weeks: CDV, CAV-1/2, CPiV, CPV, canine coronavirus and two-serogroup leptospirosis (Canicola, Icterohaemorrhagiae) · SC,IM
Care settingPreventive veterinary vaccination of a healthy dog with examination, cold-chain control and emergency treatment available
vetman score 7.5/10 Good
Evidence confidence: Medium Georgia: Yes, veterinary · № 285-11 · Verified on 21 Oct 2026

A good core vaccine whose two-serogroup leptospirosis cover and coronavirus fraction lag behind four-serogroup options. Prefer a four-serogroup product where leptospirosis exposure is real.

Regulatory and scientific credibility8.0/10

The exact product is registered in Georgia (285-11) with full strain composition and has a current Zoetis label; no EU or UK authorisation of this exact presentation was documented in the reviewed evidence.

Clinical efficacy7.0/10

The live core antigens are strong, but leptospirosis cover is limited to two serogroups and the coronavirus fraction adds little clinical value.

Safety and tolerability7.5/10

Benefit-risk is favourable in healthy dogs; allergic reactions can occur, the vaccine contains penicillin and streptomycin, and pregnant bitches must not be vaccinated.

Clinical practicality7.5/10

The label primary course is three doses three weeks apart, then one dose a year; syringes must not be chemically disinfected and the dose is used immediately.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Do not vaccinate pregnant bitches. Vaccinate only healthy dogs.
  • Allergic reactions can occur; keep epinephrine and supportive treatment ready. The vaccine contains penicillin and streptomycin.
  • Leptospirosis cover is limited to Canicola and Icterohaemorrhagiae; Grippotyphosa, Pomona and Australis are not covered.
  • WSAVA does not recommend enteric coronavirus vaccination.
  • Give three primary doses three weeks apart from 6 weeks and make sure the last core dose falls at 16 weeks or later.
  • Use aseptic technique without chemical disinfection of syringes or needles; store at 2-8 C and use immediately after reconstitution.
Assessment sources
  1. Zoetis label2026
  2. Georgia NFA register 20262026
  3. WSAVA vaccination 20242024
  4. ACVIM leptospirosis consensus 20232023
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Canine distemper virus2.5 log10 TCID50/dose Canine adenovirus2.9 log10 TCID50/dose Canine parainfluenza virus5 log10 TCID50/dose Canine parvovirus7 log10 TCID50/dose Canine coronavirus1 RP/dose Leptospira canicola600 NU/dose Leptospira icterohaemorrhagiae600 NU/dose
Formulation Type
Suspension
Administration route
Subcutaneous, Intramuscular
Manufacturer
Zoetis Inc. · United States
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ვანგარდ პლუს 5/CVL - ძაღლის ჭირის-ადენოვირუსის ტიპი-2-კორონავირუსის-პარაგრიპის-პარვოვირუსის ვაქცინა - ლეპტოსპირა კანიკოლა-იქტეროჰემორაგიული ბაქტერიები. (მოდიფიცირებული ცოცხალი და მკვდარი ვირუს ვაქცინა
№ 285-11
Verified on: 21 Oct 2026
Controlled in Georgia
Unknown
DoseSpeciesWeightRouteFrequencySource
1 ml (1 ml)
Reconstitute the lyophilisate with the entire liquid-vaccine component and inject the full 1 ml dose subcutaneously or intramuscularly. For primary immunisation from 6 weeks of age, give three doses at three-week intervals, then one dose annually. Vaccinate healthy dogs only. Do not vaccinate pregnant bitches. Individual dogs may develop an allergic reaction; administer epinephrine and supportive treatment as indicated. Use aseptic technique; do not chemically disinfect syringes or needles. Use immediately after opening/reconstitution. Contains penicillin and streptomycin. Infection incubation, malnutrition, parasites, transport/environmental stress, immunosuppression or deviation from the label may cause vaccination failure. Store at 2-8 C, do not freeze or expose to prolonged heat.
 Dog Any weight SC,IM 3 doses 3 weeks apart from 6 weeks of age; then annually
Zoetis label
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Vanguard Plus 5-CVL - official product label
Zoetis China official product information, 2026

Canine distemper virus: No dose supported by a publicly verifiable source yet

Canine adenovirus: No dose supported by a publicly verifiable source yet

Canine parainfluenza virus: No dose supported by a publicly verifiable source yet

Canine parvovirus: No dose supported by a publicly verifiable source yet

Canine coronavirus: No dose supported by a publicly verifiable source yet

Leptospira canicola: No dose supported by a publicly verifiable source yet

Leptospira icterohaemorrhagiae: No dose supported by a publicly verifiable source yet

Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

For veterinary professionals only. It does not replace clinical judgement or the product label; check the dose in the official label (SPC). vetman is not liable for harm caused by using this information.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 21 Oct 2026

All of this shows in vetman as you prescribe

The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

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