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Acetylsalicylic acid
Salicylate NSAID. Used in veterinary practice (dog, cat); overdose thresholds from published sources, not treatment doses.
Overdose
Used in veterinary practice at veterinary doses; human tablets and gels are much stronger and cannot be dosed accurately for an animal. The table shows where harm has been described after a single ingestion, mg per kg of body weight: overdose thresholds, not treatment doses.
| Species | Signs begin | Severe | Deaths reported | Source |
|---|---|---|---|---|
| Dog | not established | from 450 mg/kg | not established |
MSD Vet Manual 2024 · Wismer 2011 (ASPCA APCC)
Medium confidence
A veterinary manual; no single-dose threshold for the first signs is published. Reference book A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose. MSD Veterinary Manual, Professional version, reviewed Jul 2024, 2024 450 mg/kg acute: severe signs; repeated-dose data Scientific article A study or review published in a scientific journal. Its findings apply to the animals and conditions it studied. dvm360, Conference proceedings, 2011 150 mg/kg: decontamination cut-off, not a signs threshold |
| Cat | not established | not established | not established |
MSD Vet Manual 2024 · DeClementi 2009 (ASPCA APCC) +1
Low confidence
No single-dose threshold for cats is established; the figures in the note are per cat or from repeated dosing. Reference book A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose. MSD Veterinary Manual, Professional version, reviewed Jul 2024, 2024 half-life about 37.5 h in cats Scientific article A study or review published in a scientific journal. Its findings apply to the animals and conditions it studied. dvm360, Conference proceedings, 2009 325 mg twice daily lethal in cats Guideline or consensus statement Recommendations agreed by a panel of veterinary specialists after reviewing the evidence. They guide practice and do not authorise a product. Cornell University, Department of Animal Science, 2018 80-120 mg/kg over 10-12 days toxic |
Dog
Signs: Vomiting (may contain blood), stomach ulcers, fast deep breathing, acid-base disturbance, raised temperature, bleeding tendency, seizures, coma.
Aspirin is used in dogs only at low doses set by a veterinarian (for example against blood clots); human tablets are often stronger than a dose for a dog. Repeated doses damage the stomach at moderate amounts (25 mg/kg three times a day caused erosions in half of dogs within 2 days); 100-300 mg/kg a day for 1-4 weeks causes poisoning.
Cat
Signs: Depression, anorexia, vomiting (may contain blood), raised temperature, fast breathing, acid-base disturbance, anaemia, ataxia.
Aspirin is used in cats only at very low doses spaced days apart, prescribed by a veterinarian (for example against blood clots). Cats eliminate it very slowly (half-life about 37.5 hours), so dosing it like a human medicine makes it accumulate: 325 mg twice daily has killed cats, and 80-120 mg/kg over 10-12 days causes poisoning. Human tablets are too strong to dose accurately for a cat. No single-dose threshold is established.
Safety information
Known Contraindications
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Warning
(Cat) Cats eliminate aspirin very slowly (half-life about 37.5 hours) because they glucuronidate it poorly. Use it only at a low dose set by a veterinarian, with days between doses; given daily like a human medicine it accumulates and can be fatal.
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