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Diclofenac
Acetic acid NSAID (non-selective). Toxic doses for dog, cat from published sources; they are not treatment doses.
Toxic doses
Single acute ingestion, mg of the substance per kg of body weight. These are toxic doses, not treatment doses.
| Species | Signs begin | Severe | Deaths reported | Source |
|---|---|---|---|---|
|
Dog
also gels and creams licked off |
not established | not established | not established |
EMA CVMP 2003 · Lohmann-Menezes et al. 2024 +1
Medium confidence
No acute ingestion threshold is published; the figures in the note come from repeated-dose studies and an old regulatory LD50. Guideline or consensus statement Guidance from the scientific committees of the European Medicines Agency (EMA). European Medicines Agency, Committee for Veterinary Medicinal Products, EMEA/MRL/885/03-FINAL, 2003 oral LD50 59 mg/kg; 4- and 13-week studies; bile recycling Scientific article A study or review published in a scientific journal. Its findings apply to the animals and conditions it studied. Frontiers in Veterinary Science, Front Vet Sci 2024;11:1507390, 2024 3 mg/kg twice daily for 4 days: ulcers and raised kidney values; eye drops: erosions Guideline or consensus statement Recommendations agreed by a panel of veterinary specialists after reviewing the evidence. They guide practice and do not authorise a product. ASPCApro (ASPCA Animal Poison Control Center), Poison-centre guidance gels and creams licked or chewed |
|
Cat
also gels and creams licked off |
not established | not established | not established |
ASPCA APCC: topical creams
Low confidence
Poison-centre guidance without a dose; no threshold is established. Guideline or consensus statement Recommendations agreed by a panel of veterinary specialists after reviewing the evidence. They guide practice and do not authorise a product. ASPCApro (ASPCA Animal Poison Control Center), Poison-centre guidance cats much more sensitive; cream licked off an owner's skin |
Dog
Signs: Vomiting, bloody diarrhoea, black stool, anaemia, low blood protein, kidney injury; liver injury with repeated dosing.
No acute ingestion threshold has been published. In studies, 3 mg/kg twice daily for 4 days caused deep stomach ulcers and raised kidney values, and 1 mg/kg a day for 4 weeks severe gut damage; the old oral LD50 is 59 mg/kg. Dogs recycle diclofenac through bile, and even eye drops have caused stomach erosions. Gels and creams licked or chewed are the usual exposure.
Cat
Signs: Vomiting, stomach ulceration, anorexia, acute kidney injury.
No threshold is established; cats are considered much more sensitive than dogs, including to cream licked off an owner's skin.
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