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Ibuprofen
Propionic acid NSAID (non-selective). Toxic doses for dog, cat from published sources; they are not treatment doses.
Toxic doses
Single acute ingestion, mg of the substance per kg of body weight. These are toxic doses, not treatment doses.
| Species | Signs begin | Severe | Deaths reported | Source |
|---|---|---|---|---|
| Dog | from 25 mg/kg | from 175 mg/kg | from 600 mg/kg |
Dunayer 2004 (ASPCA APCC) · MSD Vet Manual 2024 +1
High confidence
Poison-centre case data and a clinical review; sources differ on where GI signs start (25 or 100 mg/kg), the lower figure is shown. Scientific article A study or review published in a scientific journal. Its findings apply to the animals and conditions it studied. Veterinary Medicine, Toxicology brief, July 2004, 2004 signs from 25, kidney from 175, CNS from 400, lethal from 600 Reference book A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose. MSD Veterinary Manual, Professional version, reviewed Jul 2024, 2024 GI 100-125, kidney 175-300, CNS over 400, lethal over 600 Scientific article A study or review published in a scientific journal. Its findings apply to the animals and conditions it studied. Journal of Veterinary Internal Medicine, JVIM 2023;37(1):161-172, 2023 434 dogs: kidney injury and outcome |
| Cat | from 5 mg/kg | from 20 mg/kg | from 50 mg/kg |
ASPCA APCC: feline exposures · Herrero et al. 2022 +1
Low confidence
Poison-centre guidance and case reports, no studies: low to medium confidence. Guideline or consensus statement Recommendations agreed by a panel of veterinary specialists after reviewing the evidence. They guide practice and do not authorise a product. ASPCApro (ASPCA Animal Poison Control Center), Poison-centre guidance ulcers from 5, kidney from 20 (poison-centre guidance) Scientific article A study or review published in a scientific journal. Its findings apply to the animals and conditions it studied. Journal of Feline Medicine and Surgery Open Reports, JFMS Open Rep 2022;8(1):20551169221104551, 2022 kidney injury and death reported from 50 Reference book A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose. MSD Veterinary Manual, Professional version, reviewed Jul 2024, 2024 cats about twice as sensitive as dogs |
Dog
Signs: Vomiting, blood in vomit or black stool, abdominal pain, anorexia, polyuria and polydipsia then oliguria (acute kidney injury), ataxia, seizures, coma.
Nervous-system signs from about 400 mg/kg. Old age, kidney disease, dehydration or corticosteroids lower the thresholds; repeated low doses (8 mg/kg a day) have caused ulcers without visible signs.
Cat
Signs: Vomiting, blood in vomit or black stool, abdominal pain, anorexia, acute kidney injury (marked protein loss in urine has been reported), ataxia, seizures.
Cats are about twice as sensitive as dogs (limited glucuronidation). The cat thresholds come from poison-centre guidance and case reports, not from studies.
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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 18 Oct 2026