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Active substance

Ketoconazole

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Imidazole antifungal. No registration in force in Georgia. Forms: aerosol / spray.

Dose and use

Doses

We have no dose with a cited source for this substance yet.

Before use

Safety information

No sourced safety entry is currently shown. This does not mean the substance is risk-free.

Latin name
Ketoconazole
Georgian name
კეტოკონაზოლი
Authorisation status
Authorised veterinary medicine
An authorised veterinary medicine containing this substance exists. Whether a particular use is on-label depends on the species and the indication - see each dose rule.
Registered in Georgia
0 of 1 forms
Products
Gefriderm
Human medicines in Georgia
Axytop, Ketoral, Konazol, Nizoral, Seboderm Med, Zoxin-med
Human medicines with this substance in the Georgian register of medicines (Ministry of Health), checked on 18 Oct 2026. They are human medicines, not veterinary products; strengths and forms differ.
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
All forms and registration1

Registration in Georgia and abroad: the register, number, validity and source are behind (i).

Gefriderm, Aerosol / spray

cutaneous spray solution, for dogs
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
7.3/10
Good
vetman assessment

Gefriderm

cutaneous spray solution, for dogs
Assessed clinical scopeDog · Label-concordant treatment of a proved focal acute superficial mixed infection in dogs: marbofloxacin-susceptible Pseudomonas aeruginosa or Staphylococcus pseudintermedius plus ketoconazole-susceptible Malassezia pachydermatis · On the skin
Care settingVeterinarian-directed clinic/home treatment after cytology, organism identification and susceptibility testing, with lesion preparation, exposure control and day-7/day-14 reassessment.
vetman score 7.3/10 Good
Evidence confidence: High Georgia: No · Verified on 15 Oct 2026

A well-documented licensed option for a narrow, proved focal mixed bacterial-and-Malassezia dermatitis. Its value disappears when used empirically, on diffuse/deep disease, or where an antiseptic or narrower agent is suitable.

Regulatory and scientific credibility8.0/10

Current exact UK and EU regulator records provide full composition, authorisation, dose, target-animal PK and safety, while the exact EU public assessment report exposes the pivotal efficacy review; national EU authorisations are traceable, but Georgia and the US have no exact authorisation and no independent published exact-product trial was located.

Clinical efficacy7.5/10

The regulator-reviewed exact-product GCP field trial included 56 eligible dogs, confirmed mixed infections, an active comparator and demonstrated non-inferiority with clinical cure by day 14. This supports efficacy within the narrow proved mixed-infection scope, while antiseptic-first guidance, category-B fluoroquinolone stewardship and the absence of an independent published trial limit broader value.

Safety and tolerability6.5/10

Very rare mild erythema, very low one-zone plasma exposure and a five-times one-zone tolerance study are reassuring, but multi-zone overdose was not studied and steroid-related delayed healing, epidermal thinning/adrenal suppression, reproductive risk, licking and handler inhalation/contact risks remain material.

Clinical practicality7.0/10

A metered spray is practical for focal painful or folded skin and the twice-daily 7-day plan is clear, but clipping/cleaning, 25 cm² measurement, four-zone ceiling, gloves, ventilation, lick prevention, no bathing and 20-minute child/contact restriction add substantial workflow.

Full-course cost-effectiveness-

No verified current Georgian patient-adjusted full-course price is available, so cost is excluded.

Important safety and use flags

  • Veterinary prescription medicine authorised for dogs in GB and EU national markets. Exact-product registers dated 2026-10-15 record it as not authorised in Georgia and the US; this does not negate the GB/EU dossier.
  • Use only when cytology and organism identification show a focal mixed infection: susceptible Pseudomonas or Staphylococcus plus susceptible Malassezia. Do not use for empiric, bacterial-only, yeast-only, diffuse, deep, sterile or noninfectious disease.
  • Marbofloxacin is an EMA category B Restrict fluoroquinolone. Prefer a suitable antiseptic or narrower option; use culture/susceptibility, avoid quinolone-resistant isolates and stop unnecessary components as soon as the mixed indication no longer exists.
  • Clean, clip and remove exudate/debris before dosing. Treat two sprays per 25 cm² twice daily; split larger lesions into measured zones and never exceed four zones simultaneously.
  • Treat seven days and reassess. Continue only if still indicated, never beyond 14 days; persistent infection after day 14 requires diagnosis and a different appropriate product, not automatic extension.
  • Avoid eyes, mucosa, open lesions and wounds. Prevent self- and cross-licking, separate treated dogs when needed, keep hair short and do not bathe or shampoo during administration.
  • Not recommended in pregnancy or lactation; safety is unestablished and ketoconazole was teratogenic/embryotoxic in laboratory animals. Avoid known hypersensitivity to any active or excipient.
  • Prolonged or intensive topical prednisolone can thin epidermis, delay healing and suppress adrenal function. Monitor erythema, irritation, delayed repair and systemic glucocorticoid signs, especially with multiple zones or comorbidity.
  • Avoid concurrent low-pH products because they may inhibit marbofloxacin. No interaction studies establish combined-product safety or efficacy; review every topical/systemic antimicrobial, antifungal and corticosteroid.
  • Handler safety: wear single-use impermeable gloves, spray outdoors or with good ventilation, avoid inhalation/skin/eye contact and flames, and do not let children touch the dog until dry for at least 20 minutes. Pregnant people or those trying to conceive must not administer it.
Assessment sources
  1. Gefriderm UK SPC2026
  2. Gefriderm VMD record2026
  3. Gefriderm EU record2026
  4. Gefriderm EU PuAR2020
  5. ISCAID canine pyoderma 20252025
  6. MSD pyoderma2025
  7. EMA AMEG category B2025
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Marbofloxacin1.025 mg/ml Ketoconazole2.041 mg/ml Prednisolone0.926 mg/ml
Formulation Type
Aerosol / spray
Administration route
On the skin
Manufacturer
ALPHAVET Zrt. · Hungary
Registration
Georgia No
Not registered in Georgia
Veterinary (National Food Agency)
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 22 Oct 2026
 UK Yes, veterinary
№ Vm 51645/4000
Verified on: 22 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
Information not fully verified Clean/clip and remove exudate/debris; shake and hold 10 cm away. Apply two sprays per 25 cm² twice daily for seven days. If unresolved at day 7, continue only to day 14. Divide larger lesions into 25 cm² zones; maximum four zones simultaneously. Re-evaluate and change treatment if infection persists after 14 days.

Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

For veterinary professionals only. It does not replace clinical judgement or the product label; check the dose in the official label (SPC). vetman is not liable for harm caused by using this information.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 23 Oct 2026

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The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

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