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Active substance

Ketoprofen

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Propionic acid NSAID (non-selective).

Safety

Overdose

Used in veterinary practice at veterinary doses; human tablets and gels are much stronger and cannot be dosed accurately for an animal. The table shows where harm has been described after a single ingestion, mg per kg of body weight: overdose thresholds, not treatment doses.

Species Signs begin Severe Deaths reported Source
Dog not established not established not established
EMA CVMP 1995
Low confidence
No published ingestion data; only an old regulatory LD50.
Guideline or consensus statement
Guidance from the scientific committees of the European Medicines Agency (EMA).
Ketoprofen: summary report (EMEA/MRL/020/95)
European Medicines Agency, Committee for Veterinary Medicinal Products, EMEA/MRL/020/95, 1995
LD50 about 500 mg/kg in single-dose studies of several species
Cat not established not established not established
Takata et al. 2012
Low confidence
One experimental study at a therapeutic dose; no ingestion data.
Scientific article
A study or review published in a scientific journal. Its findings apply to the animals and conditions it studied.
Comparison of gastrointestinal adverse effects of ketoprofen between adult and young cats
Journal of Veterinary Medical Science, J Vet Med Sci 2012;74(12):1545-1550, 2012
2 mg/kg a day for 3 days: stomach lesions in adult cats

Dog

Signs: Vomiting, blood in vomit or black stool, bloody diarrhoea, abdominal pain, lethargy, kidney injury, possible liver injury.

Ketoprofen is authorised for dogs in the EU (veterinary injection and tablets, EU Union Product Database). Human tablets, capsules and gels hold far more than a dose for a dog and are no substitute; an accidental ingestion of one should be checked by a veterinarian. No ingestion threshold has been published (single-dose LD50 studies: about 500 mg/kg).

Cat

Signs: Vomiting, stomach ulceration, anorexia, acute kidney injury.

Ketoprofen is authorised for cats in the EU (veterinary injection and tablets, EU Union Product Database). Cats are sensitive to NSAIDs: in one study 2 mg/kg a day for 3 days caused stomach lesions in adult cats. Human tablets are too strong to dose accurately for a cat. No ingestion threshold is established.

Dose and use

Doses

Each dose comes with its source. Check the label of the product you use.

Active substance Ketoprofen
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
1 mg/kg Dog, Cat Maintenance By mouth once daily, 3-5 days
Source: EMA UPD SPC 2017
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
KETOFEN 5 mg comprimés (kétoprofène) chats et petits chiens - RCP (Belgique)
EU Union Product Database, 2017
2 mg/kg Dog, Cat Maintenance Intravenous / Intramuscular / Subcutaneous once daily, 1-3 days
Source: EMA UPD SPC 2017
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
KETOFEN 1% solution injectable (kétoprofène 10 mg/ml) chien et chat - RCP (Belgique)
EU Union Product Database, 2017
Before use

Safety information

Known Contraindications

  • Critical
    Do not use with gastro-duodenal ulcers.
    Sources: Belgian SPC
  • Critical
    Do not use with bleeding disorders.
    Sources: Belgian SPC
  • Critical
    Do not use with renal insufficiency.
    Sources: Belgian SPC
  • Critical
    Do not use with hepatic insufficiency.
    Sources: Belgian SPC
  • Critical
    Do not use with cardiac insufficiency.
    Sources: Belgian SPC
  • Critical
    Do not use with known allergy to ketoprofen.
    Sources: Belgian SPC
  • Critical
    Do not use in dehydrated, hypovolaemic or hypotensive animals: renal toxicity rises.
    Sources: Belgian SPC
  • Warning
    Animals under 6 weeks and old animals: extra risk, monitor closely.
    Sources: Belgian SPC
  • Warning
    Do not combine with other NSAIDs, corticosteroids, diuretics or anticoagulants; avoid nephrotoxic drugs such as aminoglycosides.
    Sources: Belgian SPC

Known Drug Interactions

  • Contraindicated Robenacoxib + Ketoprofen
    Do not give robenacoxib together with other non-steroidal anti-inflammatory drugs or glucocorticoids because adverse gastrointestinal and renal effects may increase.
    Recommendation: Do not use these drugs together. Allow a treatment-free interval of at least 24 hours after the previous anti-inflammatory drug, extending it when required by that drug’s pharmacokinetics.
Latin name
Ketoprofen
Georgian name
კეტოპროფენი
Human medicines in Georgia
Artrocol, Fastenal, Fastum, Kefentech, Keto-Gel, ketoclin Plaster, KetoFLEX, Ketonal, Ketonal DUO, Ketonal Extra Plus, Ketonal forte, Solket
Human medicines with this substance in the Georgian register of medicines (Ministry of Health), checked on 18 Oct 2026. They are human medicines, not veterinary products; strengths and forms differ.

Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

For veterinary professionals only. It does not replace clinical judgement or the product label; check the dose in the official label (SPC). vetman is not liable for harm caused by using this information.

Trademarks belong to their owners; vetman is not affiliated with the manufacturers and receives no payment from them.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 19 Oct 2026

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The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

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