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Metoclopramide
D2 antagonist prokinetic. Registered in Georgia: 7 human medicines. Forms: solution, tablet.
Doses
Each dose comes with its source. Check the label of the product you use.
| Dose | Species | Indication | Route | Frequency | Source |
|---|---|---|---|---|---|
| 0.25–0.5 mg/kg | Dog, Cat | Reduced Gastrointestinal Motility; Vomiting | By mouth / Intravenous / Intramuscular / Subcutaneous | 2 times daily |
VMD SPC 2025
Official product label (SPC), VMD, UK Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there. UK Veterinary Medicines Directorate, Product Information Database, 2025 VMD SPC 2025
Official product label (SPC), VMD, UK Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there. UK Veterinary Medicines Directorate, Product Information Database, 2025 |
| 0.5 mg/kg | Dog, Cat | Vomiting | Intramuscular / Subcutaneous | every 6-8 hours |
VMD SPC 2025
Official product label (SPC), VMD, UK Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there. UK Veterinary Medicines Directorate, Product Information Database, 2025 |
Safety information
Known Contraindications
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Critical
Do not use metoclopramide in patients with gastrointestinal perforation or obstruction. Its prokinetic action can worsen these conditions.Sources: Product label
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Critical
Do not use metoclopramide in patients with gastrointestinal haemorrhage.Sources: Product label
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Critical
Known hypersensitivity to the active substance or any excipient is an absolute contraindication on all four reviewed labels. The injectable Emeprid formulation contains metacresol (2 mg/mL) as an excipient.Sources: Product label
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Warning
Avoid metoclopramide in animals with epilepsy, other seizure disorders, or head trauma because it crosses the blood-brain barrier and may lower the seizure threshold.Sources: Product label
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Warning
Reduce or otherwise adjust the metoclopramide dose in renal insufficiency because accumulation increases the risk of adverse effects, including extrapyramidal reactions. The product labels do not specify a fixed reduction percentage.Sources: Product label
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Warning
Reduce the dose in hepatic impairment, as recommended for renal impairment. Metoclopramide is metabolized in the liver.
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Warning
Do not use metoclopramide in animals with pheochromocytoma because it may provoke a hypertensive crisis.Sources: Product label
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Warning
Measure metoclopramide doses especially carefully in cats and small-breed dogs. Severe extrapyramidal or other neurological reactions are very rare but may require medical treatment.Sources: Product label
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Warning
Safety of metoclopramide in the target species during pregnancy and lactation has not been established. Use only after a veterinarian has assessed the individual benefit and risk.Sources: Product label
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Warning
After prolonged vomiting, consider fluid and electrolyte replacement. Metoclopramide controls the symptom but does not treat dehydration.Sources: Product label
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Warning
(Dog) Avoid metoclopramide in dogs with pseudopregnancy because dopamine D2 antagonism increases prolactin and may worsen clinical signs.Sources: Product label
Known Drug Interactions
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Major warning
Acepromazine + Metoclopramide
Concomitant use with phenothiazine neuroleptics such as acepromazine or with butyrophenones increases the risk of extrapyramidal effects: agitation, ataxia, tremor, abnormal movements, vocalization, and aggression. Both agents block D2 receptors, producing an additive effect.Recommendation: Avoid the combination where possible. If necessary, use the lowest metoclopramide dose and monitor the animal. Effects are transient and resolve after treatment stops; there is no specific antidote, and a quiet environment is recommended.
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Minor warning
Metoclopramide + Atropine
In animals with gastritis, avoid giving anticholinergic drugs such as atropine with metoclopramide because they can oppose its effect on gastrointestinal motility.Recommendation: Avoid the combination in gastritis because the anticholinergic can oppose metoclopramide. Concomitant diarrhoea alone is not a contraindication to anticholinergic treatment.Sources: Product label
All forms and registration7
Registration in Georgia and abroad: the register, number, validity and source are behind (i).
Metoclopramide-Darnitsa 5 mg/ml, Solution
Metoclopramide Borisov 5 mg/ml, Solution
Metoclopramide Ferein 5 mg/ml, Solution
Metoclopramide Slavia 10 mg, Tablet
Metpamid 10 mg/2 ml, Solution
Turktipsan Metoclopramide 10 mg/2 ml, Solution
Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.
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