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Naproxen
Propionic acid NSAID (non-selective). Toxic doses for dog, cat from published sources; they are not treatment doses.
Toxic doses
Single acute ingestion, mg of the substance per kg of body weight. These are toxic doses, not treatment doses.
| Species | Signs begin | Severe | Deaths reported | Source |
|---|---|---|---|---|
| Dog | from 5 mg/kg | from 13 mg/kg | not established |
DeClementi 2013 (ASPCA APCC) · Chalifoux et al. 2023 +1
Medium confidence
Poison-centre data and a clinical study; sources differ (kidney from 13 or from 25 mg/kg), the lower figure is shown. Scientific article A study or review published in a scientific journal. Its findings apply to the animals and conditions it studied. dvm360, Toxicology brief, 2013 GI signs from 7, kidney from about 13-15, half-life about 74 h Scientific article A study or review published in a scientific journal. Its findings apply to the animals and conditions it studied. Journal of Veterinary Internal Medicine, JVIM 2023;37(1):161-172, 2023 GI over 5, kidney over 25, CNS over 50 (textbook thresholds) Reference book A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose. MSD Veterinary Manual, Professional version, reviewed Jul 2024, 2024 repeated 5.6 mg/kg for a week, single 35 mg/kg |
| Cat | not established | from 10 mg/kg | not established |
ASPCA APCC: feline exposures · MSD Vet Manual 2024
Low confidence
Poison-centre guidance only: low to medium confidence. Guideline or consensus statement Recommendations agreed by a panel of veterinary specialists after reviewing the evidence. They guide practice and do not authorise a product. ASPCApro (ASPCA Animal Poison Control Center), Poison-centre guidance kidney problems at 10 (poison-centre guidance) Reference book A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose. MSD Veterinary Manual, Professional version, reviewed Jul 2024, 2024 cats probably more sensitive |
Dog
Signs: Vomiting, black stool or blood in vomit, abdominal pain, anaemia, lethargy, kidney injury; nervous-system signs from about 50 mg/kg.
Half-life in dogs is about 74 hours (enterohepatic recirculation), so small doses accumulate; one 220 mg tablet matters even for a large dog. Repeated 5.6 mg/kg for a week caused black stool and pallor.
Cat
Signs: Vomiting, black stool or blood in vomit, abdominal pain, anorexia, kidney injury.
Cat data are scarce; cats are thought to be more sensitive than dogs. Treat any ingestion as significant.
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