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Lead
lead paint, shot, fishing weights
A professional reference for veterinary specialists. It does not replace clinical judgement.
Species and toxic dose
| Species | Risk | Toxic dose |
|---|---|---|
| Dog | Toxic | Lowest reported single lethal dose 300 mg/kg; chronic effects from about 1-3.3 mg/kg a day. Scientific article A study or review published in a scientific journal. Its findings apply to the animals and conditions it studied. |
| Cat | Toxic | Not established in the open sources |
Toxic principle
Lead binds protein thiol groups, takes the place of calcium and inhibits haem synthesis; it damages neurons. Stomach acid increases absorption, which is 5-15% in adults and up to 50% in the young.
Onset
Acute and chronic forms; the sources give no timeline.
Clinical signs
Digestive: vomiting, diarrhoea, colic, loss of appetite. Nervous: behaviour change, ataxia, tremors, intermittent seizures. Weight loss. Anaemia with basophilic stippling and nucleated red cells; blood lead of 40-60 µg/dl or more supports the diagnosis.
Organs affected
Digestive tract, central nervous system, blood, kidneys, bone.
Treatment principle (for veterinarians)
Remove lead from the gut before chelation (emesis, lavage, cathartics, enema, endoscopy or surgery); activated charcoal does not bind lead. Benzodiazepines for seizures. Chelation with calcium EDTA or succimer; penicillamine and dimercaprol are alternatives.
In the reference: Diazepam
A summary of the principles in the sources, not a protocol: doses and the plan are the treating veterinarian's decision.
Sources
Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.
For veterinary professionals only. It does not replace clinical judgement or the product label; check the dose in the official label (SPC). vetman is not liable for harm caused by using this information.
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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 22 Oct 2026