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Alburex

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Albumin (human) · CSL Behring

1 form: solution. In force in Georgia: 1 of 1 (human register).

Forms and doses1 of 1 in force in Georgia

Form Dose Frequency Georgia
20%, Solution No label dose in the reference yet - Georgia Yes, human
In force until 31 Aug 2028
Human (Ministry of Health, RAMA)
In the register: ალბურექსი 20%, საინფუზიო ხსნარი
№ რ-038959, რ-038960
Verified on: 16 Oct 2026
Details: pack, label wording, sources, registration

Alburex 20%, Solution

solution for infusion, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog IV human albumin for severe or worsening hypoalbuminaemia with clinically important oedema, effusion or oncotic failure when species-specific albumin is unavailable and ICU risk-benefit assessment favours xenoprotein exposure
5.1/10
Weak evidence support
vetman assessment

Alburex

20%, solution for infusion, human medicine
Assessed clinical scopeDog · IV human albumin for severe or worsening hypoalbuminaemia with clinically important oedema, effusion or oncotic failure when species-specific albumin is unavailable and ICU risk-benefit assessment favours xenoprotein exposure · Intravenous
Care settingICU infusion with continuous cardiorespiratory and volume observation, serial albumin, haematocrit, electrolyte and urine-output checks, immediate reaction capability and delayed immune follow-up
vetman score 5.1/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, human · № რ-038959, რ-038960 · Verified on 16 Oct 2026 Off-label use

A weak, specialist rescue option rather than routine albumin replacement. The exact 20% product is transparent as a human blood product, but veterinary benefit and dosing are extrapolated and hyperoncotic xenoprotein safety is concerning; prefer species-specific albumin in dogs, treat the cause, and do not copy a 5% volume regimen.

Regulatory and scientific credibility6.5/10

The exact human product has sourced current registrations in Georgia, EU/EEA and GB, an identifiable plasma-derived composition and an accessible exact SmPC; current US checking records no exact registration. Veterinary use is off-label and human-product authorisation does not validate xenoprotein use in dogs or cats.

Clinical efficacy5.5/10

Hyperoncotic 25% HSA increased albumin, total protein and colloid osmotic pressure in retrospective canine septic-peritonitis data, without proving shorter stay or survival benefit. Applying that evidence to an exact 20% product is a concentration transfer; species-specific albumin remains preferred and treatment of the underlying protein loss is essential.

Safety and tolerability3.5/10

This hyperoncotic human xenoprotein sits close to the 25% preparations associated with anti-HSA antibodies, acute reactions, delayed type-III disease and deaths in dogs. Exact 20% veterinary safety and repeat-exposure data are absent; severe anaemia, cardiac/renal vulnerability, capillary leak, sodium load, volume expansion and transfusion traceability materially constrain use.

Clinical practicality4.5/10

The small-volume 20% presentation is physically convenient but has no directly validated veterinary regimen. Individual calculation, possible aseptic dilution with compatible crystalloid, strict rate and haemodynamic monitoring, single-use wastage and weeks of delayed-reaction surveillance make it specialist-only and error-sensitive; the 5% ml/kg protocol cannot be copied directly.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use human albumin in a healthy or normoalbuminaemic animal, as a nutritional protein source, for routine crystalloid replacement or merely to normalize a laboratory albumin value. Restrict consideration to critical illness in which severe or worsening hypoalbuminaemia is causing clinically important oncotic consequences.
  • Establish any previous human-albumin exposure before treatment. Dogs develop anti-human-albumin antibodies, and repeat infusion may provoke a more severe acute or delayed reaction; avoid repeat exposure unless a compelling life-saving benefit clearly outweighs this risk.
  • Be prepared to stop the infusion and treat anaphylaxis immediately. Warn the owner about delayed type-III disease 5–13 days later—fever, lethargy, lameness, oedema, vomiting, skin lesions or vasculitis—and arrange surveillance for at least four weeks; fatal canine cases are reported.
  • Prefer species-specific albumin for dogs when it is genuinely available. Human serum albumin is a xenoprotein in dogs and cats; document the rescue rationale and informed-owner discussion rather than presenting human-product availability as evidence of veterinary equivalence.
  • Treat the cause of albumin loss or reduced synthesis and define a clinical endpoint such as improving oedema, effusion, perfusion or oncotic status. A higher serum albumin concentration is a surrogate; available veterinary studies do not prove that numeric correction alone improves survival.
  • Individualize dose and rate from volume status and ongoing losses, not serum albumin alone. Monitor blood pressure, pulse, respiration, urine output, electrolytes, haematocrit/haemoglobin and signs of pulmonary or peripheral fluid overload throughout infusion.
  • Do not infuse in severe anaemia or cardiac failure with normal or increased intravascular volume. Use exceptional caution with renal disease, capillary leak or any state in which hypervolaemia, haemodilution or sodium load can worsen organ function.
  • Never dilute human albumin with sterile water because haemolysis may result. Use only a compatible isotonic diluent when dilution is required; do not mix the product with other medicinal products, whole blood or packed red cells in the same container or line.
  • Record the exact product and batch, inspect the solution, maintain asepsis and discard unused single-use remainder. Donor screening and viral inactivation reduce but cannot eliminate transmission of known, emerging or unknown agents from a human plasma-derived product.
  • No directly validated dog or cat regimen exists for this exact 20% concentration. Do not copy the 5% ml/kg volume: 20% contains four times as much albumin per millilitre. Direct hyperoncotic use or dilution requires an ICU specialist calculation; 20–25% xenoprotein evidence includes serious delayed immune injury.
Assessment sources
  1. Human albumin market audit2026
  2. Albunorm 5% SmPC2023
  3. Alburex 20 SmPC2018
  4. AAHA fluid therapy 20242024
  5. 5% HSA in 588 patients2010
  6. Viganó et al. 20192019
  7. Viganó et al. 20222022
  8. Cohn et al. 20072007
  9. Francis et al. 20072007
  10. 25% HSA in septic peritonitis2015
  11. 25% HSA risk-benefit review2008
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat IV human albumin for severe or worsening hypoalbuminaemia with clinically important oedema, effusion or oncotic failure when species-specific albumin is unavailable and ICU risk-benefit assessment favours xenoprotein exposure
4.8/10
Weak evidence support
vetman assessment

Alburex

20%, solution for infusion, human medicine
Assessed clinical scopeCat · IV human albumin for severe or worsening hypoalbuminaemia with clinically important oedema, effusion or oncotic failure when species-specific albumin is unavailable and ICU risk-benefit assessment favours xenoprotein exposure · Intravenous
Care settingICU infusion with continuous cardiorespiratory and volume observation, serial albumin, haematocrit, electrolyte and urine-output checks, immediate reaction capability and delayed immune follow-up
vetman score 4.8/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, human · № რ-038959, რ-038960 · Verified on 16 Oct 2026 Off-label use

A weak, specialist rescue option rather than routine albumin replacement. The exact 20% product is transparent as a human blood product, but veterinary benefit and dosing are extrapolated and hyperoncotic xenoprotein safety is concerning; prefer species-specific albumin in dogs, treat the cause, and do not copy a 5% volume regimen.

Regulatory and scientific credibility6.5/10

The exact human product has sourced current registrations in Georgia, EU/EEA and GB, an identifiable plasma-derived composition and an accessible exact SmPC; current US checking records no exact registration. Veterinary use is off-label and human-product authorisation does not validate xenoprotein use in dogs or cats.

Clinical efficacy4.5/10

Cats have useful but uncontrolled 5% HSA data; evidence for direct hyperoncotic 20–25% treatment is sparse and does not establish an outcome advantage. Applying canine/review evidence to an exact 20% feline infusion is a substantial transfer, while species-specific feline albumin is unavailable and cause-directed care remains primary.

Safety and tolerability3.5/10

This hyperoncotic human xenoprotein sits close to the 25% preparations associated with anti-HSA antibodies, acute reactions, delayed type-III disease and deaths in dogs. Exact 20% veterinary safety and repeat-exposure data are absent; severe anaemia, cardiac/renal vulnerability, capillary leak, sodium load, volume expansion and transfusion traceability materially constrain use.

Clinical practicality4.5/10

The small-volume 20% presentation is physically convenient but has no directly validated veterinary regimen. Individual calculation, possible aseptic dilution with compatible crystalloid, strict rate and haemodynamic monitoring, single-use wastage and weeks of delayed-reaction surveillance make it specialist-only and error-sensitive; the 5% ml/kg protocol cannot be copied directly.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use human albumin in a healthy or normoalbuminaemic animal, as a nutritional protein source, for routine crystalloid replacement or merely to normalize a laboratory albumin value. Restrict consideration to critical illness in which severe or worsening hypoalbuminaemia is causing clinically important oncotic consequences.
  • Establish any previous human-albumin exposure before treatment. Dogs develop anti-human-albumin antibodies, and repeat infusion may provoke a more severe acute or delayed reaction; avoid repeat exposure unless a compelling life-saving benefit clearly outweighs this risk.
  • Be prepared to stop the infusion and treat anaphylaxis immediately. Warn the owner about delayed type-III disease 5–13 days later—fever, lethargy, lameness, oedema, vomiting, skin lesions or vasculitis—and arrange surveillance for at least four weeks; fatal canine cases are reported.
  • Prefer species-specific albumin for dogs when it is genuinely available. Human serum albumin is a xenoprotein in dogs and cats; document the rescue rationale and informed-owner discussion rather than presenting human-product availability as evidence of veterinary equivalence.
  • Treat the cause of albumin loss or reduced synthesis and define a clinical endpoint such as improving oedema, effusion, perfusion or oncotic status. A higher serum albumin concentration is a surrogate; available veterinary studies do not prove that numeric correction alone improves survival.
  • Individualize dose and rate from volume status and ongoing losses, not serum albumin alone. Monitor blood pressure, pulse, respiration, urine output, electrolytes, haematocrit/haemoglobin and signs of pulmonary or peripheral fluid overload throughout infusion.
  • Do not infuse in severe anaemia or cardiac failure with normal or increased intravascular volume. Use exceptional caution with renal disease, capillary leak or any state in which hypervolaemia, haemodilution or sodium load can worsen organ function.
  • Never dilute human albumin with sterile water because haemolysis may result. Use only a compatible isotonic diluent when dilution is required; do not mix the product with other medicinal products, whole blood or packed red cells in the same container or line.
  • Record the exact product and batch, inspect the solution, maintain asepsis and discard unused single-use remainder. Donor screening and viral inactivation reduce but cannot eliminate transmission of known, emerging or unknown agents from a human plasma-derived product.
  • No directly validated dog or cat regimen exists for this exact 20% concentration. Do not copy the 5% ml/kg volume: 20% contains four times as much albumin per millilitre. Direct hyperoncotic use or dilution requires an ICU specialist calculation; 20–25% xenoprotein evidence includes serious delayed immune injury.
Assessment sources
  1. Human albumin market audit2026
  2. Albunorm 5% SmPC2023
  3. Alburex 20 SmPC2018
  4. AAHA fluid therapy 20242024
  5. 5% HSA in 588 patients2010
  6. Viganó et al. 20192019
  7. Viganó et al. 20222022
  8. Cohn et al. 20072007
  9. Francis et al. 20072007
  10. 25% HSA in septic peritonitis2015
  11. 25% HSA risk-benefit review2008
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Albumin (human)200 mg/ml
Formulation Type
Solution
Administration route
Intravenous
Manufacturer
CSL Behring · United States
Registration
Georgia Yes, human
In force until 31 Aug 2028
Human (Ministry of Health, RAMA)
In the register: ალბურექსი 20%, საინფუზიო ხსნარი
№ რ-038959, რ-038960
Verified on: 16 Oct 2026
 EU Yes, human
Verified on: 16 Oct 2026
 UK Yes, human
№ PL150360031, PL150360032
Verified on: 16 Oct 2026
 US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Albumin (human): No dose supported by a publicly verifiable source yet

Known Contraindications

  • Critical
    Repeat administration carries a separate and greater risk; always establish whether the patient has received human albumin previously. In a study of 9 healthy dogs given 25% human albumin, all 9 developed antibodies and 8 had a positive intradermal test. One dog had an anaphylactoid reaction during the first infusion; both of the 2 dogs that received a second infusion reacted. The first exposure can sensitize the patient.
  • Critical
    A reaction may be delayed, so an uneventful infusion does not establish safety. In a study of 6 healthy dogs, all 6 developed delayed reactions between days 5 and 13, including lethargy, lameness, oedema, cutaneous vasculitis, vomiting, and anorexia; 2 died despite treatment. Warn the owner about signs to watch for at home and monitor the patient weekly for at least 1 month. In a series of 73 critically ill dogs, 23% had at least one complication during or immediately after infusion and 4% had a severe delayed complication.
  • Critical
    Do not dilute with sterile water for injection as this may cause hemolysis in recipients. Do not add supplementary medication.
    Sources: FDA
  • Critical
    Severe anemia or cardiac failure with normal or increased intravascular volume.
    Sources: FDA
  • Critical
    Severe anemia or cardiac failure with normal or increased intravascular volume.
    Sources: FDA
  • Critical
    Hypersensitivity to albumin preparations or to any of the excipients.
    Sources: FDA
  • Warning
    Use with caution in conditions where hypervolemia and its consequences or hemodilution could represent a special risk to the patient.
    Sources: FDA
  • Warning
    Use cautiously in renal disease. Volume loading and haemodilution are both risks, and delayed type III hypersensitivity associated with acute kidney injury has been reported in 2 dogs. Monitor urine output during infusion and creatinine during the following weeks.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 16 Oct 2026

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The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

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