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Albunorm

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Albumin (human) · Octapharma

1 form: solution. In force in Georgia: 1 of 1 (human register).

Forms and doses1 of 1 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Dose Frequency Georgia
5%, Solution · Cat Cat 10–20 ml/kg
unlike previous findings with 25% HSA in this species.
 · once, at a rate of 2 mL/kg/h		 once, at a rate of 2 mL/kg/h Georgia Yes, human
In force until 21 Feb 2028
Human (Ministry of Health, RAMA)
№ რ-037378
Verified on: 15 Oct 2026
5%, Solution · Dog Dog 2–20.5 ml/kg
Infusion rate is as important as dose. In a prospective series of 73 critically ill dogs, 5% human albumin was given at 2.0–20.56 mL/kg using a uniform rate of 2.0 mL/kg/hour, with no type I or III hypersensitivity signs through day 28. Distinguishing features were the 5%, not 25%, solution, controlled rate, and hypoalbuminaemic critically ill patients. Determine the patient dose from albumin deficit and target colloid osmotic pressure, not a fixed value. Do not administer to healthy normoalbuminaemic animals. If available, canine-specific albumin 1 g/kg avoids foreign-protein exposure.
 · once, at a rate of 2 mL/kg/h		 once, at a rate of 2 mL/kg/h Georgia Yes, human
In force until 21 Feb 2028
Human (Ministry of Health, RAMA)
№ რ-037378
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Albunorm 5%, Solution

solution for infusion, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog IV human albumin for severe or worsening hypoalbuminaemia with clinically important oedema, effusion or oncotic failure when species-specific albumin is unavailable and ICU risk-benefit assessment favours xenoprotein exposure
6.0/10
Situational / acceptable
vetman assessment

Albunorm

5%, solution for infusion, human medicine
Assessed clinical scopeDog · IV human albumin for severe or worsening hypoalbuminaemia with clinically important oedema, effusion or oncotic failure when species-specific albumin is unavailable and ICU risk-benefit assessment favours xenoprotein exposure · Intravenous
Care settingICU infusion with continuous cardiorespiratory and volume observation, serial albumin, haematocrit, electrolyte and urine-output checks, immediate reaction capability and delayed immune follow-up
vetman score 6.0/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-037378 · Verified on 15 Oct 2026 Off-label use

A situational ICU xenoprotein option when severe hypoalbuminaemia is causing clinical oncotic failure and species-specific albumin is unavailable. Five-percent evidence is more reassuring than hyperoncotic evidence but remains uncontrolled for outcome; obtain informed consent, monitor intensively, avoid routine numeric correction and arrange delayed immune follow-up.

Regulatory and scientific credibility6.5/10

The exact human product has sourced current registrations in Georgia, EU/EEA and GB, an identifiable plasma-derived composition and an accessible exact SmPC; current US checking records no exact registration. Veterinary use is off-label and human-product authorisation does not validate xenoprotein use in dogs or cats.

Clinical efficacy6.0/10

Five-percent HSA raised albumin in a retrospective series of 418 dogs and 170 cats, but the uncontrolled design, absent long-term follow-up and lack of a species-albumin comparator prevent a proven survival benefit. Current AAHA guidance allows HSA in selected dogs or cats while preferring species-specific albumin and noting that correction of albumin concentration has not been linked reliably to improved outcome.

Safety and tolerability5.5/10

Prospective follow-up found no clinical type-I or type-III hypersensitivity after controlled 5% HSA in 73 ill dogs and 40 ill cats, and the 588-patient retrospective series reported no severe in-hospital reaction. HSA nevertheless remains a foreign protein: other concentrations caused antibodies, anaphylactoid reactions, delayed vasculitis, organ injury and deaths, especially in healthy or repeat-exposed dogs; volume overload and human blood-product risks also require active control.

Clinical practicality6.0/10

The 5% solution is ready for a peripheral controlled infusion and matches the concentration used in the largest dog/cat series, but typical 20 ml/kg daily volumes, slow administration, continuous monitoring, single-use handling and delayed follow-up create substantial ICU workload and may be unsuitable in patients at risk of fluid overload.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use human albumin in a healthy or normoalbuminaemic animal, as a nutritional protein source, for routine crystalloid replacement or merely to normalize a laboratory albumin value. Restrict consideration to critical illness in which severe or worsening hypoalbuminaemia is causing clinically important oncotic consequences.
  • Establish any previous human-albumin exposure before treatment. Dogs develop anti-human-albumin antibodies, and repeat infusion may provoke a more severe acute or delayed reaction; avoid repeat exposure unless a compelling life-saving benefit clearly outweighs this risk.
  • Be prepared to stop the infusion and treat anaphylaxis immediately. Warn the owner about delayed type-III disease 5–13 days later—fever, lethargy, lameness, oedema, vomiting, skin lesions or vasculitis—and arrange surveillance for at least four weeks; fatal canine cases are reported.
  • Prefer species-specific albumin for dogs when it is genuinely available. Human serum albumin is a xenoprotein in dogs and cats; document the rescue rationale and informed-owner discussion rather than presenting human-product availability as evidence of veterinary equivalence.
  • Treat the cause of albumin loss or reduced synthesis and define a clinical endpoint such as improving oedema, effusion, perfusion or oncotic status. A higher serum albumin concentration is a surrogate; available veterinary studies do not prove that numeric correction alone improves survival.
  • Individualize dose and rate from volume status and ongoing losses, not serum albumin alone. Monitor blood pressure, pulse, respiration, urine output, electrolytes, haematocrit/haemoglobin and signs of pulmonary or peripheral fluid overload throughout infusion.
  • Do not infuse in severe anaemia or cardiac failure with normal or increased intravascular volume. Use exceptional caution with renal disease, capillary leak or any state in which hypervolaemia, haemodilution or sodium load can worsen organ function.
  • Never dilute human albumin with sterile water because haemolysis may result. Use only a compatible isotonic diluent when dilution is required; do not mix the product with other medicinal products, whole blood or packed red cells in the same container or line.
  • Record the exact product and batch, inspect the solution, maintain asepsis and discard unused single-use remainder. Donor screening and viral inactivation reduce but cannot eliminate transmission of known, emerging or unknown agents from a human plasma-derived product.
  • The reassuring veterinary evidence is tied to controlled 5% HSA in critically ill hypoalbuminaemic patients. Preserve the studied concentration, rate and monitoring context; absence of observed reactions does not establish safety for healthy animals, repeat exposure or rapid infusion.
Assessment sources
  1. Human albumin market audit2026
  2. Albunorm 5% SmPC2023
  3. Alburex 20 SmPC2018
  4. AAHA fluid therapy 20242024
  5. 5% HSA in 588 patients2010
  6. Viganó et al. 20192019
  7. Viganó et al. 20222022
  8. Cohn et al. 20072007
  9. Francis et al. 20072007
  10. 25% HSA in septic peritonitis2015
  11. 25% HSA risk-benefit review2008
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat IV human albumin for severe or worsening hypoalbuminaemia with clinically important oedema, effusion or oncotic failure when species-specific albumin is unavailable and ICU risk-benefit assessment favours xenoprotein exposure
6.0/10
Situational / acceptable
vetman assessment

Albunorm

5%, solution for infusion, human medicine
Assessed clinical scopeCat · IV human albumin for severe or worsening hypoalbuminaemia with clinically important oedema, effusion or oncotic failure when species-specific albumin is unavailable and ICU risk-benefit assessment favours xenoprotein exposure · Intravenous
Care settingICU infusion with continuous cardiorespiratory and volume observation, serial albumin, haematocrit, electrolyte and urine-output checks, immediate reaction capability and delayed immune follow-up
vetman score 6.0/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-037378 · Verified on 15 Oct 2026 Off-label use

A situational ICU xenoprotein option when severe hypoalbuminaemia is causing clinical oncotic failure and species-specific albumin is unavailable. Five-percent evidence is more reassuring than hyperoncotic evidence but remains uncontrolled for outcome; obtain informed consent, monitor intensively, avoid routine numeric correction and arrange delayed immune follow-up.

Regulatory and scientific credibility6.5/10

The exact human product has sourced current registrations in Georgia, EU/EEA and GB, an identifiable plasma-derived composition and an accessible exact SmPC; current US checking records no exact registration. Veterinary use is off-label and human-product authorisation does not validate xenoprotein use in dogs or cats.

Clinical efficacy6.0/10

Five-percent HSA raised albumin in a retrospective series of 418 dogs and 170 cats, but the uncontrolled design, absent long-term follow-up and lack of a species-albumin comparator prevent a proven survival benefit. Current AAHA guidance allows HSA in selected dogs or cats while preferring species-specific albumin and noting that correction of albumin concentration has not been linked reliably to improved outcome.

Safety and tolerability5.5/10

Prospective follow-up found no clinical type-I or type-III hypersensitivity after controlled 5% HSA in 73 ill dogs and 40 ill cats, and the 588-patient retrospective series reported no severe in-hospital reaction. HSA nevertheless remains a foreign protein: other concentrations caused antibodies, anaphylactoid reactions, delayed vasculitis, organ injury and deaths, especially in healthy or repeat-exposed dogs; volume overload and human blood-product risks also require active control.

Clinical practicality6.0/10

The 5% solution is ready for a peripheral controlled infusion and matches the concentration used in the largest dog/cat series, but typical 20 ml/kg daily volumes, slow administration, continuous monitoring, single-use handling and delayed follow-up create substantial ICU workload and may be unsuitable in patients at risk of fluid overload.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use human albumin in a healthy or normoalbuminaemic animal, as a nutritional protein source, for routine crystalloid replacement or merely to normalize a laboratory albumin value. Restrict consideration to critical illness in which severe or worsening hypoalbuminaemia is causing clinically important oncotic consequences.
  • Establish any previous human-albumin exposure before treatment. Dogs develop anti-human-albumin antibodies, and repeat infusion may provoke a more severe acute or delayed reaction; avoid repeat exposure unless a compelling life-saving benefit clearly outweighs this risk.
  • Be prepared to stop the infusion and treat anaphylaxis immediately. Warn the owner about delayed type-III disease 5–13 days later—fever, lethargy, lameness, oedema, vomiting, skin lesions or vasculitis—and arrange surveillance for at least four weeks; fatal canine cases are reported.
  • Prefer species-specific albumin for dogs when it is genuinely available. Human serum albumin is a xenoprotein in dogs and cats; document the rescue rationale and informed-owner discussion rather than presenting human-product availability as evidence of veterinary equivalence.
  • Treat the cause of albumin loss or reduced synthesis and define a clinical endpoint such as improving oedema, effusion, perfusion or oncotic status. A higher serum albumin concentration is a surrogate; available veterinary studies do not prove that numeric correction alone improves survival.
  • Individualize dose and rate from volume status and ongoing losses, not serum albumin alone. Monitor blood pressure, pulse, respiration, urine output, electrolytes, haematocrit/haemoglobin and signs of pulmonary or peripheral fluid overload throughout infusion.
  • Do not infuse in severe anaemia or cardiac failure with normal or increased intravascular volume. Use exceptional caution with renal disease, capillary leak or any state in which hypervolaemia, haemodilution or sodium load can worsen organ function.
  • Never dilute human albumin with sterile water because haemolysis may result. Use only a compatible isotonic diluent when dilution is required; do not mix the product with other medicinal products, whole blood or packed red cells in the same container or line.
  • Record the exact product and batch, inspect the solution, maintain asepsis and discard unused single-use remainder. Donor screening and viral inactivation reduce but cannot eliminate transmission of known, emerging or unknown agents from a human plasma-derived product.
  • The reassuring veterinary evidence is tied to controlled 5% HSA in critically ill hypoalbuminaemic patients. Preserve the studied concentration, rate and monitoring context; absence of observed reactions does not establish safety for healthy animals, repeat exposure or rapid infusion.
Assessment sources
  1. Human albumin market audit2026
  2. Albunorm 5% SmPC2023
  3. Alburex 20 SmPC2018
  4. AAHA fluid therapy 20242024
  5. 5% HSA in 588 patients2010
  6. Viganó et al. 20192019
  7. Viganó et al. 20222022
  8. Cohn et al. 20072007
  9. Francis et al. 20072007
  10. 25% HSA in septic peritonitis2015
  11. 25% HSA risk-benefit review2008
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Albumin (human)50 mg/ml
Formulation Type
Solution
Administration route
Intravenous
Manufacturer
Octapharma · Switzerland
Registration
Georgia Yes, human
In force until 21 Feb 2028
Human (Ministry of Health, RAMA)
№ რ-037378
Verified on: 15 Oct 2026
 EU Yes, human
Verified on: 16 Oct 2026
 UK Yes, human
№ PL106730030, PL106730031, PL106730034, PL106730035
Verified on: 16 Oct 2026
 US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
10–20 ml/kg
unlike previous findings with 25% HSA in this species.
 Cat Any weight Intravenous once, at a rate of 2 mL/kg/h Product label (SPC)
2–20.5 ml/kg
Infusion rate is as important as dose. In a prospective series of 73 critically ill dogs, 5% human albumin was given at 2.0–20.56 mL/kg using a uniform rate of 2.0 mL/kg/hour, with no type I or III hypersensitivity signs through day 28. Distinguishing features were the 5%, not 25%, solution, controlled rate, and hypoalbuminaemic critically ill patients. Determine the patient dose from albumin deficit and target colloid osmotic pressure, not a fixed value. Do not administer to healthy normoalbuminaemic animals. If available, canine-specific albumin 1 g/kg avoids foreign-protein exposure.
 Dog Any weight Intravenous once, at a rate of 2 mL/kg/h Product label (SPC)

Known Contraindications

  • Critical
    Repeat administration carries a separate and greater risk; always establish whether the patient has received human albumin previously. In a study of 9 healthy dogs given 25% human albumin, all 9 developed antibodies and 8 had a positive intradermal test. One dog had an anaphylactoid reaction during the first infusion; both of the 2 dogs that received a second infusion reacted. The first exposure can sensitize the patient.
  • Critical
    A reaction may be delayed, so an uneventful infusion does not establish safety. In a study of 6 healthy dogs, all 6 developed delayed reactions between days 5 and 13, including lethargy, lameness, oedema, cutaneous vasculitis, vomiting, and anorexia; 2 died despite treatment. Warn the owner about signs to watch for at home and monitor the patient weekly for at least 1 month. In a series of 73 critically ill dogs, 23% had at least one complication during or immediately after infusion and 4% had a severe delayed complication.
  • Critical
    Do not dilute with sterile water for injection as this may cause hemolysis in recipients. Do not add supplementary medication.
    Sources: FDA
  • Critical
    Severe anemia or cardiac failure with normal or increased intravascular volume.
    Sources: FDA
  • Critical
    Severe anemia or cardiac failure with normal or increased intravascular volume.
    Sources: FDA
  • Critical
    Hypersensitivity to albumin preparations or to any of the excipients.
    Sources: FDA
  • Warning
    Use with caution in conditions where hypervolemia and its consequences or hemodilution could represent a special risk to the patient.
    Sources: FDA
  • Warning
    Use cautiously in renal disease. Volume loading and haemodilution are both risks, and delayed type III hypersensitivity associated with acute kidney injury has been reported in 2 dogs. Monitor urine output during infusion and creatinine during the following weeks.

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