CANGLOB DHLaPPi

Important safety and use flags

• This is heterologous passive immunoglobulin, not a vaccine. Labelled antibody protection lasts about 5 days and does not create durable active immunity or complete a puppy/adult vaccination series.
• Complete-label evidence boundary: independent controlled evidence is largely CPV-only and inconsistent; exact DHLaPPi CDV/CAV/CPiV treatment and broad unidentified-agent claims are not independently validated.
• Dose is 0.4 ml/kg IM, IV or SC, maximum 0.4 ml/kg/day. Treat daily until improvement or use every 5 days only for immediate outbreak prophylaxis; the veterinarian selects route and duration from diagnosis, severity, course, prognosis and risk.
• IV gives immediate and greatest antibody availability; IM/SC is later and weaker. Do not interpret route availability as equivalent evidence of outcome, and use appropriate asepsis, restraint, catheter and monitoring standards.
• Never substitute CANGLOB for diagnosis, isolation, active vaccination or full disease-specific supportive care. In CPV, fluid/electrolyte, nutrition, antiemetic, analgesic and sepsis/bacterial-translocation management remain outcome-critical.
• Lethargy, anorexia and fever can occur. Rare allergy or anaphylaxis may begin within minutes to hours, particularly after repeat heterologous-protein exposure; observe, keep emergency treatment ready and report serious events.
• Do not repeat prophylactically in a sensitised dog or after a prior allergic/anaphylactic reaction. A double-dose label observation does not remove uncertainty in critical illness, repeated courses, very young animals or organ dysfunction.
• Avoid active vaccination against the covered diseases during treatment and for at least 7 days afterwards. Passive antibody can interfere with vaccine response; reschedule and document active immunisation deliberately.
• Pregnancy use is allowed, but avoid late pregnancy or immediate postpartum use. Maternal administration provides little antibody transfer to offspring and must not be presented as reliable litter protection.
• Handling: warm and shake, withdraw aseptically, never mix with another product, store at 2-8 C protected from light, do not freeze, reject a damaged closure and use an opened vial within 10 hours. One 6 ml vial covers only a 15 kg dog per dose.