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Megestrol acetate · AVZ S-P Ltd

1 form: suspension. In force in Georgia: 1 of 1 (veterinary register).

Forms and doses1 of 1 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Dose Frequency Georgia
20 mg/ml oral suspension, Suspension · Cat Cat Estrus Prevention · By mouth: 0.25 mlEstrus Interruption · By mouth: 0.25 mlSuppression of Sexual Behaviour · By mouth: 0.25 ml - Georgia Yes, veterinary
In force until 14 May 2031
Veterinary (National Food Agency)
In the register: ეკს®-5
№ 001155
Verified on: 21 Oct 2026
20 mg/ml oral suspension, Suspension · Dog Dog Estrus Prevention · By mouth: 0.025 ml/kgEstrus Interruption · By mouth: 0.1 ml/kgSuppression of Sexual Behaviour · By mouth: 0.1 ml/kg - Georgia Yes, veterinary
In force until 14 May 2031
Veterinary (National Food Agency)
In the register: ეკს®-5
№ 001155
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

EX-5 20 mg/ml oral suspension, Suspension

2 ml for dogs and cats
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Full dog label: oestrus postponement and interruption in bitches and a short course for male dogs with megestrol acetate 20 mg/ml oral suspension dosed per kg
4.8/10
Weak evidence support
vetman assessment

EX-5

20 mg/ml oral suspension, 2 ml for dogs and cats
Assessed clinical scopeDog · Full dog label: oestrus postponement and interruption in bitches and a short course for male dogs with megestrol acetate 20 mg/ml oral suspension dosed per kg · By mouth
Care settingVeterinary prescription for a healthy, sexually mature dog after excluding pregnancy and reproductive and mammary disease, with exact cycle timing and follow-up checks
vetman score 4.8/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 001155 · Verified on 21 Oct 2026

A weak option: effective short-term oestrus control in a small bottle that does not suit larger dogs, with the usual uterine, mammary and endocrine risks. Prefer surgical neutering for long-term control.

Regulatory and scientific credibility4.5/10

The exact product is registered in Georgia (001155, valid to 2031) with a current Russian manufacturer instruction, but it has no EU, UK or US authorisation documented in the reviewed evidence or public dossier.

Clinical efficacy6.5/10

Megestrol acetate is an established way to postpone or interrupt oestrus in bitches, but timing is critical and no study of this product exists.

Safety and tolerability3.5/10

Progestogens can cause cystic endometrial hyperplasia and pyometra, mammary nodules, insulin resistance and acromegaly in dogs; short labelled courses lower these risks but do not remove them.

Clinical practicality4.5/10

Doses of 0.025-0.1 ml/kg are easy to calculate, but one 2 ml bottle holds only 40 mg, so a full interruption course for a 20 kg bitch needs about seven bottles.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Do not use in pregnancy or lactation, before sexual maturity, at the first oestrus, or with reproductive disease, mammary tumours or diabetes.
  • Watch for vaginal discharge, lethargy, thirst or abdominal swelling after a course; pyometra can develop weeks later.
  • Give no more than two interruption courses a year, and no more than 32 days of postponement dosing.
  • The calculator shows the full starting dose; the follow-up dose is half of it.
  • Count the 2 ml bottles a full course needs before starting it.
Assessment sources
  1. AVZ EX-52026
  2. Georgia NFA register 20262026
  3. Canine estrus control2024
  4. Estrous-cycle manipulation2025
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Full cat label: oestrus prevention and interruption in queens and suppression of sexual activity in tomcats with megestrol acetate 20 mg/ml oral suspension
4.6/10
Weak evidence support
vetman assessment

EX-5

20 mg/ml oral suspension, 2 ml for dogs and cats
Assessed clinical scopeCat · Full cat label: oestrus prevention and interruption in queens and suppression of sexual activity in tomcats with megestrol acetate 20 mg/ml oral suspension · By mouth
Care settingVeterinary prescription for a healthy, sexually mature cat after excluding pregnancy, reproductive and mammary disease and diabetes, with a measuring syringe and follow-up checks
vetman score 4.6/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 001155 · Verified on 21 Oct 2026

A weak option: megestrol in a liquid that is harder to dose accurately than a tablet, with the same diabetes, mammary and pyometra risks in cats. Prefer surgical neutering for lasting control.

Regulatory and scientific credibility4.5/10

The exact product is registered in Georgia (001155, valid to 2031) with a current Russian manufacturer instruction, but it has no EU, UK or US authorisation documented in the reviewed evidence or public dossier.

Clinical efficacy6.0/10

Megestrol acetate is an established way to prevent or interrupt oestrus in queens and to damp male sexual behaviour, but no study of this product exists and control lasts only while dosing continues.

Safety and tolerability3.0/10

Cats are especially sensitive to progestogens: diabetes mellitus, adrenal suppression, mammary hyperplasia and tumours, pyometra and weight gain are documented, and the risk grows with dose and duration up to the labelled 18 months.

Clinical practicality5.0/10

Cat doses of 0.125-0.25 ml (2.5-5 mg) are tiny volumes of a concentrated suspension from a 2 ml dropper bottle, so accurate dosing needs a 1 ml oral syringe.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Do not use in pregnancy or lactation, before sexual maturity, at the first oestrus, or with reproductive disease, mammary tumours or diabetes.
  • Check glucose and palpate the mammary glands before and during long courses; stop at the first sign of increased thirst, urination or mammary swelling.
  • Shake well and measure 0.125-0.25 ml with a 1 ml oral syringe; a dropper is imprecise at these volumes.
  • Interrupt oestrus no more than twice a year and do not exceed 18 months of continuous prevention.
  • Male cats on long or repeated courses can gain weight, change behaviour and develop mammary enlargement.
Assessment sources
  1. AVZ EX-52026
  2. Georgia NFA register 20262026
  3. Feline estrus control2024
  4. Megestrol behaviour warning2026
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Megestrol acetate20 mg/ml
Formulation Type
Suspension
Administration route
By mouth
Manufacturer
AVZ S-P Ltd · Russia
Manufacturer (register)
AVZ S-P Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1751, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 14 May 2031
Veterinary (National Food Agency)
In the register: ეკს®-5
№ 001155
Verified on: 21 Oct 2026
Controlled in Georgia
Unknown
Cat
WeightEstrus Prevention · By mouthEstrus Interruption · By mouthSuppression of Sexual Behaviour · By mouth
Any weight 0.25 ml 0.25 ml 0.25 ml
  • Estrus Prevention · By mouth (0.125 ml weekly, or use the separate 0.25 ml every-2-weeks schedule; maximum 18 months): Female cat only. Begin between cycles and outside breeding season. Do not use during pregnancy, lactation, sexual immaturity, first estrus, reproductive disease, mammary tumor or diabetes.
  • Estrus Interruption · By mouth (once daily for 5-7 days, started no later than day 3 of estrus): Female cat only. Do not interrupt estrus more than twice yearly. Observe all hormonal contraindications.
  • Suppression of Sexual Behaviour · By mouth (once daily for 5-7 days, then once weekly): Male cat only. Long or repeated use may alter behaviour, enlarge mammary glands and increase appetite and weight.
Source:
AVZ EX-5
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
EX-5 oral suspension - current official instruction
Current official manufacturer instruction, 2026
Dog
WeightEstrus Prevention · By mouthEstrus Interruption · By mouthSuppression of Sexual Behaviour · By mouth
Any weight 0.025 ml/kg 0.1 ml/kg 0.1 ml/kg
  • Estrus Prevention · By mouth (once daily, beginning 7-15 days before estrus; maximum 32 days): Bitch only. Do not use during pregnancy, lactation, sexual immaturity, first estrus, reproductive disease, mammary tumor or diabetes.
  • Estrus Interruption · By mouth (full dose daily for 3 days, then half dose daily for 7 days): Bitch only. Start no later than day 3 of estrus and do not use more than two courses yearly. The calculator shows the initial full dose; the follow-up is half that amount.
  • Suppression of Sexual Behaviour · By mouth (full dose daily for 7 days, then half dose daily for 2 weeks): Male dog only. The calculator shows the initial full dose; the follow-up is half that amount. Observe all hormonal contraindications.
Source:
AVZ EX-5
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
EX-5 oral suspension - current official instruction
Current official manufacturer instruction, 2026

Products are connected by name, active ingredients, or therapeutic group. They are not direct substitutes for one another.

Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 21 Oct 2026

All of this shows in vetman as you prescribe

The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

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