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Sex Barrier Female

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Water-soluble mepregenol acetate + Ethinylestradiol · NPK SKiFF / Astrafarm

1 form: tablet. In force in Georgia: 1 of 1 (veterinary register).

Forms and doses1 of 1 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Weight Dose Frequency Georgia
Tablet · Cat up to 5 kg Cat up to 5 kg Estrus Interruption · By mouth: 1 tabletEstrus Prevention · By mouth: -Post-mating Contraception · By mouth: - - Georgia Yes, veterinary
In force until 01 Feb 2029
Veterinary (National Food Agency)
In the register: სექს ბარიერი®
№ 000547 | 000548
Verified on: 21 Oct 2026
Tablet · Cat Any weight Cat Any weight Estrus Interruption · By mouth: -Estrus Prevention · By mouth: 1 tabletPost-mating Contraception · By mouth: 2 tablets - Georgia Yes, veterinary
In force until 01 Feb 2029
Veterinary (National Food Agency)
In the register: სექს ბარიერი®
№ 000547 | 000548
Verified on: 21 Oct 2026
Tablet · Cat 5–10 kg Cat 5–10 kg Estrus Interruption · By mouth: 1–2 tabletsEstrus Prevention · By mouth: -Post-mating Contraception · By mouth: - - Georgia Yes, veterinary
In force until 01 Feb 2029
Veterinary (National Food Agency)
In the register: სექს ბარიერი®
№ 000547 | 000548
Verified on: 21 Oct 2026
Tablet · Dog up to 5 kg Dog up to 5 kg Estrus Prevention · By mouth: 1 tabletEstrus Interruption · By mouth: 1 tabletPost-mating Contraception · By mouth: 1 tablet - Georgia Yes, veterinary
In force until 01 Feb 2029
Veterinary (National Food Agency)
In the register: სექს ბარიერი®
№ 000547 | 000548
Verified on: 21 Oct 2026
Tablet · Dog 5–10 kg Dog 5–10 kg Estrus Prevention · By mouth: 1–2 tabletsEstrus Interruption · By mouth: 1–2 tabletsPost-mating Contraception · By mouth: 1–2 tablets - Georgia Yes, veterinary
In force until 01 Feb 2029
Veterinary (National Food Agency)
In the register: სექს ბარიერი®
№ 000547 | 000548
Verified on: 21 Oct 2026
Tablet · Dog 10–30 kg Dog 10–30 kg Estrus Prevention · By mouth: 2–4 tabletsEstrus Interruption · By mouth: 2–4 tabletsPost-mating Contraception · By mouth: 2–4 tablets - Georgia Yes, veterinary
In force until 01 Feb 2029
Veterinary (National Food Agency)
In the register: სექს ბარიერი®
№ 000547 | 000548
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Sex Barrier Female, Tablet

Sex Barrier 0.1/0.001 mg tablets, N10 for female cats and dogs
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Full female label: oestrus postponement, oestrus interruption and post-mating use in bitches with mepregenol acetate 0.1 mg plus ethinylestradiol 0.001 mg tablets dosed by weight band
3.7/10
Poor / unconvincing
vetman assessment

Sex Barrier Female

Sex Barrier 0.1/0.001 mg tablets, N10 for female cats and dogs
Assessed clinical scopeDog · Full female label: oestrus postponement, oestrus interruption and post-mating use in bitches with mepregenol acetate 0.1 mg plus ethinylestradiol 0.001 mg tablets dosed by weight band · By mouth
Care settingVeterinary prescription for a healthy, sexually mature bitch after excluding pregnancy, reproductive and mammary disease, diabetes and urolithiasis, with follow-up after the course
vetman score 3.7/10 Poor / unconvincing
Evidence confidence: Low Georgia: Yes, veterinary · № 000547 | 000548 · Verified on 21 Oct 2026

A poor choice: an unproven hormone combination whose post-mating oestrogen use carries pyometra risk. Prefer surgical neutering; after mismating, aglepristone, authorised in many European countries, is the evidence-based option.

Regulatory and scientific credibility3.5/10

The female formulation is registered in Georgia (000547/000548, valid to 2029) with a 2023 Russian-language instruction, but mepregenol acetate has no EU, UK or US veterinary authorisation documented in the reviewed evidence and no public dossier exists.

Clinical efficacy3.5/10

Only manufacturer material supports this combination; there are no independent studies of oestrus postponement or of pregnancy prevention after mating in bitches.

Safety and tolerability3.0/10

Progestogens in bitches cause cystic endometrial hyperplasia, pyometra and mammary nodules, and oestrogen given after mating adds pyometra risk; the label excludes greyhounds and limits interruption to once and postponement to twice a year.

Clinical practicality5.5/10

Weight-banded tablet counts work up to 30 kg, but above 30 kg the dose follows a stepped rule, postponement must start 7-14 days before the expected oestrus, and the male and female formulations are easy to mix up.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Do not use in greyhounds, in pregnancy or lactation, before sexual maturity, or with mammary or genital tumours, reproductive disease, diabetes or urolithiasis.
  • Oestrogen after mating raises pyometra risk: check for vaginal discharge, thirst, lethargy or fever in the weeks after a course.
  • Interrupt oestrus no more than once a year and postpone it no more than twice a year.
  • Female formulation only; above 30 kg give 4 tablets plus 1 for each further 10 kg, as the label states.
  • Full reproductive function returns about 2-3 months after stopping.
Assessment sources
  1. Sex Barrier female label2023
  2. Georgia NFA register 20262026
  3. Canine estrus control2024
  4. Estrous-cycle manipulation2025
  5. Female reproductive management2026
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Full female label: oestrus prevention, oestrus interruption and post-mating use in queens with mepregenol acetate 0.1 mg plus ethinylestradiol 0.001 mg tablets
3.8/10
Poor / unconvincing
vetman assessment

Sex Barrier Female

Sex Barrier 0.1/0.001 mg tablets, N10 for female cats and dogs
Assessed clinical scopeCat · Full female label: oestrus prevention, oestrus interruption and post-mating use in queens with mepregenol acetate 0.1 mg plus ethinylestradiol 0.001 mg tablets · By mouth
Care settingVeterinary prescription for a healthy, sexually mature queen after excluding pregnancy, reproductive and mammary disease, diabetes and urolithiasis
vetman score 3.8/10 Poor / unconvincing
Evidence confidence: Low Georgia: Yes, veterinary · № 000547 | 000548 · Verified on 21 Oct 2026

A poor choice: an unproven progestogen and oestrogen combination with the full hormonal risk profile in cats. Surgical neutering is the standard; if short hormonal control is unavoidable, use a better documented product under veterinary supervision.

Regulatory and scientific credibility3.5/10

The female formulation is registered in Georgia (000547/000548, valid to 2029) with a 2023 Russian-language instruction, but mepregenol acetate has no EU, UK or US veterinary authorisation documented in the reviewed evidence and no public dossier exists.

Clinical efficacy3.5/10

Only manufacturer material supports this progestogen and oestrogen combination; there are no independent studies of oestrus control or of pregnancy prevention after mating.

Safety and tolerability3.0/10

Progestogens in cats are linked to diabetes, mammary hyperplasia and tumours, and pyometra, and an added oestrogen increases uterine risk; the label itself excludes diabetes, urolithiasis and reproductive or mammary disease.

Clinical practicality6.0/10

One tablet per cat every 14 days, or daily for 3-5 days, is easy to give, but the separate male and female formulations are easy to mix up.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Do not use in pregnancy or lactation, before sexual maturity, or with mammary or genital tumours, reproductive disease, diabetes or urolithiasis.
  • Female formulation only: never give the male tablets (0.4 mg/0.02 mg) to a queen.
  • Check glucose and the mammary glands on long courses, and watch for vaginal discharge or illness after treatment, which can signal pyometra.
  • Post-mating use (2 tablets within 24 hours) has no independent evidence of preventing pregnancy; confirm pregnancy status later.
  • Full reproductive function returns about 2-3 months after stopping.
Assessment sources
  1. Sex Barrier female label2023
  2. Georgia NFA register 20262026
  3. Feline estrus control2024
  4. Estrous-cycle manipulation2025
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Water-soluble mepregenol acetate0.1 mg/tablet Ethinylestradiol0.001 mg/tablet
Formulation Type
Tablet
Administration route
By mouth
Manufacturer
NPK SKiFF / Astrafarm · Russia
Registration
Georgia Yes, veterinary
In force until 01 Feb 2029
Veterinary (National Food Agency)
In the register: სექს ბარიერი®
№ 000547 | 000548
Verified on: 21 Oct 2026
Controlled in Georgia
Unknown
Cat
WeightEstrus Interruption · By mouthEstrus Prevention · By mouthPost-mating Contraception · By mouth
up to 5 kg 1 tablet - -
Any weight - 1 tablet 2 tablets
5–10 kg 1–2 tablets - -
  • Estrus Interruption · By mouth (once daily for 3-5 days; start no later than day 2 of estrus): Female formulation only. Do not use in pregnancy, lactation, before sexual maturity, mammary/genital neoplasia, reproductive disease, diabetes, urolithiasis or ingredient intolerance. Do not use the male formulation.
  • Estrus Prevention · By mouth (every 14 days during sexual rest; may continue without breaks): Female cats only. Observe all female-formulation contraindications. Full reproductive function returns 2-3 months after stopping.
  • Post-mating Contraception · By mouth (single dose no later than 24 hours after accidental mating): Female cats only. Observe all female-formulation contraindications. Full reproductive function returns 2-3 months after stopping.
Source:
Sex Barrier female label
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
Sex Barrier tablets for female cats and dogs - approved instruction
Rosselkhoznadzor-approved veterinary instruction, 2023
Dog
WeightEstrus Prevention · By mouthEstrus Interruption · By mouthPost-mating Contraception · By mouth
up to 5 kg 1 tablet 1 tablet 1 tablet
5–10 kg 1–2 tablets 1–2 tablets 1–2 tablets
10–30 kg 2–4 tablets 2–4 tablets 2–4 tablets
  • Estrus Prevention · By mouth (once daily for 5-7 days; start 7-14 days before expected estrus): Female dogs only. Do not use in greyhounds, pregnancy, lactation, before sexual maturity, mammary/genital neoplasia, reproductive disease, diabetes, urolithiasis or ingredient intolerance. Estrus interruption is recommended no more than once yearly; estrus delay no more than twice yearly.
  • Estrus Interruption · By mouth (once daily for 3-5 days; start no later than day 2 of estrus): Female dogs only. Do not use in greyhounds, pregnancy, lactation, before sexual maturity, mammary/genital neoplasia, reproductive disease, diabetes, urolithiasis or ingredient intolerance. Estrus interruption is recommended no more than once yearly; estrus delay no more than twice yearly.
  • Post-mating Contraception · By mouth (once daily for 2 days; start no later than 24 hours after accidental mating): Female dogs only. Do not use in greyhounds, pregnancy, lactation, before sexual maturity, mammary/genital neoplasia, reproductive disease, diabetes, urolithiasis or ingredient intolerance. Estrus interruption is recommended no more than once yearly; estrus delay no more than twice yearly.
Source:
Sex Barrier female label
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
Sex Barrier tablets for female cats and dogs - approved instruction
Rosselkhoznadzor-approved veterinary instruction, 2023

Water-soluble mepregenol acetate: No dose supported by a publicly verifiable source yet

Ethinylestradiol: No dose supported by a publicly verifiable source yet

Products are connected by name, active ingredients, or therapeutic group. They are not direct substitutes for one another.

Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

For veterinary professionals only. It does not replace clinical judgement or the product label; check the dose in the official label (SPC). vetman is not liable for harm caused by using this information.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 21 Oct 2026

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The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

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