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Sex Barrier Male

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Water-soluble mepregenol acetate + Ethinylestradiol · NPK SKiFF / Astrafarm

1 form: tablet. In force in Georgia: 1 of 1 (veterinary register).

Forms and doses1 of 1 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Weight Dose Frequency Georgia
Tablet · Cat up to 5 kg Cat up to 5 kg Suppression of Sexual Behaviour · By mouth: 1 tabletEstrus Prevention · By mouth: - - Georgia Yes, veterinary
In force until 01 Feb 2029
Veterinary (National Food Agency)
In the register: სექს ბარიერი®
№ 000547 | 000548
Verified on: 21 Oct 2026
Tablet · Cat Any weight Cat Any weight Suppression of Sexual Behaviour · By mouth: -Estrus Prevention · By mouth: 1 tablet - Georgia Yes, veterinary
In force until 01 Feb 2029
Veterinary (National Food Agency)
In the register: სექს ბარიერი®
№ 000547 | 000548
Verified on: 21 Oct 2026
Tablet · Cat 5–10 kg Cat 5–10 kg Suppression of Sexual Behaviour · By mouth: 1–2 tabletsEstrus Prevention · By mouth: - - Georgia Yes, veterinary
In force until 01 Feb 2029
Veterinary (National Food Agency)
In the register: სექს ბარიერი®
№ 000547 | 000548
Verified on: 21 Oct 2026
Tablet · Dog up to 5 kg Dog up to 5 kg Suppression of Sexual Behaviour · By mouth: 1 tablet - Georgia Yes, veterinary
In force until 01 Feb 2029
Veterinary (National Food Agency)
In the register: სექს ბარიერი®
№ 000547 | 000548
Verified on: 21 Oct 2026
Tablet · Dog 5–10 kg Dog 5–10 kg Suppression of Sexual Behaviour · By mouth: 1–2 tablets - Georgia Yes, veterinary
In force until 01 Feb 2029
Veterinary (National Food Agency)
In the register: სექს ბარიერი®
№ 000547 | 000548
Verified on: 21 Oct 2026
Tablet · Dog 10–30 kg Dog 10–30 kg Suppression of Sexual Behaviour · By mouth: 2–4 tablets - Georgia Yes, veterinary
In force until 01 Feb 2029
Veterinary (National Food Agency)
In the register: სექს ბარიერი®
№ 000547 | 000548
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Sex Barrier Male, Tablet

Sex Barrier 0.4/0.02 mg tablets, N10 for male cats and dogs
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Full male label: suppression of sexual activity in male dogs with mepregenol acetate 0.4 mg plus ethinylestradiol 0.02 mg tablets, dosed by weight band once daily for 3-5 days
3.6/10
Poor / unconvincing
vetman assessment

Sex Barrier Male

Sex Barrier 0.4/0.02 mg tablets, N10 for male cats and dogs
Assessed clinical scopeDog · Full male label: suppression of sexual activity in male dogs with mepregenol acetate 0.4 mg plus ethinylestradiol 0.02 mg tablets, dosed by weight band once daily for 3-5 days · By mouth
Care settingVeterinary prescription for a healthy, sexually mature male dog after excluding genital and urinary disease and diabetes
vetman score 3.6/10 Poor / unconvincing
Evidence confidence: Low Georgia: Yes, veterinary · № 000547 | 000548 · Verified on 21 Oct 2026

A poor choice: oestrogen-containing hormone tablets for male dogs with no independent evidence and a bone-marrow risk. Castration or an EU-authorised deslorelin implant is the better option.

Regulatory and scientific credibility3.5/10

The male formulation is registered in Georgia (000547/000548, valid to 2029) with a 2023 Russian-language instruction, but mepregenol acetate has no EU, UK or US veterinary authorisation documented in the reviewed evidence and no public dossier exists.

Clinical efficacy3.5/10

Only manufacturer material supports hormonal suppression of male sexual behaviour with this combination; no independent study exists, while castration reliably removes the behaviour.

Safety and tolerability2.5/10

Each tablet carries 0.02 mg ethinylestradiol and a 30 kg dog takes 4 or more tablets a day; oestrogens can cause dose-related, sometimes irreversible bone-marrow suppression in dogs, and no safety data for this product exist.

Clinical practicality5.5/10

A 3-5 day tablet course is easy to give, but above 30 kg the dose follows a stepped label rule and the effect lasts only while treatment continues.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Oestrogen can suppress bone marrow in dogs: check a blood count if the dog becomes lethargic or pale, bruises or develops fever after a course.
  • Do not use before sexual maturity or with genital disease, diabetes or urolithiasis.
  • Male formulation only; above 30 kg give 4 tablets plus 1 for each further 10 kg, as the label states.
  • Each repeat course adds oestrogen exposure; avoid routine repetition.
  • Full reproductive function returns about 2-3 months after stopping.
Assessment sources
  1. Sex Barrier male label2023
  2. Georgia NFA register 20262026
  3. EMA Suprelorin EPAR2024
  4. Estrous-cycle manipulation2025
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Full male label: suppression of sexual activity in tomcats with mepregenol acetate 0.4 mg plus ethinylestradiol 0.02 mg tablets, daily for 3-5 days or every 14 days
3.8/10
Poor / unconvincing
vetman assessment

Sex Barrier Male

Sex Barrier 0.4/0.02 mg tablets, N10 for male cats and dogs
Assessed clinical scopeCat · Full male label: suppression of sexual activity in tomcats with mepregenol acetate 0.4 mg plus ethinylestradiol 0.02 mg tablets, daily for 3-5 days or every 14 days · By mouth
Care settingVeterinary prescription for a healthy, sexually mature male cat after excluding genital and urinary disease and diabetes
vetman score 3.8/10 Poor / unconvincing
Evidence confidence: Low Georgia: Yes, veterinary · № 000547 | 000548 · Verified on 21 Oct 2026

A poor choice: hormonal suppression of tomcat behaviour with an unproven combination and real endocrine risk. Castration is the standard; in the EU a deslorelin implant is the authorised reversible alternative for male cats.

Regulatory and scientific credibility3.5/10

The male formulation is registered in Georgia (000547/000548, valid to 2029) with a 2023 Russian-language instruction, but mepregenol acetate has no EU, UK or US veterinary authorisation documented in the reviewed evidence and no public dossier exists.

Clinical efficacy3.5/10

Only manufacturer material supports hormonal suppression of male sexual behaviour with this combination; no independent study exists, while castration reliably removes the behaviour.

Safety and tolerability3.0/10

The male tablet contains 20 times more ethinylestradiol than the female one; progestogens in cats can cause diabetes and mammary enlargement and the oestrogen adds feminising effects, and the label excludes diabetes and urolithiasis.

Clinical practicality6.0/10

One tablet per cat is easy to give, but it must be repeated every 14 days for as long as control is wanted.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Do not use before sexual maturity or with genital disease, diabetes or urolithiasis.
  • Male formulation only: never give it to a female; it contains 0.02 mg ethinylestradiol per tablet.
  • Check glucose and watch for thirst, weight gain, mammary enlargement or urinary signs on repeated courses.
  • The effect stops when treatment ends; full reproductive function returns in about 2-3 months.
  • Castration, or an EU-authorised deslorelin implant, gives longer and better documented control.
Assessment sources
  1. Sex Barrier male label2023
  2. Georgia NFA register 20262026
  3. EMA Suprelorin EPAR2024
  4. Megestrol behaviour warning2026
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Water-soluble mepregenol acetate0.4 mg/tablet Ethinylestradiol0.02 mg/tablet
Formulation Type
Tablet
Administration route
By mouth
Manufacturer
NPK SKiFF / Astrafarm · Russia
Registration
Georgia Yes, veterinary
In force until 01 Feb 2029
Veterinary (National Food Agency)
In the register: სექს ბარიერი®
№ 000547 | 000548
Verified on: 21 Oct 2026
Controlled in Georgia
Unknown
Cat
WeightSuppression of Sexual Behaviour · By mouthEstrus Prevention · By mouth
up to 5 kg 1 tablet -
Any weight - 1 tablet
5–10 kg 1–2 tablets -
  • Suppression of Sexual Behaviour · By mouth (once daily for 3-5 days; start no later than day 2 of sexual activity): Male formulation only. Do not use before sexual maturity or with genital disease, diabetes, urolithiasis or ingredient intolerance. Do not substitute the female formulation. Full reproductive function returns 2-3 months after stopping.
  • Estrus Prevention · By mouth (once every 14 days, regularly during sexual rest): Male cats only; observe all male-formulation contraindications.
Source:
Sex Barrier male label
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
Sex Barrier tablets for male cats and dogs - approved instruction
Rosselkhoznadzor-approved veterinary instruction, 2023
Dog
WeightSuppression of Sexual Behaviour · By mouth
up to 5 kg 1 tablet
5–10 kg 1–2 tablets
10–30 kg 2–4 tablets
  • Suppression of Sexual Behaviour · By mouth (once daily for 3-5 days; start no later than day 2 of sexual activity): Male formulation only. Do not use before sexual maturity or with genital disease, diabetes, urolithiasis or ingredient intolerance. Do not substitute the female formulation. Full reproductive function returns 2-3 months after stopping.
Source:
Sex Barrier male label
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
Sex Barrier tablets for male cats and dogs - approved instruction
Rosselkhoznadzor-approved veterinary instruction, 2023

Water-soluble mepregenol acetate: No dose supported by a publicly verifiable source yet

Ethinylestradiol: No dose supported by a publicly verifiable source yet

Products are connected by name, active ingredients, or therapeutic group. They are not direct substitutes for one another.

Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

For veterinary professionals only. It does not replace clinical judgement or the product label; check the dose in the official label (SPC). vetman is not liable for harm caused by using this information.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 21 Oct 2026

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The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

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