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Active substance

Cyfluthrin

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Pyrethroid (type II) insecticide and acaricide. Toxic doses for cat from published sources; they are not treatment doses.

Cat: Toxic
Toxic to cats: do not use on cats. This is a class statement for pyrethroids.
Source: MSD Veterinary Manual, Plant-Derived Insecticide Toxicosis in Animals (Gupta RC, Doss RB; 2022) · UPD ↗
 Species safety: cats →
Toxicity

Toxic doses

Single acute ingestion, mg of the substance per kg of body weight. These are toxic doses, not treatment doses.

Species Signs begin Severe Deaths reported Source
Cat
also gels and creams licked off
 not established not established not established
Low confidence
Class statement for pyrethroids; no study or label text for this substance alone in cats was found.

Cat

Signs: Named for pyrethroids in dogs, cats and large animals: salivation, vomiting, hyperexcitability, tremors, seizures, dyspnoea, weakness, prostration and death.

Toxic to cats: do not use on cats. Cats appear to be more sensitive to pyrethroid toxicity: salivation, vomiting, tremors, seizures, death. This is a class statement: no study or label text from a recognised regulator for this substance in cats was found.

Dose and use

Doses

We have no dose with a cited source for this substance yet.

Before use

Safety information

Known Contraindications

  • Critical (Cat)
    Toxic to cats: do not use on cats. Cats appear to be more sensitive to pyrethroid toxicity: salivation, vomiting, tremors, seizures, death. This is a class statement: no study or label text from a recognised regulator for this substance in cats was found.
    Sources: MSD Vet Manual
Latin name
Cyfluthrin
Georgian name
ციფლუტრინი
Authorisation status
Authorised veterinary medicine
An authorised veterinary medicine containing this substance exists. Whether a particular use is on-label depends on the species and the indication - see each dose rule.
Registered in Georgia
5 of 5 forms
Products
BARS
Controlled in Georgia
Unknown
All forms and registration5

Registration in Georgia and abroad: the register, number, validity and source are behind (i).

BARS, Spot-on

insectoacaricidal drops 0.5 ml, 2 pipettes for cats 5-10 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
5.5/10
Weak evidence support
vetman assessment

BARS

insectoacaricidal drops 0.5 ml, 2 pipettes for cats 5-10 kg
Assessed clinical scopeCat · Full labelled feline ectoparasite scope of the fixed fipronil/cyfluthrin/piperonyl-butoxide/diflubenzuron spot-on, including labelled fleas, ticks, lice and mites · On the skin
Care settingVeterinary-selected feline ectoparasite treatment with strict prevention of licking and cross-exposure
vetman score 5.5/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000800 · Verified on 21 Oct 2026

A poorly substantiated four-component feline ectoparasiticide whose pyrethroid component and limited independent evidence warrant more caution than established cat-specific alternatives.

Regulatory and scientific credibility5.5/10

The exact feline presentation is registered in Georgia and has a Russian registration-labelled instruction, but no transparent EMA, FDA or VMD assessment dossier for this exact four-component feline combination was identified.

Clinical efficacy5.5/10

Small comparative studies report flea and tick efficacy, but the evidence is limited, substantially manufacturer-associated and not sufficient to establish broad comparative effectiveness across every labelled mite indication.

Safety and tolerability4.0/10

A small repeated-dose tolerance study reported no major abnormalities, but cats are intrinsically vulnerable to pyrethroid toxicity; the exact cyfluthrin-containing formulation lacks large independent safety and pharmacovigilance datasets.

Clinical practicality8.0/10

One pipette is simple to apply, but feline grooming behaviour makes exact skin placement, drying and separation from other animals especially important.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Evidence for this exact fixed combination is limited to small studies with substantial manufacturer involvement; do not infer the evidence depth of established fipronil-only or internationally assessed products.
  • Keep away from rabbits and other non-target species; never interchange the canine and feline presentations or weight bands.
  • Apply only to dry intact skin where licking is impossible, separate animals until fully dry and monitor for salivation, vomiting, tremor, ataxia, skin irritation or other neurologic signs.
  • Do not use in sick, convalescent, pregnant, lactating, very young or underweight animals unless the exact label explicitly permits it and an individual veterinary assessment supports use.
  • Prevent environmental contamination and entry into water; the fipronil/pyrethroid/insect-growth-regulator combination is hazardous to non-target arthropods and aquatic organisms.
Assessment sources
  1. AVZ BARS instruction2026
  2. BARS tick comparative study2023
  3. BARS flea comparative study2023
  4. BARS cat tolerance study2023
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil100 mg/ml Cyfluthrin2.5 mg/ml Piperonyl butoxide0.5 mg/ml Diflubenzuron1 mg/ml
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
AVZ S-P Ltd · Russia
Manufacturer (register)
AVZ S-P Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1318, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 04 Mar 2030
Veterinary (National Food Agency)
In the register: ბარსი®
№ 000800
Verified on: 21 Oct 2026
Controlled in Georgia
Unknown

BARS, Spot-on

insectoacaricidal drops 0.67 ml, 4 pipettes for dogs up to 10 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
5.8/10
Weak evidence support
vetman assessment

BARS

insectoacaricidal drops 0.67 ml, 4 pipettes for dogs up to 10 kg
Assessed clinical scopeDog · Full labelled canine ectoparasite scope of the fixed fipronil/cyfluthrin/piperonyl-butoxide/diflubenzuron spot-on, including labelled fleas, ticks, lice and mites · On the skin
Care settingVeterinary-selected ectoparasite treatment using the exact canine weight-band pipette after species and risk review
vetman score 5.8/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000744 · Verified on 21 Oct 2026

A convenient but weakly substantiated four-component canine ectoparasiticide: limited manufacturer-associated studies do not provide the regulatory and independent-evidence depth available for better documented alternatives.

Regulatory and scientific credibility5.5/10

The exact presentations are registered in Georgia and have a Russian registration-labelled instruction, but no transparent EMA, FDA or VMD assessment dossier for this exact four-component combination was identified.

Clinical efficacy5.5/10

Small comparative and field studies report flea, tick and repellent efficacy, but they are limited in size, narrow in endpoints and substantially manufacturer-associated; robust independent multicentre evidence for the complete combination is lacking.

Safety and tolerability5.0/10

The labelled topical use can be tolerated, but combining fipronil with a pyrethroid, synergist and insect-growth regulator increases exposure complexity; independent target-animal safety and postmarketing transparency are limited.

Clinical practicality8.0/10

A single weight-banded spot-on is operationally simple, but correct dry-skin placement, prevention of licking and strict separation from cats and other animals until dry are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Evidence for this exact fixed combination is limited to small studies with substantial manufacturer involvement; do not infer the evidence depth of established fipronil-only or internationally assessed products.
  • Keep away from rabbits and other non-target species; never interchange the canine and feline presentations or weight bands.
  • Apply only to dry intact skin where licking is impossible, separate animals until fully dry and monitor for salivation, vomiting, tremor, ataxia, skin irritation or other neurologic signs.
  • Do not use in sick, convalescent, pregnant, lactating, very young or underweight animals unless the exact label explicitly permits it and an individual veterinary assessment supports use.
  • Prevent environmental contamination and entry into water; the fipronil/pyrethroid/insect-growth-regulator combination is hazardous to non-target arthropods and aquatic organisms.
Assessment sources
  1. AVZ BARS instruction2026
  2. BARS tick comparative study2023
  3. BARS flea comparative study2023
  4. BARS repellency field study2023
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil150 mg/ml Cyfluthrin5 mg/ml Piperonyl butoxide1 mg/ml Diflubenzuron1 mg/ml
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
AVZ S-P Ltd · Russia
Manufacturer (register)
AVZ S-P Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1240, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 10 Sep 2029
Veterinary (National Food Agency)
In the register: ბარსი®
№ 000744
Verified on: 21 Oct 2026
Controlled in Georgia
Unknown

BARS, Spot-on

insectoacaricidal drops 1.34 ml for dogs over 10-20 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
5.8/10
Weak evidence support
vetman assessment

BARS

insectoacaricidal drops 1.34 ml for dogs over 10-20 kg
Assessed clinical scopeDog · Full labelled canine ectoparasite scope of the fixed fipronil/cyfluthrin/piperonyl-butoxide/diflubenzuron spot-on, including labelled fleas, ticks, lice and mites · On the skin
Care settingVeterinary-selected ectoparasite treatment using the exact canine weight-band pipette after species and risk review
vetman score 5.8/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000741 · Verified on 21 Oct 2026

A convenient but weakly substantiated four-component canine ectoparasiticide: limited manufacturer-associated studies do not provide the regulatory and independent-evidence depth available for better documented alternatives.

Regulatory and scientific credibility5.5/10

The exact presentations are registered in Georgia and have a Russian registration-labelled instruction, but no transparent EMA, FDA or VMD assessment dossier for this exact four-component combination was identified.

Clinical efficacy5.5/10

Small comparative and field studies report flea, tick and repellent efficacy, but they are limited in size, narrow in endpoints and substantially manufacturer-associated; robust independent multicentre evidence for the complete combination is lacking.

Safety and tolerability5.0/10

The labelled topical use can be tolerated, but combining fipronil with a pyrethroid, synergist and insect-growth regulator increases exposure complexity; independent target-animal safety and postmarketing transparency are limited.

Clinical practicality8.0/10

A single weight-banded spot-on is operationally simple, but correct dry-skin placement, prevention of licking and strict separation from cats and other animals until dry are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Evidence for this exact fixed combination is limited to small studies with substantial manufacturer involvement; do not infer the evidence depth of established fipronil-only or internationally assessed products.
  • Keep away from rabbits and other non-target species; never interchange the canine and feline presentations or weight bands.
  • Apply only to dry intact skin where licking is impossible, separate animals until fully dry and monitor for salivation, vomiting, tremor, ataxia, skin irritation or other neurologic signs.
  • Do not use in sick, convalescent, pregnant, lactating, very young or underweight animals unless the exact label explicitly permits it and an individual veterinary assessment supports use.
  • Prevent environmental contamination and entry into water; the fipronil/pyrethroid/insect-growth-regulator combination is hazardous to non-target arthropods and aquatic organisms.
Assessment sources
  1. AVZ BARS instruction2026
  2. BARS tick comparative study2023
  3. BARS flea comparative study2023
  4. BARS repellency field study2023
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil150 mg/ml Cyfluthrin5 mg/ml Piperonyl butoxide1 mg/ml Diflubenzuron1 mg/ml
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
AVZ S-P Ltd · Russia
Manufacturer (register)
AVZ S-P Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1237, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 10 Sep 2029
Veterinary (National Food Agency)
In the register: ბარსი®
№ 000741
Verified on: 21 Oct 2026
Controlled in Georgia
Unknown

BARS, Spot-on

insectoacaricidal drops 2.68 ml for dogs over 20-40 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
5.8/10
Weak evidence support
vetman assessment

BARS

insectoacaricidal drops 2.68 ml for dogs over 20-40 kg
Assessed clinical scopeDog · Full labelled canine ectoparasite scope of the fixed fipronil/cyfluthrin/piperonyl-butoxide/diflubenzuron spot-on, including labelled fleas, ticks, lice and mites · On the skin
Care settingVeterinary-selected ectoparasite treatment using the exact canine weight-band pipette after species and risk review
vetman score 5.8/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000699 · Verified on 21 Oct 2026

A convenient but weakly substantiated four-component canine ectoparasiticide: limited manufacturer-associated studies do not provide the regulatory and independent-evidence depth available for better documented alternatives.

Regulatory and scientific credibility5.5/10

The exact presentations are registered in Georgia and have a Russian registration-labelled instruction, but no transparent EMA, FDA or VMD assessment dossier for this exact four-component combination was identified.

Clinical efficacy5.5/10

Small comparative and field studies report flea, tick and repellent efficacy, but they are limited in size, narrow in endpoints and substantially manufacturer-associated; robust independent multicentre evidence for the complete combination is lacking.

Safety and tolerability5.0/10

The labelled topical use can be tolerated, but combining fipronil with a pyrethroid, synergist and insect-growth regulator increases exposure complexity; independent target-animal safety and postmarketing transparency are limited.

Clinical practicality8.0/10

A single weight-banded spot-on is operationally simple, but correct dry-skin placement, prevention of licking and strict separation from cats and other animals until dry are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Evidence for this exact fixed combination is limited to small studies with substantial manufacturer involvement; do not infer the evidence depth of established fipronil-only or internationally assessed products.
  • Keep away from rabbits and other non-target species; never interchange the canine and feline presentations or weight bands.
  • Apply only to dry intact skin where licking is impossible, separate animals until fully dry and monitor for salivation, vomiting, tremor, ataxia, skin irritation or other neurologic signs.
  • Do not use in sick, convalescent, pregnant, lactating, very young or underweight animals unless the exact label explicitly permits it and an individual veterinary assessment supports use.
  • Prevent environmental contamination and entry into water; the fipronil/pyrethroid/insect-growth-regulator combination is hazardous to non-target arthropods and aquatic organisms.
Assessment sources
  1. AVZ BARS instruction2026
  2. BARS tick comparative study2023
  3. BARS flea comparative study2023
  4. BARS repellency field study2023
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil150 mg/ml Cyfluthrin5 mg/ml Piperonyl butoxide1 mg/ml Diflubenzuron1 mg/ml
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
AVZ S-P Ltd · Russia
Manufacturer (register)
AVZ S-P Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1188, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 10 Sep 2029
Veterinary (National Food Agency)
In the register: ბარსი®
№ 000699
Verified on: 21 Oct 2026
Controlled in Georgia
Unknown

BARS, Spot-on

insectoacaricidal drops 4.02 ml for dogs over 40-60 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
5.8/10
Weak evidence support
vetman assessment

BARS

insectoacaricidal drops 4.02 ml for dogs over 40-60 kg
Assessed clinical scopeDog · Full labelled canine ectoparasite scope of the fixed fipronil/cyfluthrin/piperonyl-butoxide/diflubenzuron spot-on, including labelled fleas, ticks, lice and mites · On the skin
Care settingVeterinary-selected ectoparasite treatment using the exact canine weight-band pipette after species and risk review
vetman score 5.8/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000750 · Verified on 21 Oct 2026

A convenient but weakly substantiated four-component canine ectoparasiticide: limited manufacturer-associated studies do not provide the regulatory and independent-evidence depth available for better documented alternatives.

Regulatory and scientific credibility5.5/10

The exact presentations are registered in Georgia and have a Russian registration-labelled instruction, but no transparent EMA, FDA or VMD assessment dossier for this exact four-component combination was identified.

Clinical efficacy5.5/10

Small comparative and field studies report flea, tick and repellent efficacy, but they are limited in size, narrow in endpoints and substantially manufacturer-associated; robust independent multicentre evidence for the complete combination is lacking.

Safety and tolerability5.0/10

The labelled topical use can be tolerated, but combining fipronil with a pyrethroid, synergist and insect-growth regulator increases exposure complexity; independent target-animal safety and postmarketing transparency are limited.

Clinical practicality8.0/10

A single weight-banded spot-on is operationally simple, but correct dry-skin placement, prevention of licking and strict separation from cats and other animals until dry are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Evidence for this exact fixed combination is limited to small studies with substantial manufacturer involvement; do not infer the evidence depth of established fipronil-only or internationally assessed products.
  • Keep away from rabbits and other non-target species; never interchange the canine and feline presentations or weight bands.
  • Apply only to dry intact skin where licking is impossible, separate animals until fully dry and monitor for salivation, vomiting, tremor, ataxia, skin irritation or other neurologic signs.
  • Do not use in sick, convalescent, pregnant, lactating, very young or underweight animals unless the exact label explicitly permits it and an individual veterinary assessment supports use.
  • Prevent environmental contamination and entry into water; the fipronil/pyrethroid/insect-growth-regulator combination is hazardous to non-target arthropods and aquatic organisms.
Assessment sources
  1. AVZ BARS instruction2026
  2. BARS tick comparative study2023
  3. BARS flea comparative study2023
  4. BARS repellency field study2023
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil150 mg/ml Cyfluthrin5 mg/ml Piperonyl butoxide1 mg/ml Diflubenzuron1 mg/ml
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
AVZ S-P Ltd · Russia
Manufacturer (register)
AVZ S-P Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1246, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 10 Sep 2029
Veterinary (National Food Agency)
In the register: ბარსი®
№ 000750
Verified on: 21 Oct 2026
Controlled in Georgia
Unknown

Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

For veterinary professionals only. It does not replace clinical judgement or the product label; check the dose in the official label (SPC). vetman is not liable for harm caused by using this information.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 01 Nov 2026

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The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

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