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BARS

Fipronil + Cyfluthrin + Piperonyl butoxide + Diflubenzuron · AVZ S-P Ltd

5 forms: spot-on. In force in Georgia: 5 of 5 (veterinary register).

Forms and doses5 of 5 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Weight Dose Frequency Georgia
Spot-on · Cat 5–10 kg Cat 5–10 kg 1 ml (1 ml)
Apply the stated volume once, spot-on to dry intact skin in areas inaccessible to licking. Use both 0.5 ml pipettes (1.0 ml total); apply at 2-4 points. Do not use in animals under 8 weeks, infectious disease, debility or ingredient hypersensitivity. Use under veterinary supervision in pregnancy/lactation and below 2 kg. Do not use in the ear if the tympanic membrane is perforated. Avoid shampooing or natural water for 48 hours before and 24 hours after use. Keep away from rabbits, bees, fish and aquatic organisms. Rare local skin changes, salivation or transient depression can occur; wash off if hypersensitivity develops.
· apply once; repeat only if indicated, not more often than monthly
apply once; repeat only if indicated, not more often than monthly Georgia Yes, veterinary
Details: pack, label wording, sources, registration

BARS, Spot-on

insectoacaricidal drops 0.5 ml, 2 pipettes for cats 5-10 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
5.5/10
Weak evidence support
vetman assessment

BARS

insectoacaricidal drops 0.5 ml, 2 pipettes for cats 5-10 kg
Assessed clinical scopeCat · Full labelled feline ectoparasite scope of the fixed fipronil/cyfluthrin/piperonyl-butoxide/diflubenzuron spot-on, including labelled fleas, ticks, lice and mites · On the skin
Care settingVeterinary-selected feline ectoparasite treatment with strict prevention of licking and cross-exposure
vetman score 5.5/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000800 · Verified on 21 Oct 2026

A poorly substantiated four-component feline ectoparasiticide whose pyrethroid component and limited independent evidence warrant more caution than established cat-specific alternatives.

Regulatory and scientific credibility5.5/10

The exact feline presentation is registered in Georgia and has a Russian registration-labelled instruction, but no transparent EMA, FDA or VMD assessment dossier for this exact four-component feline combination was identified.

Clinical efficacy5.5/10

Small comparative studies report flea and tick efficacy, but the evidence is limited, substantially manufacturer-associated and not sufficient to establish broad comparative effectiveness across every labelled mite indication.

Safety and tolerability4.0/10

A small repeated-dose tolerance study reported no major abnormalities, but cats are intrinsically vulnerable to pyrethroid toxicity; the exact cyfluthrin-containing formulation lacks large independent safety and pharmacovigilance datasets.

Clinical practicality8.0/10

One pipette is simple to apply, but feline grooming behaviour makes exact skin placement, drying and separation from other animals especially important.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Evidence for this exact fixed combination is limited to small studies with substantial manufacturer involvement; do not infer the evidence depth of established fipronil-only or internationally assessed products.
  • Keep away from rabbits and other non-target species; never interchange the canine and feline presentations or weight bands.
  • Apply only to dry intact skin where licking is impossible, separate animals until fully dry and monitor for salivation, vomiting, tremor, ataxia, skin irritation or other neurologic signs.
  • Do not use in sick, convalescent, pregnant, lactating, very young or underweight animals unless the exact label explicitly permits it and an individual veterinary assessment supports use.
  • Prevent environmental contamination and entry into water; the fipronil/pyrethroid/insect-growth-regulator combination is hazardous to non-target arthropods and aquatic organisms.
Assessment sources
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil100 mg/ml Cyfluthrin2.5 mg/ml Piperonyl butoxide0.5 mg/ml Diflubenzuron1 mg/ml
Formulation Type
Spot-on
Administration route
TOPICAL
Manufacturer
AVZ S-P Ltd · Russia
Manufacturer (register)
AVZ S-P Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1318, 19 Oct 2026.
Registration
Georgia Yes, veterinary
Controlled in Georgia
Unknown
DoseSpeciesWeightRouteFrequencySource
1 ml (1 ml)
Apply the stated volume once, spot-on to dry intact skin in areas inaccessible to licking. Use both 0.5 ml pipettes (1.0 ml total); apply at 2-4 points. Do not use in animals under 8 weeks, infectious disease, debility or ingredient hypersensitivity. Use under veterinary supervision in pregnancy/lactation and below 2 kg. Do not use in the ear if the tympanic membrane is perforated. Avoid shampooing or natural water for 48 hours before and 24 hours after use. Keep away from rabbits, bees, fish and aquatic organisms. Rare local skin changes, salivation or transient depression can occur; wash off if hypersensitivity develops.
Cat 5–10 kg TOPICAL apply once; repeat only if indicated, not more often than monthly
AVZ BARS instruction
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
BARS insectoacaricidal drops - current veterinary instruction
AVZ official product instruction, 2026
Spot-on · Dog under 2 kg Dog under 2 kg 0.07 ml/kg
Dogs below 2 kg: 0.07 ml/kg (three drops/kg) under veterinary supervision. Apply to dry intact skin. This is a measured partial dose from the 0.67 ml presentation, not an entire pipette.
· apply once; repeat only if indicated, not more often than monthly
apply once; repeat only if indicated, not more often than monthly Georgia Yes, veterinary
Spot-on · Dog 2–10 kg Dog 2–10 kg 0.67 ml (0.67 ml)
Apply the stated volume once, spot-on to dry intact skin in areas inaccessible to licking. Use one complete 0.67 ml pipette; apply at 2-4 points. Do not use in animals under 8 weeks, infectious disease, debility or ingredient hypersensitivity. Use under veterinary supervision in pregnancy/lactation and below 2 kg. Do not use in the ear if the tympanic membrane is perforated. Avoid shampooing or natural water for 48 hours before and 24 hours after use. Keep away from rabbits, bees, fish and aquatic organisms. Rare local skin changes, salivation or transient depression can occur; wash off if hypersensitivity develops.
· apply once; repeat only if indicated, not more often than monthly
apply once; repeat only if indicated, not more often than monthly Georgia Yes, veterinary
Details: pack, label wording, sources, registration

BARS, Spot-on

insectoacaricidal drops 0.67 ml, 4 pipettes for dogs up to 10 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
5.8/10
Weak evidence support
vetman assessment

BARS

insectoacaricidal drops 0.67 ml, 4 pipettes for dogs up to 10 kg
Assessed clinical scopeDog · Full labelled canine ectoparasite scope of the fixed fipronil/cyfluthrin/piperonyl-butoxide/diflubenzuron spot-on, including labelled fleas, ticks, lice and mites · On the skin
Care settingVeterinary-selected ectoparasite treatment using the exact canine weight-band pipette after species and risk review
vetman score 5.8/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000744 · Verified on 21 Oct 2026

A convenient but weakly substantiated four-component canine ectoparasiticide: limited manufacturer-associated studies do not provide the regulatory and independent-evidence depth available for better documented alternatives.

Regulatory and scientific credibility5.5/10

The exact presentations are registered in Georgia and have a Russian registration-labelled instruction, but no transparent EMA, FDA or VMD assessment dossier for this exact four-component combination was identified.

Clinical efficacy5.5/10

Small comparative and field studies report flea, tick and repellent efficacy, but they are limited in size, narrow in endpoints and substantially manufacturer-associated; robust independent multicentre evidence for the complete combination is lacking.

Safety and tolerability5.0/10

The labelled topical use can be tolerated, but combining fipronil with a pyrethroid, synergist and insect-growth regulator increases exposure complexity; independent target-animal safety and postmarketing transparency are limited.

Clinical practicality8.0/10

A single weight-banded spot-on is operationally simple, but correct dry-skin placement, prevention of licking and strict separation from cats and other animals until dry are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Evidence for this exact fixed combination is limited to small studies with substantial manufacturer involvement; do not infer the evidence depth of established fipronil-only or internationally assessed products.
  • Keep away from rabbits and other non-target species; never interchange the canine and feline presentations or weight bands.
  • Apply only to dry intact skin where licking is impossible, separate animals until fully dry and monitor for salivation, vomiting, tremor, ataxia, skin irritation or other neurologic signs.
  • Do not use in sick, convalescent, pregnant, lactating, very young or underweight animals unless the exact label explicitly permits it and an individual veterinary assessment supports use.
  • Prevent environmental contamination and entry into water; the fipronil/pyrethroid/insect-growth-regulator combination is hazardous to non-target arthropods and aquatic organisms.
Assessment sources
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil150 mg/ml Cyfluthrin5 mg/ml Piperonyl butoxide1 mg/ml Diflubenzuron1 mg/ml
Formulation Type
Spot-on
Administration route
TOPICAL
Manufacturer
AVZ S-P Ltd · Russia
Manufacturer (register)
AVZ S-P Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1240, 19 Oct 2026.
Registration
Georgia Yes, veterinary
Controlled in Georgia
Unknown
DoseSpeciesWeightRouteFrequencySource
0.07 ml/kg
Dogs below 2 kg: 0.07 ml/kg (three drops/kg) under veterinary supervision. Apply to dry intact skin. This is a measured partial dose from the 0.67 ml presentation, not an entire pipette.
Dog under 2 kg TOPICAL apply once; repeat only if indicated, not more often than monthly
AVZ BARS instruction
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
BARS insectoacaricidal drops - current veterinary instruction
AVZ official product instruction, 2026
0.67 ml (0.67 ml)
Apply the stated volume once, spot-on to dry intact skin in areas inaccessible to licking. Use one complete 0.67 ml pipette; apply at 2-4 points. Do not use in animals under 8 weeks, infectious disease, debility or ingredient hypersensitivity. Use under veterinary supervision in pregnancy/lactation and below 2 kg. Do not use in the ear if the tympanic membrane is perforated. Avoid shampooing or natural water for 48 hours before and 24 hours after use. Keep away from rabbits, bees, fish and aquatic organisms. Rare local skin changes, salivation or transient depression can occur; wash off if hypersensitivity develops.
Dog 2–10 kg TOPICAL apply once; repeat only if indicated, not more often than monthly
AVZ BARS instruction
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
BARS insectoacaricidal drops - current veterinary instruction
AVZ official product instruction, 2026
Spot-on · Dog 10–20 kg Dog 10–20 kg 1.34 ml (1.34 ml)
Apply the stated volume once, spot-on to dry intact skin in areas inaccessible to licking. Use one complete 1.34 ml pipette (or two 0.67 ml pipettes); apply at 2-4 points. Do not use in animals under 8 weeks, infectious disease, debility or ingredient hypersensitivity. Use under veterinary supervision in pregnancy/lactation and below 2 kg. Do not use in the ear if the tympanic membrane is perforated. Avoid shampooing or natural water for 48 hours before and 24 hours after use. Keep away from rabbits, bees, fish and aquatic organisms. Rare local skin changes, salivation or transient depression can occur; wash off if hypersensitivity develops.
· apply once; repeat only if indicated, not more often than monthly
apply once; repeat only if indicated, not more often than monthly Georgia Yes, veterinary
Details: pack, label wording, sources, registration

BARS, Spot-on

insectoacaricidal drops 1.34 ml for dogs over 10-20 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
5.8/10
Weak evidence support
vetman assessment

BARS

insectoacaricidal drops 1.34 ml for dogs over 10-20 kg
Assessed clinical scopeDog · Full labelled canine ectoparasite scope of the fixed fipronil/cyfluthrin/piperonyl-butoxide/diflubenzuron spot-on, including labelled fleas, ticks, lice and mites · On the skin
Care settingVeterinary-selected ectoparasite treatment using the exact canine weight-band pipette after species and risk review
vetman score 5.8/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000741 · Verified on 21 Oct 2026

A convenient but weakly substantiated four-component canine ectoparasiticide: limited manufacturer-associated studies do not provide the regulatory and independent-evidence depth available for better documented alternatives.

Regulatory and scientific credibility5.5/10

The exact presentations are registered in Georgia and have a Russian registration-labelled instruction, but no transparent EMA, FDA or VMD assessment dossier for this exact four-component combination was identified.

Clinical efficacy5.5/10

Small comparative and field studies report flea, tick and repellent efficacy, but they are limited in size, narrow in endpoints and substantially manufacturer-associated; robust independent multicentre evidence for the complete combination is lacking.

Safety and tolerability5.0/10

The labelled topical use can be tolerated, but combining fipronil with a pyrethroid, synergist and insect-growth regulator increases exposure complexity; independent target-animal safety and postmarketing transparency are limited.

Clinical practicality8.0/10

A single weight-banded spot-on is operationally simple, but correct dry-skin placement, prevention of licking and strict separation from cats and other animals until dry are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Evidence for this exact fixed combination is limited to small studies with substantial manufacturer involvement; do not infer the evidence depth of established fipronil-only or internationally assessed products.
  • Keep away from rabbits and other non-target species; never interchange the canine and feline presentations or weight bands.
  • Apply only to dry intact skin where licking is impossible, separate animals until fully dry and monitor for salivation, vomiting, tremor, ataxia, skin irritation or other neurologic signs.
  • Do not use in sick, convalescent, pregnant, lactating, very young or underweight animals unless the exact label explicitly permits it and an individual veterinary assessment supports use.
  • Prevent environmental contamination and entry into water; the fipronil/pyrethroid/insect-growth-regulator combination is hazardous to non-target arthropods and aquatic organisms.
Assessment sources
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil150 mg/ml Cyfluthrin5 mg/ml Piperonyl butoxide1 mg/ml Diflubenzuron1 mg/ml
Formulation Type
Spot-on
Administration route
TOPICAL
Manufacturer
AVZ S-P Ltd · Russia
Manufacturer (register)
AVZ S-P Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1237, 19 Oct 2026.
Registration
Georgia Yes, veterinary
Controlled in Georgia
Unknown
DoseSpeciesWeightRouteFrequencySource
1.34 ml (1.34 ml)
Apply the stated volume once, spot-on to dry intact skin in areas inaccessible to licking. Use one complete 1.34 ml pipette (or two 0.67 ml pipettes); apply at 2-4 points. Do not use in animals under 8 weeks, infectious disease, debility or ingredient hypersensitivity. Use under veterinary supervision in pregnancy/lactation and below 2 kg. Do not use in the ear if the tympanic membrane is perforated. Avoid shampooing or natural water for 48 hours before and 24 hours after use. Keep away from rabbits, bees, fish and aquatic organisms. Rare local skin changes, salivation or transient depression can occur; wash off if hypersensitivity develops.
Dog 10–20 kg TOPICAL apply once; repeat only if indicated, not more often than monthly
AVZ BARS instruction
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
BARS insectoacaricidal drops - current veterinary instruction
AVZ official product instruction, 2026
Spot-on · Dog 20–40 kg Dog 20–40 kg 2.68 ml (2.68 ml)
Apply the stated volume once, spot-on to dry intact skin in areas inaccessible to licking. Use one complete 2.68 ml pipette; apply at 4-6 or more points. Do not use in animals under 8 weeks, infectious disease, debility or ingredient hypersensitivity. Use under veterinary supervision in pregnancy/lactation and below 2 kg. Do not use in the ear if the tympanic membrane is perforated. Avoid shampooing or natural water for 48 hours before and 24 hours after use. Keep away from rabbits, bees, fish and aquatic organisms. Rare local skin changes, salivation or transient depression can occur; wash off if hypersensitivity develops.
· apply once; repeat only if indicated, not more often than monthly
apply once; repeat only if indicated, not more often than monthly Georgia Yes, veterinary
Details: pack, label wording, sources, registration

BARS, Spot-on

insectoacaricidal drops 2.68 ml for dogs over 20-40 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
5.8/10
Weak evidence support
vetman assessment

BARS

insectoacaricidal drops 2.68 ml for dogs over 20-40 kg
Assessed clinical scopeDog · Full labelled canine ectoparasite scope of the fixed fipronil/cyfluthrin/piperonyl-butoxide/diflubenzuron spot-on, including labelled fleas, ticks, lice and mites · On the skin
Care settingVeterinary-selected ectoparasite treatment using the exact canine weight-band pipette after species and risk review
vetman score 5.8/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000699 · Verified on 21 Oct 2026

A convenient but weakly substantiated four-component canine ectoparasiticide: limited manufacturer-associated studies do not provide the regulatory and independent-evidence depth available for better documented alternatives.

Regulatory and scientific credibility5.5/10

The exact presentations are registered in Georgia and have a Russian registration-labelled instruction, but no transparent EMA, FDA or VMD assessment dossier for this exact four-component combination was identified.

Clinical efficacy5.5/10

Small comparative and field studies report flea, tick and repellent efficacy, but they are limited in size, narrow in endpoints and substantially manufacturer-associated; robust independent multicentre evidence for the complete combination is lacking.

Safety and tolerability5.0/10

The labelled topical use can be tolerated, but combining fipronil with a pyrethroid, synergist and insect-growth regulator increases exposure complexity; independent target-animal safety and postmarketing transparency are limited.

Clinical practicality8.0/10

A single weight-banded spot-on is operationally simple, but correct dry-skin placement, prevention of licking and strict separation from cats and other animals until dry are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Evidence for this exact fixed combination is limited to small studies with substantial manufacturer involvement; do not infer the evidence depth of established fipronil-only or internationally assessed products.
  • Keep away from rabbits and other non-target species; never interchange the canine and feline presentations or weight bands.
  • Apply only to dry intact skin where licking is impossible, separate animals until fully dry and monitor for salivation, vomiting, tremor, ataxia, skin irritation or other neurologic signs.
  • Do not use in sick, convalescent, pregnant, lactating, very young or underweight animals unless the exact label explicitly permits it and an individual veterinary assessment supports use.
  • Prevent environmental contamination and entry into water; the fipronil/pyrethroid/insect-growth-regulator combination is hazardous to non-target arthropods and aquatic organisms.
Assessment sources
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil150 mg/ml Cyfluthrin5 mg/ml Piperonyl butoxide1 mg/ml Diflubenzuron1 mg/ml
Formulation Type
Spot-on
Administration route
TOPICAL
Manufacturer
AVZ S-P Ltd · Russia
Manufacturer (register)
AVZ S-P Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1188, 19 Oct 2026.
Registration
Georgia Yes, veterinary
Controlled in Georgia
Unknown
DoseSpeciesWeightRouteFrequencySource
2.68 ml (2.68 ml)
Apply the stated volume once, spot-on to dry intact skin in areas inaccessible to licking. Use one complete 2.68 ml pipette; apply at 4-6 or more points. Do not use in animals under 8 weeks, infectious disease, debility or ingredient hypersensitivity. Use under veterinary supervision in pregnancy/lactation and below 2 kg. Do not use in the ear if the tympanic membrane is perforated. Avoid shampooing or natural water for 48 hours before and 24 hours after use. Keep away from rabbits, bees, fish and aquatic organisms. Rare local skin changes, salivation or transient depression can occur; wash off if hypersensitivity develops.
Dog 20–40 kg TOPICAL apply once; repeat only if indicated, not more often than monthly
AVZ BARS instruction
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
BARS insectoacaricidal drops - current veterinary instruction
AVZ official product instruction, 2026
Spot-on · Dog 40–60 kg Dog 40–60 kg 4.02 ml (4.02 ml)
Apply the stated volume once, spot-on to dry intact skin in areas inaccessible to licking. Use one complete 4.02 ml pipette; apply at 4-6 or more points. Do not use in animals under 8 weeks, infectious disease, debility or ingredient hypersensitivity. Use under veterinary supervision in pregnancy/lactation and below 2 kg. Do not use in the ear if the tympanic membrane is perforated. Avoid shampooing or natural water for 48 hours before and 24 hours after use. Keep away from rabbits, bees, fish and aquatic organisms. Rare local skin changes, salivation or transient depression can occur; wash off if hypersensitivity develops.
· apply once; repeat only if indicated, not more often than monthly
apply once; repeat only if indicated, not more often than monthly Georgia Yes, veterinary
Details: pack, label wording, sources, registration

BARS, Spot-on

insectoacaricidal drops 4.02 ml for dogs over 40-60 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
5.8/10
Weak evidence support
vetman assessment

BARS

insectoacaricidal drops 4.02 ml for dogs over 40-60 kg
Assessed clinical scopeDog · Full labelled canine ectoparasite scope of the fixed fipronil/cyfluthrin/piperonyl-butoxide/diflubenzuron spot-on, including labelled fleas, ticks, lice and mites · On the skin
Care settingVeterinary-selected ectoparasite treatment using the exact canine weight-band pipette after species and risk review
vetman score 5.8/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000750 · Verified on 21 Oct 2026

A convenient but weakly substantiated four-component canine ectoparasiticide: limited manufacturer-associated studies do not provide the regulatory and independent-evidence depth available for better documented alternatives.

Regulatory and scientific credibility5.5/10

The exact presentations are registered in Georgia and have a Russian registration-labelled instruction, but no transparent EMA, FDA or VMD assessment dossier for this exact four-component combination was identified.

Clinical efficacy5.5/10

Small comparative and field studies report flea, tick and repellent efficacy, but they are limited in size, narrow in endpoints and substantially manufacturer-associated; robust independent multicentre evidence for the complete combination is lacking.

Safety and tolerability5.0/10

The labelled topical use can be tolerated, but combining fipronil with a pyrethroid, synergist and insect-growth regulator increases exposure complexity; independent target-animal safety and postmarketing transparency are limited.

Clinical practicality8.0/10

A single weight-banded spot-on is operationally simple, but correct dry-skin placement, prevention of licking and strict separation from cats and other animals until dry are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Evidence for this exact fixed combination is limited to small studies with substantial manufacturer involvement; do not infer the evidence depth of established fipronil-only or internationally assessed products.
  • Keep away from rabbits and other non-target species; never interchange the canine and feline presentations or weight bands.
  • Apply only to dry intact skin where licking is impossible, separate animals until fully dry and monitor for salivation, vomiting, tremor, ataxia, skin irritation or other neurologic signs.
  • Do not use in sick, convalescent, pregnant, lactating, very young or underweight animals unless the exact label explicitly permits it and an individual veterinary assessment supports use.
  • Prevent environmental contamination and entry into water; the fipronil/pyrethroid/insect-growth-regulator combination is hazardous to non-target arthropods and aquatic organisms.
Assessment sources
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil150 mg/ml Cyfluthrin5 mg/ml Piperonyl butoxide1 mg/ml Diflubenzuron1 mg/ml
Formulation Type
Spot-on
Administration route
TOPICAL
Manufacturer
AVZ S-P Ltd · Russia
Manufacturer (register)
AVZ S-P Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1246, 19 Oct 2026.
Registration
Georgia Yes, veterinary
Controlled in Georgia
Unknown
DoseSpeciesWeightRouteFrequencySource
4.02 ml (4.02 ml)
Apply the stated volume once, spot-on to dry intact skin in areas inaccessible to licking. Use one complete 4.02 ml pipette; apply at 4-6 or more points. Do not use in animals under 8 weeks, infectious disease, debility or ingredient hypersensitivity. Use under veterinary supervision in pregnancy/lactation and below 2 kg. Do not use in the ear if the tympanic membrane is perforated. Avoid shampooing or natural water for 48 hours before and 24 hours after use. Keep away from rabbits, bees, fish and aquatic organisms. Rare local skin changes, salivation or transient depression can occur; wash off if hypersensitivity develops.
Dog 40–60 kg TOPICAL apply once; repeat only if indicated, not more often than monthly
AVZ BARS instruction
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
BARS insectoacaricidal drops - current veterinary instruction
AVZ official product instruction, 2026
Active substance doses, with sources
Active substance Fipronil
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
6.7 mg/kg Dog Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 67.00 mg / 60.30 mg spot-on solution for dog S - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
7.5–15 mg/kg Dog, Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Spray 0.25% w/v cutaneous spray solution - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
5 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 50.00 mg / 60.00 mg spot-on solution for cat - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
8.3 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Effipro Duo 50 mg/60 mg Spot-on Solution for Cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025

Cyfluthrin: No dose supported by a publicly verifiable source yet

Piperonyl butoxide: No dose supported by a publicly verifiable source yet

Diflubenzuron: No dose supported by a publicly verifiable source yet

Known Contraindications

  • Critical Fipronil
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Fipronil
    Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
    Sources: VMD SPC · VMD
  • Warning Fipronil (Dog)
    In the absence of available data, the veterinary medicinal product should not be used on puppies less than 8 weeks old and/or weighing less than 2 kg. Puppies and kittens from 2 days of age may be safely treated. Nepoužívat u štěňat do 3 dnů stáří.
    Sources: VMD SPC · VMD
  • Warning Fipronil (Cat)
    In the absence of available data, the veterinary medicinal product should not be used on kittens less than 8 weeks old and/or weighing less than 1 kg. Nepoužívat u koťat do 8 týdnů stáří. Puppies and kittens from 2 days of age may be safely treated.
    Sources: VMD SPC · VMD
  • Caution Fipronil (Cat)
    The potential toxicity of the veterinary medicinal product for kittens of less than 8 weeks of age in contact with a treated queen is not documented. Special care should be taken in this case. Data are not available on treatment of pregnant queens or nursing queens. Přípravek může být podán chovným, březím i laktujícím kočkám.
    Sources: VMD SPC · VMD

All of this shows in vetman as you prescribe

The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.