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Tiletamine/Zolazepam
Dissociative anaesthetic with a benzodiazepine. Registered in Georgia: 2 veterinary products. Forms: solution.
Doses
Each dose comes with its source. Check the label of the product you use.
| Dose | Species | Indication | Route | Frequency | Source |
|---|---|---|---|---|---|
| 5 mg/kg | Dog, Cat |
Anaesthesia for Tests and Procedures Causing Little Pain Loading |
Intravenous | once |
VMD SPC 2025
Official product label (SPC), VMD, UK Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there. UK Veterinary Medicines Directorate, 2025 |
| 7.5 mg/kg | Dog, Cat |
Anaesthesia for Minor Surgery or Short Anaesthesia; Anaesthesia for Orthopaedic Surgery Loading |
Intravenous | once |
VMD SPC 2025
Official product label (SPC), VMD, UK Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there. UK Veterinary Medicines Directorate, 2025 |
| 10 mg/kg | Dog, Cat |
Anaesthesia for Painful Interventions; Anaesthesia for Tests and Procedures Causing Little Pain Loading |
Intravenous / Intramuscular | once |
VMD SPC 2025
Official product label (SPC), VMD, UK Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there. UK Veterinary Medicines Directorate, 2025 |
| 7–10 mg/kg | Dog |
Anaesthesia for Tests and Procedures Causing Little Pain Loading |
Intramuscular | once |
VMD SPC 2025
Official product label (SPC), VMD, UK Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there. UK Veterinary Medicines Directorate, 2025 |
| 10–15 mg/kg | Dog |
Anaesthesia for Minor Surgery or Short Anaesthesia Loading |
Intramuscular | once |
VMD SPC 2025
Official product label (SPC), VMD, UK Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there. UK Veterinary Medicines Directorate, 2025 |
| 15–25 mg/kg | Dog |
Anaesthesia for Painful Interventions Loading |
Intramuscular | once |
VMD SPC 2025
Official product label (SPC), VMD, UK Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there. UK Veterinary Medicines Directorate, 2025 |
| 15 mg/kg | Cat |
Anaesthesia for Orthopaedic Surgery Loading |
Intramuscular | once |
VMD SPC 2025
Official product label (SPC), VMD, UK Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there. UK Veterinary Medicines Directorate, 2025 |
Safety information
Known Contraindications
-
Critical
Do not use in animals hypersensitive to tiletamine, zolazepam or the excipients (benzyl alcohol, lactose).
-
Critical
Do not use in animals with severe heart disease.
-
Critical
Do not use in animals with severe respiratory disease.
-
Critical
Do not use in animals with renal insufficiency.
-
Critical
Do not use in animals with hepatic insufficiency.
-
Critical
Do not use in severe hypertension.
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Critical
Do not use in pregnant bitches and queens or for caesarean section: it crosses the placenta and can cause fatal respiratory depression in newborns.
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Critical
Do not use tiletamine/zolazepam in dogs or cats with pancreatic disease.Sources: Zoletil 100 UK SPC · FDA
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Warning
Safety in lactation has not been established; use only after a benefit-risk assessment.
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Caution
Do not use in severe hypertension, head trauma or intracranial tumours, pancreatic insufficiency, for caesarean section, or in rabbits. Do not give chloramphenicol before or during the anaesthetic; acepromazine premedication deepens cardiorespiratory depression and hypothermia; reduce the dose with other premedicants. Eyes stay open (protect the cornea); reflexes are kept; keep warm; redosing prolongs and worsens recovery. Overdose signs from 20 mg/kg; no antidote (doxapram may help).
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Caution
Not recommended in very young animals: the solvent contains benzyl alcohol.
All forms and registration2
Registration in Georgia and abroad: the register, number, validity and source are behind (i).
Zoletil 100, Solution
Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.
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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 22 Oct 2026