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Active substance

Trilostane

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Adrenal corticosteroid synthesis inhibitor (3-beta-HSD). No registration in force in Georgia. Forms: capsule.

Dose and use

Doses

Each dose comes with its source. Check the label of the product you use.

Active substance Trilostane
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
2 mg/kg Dog Hyperadrenocorticism (Cushing's syndrome) By mouth once daily
VMD SPC
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Vetoryl 60 mg hard capsules for dogs - Summary of Product Characteristics
UK Veterinary Medicines Directorate, Product Information Database, 2025
10–30 mg per animal
off-label
 Cat Hyperadrenocorticism (Cushing's syndrome) By mouth once daily
JVIM 2013 (15 cats)
Scientific article
A study or review published in a scientific journal. Its findings apply to the animals and conditions it studied.
Trilostane therapy for treatment of spontaneous hyperadrenocorticism in cats: 15 cases (2004-2012)
Journal of Veterinary Internal Medicine 27:1471-1477, 2013
Before use

Safety information

Known Contraindications

  • Warning
    Hypoadrenocorticism, including acute Addisonian crisis (collapse), can develop at any dose; adrenal necrosis and sudden death are very rare. Check electrolytes and an ACTH stimulation test 4-6 hours after dosing at 10 days, 4 weeks, 12 weeks, then every 3 months and after every dose change. If the test is non-stimulatory, stop for 7 days and restart at a lower dose.
    Sources: VMD SPC · VMD · FDA
  • Warning
    Do not use with primary hepatic disease or renal insufficiency, in pregnant or lactating animals or animals intended for breeding. Extreme caution with anaemia; diabetes mellitus needs specific monitoring; wait at least a month after mitotane. Pancreatitis risk is raised in hyperadrenocorticism.
    Sources: VMD SPC · VMD
  • Warning
    Hyperkalaemia risk with ACE inhibitors or potassium-sparing diuretics (spironolactone); deaths, including sudden death, have been reported with an ACE inhibitor. Use together only after a risk-benefit decision.
    Sources: VMD SPC · VMD · FDA
  • Warning (Cat)
    Cat (off-label): weight loss, urinary tract infection, chronic kidney disease, seizures, recurrent pancreatitis and hypocortisolaemia were seen during treatment. Stop and recheck if the cat stops eating or becomes lethargic.
    Sources: JVIM
Latin name
Trilostane
Georgian name
ტრილოსტანი
Registered in Georgia
0 of 6 forms
Products
Vetoryl
Controlled in Georgia
Unknown
All forms and registration6

Registration in Georgia and abroad: the register, number, validity and source are behind (i).

Vetoryl 5 mg, Capsule

hard capsule, trilostane 5 mg, for dogs
Composition / strength
Trilostane5 mg
Formulation Type
Capsule
Administration route
By mouth
Registration
Georgia No
Not registered in Georgia
Veterinary (National Food Agency)
Verified on: 29 Oct 2026
 UK Yes, veterinary
№ Vm 50406/5022
Verified on: 29 Oct 2026
 US Yes, veterinary
№ NADA 141-291
Verified on: 29 Oct 2026
Controlled in Georgia
Unknown

Vetoryl 10 mg, Capsule

hard capsule, trilostane 10 mg, for dogs
Composition / strength
Trilostane10 mg
Formulation Type
Capsule
Administration route
By mouth
Registration
Georgia No
Not registered in Georgia
Veterinary (National Food Agency)
Verified on: 29 Oct 2026
 UK Yes, veterinary
№ Vm 50406/5019
Verified on: 29 Oct 2026
 US Yes, veterinary
№ NADA 141-291
Verified on: 29 Oct 2026
Controlled in Georgia
Unknown

Vetoryl 20 mg, Capsule

hard capsule, trilostane 20 mg, for dogs
Composition / strength
Trilostane20 mg
Formulation Type
Capsule
Administration route
By mouth
Registration
Georgia No
Not registered in Georgia
Veterinary (National Food Agency)
Verified on: 29 Oct 2026
 UK Yes, veterinary
№ Vm 50406/3007
Verified on: 29 Oct 2026
 US Yes, veterinary
№ NADA 141-291
Verified on: 29 Oct 2026
Controlled in Georgia
Unknown

Vetoryl 30 mg, Capsule

hard capsule, trilostane 30 mg, for dogs
Composition / strength
Trilostane30 mg
Formulation Type
Capsule
Administration route
By mouth
Registration
Georgia No
Not registered in Georgia
Veterinary (National Food Agency)
Verified on: 29 Oct 2026
 UK Yes, veterinary
№ Vm 50406/5021
Verified on: 29 Oct 2026
 US Yes, veterinary
№ NADA 141-291
Verified on: 29 Oct 2026
Controlled in Georgia
Unknown

Vetoryl 60 mg, Capsule

hard capsule, trilostane 60 mg, for dogs
Composition / strength
Trilostane60 mg
Formulation Type
Capsule
Administration route
By mouth
Registration
Georgia No
Not registered in Georgia
Veterinary (National Food Agency)
Verified on: 29 Oct 2026
 UK Yes, veterinary
№ Vm 50406/5023
Verified on: 29 Oct 2026
 US Yes, veterinary
№ NADA 141-291
Verified on: 29 Oct 2026
Controlled in Georgia
Unknown

Vetoryl 120 mg, Capsule

hard capsule, trilostane 120 mg, for dogs
Composition / strength
Trilostane120 mg
Formulation Type
Capsule
Administration route
By mouth
Registration
Georgia No
Not registered in Georgia
Veterinary (National Food Agency)
Verified on: 29 Oct 2026
 UK Yes, veterinary
№ Vm 50406/5020
Verified on: 29 Oct 2026
 US Yes, veterinary
№ NADA 141-291
Verified on: 29 Oct 2026
Controlled in Georgia
Unknown

Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

For veterinary professionals only. It does not replace clinical judgement or the product label; check the dose in the official label (SPC). vetman is not liable for harm caused by using this information.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 30 Oct 2026

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The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

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