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Dexivet

Dexmedetomidine · Bioveta

1 form: solution. In force in Georgia: 1 of 1 (veterinary register).

Forms and doses1 of 1 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Weight Dose Frequency Georgia
0.5 mg/ml, Solution · Cat Any weight Cat Any weight 0.08 ml/kg
Sedation and analgesia for non-invasive, mildly to moderately painful procedures and examinations, and premedication before general anaesthesia: the same dose for both, 40 µg/kg (0.08 ml/kg), into a muscle only. Not for repeat injection. Label table: 1-2 kg 0.1 ml; 2-3 kg 0.2 ml; 3-4 kg 0.3 ml; 4-6 kg 0.4 ml; 6-7 kg 0.5 ml; 7-8 kg 0.6 ml; 8-10 kg 0.7 ml. After premedication, induction can follow in 10 minutes (ketamine 5 mg/kg IM, or propofol IV to effect).
· once
once Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog 2–3 kg Dog 2–3 kg Sedation · Intravenous: 0.12 mlSedation · Intramuscular: 0.15 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 0.12 mlPremedication · Intravenous / Intramuscular: 0.04–0.12 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog 3–4 kg Dog 3–4 kg Sedation · Intravenous: 0.17 mlSedation · Intramuscular: 0.2 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 0.16 mlPremedication · Intravenous / Intramuscular: 0.05–0.17 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog 4–5 kg Dog 4–5 kg Sedation · Intravenous: 0.2 mlSedation · Intramuscular: 0.3 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 0.2 mlPremedication · Intravenous / Intramuscular: 0.07–0.2 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog 5–10 kg Dog 5–10 kg Sedation · Intravenous: 0.29 mlSedation · Intramuscular: 0.4 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 0.25 mlPremedication · Intravenous / Intramuscular: 0.1–0.29 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog 10–13 kg Dog 10–13 kg Sedation · Intravenous: 0.38 mlSedation · Intramuscular: 0.5 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 0.3 mlPremedication · Intravenous / Intramuscular: 0.13–0.38 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog 13–15 kg Dog 13–15 kg Sedation · Intravenous: 0.44 mlSedation · Intramuscular: 0.6 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 0.35 mlPremedication · Intravenous / Intramuscular: 0.15–0.44 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog 15–20 kg Dog 15–20 kg Sedation · Intravenous: 0.51 mlSedation · Intramuscular: 0.7 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 0.4 mlPremedication · Intravenous / Intramuscular: 0.17–0.51 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog 20–25 kg Dog 20–25 kg Sedation · Intravenous: 0.6 mlSedation · Intramuscular: 0.8 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 0.5 mlPremedication · Intravenous / Intramuscular: 0.2–0.6 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog 25–30 kg Dog 25–30 kg Sedation · Intravenous: 0.69 mlSedation · Intramuscular: 0.9 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 0.55 mlPremedication · Intravenous / Intramuscular: 0.23–0.69 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog 30–33 kg Dog 30–33 kg Sedation · Intravenous: 0.75 mlSedation · Intramuscular: 1 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 0.6 mlPremedication · Intravenous / Intramuscular: 0.25–0.75 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog 33–37 kg Dog 33–37 kg Sedation · Intravenous: 0.81 mlSedation · Intramuscular: 1.1 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 0.65 mlPremedication · Intravenous / Intramuscular: 0.27–0.81 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog 37–45 kg Dog 37–45 kg Sedation · Intravenous: 0.9 mlSedation · Intramuscular: 1.2 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 0.7 mlPremedication · Intravenous / Intramuscular: 0.3–0.9 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog 45–50 kg Dog 45–50 kg Sedation · Intravenous: 0.99 mlSedation · Intramuscular: 1.3 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 0.8 mlPremedication · Intravenous / Intramuscular: 0.33–0.99 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog 50–55 kg Dog 50–55 kg Sedation · Intravenous: 1.06 mlSedation · Intramuscular: 1.4 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 0.85 mlPremedication · Intravenous / Intramuscular: 0.35–1.06 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog 55–60 kg Dog 55–60 kg Sedation · Intravenous: 1.13 mlSedation · Intramuscular: 1.5 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 0.9 mlPremedication · Intravenous / Intramuscular: 0.38–1.13 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog 60–65 kg Dog 60–65 kg Sedation · Intravenous: 1.19 mlSedation · Intramuscular: 1.6 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 0.95 mlPremedication · Intravenous / Intramuscular: 0.4–1.19 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog 65–70 kg Dog 65–70 kg Sedation · Intravenous: 1.26 mlSedation · Intramuscular: 1.7 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 1 mlPremedication · Intravenous / Intramuscular: 0.42–1.26 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog 70–80 kg Dog 70–80 kg Sedation · Intravenous: 1.35 mlSedation · Intramuscular: 1.8 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 1.1 mlPremedication · Intravenous / Intramuscular: 0.45–1.35 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
0.5 mg/ml, Solution · Dog over 80 kg Dog over 80 kg Sedation · Intravenous: 1.42 mlSedation · Intramuscular: 1.9 mlDeep Sedation and Analgesia with Butorphanol · Intramuscular: 1.2 mlPremedication · Intravenous / Intramuscular: 0.47–1.42 ml - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
Details: pack, label wording, sources, registration

Dexivet 0.5 mg/ml, Solution

dexmedetomidine hydrochloride 0.5 mg/ml, solution for injection for dogs and cats
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Full canine label: restraint, sedation and analgesia for non-invasive mildly to moderately painful procedures; deep sedation with butorphanol; and premedication before general anaesthesia
8.0/10
Very good
vetman assessment

Dexivet

0.5 mg/ml, dexmedetomidine hydrochloride 0.5 mg/ml, solution for injection for dogs and cats
Assessed clinical scopeDog · Full canine label: restraint, sedation and analgesia for non-invasive mildly to moderately painful procedures; deep sedation with butorphanol; and premedication before general anaesthesia · IV,IM
Care settingMonitored veterinary sedation and anaesthesia with cardiorespiratory and temperature monitoring and reversal capability
vetman score 8.0/10 Very good
Evidence confidence: Medium Georgia: Yes, veterinary · Verified on 18 Oct 2026

A transparent, authorised dexmedetomidine generic that offers the established canine sedation and premedication benefits with the same need for cardiovascular monitoring and exact dosing as the reference formulation.

Regulatory and scientific credibility8.5/10

The exact 0.5 mg/ml product is registered in Georgia and valid in the EU network under a transparent generic authorisation with a regulator-hosted exact-product SPC.

Clinical efficacy8.5/10

The authorised product matches the established dexmedetomidine concentration and regimen; regulator data, independent trials and meta-analysis support the class effects without evidence that a properly authorised generic should be clinically discounted.

Safety and tolerability7.0/10

The expected safety profile is well defined but includes clinically important bradycardia, arrhythmia, blood-pressure change, respiratory depression and hypothermia requiring selection and monitoring.

Clinical practicality8.0/10

IV or IM administration and atipamezole reversal fit routine anaesthesia workflows, although body-surface-area dosing and small injectable volumes require accurate calculation and syringes.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use in animals with cardiovascular disorders, severe systemic disease, a moribund state or hypersensitivity to the product.
  • Monitor cardiac and respiratory function and body temperature frequently. Keep the patient warm, protect the cornea and have oxygen and manual or mechanical ventilation available when the protocol warrants it.
  • Other CNS depressants potentiate dexmedetomidine and require dose adjustment. Use anticholinergics cautiously; concurrent or subsequent administration can worsen hypertension, tachycardia or arrhythmia.
  • Safety during pregnancy or lactation is not established and use is not recommended. Safety in breeding males is also not established.
  • The injectable bolus is not intended for repeat injections. Calculate small volumes accurately; CRI use requires exact dilution, a syringe or infusion pump and an adjusted total fluid rate.
  • Use in puppies younger than 16 weeks has not been studied.
  • Bradycardia and mucous-membrane colour changes are very common; arrhythmia is common, and blood-pressure change, heart block, pulmonary oedema or respiratory depression may occur.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Full feline label: restraint, sedation and analgesia for non-invasive mildly to moderately painful procedures and premedication before general anaesthesia
7.9/10
Good
vetman assessment

Dexivet

0.5 mg/ml, dexmedetomidine hydrochloride 0.5 mg/ml, solution for injection for dogs and cats
Assessed clinical scopeCat · Full feline label: restraint, sedation and analgesia for non-invasive mildly to moderately painful procedures and premedication before general anaesthesia · Intramuscular
Care settingMonitored veterinary sedation and anaesthesia with warming, eye protection, cardiorespiratory monitoring and reversal capability
vetman score 7.9/10 Good
Evidence confidence: Medium Georgia: Yes, veterinary · Verified on 18 Oct 2026

A credible authorised generic for feline procedural sedation and premedication. Its efficacy is well supported by applicable dexmedetomidine evidence, while safe use still depends on active monitoring and management of common predictable alpha-2 effects.

Regulatory and scientific credibility8.5/10

The exact 0.5 mg/ml product is registered in Georgia and valid in the EU network under a transparent generic authorisation with a regulator-hosted exact-product SPC.

Clinical efficacy8.5/10

The exact authorised product uses the established feline dexmedetomidine regimen, while blinded clinical and regulator field studies support procedural sedation, analgesia, anaesthetic dose-sparing and reversal for this concentration.

Safety and tolerability6.5/10

Expected alpha-2 adverse effects are well characterised: vomiting, bradycardia, arrhythmia and heart block are prominent, with possible hypothermia, reduced oxygenation and apnoea.

Clinical practicality8.0/10

A single IM dose and atipamezole reversal are workable in practice, but small-volume accuracy, warming, corneal protection and ketamine-aware recovery require an equipped clinic.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use in animals with cardiovascular disorders, severe systemic disease, a moribund state or hypersensitivity to the product.
  • Monitor cardiac and respiratory function and body temperature frequently. Keep the patient warm, protect the cornea and have oxygen and manual or mechanical ventilation available when the protocol warrants it.
  • Other CNS depressants potentiate dexmedetomidine and require dose adjustment. Use anticholinergics cautiously; concurrent or subsequent administration can worsen hypertension, tachycardia or arrhythmia.
  • Safety during pregnancy or lactation is not established and use is not recommended. Safety in breeding males is also not established.
  • The injectable bolus is not intended for repeat injections. Calculate small volumes accurately; CRI use requires exact dilution, a syringe or infusion pump and an adjusted total fluid rate.
  • Use in kittens younger than 12 weeks has not been studied.
  • Vomiting, bradycardia, arrhythmia and heart block are very common. Hypothermia, decreased oxygenation and apnoea can occur; ketamine combinations require ventilation readiness and correct reversal timing.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Dexmedetomidine0.5 mg/ml
Formulation Type
Solution
Administration route
Intravenous, Intramuscular
Manufacturer
Bioveta · Czechia
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: დექსივეტი 0.5 მგ/მლ საინექციო ხსნარი
Verified on: 18 Oct 2026
EU Yes, veterinary
№ 96/012/23-C
Verified on: 18 Oct 2026
UK No
Verified on: 18 Oct 2026
US No
Verified on: 18 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
0.08 ml/kg
Sedation and analgesia for non-invasive, mildly to moderately painful procedures and examinations, and premedication before general anaesthesia: the same dose for both, 40 µg/kg (0.08 ml/kg), into a muscle only. Not for repeat injection. Label table: 1-2 kg 0.1 ml; 2-3 kg 0.2 ml; 3-4 kg 0.3 ml; 4-6 kg 0.4 ml; 6-7 kg 0.5 ml; 7-8 kg 0.6 ml; 8-10 kg 0.7 ml. After premedication, induction can follow in 10 minutes (ketamine 5 mg/kg IM, or propofol IV to effect).
Cat Any weight Intramuscular once
UPD SPC 2025
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
DEXIVET 0.5 mg/ml solution for injection - SPC (Czech Republic)
EU Union Product Database, 2025
Dog
WeightSedation · IntravenousSedation · IntramuscularDeep Sedation and Analgesia with Butorphanol · IntramuscularPremedication · Intravenous / Intramuscular
2–3 kg 0.12 ml 0.15 ml 0.12 ml 0.04–0.12 ml
3–4 kg 0.17 ml 0.2 ml 0.16 ml 0.05–0.17 ml
4–5 kg 0.2 ml 0.3 ml 0.2 ml 0.07–0.2 ml
5–10 kg 0.29 ml 0.4 ml 0.25 ml 0.1–0.29 ml
10–13 kg 0.38 ml 0.5 ml 0.3 ml 0.13–0.38 ml
13–15 kg 0.44 ml 0.6 ml 0.35 ml 0.15–0.44 ml
15–20 kg 0.51 ml 0.7 ml 0.4 ml 0.17–0.51 ml
20–25 kg 0.6 ml 0.8 ml 0.5 ml 0.2–0.6 ml
25–30 kg 0.69 ml 0.9 ml 0.55 ml 0.23–0.69 ml
30–33 kg 0.75 ml 1 ml 0.6 ml 0.25–0.75 ml
33–37 kg 0.81 ml 1.1 ml 0.65 ml 0.27–0.81 ml
37–45 kg 0.9 ml 1.2 ml 0.7 ml 0.3–0.9 ml
45–50 kg 0.99 ml 1.3 ml 0.8 ml 0.33–0.99 ml
50–55 kg 1.06 ml 1.4 ml 0.85 ml 0.35–1.06 ml
55–60 kg 1.13 ml 1.5 ml 0.9 ml 0.38–1.13 ml
60–65 kg 1.19 ml 1.6 ml 0.95 ml 0.4–1.19 ml
65–70 kg 1.26 ml 1.7 ml 1 ml 0.42–1.26 ml
70–80 kg 1.35 ml 1.8 ml 1.1 ml 0.45–1.35 ml
over 80 kg 1.42 ml 1.9 ml 1.2 ml 0.47–1.42 ml
  • Sedation · Intravenous (once; not for repeat injection): Sedation and analgesia for non-invasive, mildly to moderately painful procedures and examinations: up to 375 µg/m² into a vein, given as the label volume for the weight band. Not for repeat injection.
  • Sedation · Intramuscular (once; not for repeat injection): Sedation and analgesia for non-invasive, mildly to moderately painful procedures and examinations: up to 500 µg/m² into a muscle, given as the label volume for the weight band. Not for repeat injection.
  • Deep Sedation and Analgesia with Butorphanol · Intramuscular (once, with butorphanol 0.1 mg/kg): Deep sedation and analgesia for medical and minor surgical procedures, with butorphanol 0.1 mg/kg (the two may share a syringe): 300 µg/m² into a muscle. Effect within 15 minutes, peak at 30; sedation lasts at least 120 minutes, analgesia at least 90.
  • Premedication · Intravenous / Intramuscular (once, 20 minutes before induction): Premedication before induction and maintenance of general anaesthesia: 125-375 µg/m² into a vein or a muscle, adjusted to the type and length of surgery and to temperament. Give induction and maintenance drugs to effect (in the label study propofol needs fell by 30%, thiopental by 60%).
Source:
UPD SPC 2025
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
DEXIVET 0.5 mg/ml solution for injection - SPC (Czech Republic)
EU Union Product Database, 2025
Active substance doses, with sources
Active substance Dexmedetomidine
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
0.125–0.375 mg/m² (BSA) Dog Premedication Intravenous / Intramuscular once, 20 minutes before induction
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Dexdomitor 0.5 mg/ml solution for injection for dogs and cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
0.375 mg/m² (BSA) Dog Sedation Intravenous single dose; do not repeat
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Dexdomitor 0.5 mg/ml solution for injection for dogs and cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
0.5 mg/m² (BSA) Dog Sedation Intramuscular single dose; do not repeat
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Dexdomitor 0.5 mg/ml solution for injection for dogs and cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
0.3 mg/m² (BSA) Dog Deep Sedation and Analgesia with Butorphanol
Sedation
Intramuscular once with butorphanol 0.1 mg/kg
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Dexdomitor 0.5 mg/ml solution for injection for dogs and cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
40 mcg/kg Cat Premedication Intramuscular once; induce anaesthesia 10 minutes later
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Dexdomitor 0.5 mg/ml solution for injection for dogs and cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
40 mcg/kg Cat Sedation Intramuscular single dose; do not repeat
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Dexdomitor 0.5 mg/ml solution for injection for dogs and cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026

Known Contraindications

  • Critical
    Do not use dexmedetomidine in dogs or cats with cardiovascular disease.
    Sources: FDA
  • Critical
    Do not use dexmedetomidine in animals with clinically important bradyarrhythmia. It can cause profound sinus bradycardia, first- or second-degree atrioventricular block, and sinus arrest.
  • Critical
    Do not use DEXDOMITOR in dogs or cats with... respiratory disorders
    Sources: FDA
  • Critical
    Do not use dexmedetomidine in dogs or cats with hepatic disease because reduced hepatic blood flow or metabolism may prolong and intensify its effects.
    Sources: FDA
  • Critical
    Do not use DEXDOMITOR in dogs or cats with... liver or kidney diseases
    Sources: FDA
  • Critical
    Known hypersensitivity to dexmedetomidine or any excipient, including methyl- or propyl parahydroxybenzoate, is a contraindication.
  • Warning
    Dexmedetomidine is not recommended during pregnancy because safety in the target species has not been established.
  • Warning
    Dexmedetomidine is not recommended during lactation because safety in the target species has not been established.
    Sources: Dexdomitor SPC
  • Caution
    Do not use this anaesthetic product in animals with severe systemic disease, shock, profound debilitation, moribund status, or severe stress from extreme temperature or fatigue. It is not intended for repeated injections.
    Sources: FDA
  • Caution
    Dexmedetomidine has not been studied in puppies younger than 16 weeks or kittens younger than 12 weeks. Use cautiously in elderly animals.

Known Drug Interactions

  • Minor warning Dexmedetomidine + Acepromazine
    Other central nervous system depressants can potentiate dexmedetomidine; adjust the dose appropriately when they are used together.
    Recommendation: to effect
    Sources: Dexdomitor SPC
  • Minor warning Dexmedetomidine + Atropine
    Use anticholinergic drugs cautiously with dexmedetomidine because marked cardiovascular effects may occur.
    Recommendation: Do not administer together routinely; manage bradycardia individually with monitoring.
    Sources: Dexdomitor SPC · FDA
  • Minor warning Buprenorphine + Dexmedetomidine
    Centrally acting drugs, including tranquillisers, sedatives, and hypnotics, can increase buprenorphine-induced drowsiness. Combined use with sedatives can also increase depression of heart rate and respiration.
    Recommendation: Reduce the sedative dose during premedication; monitor heart rate and respiration.
  • Minor warning Butorphanol + Dexmedetomidine
    Other central nervous system depressants can potentiate dexmedetomidine; adjust the dose appropriately when they are used together.
    Recommendation: to effect
    Sources: Dexdomitor SPC
  • Minor warning Ketamine + Dexmedetomidine
    Other central nervous system depressants can potentiate dexmedetomidine; adjust the dose appropriately when they are used together.
    Recommendation: to effect
    Sources: Dexdomitor SPC
  • Minor warning Propofol + Dexmedetomidine
    Other central nervous system depressants can potentiate dexmedetomidine; adjust the dose appropriately when they are used together.
    Recommendation: to effect
    Sources: Dexdomitor SPC
  • Minor warning Methadone + Dexmedetomidine
    Methadone can potentiate analgesics, central nervous system depressants, and drugs that cause respiratory depression. Lower doses may be needed when these medicines are combined.
    Recommendation: Reduce doses when used in combination; monitor heart rate and respiration.
    Sources: Comfortan SPC
  • Minor warning Dexmedetomidine + Diazepam
    Other central nervous system depressants can potentiate dexmedetomidine; adjust the dose appropriately when they are used together.
    Recommendation: to effect
    Sources: Dexdomitor SPC
  • Minor warning Dexmedetomidine + Glycopyrrolate
    Use anticholinergic drugs cautiously with dexmedetomidine because marked cardiovascular effects may occur.
    Recommendation: Do not administer together routinely; manage bradycardia individually with monitoring.
    Sources: Dexdomitor SPC · FDA
  • Minor warning Dexmedetomidine + Midazolam
    Other central nervous system depressants can potentiate dexmedetomidine; adjust the dose appropriately when they are used together.
    Recommendation: to effect
    Sources: Dexdomitor SPC

All of this shows in vetman as you prescribe

The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.