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Active substance

Esafoxolaner

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Isoxazoline. Registered in Georgia: 2 veterinary products. Forms: spot-on.

Dose and use

Doses

Each dose comes with its source. Check the label of the product you use.

Active substance Esafoxolaner
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
1.44 mg/kg Cat Maintenance On the skin once
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
NexGard Combo spot-on solution for cats 2.5-7.5 kg - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
Before use

Safety information

Known Contraindications

  • Critical
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Warning (Cat)
    The safety of the veterinary medicinal product has not been tested in kittens under 8 weeks of age. The product is for use in cats weighing at least 0.8 kg and from 8 weeks of age.
    Sources: VMD SPC · VMD
  • Warning (Cat)
    Target animal safety has not been evaluated beyond 6 consecutive monthly treatments and accumulation of esafoxolaner and eprinomectin was observed up to the 5th monthly administration (see also sections 3.10 and 4.3). Repeated treatments beyond 6 consecutive months should be restricted to limited individual situations (see section 3.9 for treatment guidance), with a minimum treatment interval of 4 weeks, according to a benefit-risk evaluation by the responsible veterinarian.
    Sources: VMD SPC · VMD
Latin name
Esafoxolaner
Georgian name
ესაფოქსოლანერი
Authorisation status
Authorised veterinary medicine
An authorised veterinary medicine containing this substance exists. Whether a particular use is on-label depends on the species and the indication - see each dose rule.
Registered in Georgia
2 of 2 forms
Products
NexGard Combo
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
All forms and registration2

Registration in Georgia and abroad: the register, number, validity and source are behind (i).

NexGard Combo, Spot-on

esafoxolaner 3.60 mg + eprinomectin 1.20 mg + praziquantel 24.90 mg, spot-on solution for cats 0.8-<2.5 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
8.5/10
Very good
vetman assessment

NexGard Combo

esafoxolaner 3.60 mg + eprinomectin 1.20 mg + praziquantel 24.90 mg, spot-on solution for cats 0.8-<2.5 kg
Assessed clinical scopeCat · Full labelled feline mixed-infestation scope, exclusively when ectoparasites, gastrointestinal nematodes and cestodes are all targeted together, including labelled flea, tick, mite, worm and cardiopulmonary indications · On the skin
Care settingVeterinary-selected integrated feline parasite treatment after diagnosis and exposure-risk assessment
vetman score 8.5/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 77-11, 28-11 · Verified on 15 Oct 2026

A highly effective all-in-one feline option when ectoparasites, nematodes and cestodes must all be targeted; avoid routine use when the full fixed spectrum is unnecessary.

Regulatory and scientific credibility9.5/10

Both exact applicators are centrally authorised in the EU, covered by current official product information and actively registered in Georgia, with a broad indication-specific evidence package.

Clinical efficacy9.0/10

Controlled and field studies support high efficacy against the major labelled ecto- and endoparasites; the benefit depends on selecting a patient in whom all three required parasite groups genuinely need simultaneous treatment.

Safety and tolerability7.0/10

The labelled safety profile is generally favourable, including in pregnancy and lactation, but young or underweight kittens, accumulation with repeated monthly use, rare neurologic toxicity at marked overdose and adult-heartworm assessment require attention.

Clinical practicality8.5/10

One topical applicator treats a very broad mixed infestation and can be used as a single dose, but exact skin placement, prevention of licking, weight-band selection and veterinarian-directed rather than automatic monthly repetition are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use exclusively when ectoparasites, gastrointestinal nematodes and cestodes are all targeted at the same time; do not use the fixed triple combination for an incomplete target set.
  • Use only from 8 weeks of age and at least 0.8 kg; apply the exact whole applicator to skin where the cat cannot lick it and avoid shampooing for two days.
  • In heartworm-endemic areas, test cats aged 6 months or older for adult infection before prevention; no adulticidal heartworm effect is established.
  • Safety beyond six consecutive monthly treatments has not been evaluated; repeated treatment beyond this is limited to individual benefit-risk decisions with at least four-week intervals.
Assessment sources
  1. VMD SPC 20252025
  2. EMA NexGard Combo EPAR2025
  3. NexGard Combo flea field studies2021
  4. NexGard Combo helminth RCTs2021
  5. NexGard Combo safety studies2021
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Esafoxolaner3.6 mg Eprinomectin1.2 mg Praziquantel24.9 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ნექსგარდ® კომბო დასაწვეთებელი ხსნარი <2.5კგ კატებისათვის
№ 77-11, 28-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ NADA 141-570
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

NexGard Combo, Spot-on

esafoxolaner 10.80 mg + eprinomectin 3.60 mg + praziquantel 74.70 mg, spot-on solution for cats 2.5-<7.5 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
8.5/10
Very good
vetman assessment

NexGard Combo

esafoxolaner 10.80 mg + eprinomectin 3.60 mg + praziquantel 74.70 mg, spot-on solution for cats 2.5-<7.5 kg
Assessed clinical scopeCat · Full labelled feline mixed-infestation scope, exclusively when ectoparasites, gastrointestinal nematodes and cestodes are all targeted together, including labelled flea, tick, mite, worm and cardiopulmonary indications · On the skin
Care settingVeterinary-selected integrated feline parasite treatment after diagnosis and exposure-risk assessment
vetman score 8.5/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 5-11 · Verified on 15 Oct 2026

A highly effective all-in-one feline option when ectoparasites, nematodes and cestodes must all be targeted; avoid routine use when the full fixed spectrum is unnecessary.

Regulatory and scientific credibility9.5/10

Both exact applicators are centrally authorised in the EU, covered by current official product information and actively registered in Georgia, with a broad indication-specific evidence package.

Clinical efficacy9.0/10

Controlled and field studies support high efficacy against the major labelled ecto- and endoparasites; the benefit depends on selecting a patient in whom all three required parasite groups genuinely need simultaneous treatment.

Safety and tolerability7.0/10

The labelled safety profile is generally favourable, including in pregnancy and lactation, but young or underweight kittens, accumulation with repeated monthly use, rare neurologic toxicity at marked overdose and adult-heartworm assessment require attention.

Clinical practicality8.5/10

One topical applicator treats a very broad mixed infestation and can be used as a single dose, but exact skin placement, prevention of licking, weight-band selection and veterinarian-directed rather than automatic monthly repetition are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use exclusively when ectoparasites, gastrointestinal nematodes and cestodes are all targeted at the same time; do not use the fixed triple combination for an incomplete target set.
  • Use only from 8 weeks of age and at least 0.8 kg; apply the exact whole applicator to skin where the cat cannot lick it and avoid shampooing for two days.
  • In heartworm-endemic areas, test cats aged 6 months or older for adult infection before prevention; no adulticidal heartworm effect is established.
  • Safety beyond six consecutive monthly treatments has not been evaluated; repeated treatment beyond this is limited to individual benefit-risk decisions with at least four-week intervals.
Assessment sources
  1. VMD SPC 20252025
  2. EMA NexGard Combo EPAR2025
  3. NexGard Combo flea field studies2021
  4. NexGard Combo helminth RCTs2021
  5. NexGard Combo safety studies2021
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Esafoxolaner10.8 mg Eprinomectin3.6 mg Praziquantel74.7 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Manufacturer (register)
SCS Boehringer Ingelheim Animal Health France SCS, France
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1636, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ნექსგარდ® კომბო დასაწვეთებელი ხსნარი 2.5-7.5 კგ კატებისათვის
№ 5-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ NADA 141-570
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

For veterinary professionals only. It does not replace clinical judgement or the product label; check the dose in the official label (SPC). vetman is not liable for harm caused by using this information.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 16 Oct 2026

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