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NexGard Combo

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Esafoxolaner + Eprinomectin + Praziquantel · Boehringer Ingelheim

2 forms: spot-on. In force in Georgia: 2 of 2 (veterinary register).

Forms and doses2 of 2 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Weight Dose Frequency Georgia
Spot-on · Cat 0.8–2.5 kg Cat 0.8–2.5 kg 1 pipette
The recommended minimum doses are 1.44 mg esafoxolaner, 0.48 mg eprinomectin and 10 mg praziquantel per kg bodyweight. appropriate combination of applicators The need for and frequency of re-treatment(s) should be in accordance with the advice of the prescribing veterinarian The veterinary medicinal product is exclusively indicated when all three groups are targeted at the same time. Can be used in pregnant and lactating queens.
 · once; repeat as assessed by the veterinarian, at least 4 weeks apart		 once; repeat as assessed by the veterinarian, at least 4 weeks apart Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ნექსგარდ® კომბო დასაწვეთებელი ხსნარი <2.5კგ კატებისათვის
№ 77-11, 28-11
Verified on: 15 Oct 2026
Spot-on · Dog Any weight Dog Any weight No dose for this species
This product is labelled only for cats; no canine dose is established.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ნექსგარდ® კომბო დასაწვეთებელი ხსნარი <2.5კგ კატებისათვის
№ 77-11, 28-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

NexGard Combo, Spot-on

esafoxolaner 3.60 mg + eprinomectin 1.20 mg + praziquantel 24.90 mg, spot-on solution for cats 0.8-<2.5 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
8.5/10
Very good
vetman assessment

NexGard Combo

esafoxolaner 3.60 mg + eprinomectin 1.20 mg + praziquantel 24.90 mg, spot-on solution for cats 0.8-<2.5 kg
Assessed clinical scopeCat · Full labelled feline mixed-infestation scope, exclusively when ectoparasites, gastrointestinal nematodes and cestodes are all targeted together, including labelled flea, tick, mite, worm and cardiopulmonary indications · On the skin
Care settingVeterinary-selected integrated feline parasite treatment after diagnosis and exposure-risk assessment
vetman score 8.5/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 77-11, 28-11 · Verified on 15 Oct 2026

A highly effective all-in-one feline option when ectoparasites, nematodes and cestodes must all be targeted; avoid routine use when the full fixed spectrum is unnecessary.

Regulatory and scientific credibility9.5/10

Both exact applicators are centrally authorised in the EU, covered by current official product information and actively registered in Georgia, with a broad indication-specific evidence package.

Clinical efficacy9.0/10

Controlled and field studies support high efficacy against the major labelled ecto- and endoparasites; the benefit depends on selecting a patient in whom all three required parasite groups genuinely need simultaneous treatment.

Safety and tolerability7.0/10

The labelled safety profile is generally favourable, including in pregnancy and lactation, but young or underweight kittens, accumulation with repeated monthly use, rare neurologic toxicity at marked overdose and adult-heartworm assessment require attention.

Clinical practicality8.5/10

One topical applicator treats a very broad mixed infestation and can be used as a single dose, but exact skin placement, prevention of licking, weight-band selection and veterinarian-directed rather than automatic monthly repetition are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use exclusively when ectoparasites, gastrointestinal nematodes and cestodes are all targeted at the same time; do not use the fixed triple combination for an incomplete target set.
  • Use only from 8 weeks of age and at least 0.8 kg; apply the exact whole applicator to skin where the cat cannot lick it and avoid shampooing for two days.
  • In heartworm-endemic areas, test cats aged 6 months or older for adult infection before prevention; no adulticidal heartworm effect is established.
  • Safety beyond six consecutive monthly treatments has not been evaluated; repeated treatment beyond this is limited to individual benefit-risk decisions with at least four-week intervals.
Assessment sources
  1. VMD SPC 20252025
  2. EMA NexGard Combo EPAR2025
  3. NexGard Combo flea field studies2021
  4. NexGard Combo helminth RCTs2021
  5. NexGard Combo safety studies2021
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Esafoxolaner3.6 mg Eprinomectin1.2 mg Praziquantel24.9 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ნექსგარდ® კომბო დასაწვეთებელი ხსნარი <2.5კგ კატებისათვის
№ 77-11, 28-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ NADA 141-570
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 pipette
The recommended minimum doses are 1.44 mg esafoxolaner, 0.48 mg eprinomectin and 10 mg praziquantel per kg bodyweight. appropriate combination of applicators The need for and frequency of re-treatment(s) should be in accordance with the advice of the prescribing veterinarian The veterinary medicinal product is exclusively indicated when all three groups are targeted at the same time. Can be used in pregnant and lactating queens.
 Cat 0.8–2.5 kg On the skin once; repeat as assessed by the veterinarian, at least 4 weeks apart Product label (SPC)
No dose for this species
This product is labelled only for cats; no canine dose is established.
 Dog Any weight On the skin - Product label (SPC)
Spot-on · Cat 2.5–7.5 kg Cat 2.5–7.5 kg 1 pipette
The recommended minimum doses are 1.44 mg esafoxolaner, 0.48 mg eprinomectin and 10 mg praziquantel per kg bodyweight. appropriate combination of applicators Can be used in pregnant and lactating queens.
 · once; repeat as assessed by the veterinarian, at least 4 weeks apart		 once; repeat as assessed by the veterinarian, at least 4 weeks apart Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ნექსგარდ® კომბო დასაწვეთებელი ხსნარი 2.5-7.5 კგ კატებისათვის
№ 5-11
Verified on: 15 Oct 2026
Spot-on · Dog Any weight Dog Any weight No dose for this species
This product is labelled only for cats; no canine dose is established.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ნექსგარდ® კომბო დასაწვეთებელი ხსნარი 2.5-7.5 კგ კატებისათვის
№ 5-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

NexGard Combo, Spot-on

esafoxolaner 10.80 mg + eprinomectin 3.60 mg + praziquantel 74.70 mg, spot-on solution for cats 2.5-<7.5 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
8.5/10
Very good
vetman assessment

NexGard Combo

esafoxolaner 10.80 mg + eprinomectin 3.60 mg + praziquantel 74.70 mg, spot-on solution for cats 2.5-<7.5 kg
Assessed clinical scopeCat · Full labelled feline mixed-infestation scope, exclusively when ectoparasites, gastrointestinal nematodes and cestodes are all targeted together, including labelled flea, tick, mite, worm and cardiopulmonary indications · On the skin
Care settingVeterinary-selected integrated feline parasite treatment after diagnosis and exposure-risk assessment
vetman score 8.5/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 5-11 · Verified on 15 Oct 2026

A highly effective all-in-one feline option when ectoparasites, nematodes and cestodes must all be targeted; avoid routine use when the full fixed spectrum is unnecessary.

Regulatory and scientific credibility9.5/10

Both exact applicators are centrally authorised in the EU, covered by current official product information and actively registered in Georgia, with a broad indication-specific evidence package.

Clinical efficacy9.0/10

Controlled and field studies support high efficacy against the major labelled ecto- and endoparasites; the benefit depends on selecting a patient in whom all three required parasite groups genuinely need simultaneous treatment.

Safety and tolerability7.0/10

The labelled safety profile is generally favourable, including in pregnancy and lactation, but young or underweight kittens, accumulation with repeated monthly use, rare neurologic toxicity at marked overdose and adult-heartworm assessment require attention.

Clinical practicality8.5/10

One topical applicator treats a very broad mixed infestation and can be used as a single dose, but exact skin placement, prevention of licking, weight-band selection and veterinarian-directed rather than automatic monthly repetition are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use exclusively when ectoparasites, gastrointestinal nematodes and cestodes are all targeted at the same time; do not use the fixed triple combination for an incomplete target set.
  • Use only from 8 weeks of age and at least 0.8 kg; apply the exact whole applicator to skin where the cat cannot lick it and avoid shampooing for two days.
  • In heartworm-endemic areas, test cats aged 6 months or older for adult infection before prevention; no adulticidal heartworm effect is established.
  • Safety beyond six consecutive monthly treatments has not been evaluated; repeated treatment beyond this is limited to individual benefit-risk decisions with at least four-week intervals.
Assessment sources
  1. VMD SPC 20252025
  2. EMA NexGard Combo EPAR2025
  3. NexGard Combo flea field studies2021
  4. NexGard Combo helminth RCTs2021
  5. NexGard Combo safety studies2021
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Esafoxolaner10.8 mg Eprinomectin3.6 mg Praziquantel74.7 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Manufacturer (register)
SCS Boehringer Ingelheim Animal Health France SCS, France
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1636, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ნექსგარდ® კომბო დასაწვეთებელი ხსნარი 2.5-7.5 კგ კატებისათვის
№ 5-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ NADA 141-570
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 pipette
The recommended minimum doses are 1.44 mg esafoxolaner, 0.48 mg eprinomectin and 10 mg praziquantel per kg bodyweight. appropriate combination of applicators Can be used in pregnant and lactating queens.
 Cat 2.5–7.5 kg On the skin once; repeat as assessed by the veterinarian, at least 4 weeks apart Product label (SPC)
No dose for this species
This product is labelled only for cats; no canine dose is established.
 Dog Any weight On the skin - Product label (SPC)
Active substance doses, with sources
Active substance Esafoxolaner
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
1.44 mg/kg Cat Maintenance On the skin once
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
NexGard Combo spot-on solution for cats 2.5-7.5 kg - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
Active substance Eprinomectin
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
0.48 mg/kg Cat Maintenance On the skin once
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
NexGard Combo spot-on solution for cats 2.5-7.5 kg - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
Active substance Praziquantel
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
5 mg/kg Dog, Cat Maintenance By mouth once
VMD SPC 2022
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Krka Multiwormer 50/144/150 mg tablets for dogs - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2022
VMD SPC 2024
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Krka Wormer 230 mg/20 mg film-coated tablets for cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2024

Known Contraindications

  • Critical Eprinomectin
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Warning Eprinomectin (Cat)
    The safety of the veterinary medicinal product has not been tested in kittens under 8 weeks of age. The product is for use in cats weighing at least 0.8 kg and from 8 weeks of age.
    Sources: VMD SPC · VMD
  • Warning Eprinomectin (Cat)
    Target animal safety has not been evaluated beyond 6 consecutive monthly treatments and accumulation of esafoxolaner and eprinomectin was observed up to the 5th monthly administration (see also sections 3.10 and 4.3). Repeated treatments beyond 6 consecutive months should be restricted to limited individual situations (see section 3.9 for treatment guidance), with a minimum treatment interval of 4 weeks, according to a benefit-risk evaluation by the responsible veterinarian.
    Sources: VMD SPC · VMD
  • Caution Eprinomectin (Cat)
    Although the veterinary medicinal product may be safely administered to cats infected with adult heartworms, no therapeutic effect against adult Dirofilaria immitis has been established. It is, therefore, recommended that all cats 6 months of age or older, living in endemic areas for heartworm, should be tested for existing adult heartworm infection before being treated with the product for heartworm disease prevention.
    Sources: VMD SPC · VMD
  • Critical Esafoxolaner
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Warning Esafoxolaner (Cat)
    The safety of the veterinary medicinal product has not been tested in kittens under 8 weeks of age. The product is for use in cats weighing at least 0.8 kg and from 8 weeks of age.
    Sources: VMD SPC · VMD
  • Warning Esafoxolaner (Cat)
    Target animal safety has not been evaluated beyond 6 consecutive monthly treatments and accumulation of esafoxolaner and eprinomectin was observed up to the 5th monthly administration (see also sections 3.10 and 4.3). Repeated treatments beyond 6 consecutive months should be restricted to limited individual situations (see section 3.9 for treatment guidance), with a minimum treatment interval of 4 weeks, according to a benefit-risk evaluation by the responsible veterinarian.
    Sources: VMD SPC · VMD
  • Critical Praziquantel
    Do not use in cases of known hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 16 Oct 2026

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The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

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