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Active substance

Benzathine Benzylpenicillin

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Natural penicillin. Registered in Georgia: 2 veterinary products. Forms: suspension.

Dose and use

Doses

We have no dose with a cited source for this substance yet.

Before use

Safety information

Known Contraindications

  • Critical
    No established benzathine benzylpenicillin dose exists for dogs or cats. Use in these species is not merely off-label: the component itself lacks an established small-animal dose, and its depot action determines the 72-hour interval.
    Source: EMA Sources: VMD · FDA · EMA

Known Drug Interactions

  • Major warning Oxytetracycline + Benzathine Benzylpenicillin
    Do not give oxytetracycline at the same time as bactericidal antimicrobials such as penicillins or cephalosporins because their antibacterial effects may be antagonistic.
    Recommendation: Do not administer concurrently.
Latin name
Benzathine Benzylpenicillin
Georgian name
ბენზათინ ბენზილპენიცილინი
Authorisation status
Authorised veterinary medicine
An authorised veterinary medicine containing this substance exists. Whether a particular use is on-label depends on the species and the indication - see each dose rule.
Registered in Georgia
2 of 2 forms
Products
Penstrep-400 LA, Shotapen
Human medicines in Georgia
Deposilin
Human medicines with this substance in the Georgian register of medicines (Ministry of Health), checked on 18 Oct 2026. They are human medicines, not veterinary products; strengths and forms differ.
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
All forms and registration2

Registration in Georgia and abroad: the register, number, validity and source are behind (i).

Penstrep-400 LA 200 000 IU + 200 mg/ml, Suspension

suspension for injection
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Proposed intramuscular treatment of a susceptible bacterial infection in a dog with exact Interchemie Penstrep-400 LA
Not rateable
No numerical score assigned
vetman assessment

Penstrep-400 LA

200 000 IU + 200 mg/ml, suspension for injection
Assessed clinical scopeDog · Proposed intramuscular treatment of a susceptible bacterial infection in a dog with exact Interchemie Penstrep-400 LA · Intramuscular
Care settingNot an established companion-animal pathway; use a product and regimen with exact dog/cat evidence rather than extrapolating a food-animal benzathine depot schedule
vetman score Not rateable No numerical score assigned
Evidence confidence: Medium Georgia: Yes, veterinary · № 001103 · Verified on 15 Oct 2026 Off-label use
Not rateable

A numerical canine product score cannot responsibly be calculated. Exact Interchemie Penstrep-400 LA is identifiable and registered in Georgia, but its current official instruction and register record cover food animals only. The published 0.1 ml/kg q72h regimen is a benzathine-containing depot schedule for cattle, calves, sheep, goats and pigs; no exact-product dog/cat dose, pharmacokinetic bridge, target-animal safety study or clinical outcome evidence was found. Shotapen has a different authorised product dossier and IM/SC dog/cat label, while Dutch dog/cat penicillin-dihydrostreptomycin products cannot establish equivalence to this Interchemie depot. The fixed aminoglycoside also adds renal, otic and neuromuscular risk. Assigning a low number would imply a quantifiable companion-animal benefit-risk that the evidence does not support.

The exact product is transparent enough to identify why it should not receive a dog/cat number: its public benefit-risk and 72-hour depot regimen belong to different target species. Georgian registration remains visible, but registration for food animals is not a companion-animal indication.

Important safety and use flags

  • Verify exact Interchemie Penstrep-400 LA (IPBS): 100,000 IU/ml procaine penicillin G + 100,000 IU/ml benzathine penicillin G + 200 mg/ml dihydrostreptomycin. Do not confuse it with plain Penstrep-400, Shotapen, Penstrep-ject or another similarly named product.
  • No dog or cat dose is established for this exact product. Do not use the food-animal 0.1 ml/kg every 72 hours regimen, and do not copy a daily two-component or another manufacturer’s dog/cat schedule; benzathine depot exposure is the unresolved difference.
  • Use systemic antibiotics only for a diagnosed or strongly supported bacterial infection. Obtain culture and susceptibility whenever feasible, prioritise source control and narrower first-line therapy, and reassess promptly rather than treating a broad syndrome list empirically.
  • The fixed combination does not guarantee coverage: penicillinase-producing staphylococci, resistant Enterobacterales, Pseudomonas and other resistant or intrinsically nonsusceptible organisms may fail. The two components cannot be independently PK/PD-optimised.
  • Dihydrostreptomycin is nephrotoxic. Avoid in dehydration, hypovolaemia or serious renal impairment and review renal function, urine findings and concurrent nephrotoxins before any aminoglycoside exposure; accumulation risk increases when clearance is reduced.
  • Aminoglycosides can cause irreversible cochlear/vestibular toxicity, neurotoxicity and neuromuscular blockade. Monitor hearing, balance, weakness and respiration; anaesthesia, neuromuscular blockers and electrolyte abnormalities can increase blockade risk.
  • Do not use with penicillin, procaine or aminoglycoside hypersensitivity. Urticaria and anaphylaxis are possible; accidental intravascular procaine exposure can cause tremor, vomiting, incoordination and other acute neurologic signs.
  • The exact instruction contraindicates concurrent tetracyclines, chloramphenicol, macrolides and lincosamides because of possible antagonism. Avoid other aminoglycosides, loop diuretics and potentially nephrotoxic/ototoxic drugs unless a specialist documents the rationale and monitoring.
  • Companion-animal pregnancy, lactation, neonatal, geriatric and reproductive safety is not established for this exact depot product. Do not infer it from food-animal withdrawal information or from a different penicillin preparation.
  • The exact product is IM-only and must be shaken well. Food-animal per-site volume limits, withdrawal periods and the 48-72-hour interval do not validate dog/cat injection volume, site tolerance, repeat dosing or handling; avoid accidental self-injection and seek urgent care for human hypersensitivity symptoms.
Assessment sources
  1. Interchemie Penstrep-400 LA2026
  2. Penstrep-400 LA GE register2026
  3. Kenya VMD Penstrep-400 LA2023
  4. Republika Srpska register 20252025
  5. UPD SPC 20242024
  6. EMA AMEG 20252025
  7. MSD Vet Manual 20262026
  8. AAFP AAHA stewardship2022
Assessed: 22 Oct 2026No axis or overall score is shown when the available evidence does not support a responsible numerical assessment.
Cat Proposed intramuscular treatment of a susceptible bacterial infection in a cat with exact Interchemie Penstrep-400 LA
Not rateable
No numerical score assigned
vetman assessment

Penstrep-400 LA

200 000 IU + 200 mg/ml, suspension for injection
Assessed clinical scopeCat · Proposed intramuscular treatment of a susceptible bacterial infection in a cat with exact Interchemie Penstrep-400 LA · Intramuscular
Care settingNot an established companion-animal pathway; use a product and regimen with exact dog/cat evidence rather than extrapolating a food-animal benzathine depot schedule
vetman score Not rateable No numerical score assigned
Evidence confidence: Medium Georgia: Yes, veterinary · № 001103 · Verified on 15 Oct 2026 Off-label use
Not rateable

A numerical feline product score cannot responsibly be calculated. Exact Interchemie Penstrep-400 LA is identifiable and registered in Georgia, but its current official instruction and register record cover food animals only. The published 0.1 ml/kg q72h regimen is a benzathine-containing depot schedule for cattle, calves, sheep, goats and pigs; no exact-product dog/cat dose, pharmacokinetic bridge, target-animal safety study or clinical outcome evidence was found. Shotapen has a different authorised product dossier and IM/SC dog/cat label, while Dutch dog/cat penicillin-dihydrostreptomycin products cannot establish equivalence to this Interchemie depot. The fixed aminoglycoside also adds renal, otic and neuromuscular risk. Assigning a low number would imply a quantifiable companion-animal benefit-risk that the evidence does not support.

The exact product is transparent enough to identify why it should not receive a dog/cat number: its public benefit-risk and 72-hour depot regimen belong to different target species. Georgian registration remains visible, but registration for food animals is not a companion-animal indication.

Important safety and use flags

  • Verify exact Interchemie Penstrep-400 LA (IPBS): 100,000 IU/ml procaine penicillin G + 100,000 IU/ml benzathine penicillin G + 200 mg/ml dihydrostreptomycin. Do not confuse it with plain Penstrep-400, Shotapen, Penstrep-ject or another similarly named product.
  • No dog or cat dose is established for this exact product. Do not use the food-animal 0.1 ml/kg every 72 hours regimen, and do not copy a daily two-component or another manufacturer’s dog/cat schedule; benzathine depot exposure is the unresolved difference.
  • Use systemic antibiotics only for a diagnosed or strongly supported bacterial infection. Obtain culture and susceptibility whenever feasible, prioritise source control and narrower first-line therapy, and reassess promptly rather than treating a broad syndrome list empirically.
  • The fixed combination does not guarantee coverage: penicillinase-producing staphylococci, resistant Enterobacterales, Pseudomonas and other resistant or intrinsically nonsusceptible organisms may fail. The two components cannot be independently PK/PD-optimised.
  • Dihydrostreptomycin is nephrotoxic. Avoid in dehydration, hypovolaemia or serious renal impairment and review renal function, urine findings and concurrent nephrotoxins before any aminoglycoside exposure; accumulation risk increases when clearance is reduced.
  • Aminoglycosides can cause irreversible cochlear/vestibular toxicity, neurotoxicity and neuromuscular blockade. Monitor hearing, balance, weakness and respiration; anaesthesia, neuromuscular blockers and electrolyte abnormalities can increase blockade risk.
  • Do not use with penicillin, procaine or aminoglycoside hypersensitivity. Urticaria and anaphylaxis are possible; accidental intravascular procaine exposure can cause tremor, vomiting, incoordination and other acute neurologic signs.
  • The exact instruction contraindicates concurrent tetracyclines, chloramphenicol, macrolides and lincosamides because of possible antagonism. Avoid other aminoglycosides, loop diuretics and potentially nephrotoxic/ototoxic drugs unless a specialist documents the rationale and monitoring.
  • Companion-animal pregnancy, lactation, neonatal, geriatric and reproductive safety is not established for this exact depot product. Do not infer it from food-animal withdrawal information or from a different penicillin preparation.
  • The exact product is IM-only and must be shaken well. Food-animal per-site volume limits, withdrawal periods and the 48-72-hour interval do not validate dog/cat injection volume, site tolerance, repeat dosing or handling; avoid accidental self-injection and seek urgent care for human hypersensitivity symptoms.
Assessment sources
  1. Interchemie Penstrep-400 LA2026
  2. Penstrep-400 LA GE register2026
  3. Kenya VMD Penstrep-400 LA2023
  4. Republika Srpska register 20252025
  5. UPD SPC 20242024
  6. EMA AMEG 20252025
  7. MSD Vet Manual 20262026
  8. AAFP AAHA stewardship2022
Assessed: 22 Oct 2026No axis or overall score is shown when the available evidence does not support a responsible numerical assessment.
Composition / strength
Procaine Benzylpenicillin100000 IU/ml Benzathine Benzylpenicillin100000 IU/ml Dihydrostreptomycin200 mg/ml
Formulation Type
Suspension
Administration route
Intramuscular
Registration
Georgia Yes, veterinary
In force until 11 May 2029
Veterinary (National Food Agency)
In the register: პენსტრეპ 400 ლა
№ 001103
Verified on: 15 Oct 2026
 EU No
Verified on: 15 Oct 2026
 UK No
Verified on: 15 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Shotapen, Suspension

procaine benzylpenicillin 100 mg + benzathine benzylpenicillin 100 mg + dihydrostreptomycin 200 mg/ml, suspension for injection
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Labelled treatment of infections caused by bacteria susceptible to the fixed penicillin-dihydrostreptomycin combination
6.5/10
Situational / acceptable
vetman assessment

Shotapen

procaine benzylpenicillin 100 mg + benzathine benzylpenicillin 100 mg + dihydrostreptomycin 200 mg/ml, suspension for injection
Assessed clinical scopeDog · Labelled treatment of infections caused by bacteria susceptible to the fixed penicillin-dihydrostreptomycin combination · IM,SC
Care settingVeterinary clinic treatment selected by likely pathogen, culture and patient renal status
vetman score 6.5/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, veterinary · Verified on 18 Oct 2026

A legally well-documented but clinically narrow fixed antibiotic combination; reserve for a justified susceptible infection when safer, more targeted options are unsuitable.

Regulatory and scientific credibility8.0/10

The exact long-acting combination has a current valid French authorisation, transparent SPC and an active Georgian veterinary registration record.

Clinical efficacy5.5/10

The components can be active against susceptible organisms, but the fixed broad combination, old evidence base, resistance risk and inability to independently optimise beta-lactam and aminoglycoside exposure make it a narrow culture-directed choice.

Safety and tolerability5.0/10

Dihydrostreptomycin adds clinically important nephrotoxic and ototoxic risk, especially with dehydration or renal impairment; penicillin/procaine hypersensitivity is a hard contraindication.

Clinical practicality8.0/10

A single IM or SC injection, with at most one repeat after 72 hours, is operationally simple in clinic; the suspension must be shaken and the weight-based range selected carefully.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use with penicillin or procaine hypersensitivity; avoid accidental exposure in rabbits, guinea pigs, hamsters and gerbils.
  • Avoid or use only with strict monitoring in dehydration or renal impairment because the aminoglycoside component is nephrotoxic and ototoxic.
  • Reserve the fixed combination for a justified susceptible infection; culture and susceptibility are preferred whenever feasible.
Assessment sources
  1. UPD SPC 20242024
  2. EMA AMEG 20252025
  3. MSD Vet Manual 20262026
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Labelled treatment of infections caused by bacteria susceptible to the fixed penicillin-dihydrostreptomycin combination
6.5/10
Situational / acceptable
vetman assessment

Shotapen

procaine benzylpenicillin 100 mg + benzathine benzylpenicillin 100 mg + dihydrostreptomycin 200 mg/ml, suspension for injection
Assessed clinical scopeCat · Labelled treatment of infections caused by bacteria susceptible to the fixed penicillin-dihydrostreptomycin combination · IM,SC
Care settingVeterinary clinic treatment selected by likely pathogen, culture and patient renal status
vetman score 6.5/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, veterinary · Verified on 18 Oct 2026

A legally well-documented but clinically narrow fixed antibiotic combination; reserve for a justified susceptible infection when safer, more targeted options are unsuitable.

Regulatory and scientific credibility8.0/10

The exact long-acting combination has a current valid French authorisation, transparent SPC and an active Georgian veterinary registration record.

Clinical efficacy5.5/10

The components can be active against susceptible organisms, but the fixed broad combination, old evidence base, resistance risk and inability to independently optimise beta-lactam and aminoglycoside exposure make it a narrow culture-directed choice.

Safety and tolerability5.0/10

Dihydrostreptomycin adds clinically important nephrotoxic and ototoxic risk, especially with dehydration or renal impairment; penicillin/procaine hypersensitivity is a hard contraindication.

Clinical practicality8.0/10

A single IM or SC injection, with at most one repeat after 72 hours, is operationally simple in clinic; the suspension must be shaken and the weight-based range selected carefully.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use with penicillin or procaine hypersensitivity; avoid accidental exposure in rabbits, guinea pigs, hamsters and gerbils.
  • Avoid or use only with strict monitoring in dehydration or renal impairment because the aminoglycoside component is nephrotoxic and ototoxic.
  • Reserve the fixed combination for a justified susceptible infection; culture and susceptibility are preferred whenever feasible.
Assessment sources
  1. UPD SPC 20242024
  2. EMA AMEG 20252025
  3. MSD Vet Manual 20262026
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Procaine Benzylpenicillin100 mg/ml Benzathine Benzylpenicillin100 mg/ml Dihydrostreptomycin200 mg/ml
Formulation Type
Suspension
Administration route
Intramuscular, Subcutaneous
Manufacturer
Virbac · France
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: შოტაპენი®
Verified on: 18 Oct 2026
 EU Yes, veterinary
№ FR/V/9639616 8/1991
Verified on: 18 Oct 2026
 UK No
Verified on: 18 Oct 2026
 US No
Verified on: 18 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 18 Oct 2026

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