KA/EN
Register
Medicines reference
Search
Search
Product

Penstrep-400 LA

Favourites

Procaine Benzylpenicillin + Benzathine Benzylpenicillin + Dihydrostreptomycin · Interchemie werken De Adelaar Eesti AS

1 form: suspension. In force in Georgia: 1 of 1 (veterinary register).

Forms and doses1 of 1 in force in Georgia

Form Dose Frequency Georgia
200 000 IU + 200 mg/ml, Suspension No label dose in the reference yet - Georgia Yes, veterinary
In force until 11 May 2029
Veterinary (National Food Agency)
In the register: პენსტრეპ 400 ლა
№ 001103
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Penstrep-400 LA 200 000 IU + 200 mg/ml, Suspension

suspension for injection
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Proposed intramuscular treatment of a susceptible bacterial infection in a dog with exact Interchemie Penstrep-400 LA
Not rateable
No numerical score assigned
vetman assessment

Penstrep-400 LA

200 000 IU + 200 mg/ml, suspension for injection
Assessed clinical scopeDog · Proposed intramuscular treatment of a susceptible bacterial infection in a dog with exact Interchemie Penstrep-400 LA · Intramuscular
Care settingNot an established companion-animal pathway; use a product and regimen with exact dog/cat evidence rather than extrapolating a food-animal benzathine depot schedule
vetman score Not rateable No numerical score assigned
Evidence confidence: Medium Georgia: Yes, veterinary · № 001103 · Verified on 15 Oct 2026 Off-label use
Not rateable

A numerical canine product score cannot responsibly be calculated. Exact Interchemie Penstrep-400 LA is identifiable and registered in Georgia, but its current official instruction and register record cover food animals only. The published 0.1 ml/kg q72h regimen is a benzathine-containing depot schedule for cattle, calves, sheep, goats and pigs; no exact-product dog/cat dose, pharmacokinetic bridge, target-animal safety study or clinical outcome evidence was found. Shotapen has a different authorised product dossier and IM/SC dog/cat label, while Dutch dog/cat penicillin-dihydrostreptomycin products cannot establish equivalence to this Interchemie depot. The fixed aminoglycoside also adds renal, otic and neuromuscular risk. Assigning a low number would imply a quantifiable companion-animal benefit-risk that the evidence does not support.

The exact product is transparent enough to identify why it should not receive a dog/cat number: its public benefit-risk and 72-hour depot regimen belong to different target species. Georgian registration remains visible, but registration for food animals is not a companion-animal indication.

Important safety and use flags

  • Verify exact Interchemie Penstrep-400 LA (IPBS): 100,000 IU/ml procaine penicillin G + 100,000 IU/ml benzathine penicillin G + 200 mg/ml dihydrostreptomycin. Do not confuse it with plain Penstrep-400, Shotapen, Penstrep-ject or another similarly named product.
  • No dog or cat dose is established for this exact product. Do not use the food-animal 0.1 ml/kg every 72 hours regimen, and do not copy a daily two-component or another manufacturer’s dog/cat schedule; benzathine depot exposure is the unresolved difference.
  • Use systemic antibiotics only for a diagnosed or strongly supported bacterial infection. Obtain culture and susceptibility whenever feasible, prioritise source control and narrower first-line therapy, and reassess promptly rather than treating a broad syndrome list empirically.
  • The fixed combination does not guarantee coverage: penicillinase-producing staphylococci, resistant Enterobacterales, Pseudomonas and other resistant or intrinsically nonsusceptible organisms may fail. The two components cannot be independently PK/PD-optimised.
  • Dihydrostreptomycin is nephrotoxic. Avoid in dehydration, hypovolaemia or serious renal impairment and review renal function, urine findings and concurrent nephrotoxins before any aminoglycoside exposure; accumulation risk increases when clearance is reduced.
  • Aminoglycosides can cause irreversible cochlear/vestibular toxicity, neurotoxicity and neuromuscular blockade. Monitor hearing, balance, weakness and respiration; anaesthesia, neuromuscular blockers and electrolyte abnormalities can increase blockade risk.
  • Do not use with penicillin, procaine or aminoglycoside hypersensitivity. Urticaria and anaphylaxis are possible; accidental intravascular procaine exposure can cause tremor, vomiting, incoordination and other acute neurologic signs.
  • The exact instruction contraindicates concurrent tetracyclines, chloramphenicol, macrolides and lincosamides because of possible antagonism. Avoid other aminoglycosides, loop diuretics and potentially nephrotoxic/ototoxic drugs unless a specialist documents the rationale and monitoring.
  • Companion-animal pregnancy, lactation, neonatal, geriatric and reproductive safety is not established for this exact depot product. Do not infer it from food-animal withdrawal information or from a different penicillin preparation.
  • The exact product is IM-only and must be shaken well. Food-animal per-site volume limits, withdrawal periods and the 48-72-hour interval do not validate dog/cat injection volume, site tolerance, repeat dosing or handling; avoid accidental self-injection and seek urgent care for human hypersensitivity symptoms.
Assessment sources
  1. Interchemie Penstrep-400 LA2026
  2. Penstrep-400 LA GE register2026
  3. Kenya VMD Penstrep-400 LA2023
  4. Republika Srpska register 20252025
  5. UPD SPC 20242024
  6. EMA AMEG 20252025
  7. MSD Vet Manual 20262026
  8. AAFP AAHA stewardship2022
Assessed: 22 Oct 2026No axis or overall score is shown when the available evidence does not support a responsible numerical assessment.
Cat Proposed intramuscular treatment of a susceptible bacterial infection in a cat with exact Interchemie Penstrep-400 LA
Not rateable
No numerical score assigned
vetman assessment

Penstrep-400 LA

200 000 IU + 200 mg/ml, suspension for injection
Assessed clinical scopeCat · Proposed intramuscular treatment of a susceptible bacterial infection in a cat with exact Interchemie Penstrep-400 LA · Intramuscular
Care settingNot an established companion-animal pathway; use a product and regimen with exact dog/cat evidence rather than extrapolating a food-animal benzathine depot schedule
vetman score Not rateable No numerical score assigned
Evidence confidence: Medium Georgia: Yes, veterinary · № 001103 · Verified on 15 Oct 2026 Off-label use
Not rateable

A numerical feline product score cannot responsibly be calculated. Exact Interchemie Penstrep-400 LA is identifiable and registered in Georgia, but its current official instruction and register record cover food animals only. The published 0.1 ml/kg q72h regimen is a benzathine-containing depot schedule for cattle, calves, sheep, goats and pigs; no exact-product dog/cat dose, pharmacokinetic bridge, target-animal safety study or clinical outcome evidence was found. Shotapen has a different authorised product dossier and IM/SC dog/cat label, while Dutch dog/cat penicillin-dihydrostreptomycin products cannot establish equivalence to this Interchemie depot. The fixed aminoglycoside also adds renal, otic and neuromuscular risk. Assigning a low number would imply a quantifiable companion-animal benefit-risk that the evidence does not support.

The exact product is transparent enough to identify why it should not receive a dog/cat number: its public benefit-risk and 72-hour depot regimen belong to different target species. Georgian registration remains visible, but registration for food animals is not a companion-animal indication.

Important safety and use flags

  • Verify exact Interchemie Penstrep-400 LA (IPBS): 100,000 IU/ml procaine penicillin G + 100,000 IU/ml benzathine penicillin G + 200 mg/ml dihydrostreptomycin. Do not confuse it with plain Penstrep-400, Shotapen, Penstrep-ject or another similarly named product.
  • No dog or cat dose is established for this exact product. Do not use the food-animal 0.1 ml/kg every 72 hours regimen, and do not copy a daily two-component or another manufacturer’s dog/cat schedule; benzathine depot exposure is the unresolved difference.
  • Use systemic antibiotics only for a diagnosed or strongly supported bacterial infection. Obtain culture and susceptibility whenever feasible, prioritise source control and narrower first-line therapy, and reassess promptly rather than treating a broad syndrome list empirically.
  • The fixed combination does not guarantee coverage: penicillinase-producing staphylococci, resistant Enterobacterales, Pseudomonas and other resistant or intrinsically nonsusceptible organisms may fail. The two components cannot be independently PK/PD-optimised.
  • Dihydrostreptomycin is nephrotoxic. Avoid in dehydration, hypovolaemia or serious renal impairment and review renal function, urine findings and concurrent nephrotoxins before any aminoglycoside exposure; accumulation risk increases when clearance is reduced.
  • Aminoglycosides can cause irreversible cochlear/vestibular toxicity, neurotoxicity and neuromuscular blockade. Monitor hearing, balance, weakness and respiration; anaesthesia, neuromuscular blockers and electrolyte abnormalities can increase blockade risk.
  • Do not use with penicillin, procaine or aminoglycoside hypersensitivity. Urticaria and anaphylaxis are possible; accidental intravascular procaine exposure can cause tremor, vomiting, incoordination and other acute neurologic signs.
  • The exact instruction contraindicates concurrent tetracyclines, chloramphenicol, macrolides and lincosamides because of possible antagonism. Avoid other aminoglycosides, loop diuretics and potentially nephrotoxic/ototoxic drugs unless a specialist documents the rationale and monitoring.
  • Companion-animal pregnancy, lactation, neonatal, geriatric and reproductive safety is not established for this exact depot product. Do not infer it from food-animal withdrawal information or from a different penicillin preparation.
  • The exact product is IM-only and must be shaken well. Food-animal per-site volume limits, withdrawal periods and the 48-72-hour interval do not validate dog/cat injection volume, site tolerance, repeat dosing or handling; avoid accidental self-injection and seek urgent care for human hypersensitivity symptoms.
Assessment sources
  1. Interchemie Penstrep-400 LA2026
  2. Penstrep-400 LA GE register2026
  3. Kenya VMD Penstrep-400 LA2023
  4. Republika Srpska register 20252025
  5. UPD SPC 20242024
  6. EMA AMEG 20252025
  7. MSD Vet Manual 20262026
  8. AAFP AAHA stewardship2022
Assessed: 22 Oct 2026No axis or overall score is shown when the available evidence does not support a responsible numerical assessment.
Composition / strength
Procaine Benzylpenicillin100000 IU/ml Benzathine Benzylpenicillin100000 IU/ml Dihydrostreptomycin200 mg/ml
Formulation Type
Suspension
Administration route
Intramuscular
Registration
Georgia Yes, veterinary
In force until 11 May 2029
Veterinary (National Food Agency)
In the register: პენსტრეპ 400 ლა
№ 001103
Verified on: 15 Oct 2026
 EU No
Verified on: 15 Oct 2026
 UK No
Verified on: 15 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

The dose of a combination product is determined by its own product information. The doses below apply to the individual active substances and should not be used as the dose of this product.

Active substance doses, with sources
Active substance Procaine Benzylpenicillin
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
20 mg/kg Dog, Cat Bacterial Infection Intramuscular once daily
EMA referral 2023
Official product label (SPC), EMA, EU
Approved by the European Medicines Agency (EMA) as part of the product's authorisation. It applies to that product as authorised there.
Procaine benzylpenicillin - Article 82 referral, Annexes I, II and III
European Medicines Agency, Committee for Veterinary Medicinal Products, 2023
30 mg/kg Dog, Cat Bacterial Infection Subcutaneous once daily
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Depocillin 300 mg/ml suspension for injection - Summary of Product Characteristics
UK Veterinary Medicines Directorate, Product Information Database, 2026
Active substance Dihydrostreptomycin
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
20 mg/kg Dog, Cat Bacterial Infection Intramuscular once daily
CBG Penstrep-ject SPC
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
Penstrep-ject suspension for injection - Summary of Product Characteristics
CBG-MEB Veterinary Medicines Information Bank, 2025
11 mg/kg
off-label
 Dog Bacterial Infection Intramuscular 2 times daily
MSD Vet Manual 2026
Reference book
A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose.
Aminoglycosides Use in Animals
MSD/Merck Veterinary Manual, 2026

Benzathine Benzylpenicillin: No dose supported by a publicly verifiable source yet

Known Contraindications

  • Critical Benzathine Benzylpenicillin
    No established benzathine benzylpenicillin dose exists for dogs or cats. Use in these species is not merely off-label: the component itself lacks an established small-animal dose, and its depot action determines the 72-hour interval.
    Source: EMA Sources: VMD · FDA · EMA
  • Critical Dihydrostreptomycin
    Do not use the penicillin-dihydrostreptomycin combination in renal insufficiency because the aminoglycoside component is contraindicated.
    Sources: MSD Vet Manual
  • Critical Dihydrostreptomycin
    Dehydration and hypovolaemia directly increase aminoglycoside nephrotoxicity, as do acidosis, aciduria, hypomagnesaemia, severe sepsis, and endotoxaemia. Restore hydration before treatment; dehydration is a contraindication for some products.
    Sources: MSD Vet Manual
  • Warning Dihydrostreptomycin
    Safety during pregnancy and lactation has not been established. Because dihydrostreptomycin can be nephrotoxic and ototoxic, use only after a careful benefit-risk assessment.
  • Warning Dihydrostreptomycin
    Lengthen the dosing interval in neonates (especially puppies and foals), in animals with kidney failure and in obese animals.
    Sources: MSD Vet Manual
  • Warning Dihydrostreptomycin
    Safety of the penicillin-dihydrostreptomycin combination during pregnancy and lactation has not been established. The restriction is driven by the aminoglycoside component; use only after a careful benefit-risk assessment.
  • Warning Dihydrostreptomycin
    Aminoglycosides can cause neuromuscular blockade. This is particularly important during general anaesthesia and when other neuromuscular-blocking drugs are used.
    Sources: MSD Vet Manual
  • Warning Dihydrostreptomycin (Dog)
    Avoid aminoglycosides in working dogs that depend on hearing, such as guide dogs. Hearing loss begins at high frequencies, may progress to deafness, and can be permanent.
    Sources: MSD Vet Manual
  • Warning Dihydrostreptomycin (Cat)
    Cats are particularly sensitive to toxic vestibular effects, although these are unlikely at therapeutic concentrations after systemic administration. Vestibular injury can cause nystagmus, incoordination, and loss of the righting reflex and is often irreversible. Do not instil an aminoglycoside into the ear if the tympanic membrane is not intact.
    Sources: MSD Vet Manual
  • Critical Procaine Benzylpenicillin
    Do not use in animals hypersensitive to the active substance or any excipient. Rare reactions include life-threatening anaphylaxis. Avoid intravascular injection: sudden systemic procaine exposure may cause tremor, vomiting, incoordination, and fever.
    Sources: VMD SPC · VMD
  • Critical Procaine Benzylpenicillin
    Do not use procaine penicillin in rabbits, guinea pigs, hamsters, or gerbils. Guinea pigs, chinchillas, birds, snakes, and turtles are sensitive to procaine penicillin, and exposure may be fatal.
    Sources: VMD SPC · VMD · MSD Vet Manual

Known Drug Interactions

  • Contraindicated Furosemide + Dihydrostreptomycin
    Do not use concurrently with aminoglycoside antibiotic treatment. In cats, do not use furosemide with ototoxic antibiotics. Concomitant use with aminoglycosides or cephalosporins may increase the risk of nephrotoxicity.
    Recommendation: Do not administer concurrently. If an aminoglycoside is essential, choose a diuretic from another class.
    Sources: VMD SPC · VMD
  • Major warning Oxytetracycline + Benzathine Benzylpenicillin
    Do not give oxytetracycline at the same time as bactericidal antimicrobials such as penicillins or cephalosporins because their antibacterial effects may be antagonistic.
    Recommendation: Do not administer concurrently.
  • Major warning Ampicillin + Dihydrostreptomycin
    Ampicillin and Sulbactam for Injection and aminoglycosides should not be reconstituted together due to the in vitro inactivation of aminoglycosides by the ampicillin component.
    Recommendation: Reconstitute and administer separately at different sites. Do not run them concurrently through the same line.
    Sources: FDA
  • Major warning Carprofen + Dihydrostreptomycin
    Avoid giving carprofen with potentially nephrotoxic drugs because renal toxicity may increase.
    Recommendation: Avoid concomitant use; if unavoidable, monitor renal function.
  • Major warning Robenacoxib + Dihydrostreptomycin
    Avoid combining robenacoxib with potentially nephrotoxic medicines because the risk of renal toxicity may increase.
    Recommendation: Avoid concomitant use; if unavoidable, monitor renal function.
  • Major warning Doxycycline + Procaine Benzylpenicillin
    Tetracyclines, chloramphenicol, macrolides, and lincosamides may antagonise the bactericidal action of benzylpenicillin.
    Recommendation: Do not administer concurrently. Choose one mechanism based on susceptibility testing.
    Sources: VMD SPC · VMD
  • Major warning Oxytetracycline + Procaine Benzylpenicillin
    Do not give oxytetracycline at the same time as bactericidal antimicrobials such as penicillins or cephalosporins because their antibacterial effects may be antagonistic.
    Recommendation: Do not administer concurrently.
  • Minor warning Amoxicillin + Dihydrostreptomycin
    Penicillins may increase the effect of aminoglycosides.
    Recommendation: An enhanced effect is expected; monitor for aminoglycoside toxicity. Do not mix in the same syringe.
    Sources: VMD SPC · VMD
  • Minor warning Trimethoprim/Sulfonamide + Procaine Benzylpenicillin
    Procaine (in procaine benzylpenicillin) is an ester of para-aminobenzoic acid (PABA). Like other PABA-ester local anaesthetics such as tetracaine, it can reduce the effect of potentiated sulfonamides, at least locally.
    Recommendation: Account for a reduced sulfonamide effect during concomitant administration.
    Sources: MSD Vet Manual

Products are connected by name, active ingredients, or therapeutic group. They are not direct substitutes for one another.

Show all related products (59 more) Hide additional products

Same therapeutic group 59

Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

For veterinary professionals only. It does not replace clinical judgement or the product label; check the dose in the official label (SPC). vetman is not liable for harm caused by using this information.

Trademarks belong to their owners; vetman is not affiliated with the manufacturers and receives no payment from them.

The database is protected under Chapter VII of the Law of Georgia on Copyright and Related Rights; automated or bulk copying is prohibited.

This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 16 Oct 2026

All of this shows in vetman as you prescribe

The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

Register Demo ↗