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Procaine Benzylpenicillin + Benzathine Benzylpenicillin + Dihydrostreptomycin · Virbac

1 form: suspension. In force in Georgia: 1 of 1 (veterinary register).

Forms and doses1 of 1 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Dose Frequency Georgia
Suspension · Cat Cat 0.04–0.08 ml/kg
1-2 ml per 25 kg (0.04-0.08 ml/kg) into a muscle or under the skin, once; repeat once after 72 hours if needed. Long-acting: not daily. Shake well. Take care in kidney insufficiency or dehydration. Not in penicillin or procaine allergy.
 · once; repeat once after 72 hours if needed		 once; repeat once after 72 hours if needed Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: შოტაპენი®
Verified on: 18 Oct 2026
Suspension · Dog Dog 0.04–0.08 ml/kg
1-2 ml per 25 kg (0.04-0.08 ml/kg) into a muscle or under the skin, once; repeat once after 72 hours if needed. Long-acting: not daily. Shake well. Take care in kidney insufficiency or dehydration. Not in penicillin or procaine allergy.
 · once; repeat once after 72 hours if needed		 once; repeat once after 72 hours if needed Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: შოტაპენი®
Verified on: 18 Oct 2026
Details: pack, label wording, sources, registration

Shotapen, Suspension

procaine benzylpenicillin 100 mg + benzathine benzylpenicillin 100 mg + dihydrostreptomycin 200 mg/ml, suspension for injection
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Labelled treatment of infections caused by bacteria susceptible to the fixed penicillin-dihydrostreptomycin combination
6.5/10
Situational / acceptable
vetman assessment

Shotapen

procaine benzylpenicillin 100 mg + benzathine benzylpenicillin 100 mg + dihydrostreptomycin 200 mg/ml, suspension for injection
Assessed clinical scopeDog · Labelled treatment of infections caused by bacteria susceptible to the fixed penicillin-dihydrostreptomycin combination · IM,SC
Care settingVeterinary clinic treatment selected by likely pathogen, culture and patient renal status
vetman score 6.5/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, veterinary · Verified on 18 Oct 2026

A legally well-documented but clinically narrow fixed antibiotic combination; reserve for a justified susceptible infection when safer, more targeted options are unsuitable.

Regulatory and scientific credibility8.0/10

The exact long-acting combination has a current valid French authorisation, transparent SPC and an active Georgian veterinary registration record.

Clinical efficacy5.5/10

The components can be active against susceptible organisms, but the fixed broad combination, old evidence base, resistance risk and inability to independently optimise beta-lactam and aminoglycoside exposure make it a narrow culture-directed choice.

Safety and tolerability5.0/10

Dihydrostreptomycin adds clinically important nephrotoxic and ototoxic risk, especially with dehydration or renal impairment; penicillin/procaine hypersensitivity is a hard contraindication.

Clinical practicality8.0/10

A single IM or SC injection, with at most one repeat after 72 hours, is operationally simple in clinic; the suspension must be shaken and the weight-based range selected carefully.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use with penicillin or procaine hypersensitivity; avoid accidental exposure in rabbits, guinea pigs, hamsters and gerbils.
  • Avoid or use only with strict monitoring in dehydration or renal impairment because the aminoglycoside component is nephrotoxic and ototoxic.
  • Reserve the fixed combination for a justified susceptible infection; culture and susceptibility are preferred whenever feasible.
Assessment sources
  1. UPD SPC 20242024
  2. EMA AMEG 20252025
  3. MSD Vet Manual 20262026
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Labelled treatment of infections caused by bacteria susceptible to the fixed penicillin-dihydrostreptomycin combination
6.5/10
Situational / acceptable
vetman assessment

Shotapen

procaine benzylpenicillin 100 mg + benzathine benzylpenicillin 100 mg + dihydrostreptomycin 200 mg/ml, suspension for injection
Assessed clinical scopeCat · Labelled treatment of infections caused by bacteria susceptible to the fixed penicillin-dihydrostreptomycin combination · IM,SC
Care settingVeterinary clinic treatment selected by likely pathogen, culture and patient renal status
vetman score 6.5/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, veterinary · Verified on 18 Oct 2026

A legally well-documented but clinically narrow fixed antibiotic combination; reserve for a justified susceptible infection when safer, more targeted options are unsuitable.

Regulatory and scientific credibility8.0/10

The exact long-acting combination has a current valid French authorisation, transparent SPC and an active Georgian veterinary registration record.

Clinical efficacy5.5/10

The components can be active against susceptible organisms, but the fixed broad combination, old evidence base, resistance risk and inability to independently optimise beta-lactam and aminoglycoside exposure make it a narrow culture-directed choice.

Safety and tolerability5.0/10

Dihydrostreptomycin adds clinically important nephrotoxic and ototoxic risk, especially with dehydration or renal impairment; penicillin/procaine hypersensitivity is a hard contraindication.

Clinical practicality8.0/10

A single IM or SC injection, with at most one repeat after 72 hours, is operationally simple in clinic; the suspension must be shaken and the weight-based range selected carefully.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use with penicillin or procaine hypersensitivity; avoid accidental exposure in rabbits, guinea pigs, hamsters and gerbils.
  • Avoid or use only with strict monitoring in dehydration or renal impairment because the aminoglycoside component is nephrotoxic and ototoxic.
  • Reserve the fixed combination for a justified susceptible infection; culture and susceptibility are preferred whenever feasible.
Assessment sources
  1. UPD SPC 20242024
  2. EMA AMEG 20252025
  3. MSD Vet Manual 20262026
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Procaine Benzylpenicillin100 mg/ml Benzathine Benzylpenicillin100 mg/ml Dihydrostreptomycin200 mg/ml
Formulation Type
Suspension
Administration route
Intramuscular, Subcutaneous
Manufacturer
Virbac · France
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: შოტაპენი®
Verified on: 18 Oct 2026
 EU Yes, veterinary
№ FR/V/9639616 8/1991
Verified on: 18 Oct 2026
 UK No
Verified on: 18 Oct 2026
 US No
Verified on: 18 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
0.04–0.08 ml/kg
1-2 ml per 25 kg (0.04-0.08 ml/kg) into a muscle or under the skin, once; repeat once after 72 hours if needed. Long-acting: not daily. Shake well. Take care in kidney insufficiency or dehydration. Not in penicillin or procaine allergy.
 Cat Any weight IM,SC once; repeat once after 72 hours if needed
UPD SPC 2024
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
SHOTAPEN suspension injectable pour bovins, porcins, chiens et chats - RCP (France)
EU Union Product Database (France, FR/V/9639616 8/1991), 2024
0.04–0.08 ml/kg
1-2 ml per 25 kg (0.04-0.08 ml/kg) into a muscle or under the skin, once; repeat once after 72 hours if needed. Long-acting: not daily. Shake well. Take care in kidney insufficiency or dehydration. Not in penicillin or procaine allergy.
 Dog Any weight IM,SC once; repeat once after 72 hours if needed
UPD SPC 2024
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
SHOTAPEN suspension injectable pour bovins, porcins, chiens et chats - RCP (France)
EU Union Product Database (France, FR/V/9639616 8/1991), 2024
Active substance doses, with sources
Active substance Procaine Benzylpenicillin
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
20 mg/kg Dog, Cat Bacterial Infection Intramuscular once daily
EMA referral 2023
Official product label (SPC), EMA, EU
Approved by the European Medicines Agency (EMA) as part of the product's authorisation. It applies to that product as authorised there.
Procaine benzylpenicillin - Article 82 referral, Annexes I, II and III
European Medicines Agency, Committee for Veterinary Medicinal Products, 2023
30 mg/kg Dog, Cat Bacterial Infection Subcutaneous once daily
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Depocillin 300 mg/ml suspension for injection - Summary of Product Characteristics
UK Veterinary Medicines Directorate, Product Information Database, 2026
Active substance Dihydrostreptomycin
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
20 mg/kg Dog, Cat Bacterial Infection Intramuscular once daily
CBG Penstrep-ject SPC
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
Penstrep-ject suspension for injection - Summary of Product Characteristics
CBG-MEB Veterinary Medicines Information Bank, 2025
11 mg/kg
off-label
 Dog Bacterial Infection Intramuscular 2 times daily
MSD Vet Manual 2026
Reference book
A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose.
Aminoglycosides Use in Animals
MSD/Merck Veterinary Manual, 2026

Benzathine Benzylpenicillin: No dose supported by a publicly verifiable source yet

Known Contraindications

  • Critical Benzathine Benzylpenicillin
    No established benzathine benzylpenicillin dose exists for dogs or cats. Use in these species is not merely off-label: the component itself lacks an established small-animal dose, and its depot action determines the 72-hour interval.
    Source: EMA Sources: VMD · FDA · EMA
  • Critical Dihydrostreptomycin
    Do not use the penicillin-dihydrostreptomycin combination in renal insufficiency because the aminoglycoside component is contraindicated.
    Sources: MSD Vet Manual
  • Critical Dihydrostreptomycin
    Dehydration and hypovolaemia directly increase aminoglycoside nephrotoxicity, as do acidosis, aciduria, hypomagnesaemia, severe sepsis, and endotoxaemia. Restore hydration before treatment; dehydration is a contraindication for some products.
    Sources: MSD Vet Manual
  • Warning Dihydrostreptomycin
    Safety during pregnancy and lactation has not been established. Because dihydrostreptomycin can be nephrotoxic and ototoxic, use only after a careful benefit-risk assessment.
  • Warning Dihydrostreptomycin
    Lengthen the dosing interval in neonates (especially puppies and foals), in animals with kidney failure and in obese animals.
    Sources: MSD Vet Manual
  • Warning Dihydrostreptomycin
    Safety of the penicillin-dihydrostreptomycin combination during pregnancy and lactation has not been established. The restriction is driven by the aminoglycoside component; use only after a careful benefit-risk assessment.
  • Warning Dihydrostreptomycin
    Aminoglycosides can cause neuromuscular blockade. This is particularly important during general anaesthesia and when other neuromuscular-blocking drugs are used.
    Sources: MSD Vet Manual
  • Warning Dihydrostreptomycin (Dog)
    Avoid aminoglycosides in working dogs that depend on hearing, such as guide dogs. Hearing loss begins at high frequencies, may progress to deafness, and can be permanent.
    Sources: MSD Vet Manual
  • Warning Dihydrostreptomycin (Cat)
    Cats are particularly sensitive to toxic vestibular effects, although these are unlikely at therapeutic concentrations after systemic administration. Vestibular injury can cause nystagmus, incoordination, and loss of the righting reflex and is often irreversible. Do not instil an aminoglycoside into the ear if the tympanic membrane is not intact.
    Sources: MSD Vet Manual
  • Critical Procaine Benzylpenicillin
    Do not use in animals hypersensitive to the active substance or any excipient. Rare reactions include life-threatening anaphylaxis. Avoid intravascular injection: sudden systemic procaine exposure may cause tremor, vomiting, incoordination, and fever.
    Sources: VMD SPC · VMD
  • Critical Procaine Benzylpenicillin
    Do not use procaine penicillin in rabbits, guinea pigs, hamsters, or gerbils. Guinea pigs, chinchillas, birds, snakes, and turtles are sensitive to procaine penicillin, and exposure may be fatal.
    Sources: VMD SPC · VMD · MSD Vet Manual

Known Drug Interactions

  • Contraindicated Furosemide + Dihydrostreptomycin
    Do not use concurrently with aminoglycoside antibiotic treatment. In cats, do not use furosemide with ototoxic antibiotics. Concomitant use with aminoglycosides or cephalosporins may increase the risk of nephrotoxicity.
    Recommendation: Do not administer concurrently. If an aminoglycoside is essential, choose a diuretic from another class.
    Sources: VMD SPC · VMD
  • Major warning Oxytetracycline + Benzathine Benzylpenicillin
    Do not give oxytetracycline at the same time as bactericidal antimicrobials such as penicillins or cephalosporins because their antibacterial effects may be antagonistic.
    Recommendation: Do not administer concurrently.
  • Major warning Ampicillin + Dihydrostreptomycin
    Ampicillin and Sulbactam for Injection and aminoglycosides should not be reconstituted together due to the in vitro inactivation of aminoglycosides by the ampicillin component.
    Recommendation: Reconstitute and administer separately at different sites. Do not run them concurrently through the same line.
    Sources: FDA
  • Major warning Carprofen + Dihydrostreptomycin
    Avoid giving carprofen with potentially nephrotoxic drugs because renal toxicity may increase.
    Recommendation: Avoid concomitant use; if unavoidable, monitor renal function.
  • Major warning Robenacoxib + Dihydrostreptomycin
    Avoid combining robenacoxib with potentially nephrotoxic medicines because the risk of renal toxicity may increase.
    Recommendation: Avoid concomitant use; if unavoidable, monitor renal function.
  • Major warning Doxycycline + Procaine Benzylpenicillin
    Tetracyclines, chloramphenicol, macrolides, and lincosamides may antagonise the bactericidal action of benzylpenicillin.
    Recommendation: Do not administer concurrently. Choose one mechanism based on susceptibility testing.
    Sources: VMD SPC · VMD
  • Major warning Oxytetracycline + Procaine Benzylpenicillin
    Do not give oxytetracycline at the same time as bactericidal antimicrobials such as penicillins or cephalosporins because their antibacterial effects may be antagonistic.
    Recommendation: Do not administer concurrently.
  • Minor warning Amoxicillin + Dihydrostreptomycin
    Penicillins may increase the effect of aminoglycosides.
    Recommendation: An enhanced effect is expected; monitor for aminoglycoside toxicity. Do not mix in the same syringe.
    Sources: VMD SPC · VMD
  • Minor warning Trimethoprim/Sulfonamide + Procaine Benzylpenicillin
    Procaine (in procaine benzylpenicillin) is an ester of para-aminobenzoic acid (PABA). Like other PABA-ester local anaesthetics such as tetracaine, it can reduce the effect of potentiated sulfonamides, at least locally.
    Recommendation: Account for a reduced sulfonamide effect during concomitant administration.
    Sources: MSD Vet Manual

Products are connected by name, active ingredients, or therapeutic group. They are not direct substitutes for one another.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 18 Oct 2026

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