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Active substance

(S)-Methoprene

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Insect growth regulator (juvenile hormone analogue). Registered in Georgia: 5 veterinary products. Forms: spot-on.

Dose and use

Doses

Each dose comes with its source. Check the label of the product you use.

Active substance (S)-Methoprene
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
6 mg/kg Dog, Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 67.00 mg / 60.30 mg spot-on solution for dog S - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 50.00 mg / 60.00 mg spot-on solution for cat - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
Before use

Safety information

Known Contraindications

  • Critical
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
Latin name
(S)-Methoprene
Georgian name
(S)-მეთოპრენი
Authorisation status
Authorised veterinary medicine
An authorised veterinary medicine containing this substance exists. Whether a particular use is on-label depends on the species and the indication - see each dose rule.
Registered in Georgia
5 of 7 forms
Products
Broadline, Frontline Combo
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
All forms and registration7

Registration in Georgia and abroad: the register, number, validity and source are behind (i).

Broadline, Spot-on

fipronil 24.9 mg + (S)-methoprene 30.0 mg + eprinomectin 1.20 mg + praziquantel 24.9 mg, spot-on solution for cats <2.5 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
8.3/10
Very good
vetman assessment

Broadline

fipronil 24.9 mg + (S)-methoprene 30.0 mg + eprinomectin 1.20 mg + praziquantel 24.9 mg, spot-on solution for cats <2.5 kg
Assessed clinical scopeCat · Full feline EU label when ectoparasites, nematodes and cestodes are all targeted: fleas/FAD, Ixodes ricinus, Notoedres cati, listed tapeworms, gastrointestinal, lung and vesical worms, and heartworm prevention · On the skin
Care settingVeterinary-prescribed feline multiparasite treatment after individual clinical, lifestyle and epidemiological assessment
vetman score 8.3/10 Very good
Evidence confidence: High Georgia: No · Verified on 15 Oct 2026

A highly effective, unusually broad feline endectoparasiticide when all three parasite groups genuinely need concurrent treatment. Its strong EU evidence does not change its absence from the Georgian register, and broad coverage should not replace narrower first-line therapy when mixed risk is absent.

Regulatory and scientific credibility8.2/10

The exact presentation has a valid central EU authorisation and a current UPD record, supported by detailed official product information and a mature EPAR. It is not registered in Georgia or the US; the separate GB national authorisation expired on 3 July 2026, while EU authorisation including Northern Ireland remains valid.

Clinical efficacy9.0/10

Controlled and multicentre field evidence supports high activity across fleas, major gastrointestinal helminths, lungworms, eyeworm and heartworm prevention. The label is deliberately restricted to simultaneous three-group need; tick protection is shorter than flea protection, and some parasite-specific follow-up or repeat dosing remains necessary.

Safety and tolerability7.5/10

Correct topical use is generally well tolerated and has a wide experimental safety margin, but common local coat or skin changes and salivation can occur. Accidental licking can cause gastrointestinal or transient neurological signs; very rare tremor or visual impairment, reproductive uncertainty and important species and health restrictions require counselling.

Clinical practicality8.4/10

One whole applicator gives broad single-dose coverage and is easier than several separate products, but it must reach the skin at an inaccessible neck site, the cat must not be bathed for two days, exact weight-band selection is required and cats above 7.5 kg need a veterinarian-selected applicator combination.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use in sick or convalescent animals, rabbits, or with hypersensitivity to an ingredient. This feline product is not intended for dogs; prevent oral exposure, especially in Collies, Old English Sheepdogs and related breeds.
  • Do not use below 0.6 kg or under 7 weeks of age. Safety in pregnancy and lactation is not established; use only after veterinary benefit-risk assessment. Safety at intervals shorter than two weeks has not been tested.
  • Counsel for common transient coat clumping, local itching or hair loss and salivation. Accidental licking can cause vomiting, hypersalivation, ataxia, disorientation, apathy or pupil dilation; tremor and transient blindness or impaired vision are very rare. Reassess signs persisting beyond 24 hours.
  • Use only for confirmed mixed infestation or substantial concurrent risk involving ectoparasites, nematodes and cestodes. If three-group risk is absent, choose a narrower first-line parasiticide; avoid unnecessary frequent use and underdosing that can select resistance.
  • Flea treatment and environmental-stage control last at least one month, while Ixodes ricinus protection lasts up to three weeks. Tick attachment and pathogen transmission cannot be completely excluded; treat household animals and the environment when clinically indicated.
  • For heartworm prevention, test cats aged at least 6 months in endemic areas because adult Dirofilaria is not treated. Aelurostrongylus may need a second dose after one month; Joyeuxiella needs post-treatment follow-up, and tapeworm control requires management of fleas, rodents and other intermediate hosts.
  • Weigh exactly and empty the whole applicator onto visible skin at the midline of the neck where licking is prevented. Use 0.3 ml below 2.5 kg and 0.9 ml at 2.5-7.5 kg; above 7.5 kg use a veterinarian-selected applicator combination. Avoid bathing for two days, wear gloves, limit handling until dry and keep product or containers out of watercourses.
Assessment sources
  1. EU UPD Broadline 0.3 ml2026
  2. EC Broadline product information2021
  3. EMA Broadline EPAR2026
  4. Georgia NFA register 20262026
  5. Broadline European field study2014
  6. Broadline Brazil field study2022
  7. Broadline lungworm field study2015
  8. Broadline Thelazia field trial2021
  9. Broadline heartworm studies2014
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil24.9 mg (S)-Methoprene30 mg Eprinomectin1.2 mg Praziquantel24.9 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Registration
Georgia No
Not registered in Georgia
Veterinary (National Food Agency)
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Expired
Expired on 03 Jul 2026, not renewed yet
№ 61700/5085
Verified on: 22 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Broadline, Spot-on

fipronil 74.7 mg + (S)-methoprene 90.0 mg + eprinomectin 3.60 mg + praziquantel 74.7 mg, spot-on solution for cats 2.5-7.5 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
8.3/10
Very good
vetman assessment

Broadline

fipronil 74.7 mg + (S)-methoprene 90.0 mg + eprinomectin 3.60 mg + praziquantel 74.7 mg, spot-on solution for cats 2.5-7.5 kg
Assessed clinical scopeCat · Full feline EU label when ectoparasites, nematodes and cestodes are all targeted: fleas/FAD, Ixodes ricinus, Notoedres cati, listed tapeworms, gastrointestinal, lung and vesical worms, and heartworm prevention · On the skin
Care settingVeterinary-prescribed feline multiparasite treatment after individual clinical, lifestyle and epidemiological assessment
vetman score 8.3/10 Very good
Evidence confidence: High Georgia: No · Verified on 15 Oct 2026

A highly effective, unusually broad feline endectoparasiticide when all three parasite groups genuinely need concurrent treatment. Its strong EU evidence does not change its absence from the Georgian register, and broad coverage should not replace narrower first-line therapy when mixed risk is absent.

Regulatory and scientific credibility8.2/10

The exact presentation has a valid central EU authorisation and a current UPD record, supported by detailed official product information and a mature EPAR. It is not registered in Georgia or the US; the separate GB national authorisation expired on 3 July 2026, while EU authorisation including Northern Ireland remains valid.

Clinical efficacy9.0/10

Controlled and multicentre field evidence supports high activity across fleas, major gastrointestinal helminths, lungworms, eyeworm and heartworm prevention. The label is deliberately restricted to simultaneous three-group need; tick protection is shorter than flea protection, and some parasite-specific follow-up or repeat dosing remains necessary.

Safety and tolerability7.5/10

Correct topical use is generally well tolerated and has a wide experimental safety margin, but common local coat or skin changes and salivation can occur. Accidental licking can cause gastrointestinal or transient neurological signs; very rare tremor or visual impairment, reproductive uncertainty and important species and health restrictions require counselling.

Clinical practicality8.4/10

One whole applicator gives broad single-dose coverage and is easier than several separate products, but it must reach the skin at an inaccessible neck site, the cat must not be bathed for two days, exact weight-band selection is required and cats above 7.5 kg need a veterinarian-selected applicator combination.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use in sick or convalescent animals, rabbits, or with hypersensitivity to an ingredient. This feline product is not intended for dogs; prevent oral exposure, especially in Collies, Old English Sheepdogs and related breeds.
  • Do not use below 0.6 kg or under 7 weeks of age. Safety in pregnancy and lactation is not established; use only after veterinary benefit-risk assessment. Safety at intervals shorter than two weeks has not been tested.
  • Counsel for common transient coat clumping, local itching or hair loss and salivation. Accidental licking can cause vomiting, hypersalivation, ataxia, disorientation, apathy or pupil dilation; tremor and transient blindness or impaired vision are very rare. Reassess signs persisting beyond 24 hours.
  • Use only for confirmed mixed infestation or substantial concurrent risk involving ectoparasites, nematodes and cestodes. If three-group risk is absent, choose a narrower first-line parasiticide; avoid unnecessary frequent use and underdosing that can select resistance.
  • Flea treatment and environmental-stage control last at least one month, while Ixodes ricinus protection lasts up to three weeks. Tick attachment and pathogen transmission cannot be completely excluded; treat household animals and the environment when clinically indicated.
  • For heartworm prevention, test cats aged at least 6 months in endemic areas because adult Dirofilaria is not treated. Aelurostrongylus may need a second dose after one month; Joyeuxiella needs post-treatment follow-up, and tapeworm control requires management of fleas, rodents and other intermediate hosts.
  • Weigh exactly and empty the whole applicator onto visible skin at the midline of the neck where licking is prevented. Use 0.3 ml below 2.5 kg and 0.9 ml at 2.5-7.5 kg; above 7.5 kg use a veterinarian-selected applicator combination. Avoid bathing for two days, wear gloves, limit handling until dry and keep product or containers out of watercourses.
Assessment sources
  1. EU UPD Broadline 0.9 ml2026
  2. EC Broadline product information2021
  3. EMA Broadline EPAR2026
  4. Georgia NFA register 20262026
  5. Broadline European field study2014
  6. Broadline Brazil field study2022
  7. Broadline lungworm field study2015
  8. Broadline Thelazia field trial2021
  9. Broadline heartworm studies2014
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil74.7 mg (S)-Methoprene90 mg Eprinomectin3.6 mg Praziquantel74.7 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Registration
Georgia No
Not registered in Georgia
Veterinary (National Food Agency)
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Expired
Expired on 03 Jul 2026, not renewed yet
№ 61700/5084
Verified on: 22 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Frontline Combo 50 mg/60 mg, Spot-on

fipronil 50 mg + (S)-methoprene 60 mg, spot-on solution for cats
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
8.1/10
Very good
vetman assessment

Frontline Combo

50 mg/60 mg, fipronil 50 mg + (S)-methoprene 60 mg, spot-on solution for cats
Assessed clinical scopeCat · Full feline label scope: flea infestation, alone or with labelled tick and biting-louse infestations, flea life-cycle suppression and use within a flea-allergy-dermatitis control strategy · On the skin
Care settingSingle correctly matched pipette applied to intact, dry skin after weighing and parasite assessment, alongside environmental flea control when infestation is established
vetman score 8.1/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 182-11, 24-11 · Verified on 15 Oct 2026

A mature, well-documented and locally registered flea-centred ectoparasiticide with useful life-cycle control. It remains a strong option when the exact species and weight pipette is used, but is not a repellent and should not be treated as guaranteed prevention of vector attachment or transmission.

Regulatory and scientific credibility9.0/10

Every exact presentation is currently registered in Georgia and remains authorised in the UK, with current official product records, exact SPCs and more than two decades of regulatory history.

Clinical efficacy7.5/10

Controlled and household field studies support adult-flea control and the added inhibition of eggs and immature stages; labelled tick and biting-louse efficacy is established, but performance depends on correct skin application, parasite species, bathing and local susceptibility.

Safety and tolerability8.0/10

Systemic exposure is low and labelled-dose tolerability is generally favourable, but application-site reactions, transient hypersalivation after licking and rare reversible neurologic or systemic signs can occur. Rabbits must not be treated, and age, weight and illness restrictions apply.

Clinical practicality8.0/10

Monthly weight-band pipettes are straightforward and cover adult fleas plus environmental life stages, but the coat must be parted to reach skin, the site must stay dry, grooming and cross-licking must be prevented, and heavy household infestations require environmental management.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • The combined label is flea-centred: use for fleas alone or when fleas occur with labelled ticks and/or biting lice. Do not use the fixed combination for a tick-only or louse-only problem when the added flea life-cycle component is not justified.
  • Never use on rabbits because serious reactions and death can occur. Do not use on sick, febrile or convalescent animals, and observe the exact minimum age and weight limits.
  • Apply directly to intact skin where the animal cannot lick it; separate treated animals until dry. Licking can cause brief marked salivation, and accidental eye or human skin exposure should be rinsed promptly.
  • This product kills after exposure and is not a repellent. Parasites may attach before they die, so transmission of vector-borne infection cannot be completely excluded.
  • Avoid bathing or shampooing around treatment as directed by the exact label, keep the animal away from watercourses during the restricted period, and combine animal treatment with environmental flea control when needed.
  • Use only the feline pipette in cats; dog pipettes are not interchangeable. Confirm body weight and avoid use in kittens younger than 8 weeks or below the exact label minimum weight.
Assessment sources
  1. VMD Frontline Combo register2026
  2. VMD SPC 20252025
  3. Fipronil/methoprene flea lifecycle study2004
  4. Household flea field study2013
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil50 mg (S)-Methoprene60 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ ქეთ
№ 182-11, 24-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ EPA 65331-4, 65331-5
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Frontline Combo 67 mg/60.3 mg, Spot-on

fipronil 67 mg + (S)-methoprene 60.3 mg, spot-on solution for dogs 2-10 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.1/10
Very good
vetman assessment

Frontline Combo

67 mg/60.3 mg, fipronil 67 mg + (S)-methoprene 60.3 mg, spot-on solution for dogs 2-10 kg
Assessed clinical scopeDog · Full canine label scope: flea infestation, alone or with labelled tick and biting-louse infestations, flea life-cycle suppression and use within a flea-allergy-dermatitis control strategy · On the skin
Care settingSingle correctly matched pipette applied to intact, dry skin after weighing and parasite assessment, alongside environmental flea control when infestation is established
vetman score 8.1/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 180-11, 21-11 · Verified on 15 Oct 2026

A mature, well-documented and locally registered flea-centred ectoparasiticide with useful life-cycle control. It remains a strong option when the exact species and weight pipette is used, but is not a repellent and should not be treated as guaranteed prevention of vector attachment or transmission.

Regulatory and scientific credibility9.0/10

Every exact presentation is currently registered in Georgia and remains authorised in the UK, with current official product records, exact SPCs and more than two decades of regulatory history.

Clinical efficacy7.5/10

Controlled and household field studies support adult-flea control and the added inhibition of eggs and immature stages; labelled tick and biting-louse efficacy is established, but performance depends on correct skin application, parasite species, bathing and local susceptibility.

Safety and tolerability8.0/10

Systemic exposure is low and labelled-dose tolerability is generally favourable, but application-site reactions, transient hypersalivation after licking and rare reversible neurologic or systemic signs can occur. Rabbits must not be treated, and age, weight and illness restrictions apply.

Clinical practicality8.0/10

Monthly weight-band pipettes are straightforward and cover adult fleas plus environmental life stages, but the coat must be parted to reach skin, the site must stay dry, grooming and cross-licking must be prevented, and heavy household infestations require environmental management.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • The combined label is flea-centred: use for fleas alone or when fleas occur with labelled ticks and/or biting lice. Do not use the fixed combination for a tick-only or louse-only problem when the added flea life-cycle component is not justified.
  • Never use on rabbits because serious reactions and death can occur. Do not use on sick, febrile or convalescent animals, and observe the exact minimum age and weight limits.
  • Apply directly to intact skin where the animal cannot lick it; separate treated animals until dry. Licking can cause brief marked salivation, and accidental eye or human skin exposure should be rinsed promptly.
  • This product kills after exposure and is not a repellent. Parasites may attach before they die, so transmission of vector-borne infection cannot be completely excluded.
  • Avoid bathing or shampooing around treatment as directed by the exact label, keep the animal away from watercourses during the restricted period, and combine animal treatment with environmental flea control when needed.
  • Use only the correctly matched canine weight-band pipette. Do not use canine presentations in cats or ferrets because overdose may result; avoid use in puppies younger than 8 weeks or below 2 kg.
Assessment sources
  1. VMD Frontline Combo register2026
  2. VMD SPC 20252025
  3. Fipronil/methoprene flea lifecycle study2004
  4. Household flea field study2013
  5. Frontline biting-lice trial2002
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil67 mg (S)-Methoprene60.3 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ დოგ ეს
№ 180-11, 21-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ EPA 65331-4, 65331-5
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Frontline Combo 134 mg/120.6 mg, Spot-on

fipronil 134 mg + (S)-methoprene 120.6 mg, spot-on solution for dogs 10-20 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.1/10
Very good
vetman assessment

Frontline Combo

134 mg/120.6 mg, fipronil 134 mg + (S)-methoprene 120.6 mg, spot-on solution for dogs 10-20 kg
Assessed clinical scopeDog · Full canine label scope: flea infestation, alone or with labelled tick and biting-louse infestations, flea life-cycle suppression and use within a flea-allergy-dermatitis control strategy · On the skin
Care settingSingle correctly matched pipette applied to intact, dry skin after weighing and parasite assessment, alongside environmental flea control when infestation is established
vetman score 8.1/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 183-11, 22-11 · Verified on 15 Oct 2026

A mature, well-documented and locally registered flea-centred ectoparasiticide with useful life-cycle control. It remains a strong option when the exact species and weight pipette is used, but is not a repellent and should not be treated as guaranteed prevention of vector attachment or transmission.

Regulatory and scientific credibility9.0/10

Every exact presentation is currently registered in Georgia and remains authorised in the UK, with current official product records, exact SPCs and more than two decades of regulatory history.

Clinical efficacy7.5/10

Controlled and household field studies support adult-flea control and the added inhibition of eggs and immature stages; labelled tick and biting-louse efficacy is established, but performance depends on correct skin application, parasite species, bathing and local susceptibility.

Safety and tolerability8.0/10

Systemic exposure is low and labelled-dose tolerability is generally favourable, but application-site reactions, transient hypersalivation after licking and rare reversible neurologic or systemic signs can occur. Rabbits must not be treated, and age, weight and illness restrictions apply.

Clinical practicality8.0/10

Monthly weight-band pipettes are straightforward and cover adult fleas plus environmental life stages, but the coat must be parted to reach skin, the site must stay dry, grooming and cross-licking must be prevented, and heavy household infestations require environmental management.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • The combined label is flea-centred: use for fleas alone or when fleas occur with labelled ticks and/or biting lice. Do not use the fixed combination for a tick-only or louse-only problem when the added flea life-cycle component is not justified.
  • Never use on rabbits because serious reactions and death can occur. Do not use on sick, febrile or convalescent animals, and observe the exact minimum age and weight limits.
  • Apply directly to intact skin where the animal cannot lick it; separate treated animals until dry. Licking can cause brief marked salivation, and accidental eye or human skin exposure should be rinsed promptly.
  • This product kills after exposure and is not a repellent. Parasites may attach before they die, so transmission of vector-borne infection cannot be completely excluded.
  • Avoid bathing or shampooing around treatment as directed by the exact label, keep the animal away from watercourses during the restricted period, and combine animal treatment with environmental flea control when needed.
  • Use only the correctly matched canine weight-band pipette. Do not use canine presentations in cats or ferrets because overdose may result; avoid use in puppies younger than 8 weeks or below 2 kg.
Assessment sources
  1. VMD Frontline Combo register2026
  2. VMD Frontline Combo dog M SPC2025
  3. Fipronil/methoprene flea lifecycle study2004
  4. Household flea field study2013
  5. Frontline biting-lice trial2002
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil134 mg (S)-Methoprene120.6 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ დოგ ემ
№ 183-11, 22-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ EPA 65331-4, 65331-5
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Frontline Combo 268 mg/241.2 mg, Spot-on

fipronil 268 mg + (S)-methoprene 241.2 mg, spot-on solution for dogs 20-40 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.1/10
Very good
vetman assessment

Frontline Combo

268 mg/241.2 mg, fipronil 268 mg + (S)-methoprene 241.2 mg, spot-on solution for dogs 20-40 kg
Assessed clinical scopeDog · Full canine label scope: flea infestation, alone or with labelled tick and biting-louse infestations, flea life-cycle suppression and use within a flea-allergy-dermatitis control strategy · On the skin
Care settingSingle correctly matched pipette applied to intact, dry skin after weighing and parasite assessment, alongside environmental flea control when infestation is established
vetman score 8.1/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 181-11, 23-11 · Verified on 15 Oct 2026

A mature, well-documented and locally registered flea-centred ectoparasiticide with useful life-cycle control. It remains a strong option when the exact species and weight pipette is used, but is not a repellent and should not be treated as guaranteed prevention of vector attachment or transmission.

Regulatory and scientific credibility9.0/10

Every exact presentation is currently registered in Georgia and remains authorised in the UK, with current official product records, exact SPCs and more than two decades of regulatory history.

Clinical efficacy7.5/10

Controlled and household field studies support adult-flea control and the added inhibition of eggs and immature stages; labelled tick and biting-louse efficacy is established, but performance depends on correct skin application, parasite species, bathing and local susceptibility.

Safety and tolerability8.0/10

Systemic exposure is low and labelled-dose tolerability is generally favourable, but application-site reactions, transient hypersalivation after licking and rare reversible neurologic or systemic signs can occur. Rabbits must not be treated, and age, weight and illness restrictions apply.

Clinical practicality8.0/10

Monthly weight-band pipettes are straightforward and cover adult fleas plus environmental life stages, but the coat must be parted to reach skin, the site must stay dry, grooming and cross-licking must be prevented, and heavy household infestations require environmental management.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • The combined label is flea-centred: use for fleas alone or when fleas occur with labelled ticks and/or biting lice. Do not use the fixed combination for a tick-only or louse-only problem when the added flea life-cycle component is not justified.
  • Never use on rabbits because serious reactions and death can occur. Do not use on sick, febrile or convalescent animals, and observe the exact minimum age and weight limits.
  • Apply directly to intact skin where the animal cannot lick it; separate treated animals until dry. Licking can cause brief marked salivation, and accidental eye or human skin exposure should be rinsed promptly.
  • This product kills after exposure and is not a repellent. Parasites may attach before they die, so transmission of vector-borne infection cannot be completely excluded.
  • Avoid bathing or shampooing around treatment as directed by the exact label, keep the animal away from watercourses during the restricted period, and combine animal treatment with environmental flea control when needed.
  • Use only the correctly matched canine weight-band pipette. Do not use canine presentations in cats or ferrets because overdose may result; avoid use in puppies younger than 8 weeks or below 2 kg.
Assessment sources
  1. VMD Frontline Combo register2026
  2. VMD Frontline Combo dog L SPC2025
  3. Fipronil/methoprene flea lifecycle study2004
  4. Household flea field study2013
  5. Frontline biting-lice trial2002
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil268 mg (S)-Methoprene241.2 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ დოგ ელ
№ 181-11, 23-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ EPA 65331-4, 65331-5
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Frontline Combo 402 mg/361.8 mg, Spot-on

fipronil 402 mg + (S)-methoprene 361.8 mg, spot-on solution for dogs over 40 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.1/10
Very good
vetman assessment

Frontline Combo

402 mg/361.8 mg, fipronil 402 mg + (S)-methoprene 361.8 mg, spot-on solution for dogs over 40 kg
Assessed clinical scopeDog · Full canine label scope: flea infestation, alone or with labelled tick and biting-louse infestations, flea life-cycle suppression and use within a flea-allergy-dermatitis control strategy · On the skin
Care settingSingle correctly matched pipette applied to intact, dry skin after weighing and parasite assessment, alongside environmental flea control when infestation is established
vetman score 8.1/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 184-11, 115-11 · Verified on 15 Oct 2026

A mature, well-documented and locally registered flea-centred ectoparasiticide with useful life-cycle control. It remains a strong option when the exact species and weight pipette is used, but is not a repellent and should not be treated as guaranteed prevention of vector attachment or transmission.

Regulatory and scientific credibility9.0/10

Every exact presentation is currently registered in Georgia and remains authorised in the UK, with current official product records, exact SPCs and more than two decades of regulatory history.

Clinical efficacy7.5/10

Controlled and household field studies support adult-flea control and the added inhibition of eggs and immature stages; labelled tick and biting-louse efficacy is established, but performance depends on correct skin application, parasite species, bathing and local susceptibility.

Safety and tolerability8.0/10

Systemic exposure is low and labelled-dose tolerability is generally favourable, but application-site reactions, transient hypersalivation after licking and rare reversible neurologic or systemic signs can occur. Rabbits must not be treated, and age, weight and illness restrictions apply.

Clinical practicality8.0/10

Monthly weight-band pipettes are straightforward and cover adult fleas plus environmental life stages, but the coat must be parted to reach skin, the site must stay dry, grooming and cross-licking must be prevented, and heavy household infestations require environmental management.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • The combined label is flea-centred: use for fleas alone or when fleas occur with labelled ticks and/or biting lice. Do not use the fixed combination for a tick-only or louse-only problem when the added flea life-cycle component is not justified.
  • Never use on rabbits because serious reactions and death can occur. Do not use on sick, febrile or convalescent animals, and observe the exact minimum age and weight limits.
  • Apply directly to intact skin where the animal cannot lick it; separate treated animals until dry. Licking can cause brief marked salivation, and accidental eye or human skin exposure should be rinsed promptly.
  • This product kills after exposure and is not a repellent. Parasites may attach before they die, so transmission of vector-borne infection cannot be completely excluded.
  • Avoid bathing or shampooing around treatment as directed by the exact label, keep the animal away from watercourses during the restricted period, and combine animal treatment with environmental flea control when needed.
  • Use only the correctly matched canine weight-band pipette. Do not use canine presentations in cats or ferrets because overdose may result; avoid use in puppies younger than 8 weeks or below 2 kg.
Assessment sources
  1. VMD Frontline Combo register2026
  2. VMD Frontline Combo dog XL2026
  3. Fipronil/methoprene flea lifecycle study2004
  4. Household flea field study2013
  5. Frontline biting-lice trial2002
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil402 mg (S)-Methoprene361.8 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Manufacturer (register)
Merial, France
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 81, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ დოგ იქს ელ
№ 184-11, 115-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ EPA 65331-4, 65331-5
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

For veterinary professionals only. It does not replace clinical judgement or the product label; check the dose in the official label (SPC). vetman is not liable for harm caused by using this information.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 22 Oct 2026

All of this shows in vetman as you prescribe

The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

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