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Frontline Combo

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Fipronil + (S)-Methoprene · Boehringer Ingelheim

5 forms: spot-on. In force in Georgia: 5 of 5 (veterinary register).

Forms and doses5 of 5 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Weight Dose Frequency Georgia
50 mg/60 mg, Spot-on · Cat 1 kg and over Cat 1 kg and over 1 pipette
The minimum dose is 5 mg/kg bw of fipronil and 6 mg/kg bw of (S)-methoprene, corresponding to one pipette of 0.5 ml per cat. In the absence of safety studies, the minimum treatment interval is 4 weeks.
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ ქეთ
№ 182-11, 24-11
Verified on: 15 Oct 2026
50 mg/60 mg, Spot-on · Dog Any weight Dog Any weight No dose for this species
This pipette is for cats and ferrets. For dogs, use the appropriate Frontline Combo S, M, L, or XL presentation.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ ქეთ
№ 182-11, 24-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Frontline Combo 50 mg/60 mg, Spot-on

fipronil 50 mg + (S)-methoprene 60 mg, spot-on solution for cats
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
8.1/10
Very good
vetman assessment

Frontline Combo

50 mg/60 mg, fipronil 50 mg + (S)-methoprene 60 mg, spot-on solution for cats
Assessed clinical scopeCat · Full feline label scope: flea infestation, alone or with labelled tick and biting-louse infestations, flea life-cycle suppression and use within a flea-allergy-dermatitis control strategy · On the skin
Care settingSingle correctly matched pipette applied to intact, dry skin after weighing and parasite assessment, alongside environmental flea control when infestation is established
vetman score 8.1/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 182-11, 24-11 · Verified on 15 Oct 2026

A mature, well-documented and locally registered flea-centred ectoparasiticide with useful life-cycle control. It remains a strong option when the exact species and weight pipette is used, but is not a repellent and should not be treated as guaranteed prevention of vector attachment or transmission.

Regulatory and scientific credibility9.0/10

Every exact presentation is currently registered in Georgia and remains authorised in the UK, with current official product records, exact SPCs and more than two decades of regulatory history.

Clinical efficacy7.5/10

Controlled and household field studies support adult-flea control and the added inhibition of eggs and immature stages; labelled tick and biting-louse efficacy is established, but performance depends on correct skin application, parasite species, bathing and local susceptibility.

Safety and tolerability8.0/10

Systemic exposure is low and labelled-dose tolerability is generally favourable, but application-site reactions, transient hypersalivation after licking and rare reversible neurologic or systemic signs can occur. Rabbits must not be treated, and age, weight and illness restrictions apply.

Clinical practicality8.0/10

Monthly weight-band pipettes are straightforward and cover adult fleas plus environmental life stages, but the coat must be parted to reach skin, the site must stay dry, grooming and cross-licking must be prevented, and heavy household infestations require environmental management.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • The combined label is flea-centred: use for fleas alone or when fleas occur with labelled ticks and/or biting lice. Do not use the fixed combination for a tick-only or louse-only problem when the added flea life-cycle component is not justified.
  • Never use on rabbits because serious reactions and death can occur. Do not use on sick, febrile or convalescent animals, and observe the exact minimum age and weight limits.
  • Apply directly to intact skin where the animal cannot lick it; separate treated animals until dry. Licking can cause brief marked salivation, and accidental eye or human skin exposure should be rinsed promptly.
  • This product kills after exposure and is not a repellent. Parasites may attach before they die, so transmission of vector-borne infection cannot be completely excluded.
  • Avoid bathing or shampooing around treatment as directed by the exact label, keep the animal away from watercourses during the restricted period, and combine animal treatment with environmental flea control when needed.
  • Use only the feline pipette in cats; dog pipettes are not interchangeable. Confirm body weight and avoid use in kittens younger than 8 weeks or below the exact label minimum weight.
Assessment sources
  1. VMD Frontline Combo register2026
  2. VMD SPC 20252025
  3. Fipronil/methoprene flea lifecycle study2004
  4. Household flea field study2013
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil50 mg (S)-Methoprene60 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ ქეთ
№ 182-11, 24-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ EPA 65331-4, 65331-5
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 pipette
The minimum dose is 5 mg/kg bw of fipronil and 6 mg/kg bw of (S)-methoprene, corresponding to one pipette of 0.5 ml per cat. In the absence of safety studies, the minimum treatment interval is 4 weeks.
 Cat 1 kg and over On the skin not more often than every 4 weeks Product label (SPC)
No dose for this species
This pipette is for cats and ferrets. For dogs, use the appropriate Frontline Combo S, M, L, or XL presentation.
 Dog Any weight On the skin - Product label (SPC)
67 mg/60.3 mg, Spot-on · Cat Any weight Cat Any weight No dose for this species
Do not use this presentation in cats or ferrets because overdose may occur. For cats, use Frontline Combo 50 mg/60 mg.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ დოგ ეს
№ 180-11, 21-11
Verified on: 15 Oct 2026
67 mg/60.3 mg, Spot-on · Dog 2–10 kg Dog 2–10 kg 1 pipette
corresponding to one pipette of 0.67 ml (S) per dog (weighing over 2 and up to 10 kg). In the absence of safety studies, the minimum treatment interval is 4 weeks. Do not use in cats and ferrets, as this could lead to overdosing.
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ დოგ ეს
№ 180-11, 21-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Frontline Combo 67 mg/60.3 mg, Spot-on

fipronil 67 mg + (S)-methoprene 60.3 mg, spot-on solution for dogs 2-10 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.1/10
Very good
vetman assessment

Frontline Combo

67 mg/60.3 mg, fipronil 67 mg + (S)-methoprene 60.3 mg, spot-on solution for dogs 2-10 kg
Assessed clinical scopeDog · Full canine label scope: flea infestation, alone or with labelled tick and biting-louse infestations, flea life-cycle suppression and use within a flea-allergy-dermatitis control strategy · On the skin
Care settingSingle correctly matched pipette applied to intact, dry skin after weighing and parasite assessment, alongside environmental flea control when infestation is established
vetman score 8.1/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 180-11, 21-11 · Verified on 15 Oct 2026

A mature, well-documented and locally registered flea-centred ectoparasiticide with useful life-cycle control. It remains a strong option when the exact species and weight pipette is used, but is not a repellent and should not be treated as guaranteed prevention of vector attachment or transmission.

Regulatory and scientific credibility9.0/10

Every exact presentation is currently registered in Georgia and remains authorised in the UK, with current official product records, exact SPCs and more than two decades of regulatory history.

Clinical efficacy7.5/10

Controlled and household field studies support adult-flea control and the added inhibition of eggs and immature stages; labelled tick and biting-louse efficacy is established, but performance depends on correct skin application, parasite species, bathing and local susceptibility.

Safety and tolerability8.0/10

Systemic exposure is low and labelled-dose tolerability is generally favourable, but application-site reactions, transient hypersalivation after licking and rare reversible neurologic or systemic signs can occur. Rabbits must not be treated, and age, weight and illness restrictions apply.

Clinical practicality8.0/10

Monthly weight-band pipettes are straightforward and cover adult fleas plus environmental life stages, but the coat must be parted to reach skin, the site must stay dry, grooming and cross-licking must be prevented, and heavy household infestations require environmental management.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • The combined label is flea-centred: use for fleas alone or when fleas occur with labelled ticks and/or biting lice. Do not use the fixed combination for a tick-only or louse-only problem when the added flea life-cycle component is not justified.
  • Never use on rabbits because serious reactions and death can occur. Do not use on sick, febrile or convalescent animals, and observe the exact minimum age and weight limits.
  • Apply directly to intact skin where the animal cannot lick it; separate treated animals until dry. Licking can cause brief marked salivation, and accidental eye or human skin exposure should be rinsed promptly.
  • This product kills after exposure and is not a repellent. Parasites may attach before they die, so transmission of vector-borne infection cannot be completely excluded.
  • Avoid bathing or shampooing around treatment as directed by the exact label, keep the animal away from watercourses during the restricted period, and combine animal treatment with environmental flea control when needed.
  • Use only the correctly matched canine weight-band pipette. Do not use canine presentations in cats or ferrets because overdose may result; avoid use in puppies younger than 8 weeks or below 2 kg.
Assessment sources
  1. VMD Frontline Combo register2026
  2. VMD SPC 20252025
  3. Fipronil/methoprene flea lifecycle study2004
  4. Household flea field study2013
  5. Frontline biting-lice trial2002
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil67 mg (S)-Methoprene60.3 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ დოგ ეს
№ 180-11, 21-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ EPA 65331-4, 65331-5
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
Do not use this presentation in cats or ferrets because overdose may occur. For cats, use Frontline Combo 50 mg/60 mg.
 Cat Any weight On the skin - Product label (SPC)
1 pipette
corresponding to one pipette of 0.67 ml (S) per dog (weighing over 2 and up to 10 kg). In the absence of safety studies, the minimum treatment interval is 4 weeks. Do not use in cats and ferrets, as this could lead to overdosing.
 Dog 2–10 kg On the skin not more often than every 4 weeks Product label (SPC)
134 mg/120.6 mg, Spot-on · Cat Any weight Cat Any weight No dose for this species
Do not use this presentation in cats or ferrets because overdose may occur.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ დოგ ემ
№ 183-11, 22-11
Verified on: 15 Oct 2026
134 mg/120.6 mg, Spot-on · Dog 10–20 kg Dog 10–20 kg 1 pipette
corresponding to one pipette of 1.34 ml (M) per dog (weighing over 10 and up to 20 kg).
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ დოგ ემ
№ 183-11, 22-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Frontline Combo 134 mg/120.6 mg, Spot-on

fipronil 134 mg + (S)-methoprene 120.6 mg, spot-on solution for dogs 10-20 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.1/10
Very good
vetman assessment

Frontline Combo

134 mg/120.6 mg, fipronil 134 mg + (S)-methoprene 120.6 mg, spot-on solution for dogs 10-20 kg
Assessed clinical scopeDog · Full canine label scope: flea infestation, alone or with labelled tick and biting-louse infestations, flea life-cycle suppression and use within a flea-allergy-dermatitis control strategy · On the skin
Care settingSingle correctly matched pipette applied to intact, dry skin after weighing and parasite assessment, alongside environmental flea control when infestation is established
vetman score 8.1/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 183-11, 22-11 · Verified on 15 Oct 2026

A mature, well-documented and locally registered flea-centred ectoparasiticide with useful life-cycle control. It remains a strong option when the exact species and weight pipette is used, but is not a repellent and should not be treated as guaranteed prevention of vector attachment or transmission.

Regulatory and scientific credibility9.0/10

Every exact presentation is currently registered in Georgia and remains authorised in the UK, with current official product records, exact SPCs and more than two decades of regulatory history.

Clinical efficacy7.5/10

Controlled and household field studies support adult-flea control and the added inhibition of eggs and immature stages; labelled tick and biting-louse efficacy is established, but performance depends on correct skin application, parasite species, bathing and local susceptibility.

Safety and tolerability8.0/10

Systemic exposure is low and labelled-dose tolerability is generally favourable, but application-site reactions, transient hypersalivation after licking and rare reversible neurologic or systemic signs can occur. Rabbits must not be treated, and age, weight and illness restrictions apply.

Clinical practicality8.0/10

Monthly weight-band pipettes are straightforward and cover adult fleas plus environmental life stages, but the coat must be parted to reach skin, the site must stay dry, grooming and cross-licking must be prevented, and heavy household infestations require environmental management.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • The combined label is flea-centred: use for fleas alone or when fleas occur with labelled ticks and/or biting lice. Do not use the fixed combination for a tick-only or louse-only problem when the added flea life-cycle component is not justified.
  • Never use on rabbits because serious reactions and death can occur. Do not use on sick, febrile or convalescent animals, and observe the exact minimum age and weight limits.
  • Apply directly to intact skin where the animal cannot lick it; separate treated animals until dry. Licking can cause brief marked salivation, and accidental eye or human skin exposure should be rinsed promptly.
  • This product kills after exposure and is not a repellent. Parasites may attach before they die, so transmission of vector-borne infection cannot be completely excluded.
  • Avoid bathing or shampooing around treatment as directed by the exact label, keep the animal away from watercourses during the restricted period, and combine animal treatment with environmental flea control when needed.
  • Use only the correctly matched canine weight-band pipette. Do not use canine presentations in cats or ferrets because overdose may result; avoid use in puppies younger than 8 weeks or below 2 kg.
Assessment sources
  1. VMD Frontline Combo register2026
  2. VMD Frontline Combo dog M SPC2025
  3. Fipronil/methoprene flea lifecycle study2004
  4. Household flea field study2013
  5. Frontline biting-lice trial2002
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil134 mg (S)-Methoprene120.6 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ დოგ ემ
№ 183-11, 22-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ EPA 65331-4, 65331-5
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
Do not use this presentation in cats or ferrets because overdose may occur.
 Cat Any weight On the skin - Product label (SPC)
1 pipette
corresponding to one pipette of 1.34 ml (M) per dog (weighing over 10 and up to 20 kg).
 Dog 10–20 kg On the skin not more often than every 4 weeks Product label (SPC)
268 mg/241.2 mg, Spot-on · Cat Any weight Cat Any weight No dose for this species
Do not use this presentation in cats or ferrets because overdose may occur.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ დოგ ელ
№ 181-11, 23-11
Verified on: 15 Oct 2026
268 mg/241.2 mg, Spot-on · Dog 20–40 kg Dog 20–40 kg 1 pipette
corresponding to one pipette of 2.68 ml (L) per dog (weighing over 20 and up to 40 kg).
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ დოგ ელ
№ 181-11, 23-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Frontline Combo 268 mg/241.2 mg, Spot-on

fipronil 268 mg + (S)-methoprene 241.2 mg, spot-on solution for dogs 20-40 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.1/10
Very good
vetman assessment

Frontline Combo

268 mg/241.2 mg, fipronil 268 mg + (S)-methoprene 241.2 mg, spot-on solution for dogs 20-40 kg
Assessed clinical scopeDog · Full canine label scope: flea infestation, alone or with labelled tick and biting-louse infestations, flea life-cycle suppression and use within a flea-allergy-dermatitis control strategy · On the skin
Care settingSingle correctly matched pipette applied to intact, dry skin after weighing and parasite assessment, alongside environmental flea control when infestation is established
vetman score 8.1/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 181-11, 23-11 · Verified on 15 Oct 2026

A mature, well-documented and locally registered flea-centred ectoparasiticide with useful life-cycle control. It remains a strong option when the exact species and weight pipette is used, but is not a repellent and should not be treated as guaranteed prevention of vector attachment or transmission.

Regulatory and scientific credibility9.0/10

Every exact presentation is currently registered in Georgia and remains authorised in the UK, with current official product records, exact SPCs and more than two decades of regulatory history.

Clinical efficacy7.5/10

Controlled and household field studies support adult-flea control and the added inhibition of eggs and immature stages; labelled tick and biting-louse efficacy is established, but performance depends on correct skin application, parasite species, bathing and local susceptibility.

Safety and tolerability8.0/10

Systemic exposure is low and labelled-dose tolerability is generally favourable, but application-site reactions, transient hypersalivation after licking and rare reversible neurologic or systemic signs can occur. Rabbits must not be treated, and age, weight and illness restrictions apply.

Clinical practicality8.0/10

Monthly weight-band pipettes are straightforward and cover adult fleas plus environmental life stages, but the coat must be parted to reach skin, the site must stay dry, grooming and cross-licking must be prevented, and heavy household infestations require environmental management.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • The combined label is flea-centred: use for fleas alone or when fleas occur with labelled ticks and/or biting lice. Do not use the fixed combination for a tick-only or louse-only problem when the added flea life-cycle component is not justified.
  • Never use on rabbits because serious reactions and death can occur. Do not use on sick, febrile or convalescent animals, and observe the exact minimum age and weight limits.
  • Apply directly to intact skin where the animal cannot lick it; separate treated animals until dry. Licking can cause brief marked salivation, and accidental eye or human skin exposure should be rinsed promptly.
  • This product kills after exposure and is not a repellent. Parasites may attach before they die, so transmission of vector-borne infection cannot be completely excluded.
  • Avoid bathing or shampooing around treatment as directed by the exact label, keep the animal away from watercourses during the restricted period, and combine animal treatment with environmental flea control when needed.
  • Use only the correctly matched canine weight-band pipette. Do not use canine presentations in cats or ferrets because overdose may result; avoid use in puppies younger than 8 weeks or below 2 kg.
Assessment sources
  1. VMD Frontline Combo register2026
  2. VMD Frontline Combo dog L SPC2025
  3. Fipronil/methoprene flea lifecycle study2004
  4. Household flea field study2013
  5. Frontline biting-lice trial2002
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil268 mg (S)-Methoprene241.2 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ დოგ ელ
№ 181-11, 23-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ EPA 65331-4, 65331-5
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
Do not use this presentation in cats or ferrets because overdose may occur.
 Cat Any weight On the skin - Product label (SPC)
1 pipette
corresponding to one pipette of 2.68 ml (L) per dog (weighing over 20 and up to 40 kg).
 Dog 20–40 kg On the skin not more often than every 4 weeks Product label (SPC)
402 mg/361.8 mg, Spot-on · Cat Any weight Cat Any weight No dose for this species
Do not use this presentation in cats or ferrets because overdose may occur.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ დოგ იქს ელ
№ 184-11, 115-11
Verified on: 15 Oct 2026
402 mg/361.8 mg, Spot-on · Dog over 40 kg Dog over 40 kg 1 pipette
Dogs (weighing over 40 kg bw). corresponding to one pipette of 4.02 ml (XL) per dog (weighing over 40 kg).
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ დოგ იქს ელ
№ 184-11, 115-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Frontline Combo 402 mg/361.8 mg, Spot-on

fipronil 402 mg + (S)-methoprene 361.8 mg, spot-on solution for dogs over 40 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.1/10
Very good
vetman assessment

Frontline Combo

402 mg/361.8 mg, fipronil 402 mg + (S)-methoprene 361.8 mg, spot-on solution for dogs over 40 kg
Assessed clinical scopeDog · Full canine label scope: flea infestation, alone or with labelled tick and biting-louse infestations, flea life-cycle suppression and use within a flea-allergy-dermatitis control strategy · On the skin
Care settingSingle correctly matched pipette applied to intact, dry skin after weighing and parasite assessment, alongside environmental flea control when infestation is established
vetman score 8.1/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 184-11, 115-11 · Verified on 15 Oct 2026

A mature, well-documented and locally registered flea-centred ectoparasiticide with useful life-cycle control. It remains a strong option when the exact species and weight pipette is used, but is not a repellent and should not be treated as guaranteed prevention of vector attachment or transmission.

Regulatory and scientific credibility9.0/10

Every exact presentation is currently registered in Georgia and remains authorised in the UK, with current official product records, exact SPCs and more than two decades of regulatory history.

Clinical efficacy7.5/10

Controlled and household field studies support adult-flea control and the added inhibition of eggs and immature stages; labelled tick and biting-louse efficacy is established, but performance depends on correct skin application, parasite species, bathing and local susceptibility.

Safety and tolerability8.0/10

Systemic exposure is low and labelled-dose tolerability is generally favourable, but application-site reactions, transient hypersalivation after licking and rare reversible neurologic or systemic signs can occur. Rabbits must not be treated, and age, weight and illness restrictions apply.

Clinical practicality8.0/10

Monthly weight-band pipettes are straightforward and cover adult fleas plus environmental life stages, but the coat must be parted to reach skin, the site must stay dry, grooming and cross-licking must be prevented, and heavy household infestations require environmental management.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • The combined label is flea-centred: use for fleas alone or when fleas occur with labelled ticks and/or biting lice. Do not use the fixed combination for a tick-only or louse-only problem when the added flea life-cycle component is not justified.
  • Never use on rabbits because serious reactions and death can occur. Do not use on sick, febrile or convalescent animals, and observe the exact minimum age and weight limits.
  • Apply directly to intact skin where the animal cannot lick it; separate treated animals until dry. Licking can cause brief marked salivation, and accidental eye or human skin exposure should be rinsed promptly.
  • This product kills after exposure and is not a repellent. Parasites may attach before they die, so transmission of vector-borne infection cannot be completely excluded.
  • Avoid bathing or shampooing around treatment as directed by the exact label, keep the animal away from watercourses during the restricted period, and combine animal treatment with environmental flea control when needed.
  • Use only the correctly matched canine weight-band pipette. Do not use canine presentations in cats or ferrets because overdose may result; avoid use in puppies younger than 8 weeks or below 2 kg.
Assessment sources
  1. VMD Frontline Combo register2026
  2. VMD Frontline Combo dog XL2026
  3. Fipronil/methoprene flea lifecycle study2004
  4. Household flea field study2013
  5. Frontline biting-lice trial2002
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil402 mg (S)-Methoprene361.8 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Manufacturer (register)
Merial, France
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 81, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინ კომბო სპოტ-ონ დოგ იქს ელ
№ 184-11, 115-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ EPA 65331-4, 65331-5
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
Do not use this presentation in cats or ferrets because overdose may occur.
 Cat Any weight On the skin - Product label (SPC)
1 pipette
Dogs (weighing over 40 kg bw). corresponding to one pipette of 4.02 ml (XL) per dog (weighing over 40 kg).
 Dog over 40 kg On the skin not more often than every 4 weeks Product label (SPC)
Active substance doses, with sources
Active substance Fipronil
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
6.7 mg/kg Dog Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 67.00 mg / 60.30 mg spot-on solution for dog S - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
7.5–15 mg/kg Dog, Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Spray 0.25% w/v cutaneous spray solution - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
5 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 50.00 mg / 60.00 mg spot-on solution for cat - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
8.3 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Effipro Duo 50 mg/60 mg Spot-on Solution for Cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
Active substance (S)-Methoprene
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
6 mg/kg Dog, Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 67.00 mg / 60.30 mg spot-on solution for dog S - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 50.00 mg / 60.00 mg spot-on solution for cat - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025

Known Contraindications

  • Critical (S)-Methoprene
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Fipronil
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Fipronil
    Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
    Sources: VMD SPC · VMD
  • Warning Fipronil (Dog)
    In the absence of available data, the veterinary medicinal product should not be used on puppies less than 8 weeks old and/or weighing less than 2 kg. Puppies and kittens from 2 days of age may be safely treated. Nepoužívat u štěňat do 3 dnů stáří.
    Sources: VMD SPC · VMD
  • Warning Fipronil (Cat)
    In the absence of available data, the veterinary medicinal product should not be used on kittens less than 8 weeks old and/or weighing less than 1 kg. Nepoužívat u koťat do 8 týdnů stáří. Puppies and kittens from 2 days of age may be safely treated.
    Sources: VMD SPC · VMD
  • Caution Fipronil (Cat)
    The potential toxicity of the veterinary medicinal product for kittens of less than 8 weeks of age in contact with a treated queen is not documented. Special care should be taken in this case. Data are not available on treatment of pregnant queens or nursing queens. Přípravek může být podán chovným, březím i laktujícím kočkám.
    Sources: VMD SPC · VMD

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