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Fipronil + (S)-Methoprene + Eprinomectin + Praziquantel · Boehringer Ingelheim

2 forms: spot-on. No registration in force in Georgia.

Forms and doses0 of 2 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Weight Dose Frequency Georgia
Spot-on · Cat 0.6–2.49 kg Cat 0.6–2.49 kg 1 pipette
The recommended minimum doses are 10 mg/kg bodyweight for fipronil, 12 mg/kg for (S)-methoprene, 0.5 mg/kg for eprinomectin and 10 mg/kg for praziquantel. appropriate combination of applicators Spot-on application only. Do not inject, do not administer orally or via any other route. The veterinary medicinal product is exclusively indicated when all three groups are targeted at the same time. at least one month up to 3 weeks Do not use in sick or convalescent animals. Do not use in rabbits. The product is not for use in kittens weighing less than 0.6 kg and/or under 7 weeks of age. The safety of the veterinary medicinal product has not been established during pregnancy and lactation.
 · once; flea and heartworm protection - one month		 once; flea and heartworm protection - one month Georgia No
Not registered in Georgia
Veterinary (National Food Agency)
Verified on: 15 Oct 2026
Spot-on · Dog Any weight Dog Any weight No dose for this species
This feline product is not intended for dogs. Prevent oral exposure, especially in Collies, Old English Sheepdogs, and related breeds that may be susceptible to macrocyclic-lactone neurotoxicity.
 - Georgia No
Not registered in Georgia
Veterinary (National Food Agency)
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Broadline, Spot-on

fipronil 24.9 mg + (S)-methoprene 30.0 mg + eprinomectin 1.20 mg + praziquantel 24.9 mg, spot-on solution for cats <2.5 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
8.3/10
Very good
vetman assessment

Broadline

fipronil 24.9 mg + (S)-methoprene 30.0 mg + eprinomectin 1.20 mg + praziquantel 24.9 mg, spot-on solution for cats <2.5 kg
Assessed clinical scopeCat · Full feline EU label when ectoparasites, nematodes and cestodes are all targeted: fleas/FAD, Ixodes ricinus, Notoedres cati, listed tapeworms, gastrointestinal, lung and vesical worms, and heartworm prevention · On the skin
Care settingVeterinary-prescribed feline multiparasite treatment after individual clinical, lifestyle and epidemiological assessment
vetman score 8.3/10 Very good
Evidence confidence: High Georgia: No · Verified on 15 Oct 2026

A highly effective, unusually broad feline endectoparasiticide when all three parasite groups genuinely need concurrent treatment. Its strong EU evidence does not change its absence from the Georgian register, and broad coverage should not replace narrower first-line therapy when mixed risk is absent.

Regulatory and scientific credibility8.2/10

The exact presentation has a valid central EU authorisation and a current UPD record, supported by detailed official product information and a mature EPAR. It is not registered in Georgia or the US; the separate GB national authorisation expired on 3 July 2026, while EU authorisation including Northern Ireland remains valid.

Clinical efficacy9.0/10

Controlled and multicentre field evidence supports high activity across fleas, major gastrointestinal helminths, lungworms, eyeworm and heartworm prevention. The label is deliberately restricted to simultaneous three-group need; tick protection is shorter than flea protection, and some parasite-specific follow-up or repeat dosing remains necessary.

Safety and tolerability7.5/10

Correct topical use is generally well tolerated and has a wide experimental safety margin, but common local coat or skin changes and salivation can occur. Accidental licking can cause gastrointestinal or transient neurological signs; very rare tremor or visual impairment, reproductive uncertainty and important species and health restrictions require counselling.

Clinical practicality8.4/10

One whole applicator gives broad single-dose coverage and is easier than several separate products, but it must reach the skin at an inaccessible neck site, the cat must not be bathed for two days, exact weight-band selection is required and cats above 7.5 kg need a veterinarian-selected applicator combination.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use in sick or convalescent animals, rabbits, or with hypersensitivity to an ingredient. This feline product is not intended for dogs; prevent oral exposure, especially in Collies, Old English Sheepdogs and related breeds.
  • Do not use below 0.6 kg or under 7 weeks of age. Safety in pregnancy and lactation is not established; use only after veterinary benefit-risk assessment. Safety at intervals shorter than two weeks has not been tested.
  • Counsel for common transient coat clumping, local itching or hair loss and salivation. Accidental licking can cause vomiting, hypersalivation, ataxia, disorientation, apathy or pupil dilation; tremor and transient blindness or impaired vision are very rare. Reassess signs persisting beyond 24 hours.
  • Use only for confirmed mixed infestation or substantial concurrent risk involving ectoparasites, nematodes and cestodes. If three-group risk is absent, choose a narrower first-line parasiticide; avoid unnecessary frequent use and underdosing that can select resistance.
  • Flea treatment and environmental-stage control last at least one month, while Ixodes ricinus protection lasts up to three weeks. Tick attachment and pathogen transmission cannot be completely excluded; treat household animals and the environment when clinically indicated.
  • For heartworm prevention, test cats aged at least 6 months in endemic areas because adult Dirofilaria is not treated. Aelurostrongylus may need a second dose after one month; Joyeuxiella needs post-treatment follow-up, and tapeworm control requires management of fleas, rodents and other intermediate hosts.
  • Weigh exactly and empty the whole applicator onto visible skin at the midline of the neck where licking is prevented. Use 0.3 ml below 2.5 kg and 0.9 ml at 2.5-7.5 kg; above 7.5 kg use a veterinarian-selected applicator combination. Avoid bathing for two days, wear gloves, limit handling until dry and keep product or containers out of watercourses.
Assessment sources
  1. EU UPD Broadline 0.3 ml2026
  2. EC Broadline product information2021
  3. EMA Broadline EPAR2026
  4. Georgia NFA register 20262026
  5. Broadline European field study2014
  6. Broadline Brazil field study2022
  7. Broadline lungworm field study2015
  8. Broadline Thelazia field trial2021
  9. Broadline heartworm studies2014
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil24.9 mg (S)-Methoprene30 mg Eprinomectin1.2 mg Praziquantel24.9 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Registration
Georgia No
Not registered in Georgia
Veterinary (National Food Agency)
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Expired
Expired on 03 Jul 2026, not renewed yet
№ 61700/5085
Verified on: 22 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 pipette
The recommended minimum doses are 10 mg/kg bodyweight for fipronil, 12 mg/kg for (S)-methoprene, 0.5 mg/kg for eprinomectin and 10 mg/kg for praziquantel. appropriate combination of applicators Spot-on application only. Do not inject, do not administer orally or via any other route. The veterinary medicinal product is exclusively indicated when all three groups are targeted at the same time. at least one month up to 3 weeks Do not use in sick or convalescent animals. Do not use in rabbits. The product is not for use in kittens weighing less than 0.6 kg and/or under 7 weeks of age. The safety of the veterinary medicinal product has not been established during pregnancy and lactation.
 Cat 0.6–2.49 kg On the skin once; flea and heartworm protection - one month Product label (SPC)
No dose for this species
This feline product is not intended for dogs. Prevent oral exposure, especially in Collies, Old English Sheepdogs, and related breeds that may be susceptible to macrocyclic-lactone neurotoxicity.
 Dog Any weight On the skin - Product label (SPC)
Spot-on · Cat 2.49–7.5 kg Cat 2.49–7.5 kg 1 pipette
The recommended minimum doses are 10 mg/kg bodyweight for fipronil, 12 mg/kg for (S)-methoprene, 0.5 mg/kg for eprinomectin and 10 mg/kg for praziquantel. Do not use in sick or convalescent animals.
 · once; flea and heartworm protection - one month		 once; flea and heartworm protection - one month Georgia No
Not registered in Georgia
Veterinary (National Food Agency)
Verified on: 15 Oct 2026
Spot-on · Dog Any weight Dog Any weight No dose for this species
This feline product is not intended for dogs. Prevent oral exposure, particularly in Collies, Old English Sheepdogs, and related breeds.
 - Georgia No
Not registered in Georgia
Veterinary (National Food Agency)
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Broadline, Spot-on

fipronil 74.7 mg + (S)-methoprene 90.0 mg + eprinomectin 3.60 mg + praziquantel 74.7 mg, spot-on solution for cats 2.5-7.5 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
8.3/10
Very good
vetman assessment

Broadline

fipronil 74.7 mg + (S)-methoprene 90.0 mg + eprinomectin 3.60 mg + praziquantel 74.7 mg, spot-on solution for cats 2.5-7.5 kg
Assessed clinical scopeCat · Full feline EU label when ectoparasites, nematodes and cestodes are all targeted: fleas/FAD, Ixodes ricinus, Notoedres cati, listed tapeworms, gastrointestinal, lung and vesical worms, and heartworm prevention · On the skin
Care settingVeterinary-prescribed feline multiparasite treatment after individual clinical, lifestyle and epidemiological assessment
vetman score 8.3/10 Very good
Evidence confidence: High Georgia: No · Verified on 15 Oct 2026

A highly effective, unusually broad feline endectoparasiticide when all three parasite groups genuinely need concurrent treatment. Its strong EU evidence does not change its absence from the Georgian register, and broad coverage should not replace narrower first-line therapy when mixed risk is absent.

Regulatory and scientific credibility8.2/10

The exact presentation has a valid central EU authorisation and a current UPD record, supported by detailed official product information and a mature EPAR. It is not registered in Georgia or the US; the separate GB national authorisation expired on 3 July 2026, while EU authorisation including Northern Ireland remains valid.

Clinical efficacy9.0/10

Controlled and multicentre field evidence supports high activity across fleas, major gastrointestinal helminths, lungworms, eyeworm and heartworm prevention. The label is deliberately restricted to simultaneous three-group need; tick protection is shorter than flea protection, and some parasite-specific follow-up or repeat dosing remains necessary.

Safety and tolerability7.5/10

Correct topical use is generally well tolerated and has a wide experimental safety margin, but common local coat or skin changes and salivation can occur. Accidental licking can cause gastrointestinal or transient neurological signs; very rare tremor or visual impairment, reproductive uncertainty and important species and health restrictions require counselling.

Clinical practicality8.4/10

One whole applicator gives broad single-dose coverage and is easier than several separate products, but it must reach the skin at an inaccessible neck site, the cat must not be bathed for two days, exact weight-band selection is required and cats above 7.5 kg need a veterinarian-selected applicator combination.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use in sick or convalescent animals, rabbits, or with hypersensitivity to an ingredient. This feline product is not intended for dogs; prevent oral exposure, especially in Collies, Old English Sheepdogs and related breeds.
  • Do not use below 0.6 kg or under 7 weeks of age. Safety in pregnancy and lactation is not established; use only after veterinary benefit-risk assessment. Safety at intervals shorter than two weeks has not been tested.
  • Counsel for common transient coat clumping, local itching or hair loss and salivation. Accidental licking can cause vomiting, hypersalivation, ataxia, disorientation, apathy or pupil dilation; tremor and transient blindness or impaired vision are very rare. Reassess signs persisting beyond 24 hours.
  • Use only for confirmed mixed infestation or substantial concurrent risk involving ectoparasites, nematodes and cestodes. If three-group risk is absent, choose a narrower first-line parasiticide; avoid unnecessary frequent use and underdosing that can select resistance.
  • Flea treatment and environmental-stage control last at least one month, while Ixodes ricinus protection lasts up to three weeks. Tick attachment and pathogen transmission cannot be completely excluded; treat household animals and the environment when clinically indicated.
  • For heartworm prevention, test cats aged at least 6 months in endemic areas because adult Dirofilaria is not treated. Aelurostrongylus may need a second dose after one month; Joyeuxiella needs post-treatment follow-up, and tapeworm control requires management of fleas, rodents and other intermediate hosts.
  • Weigh exactly and empty the whole applicator onto visible skin at the midline of the neck where licking is prevented. Use 0.3 ml below 2.5 kg and 0.9 ml at 2.5-7.5 kg; above 7.5 kg use a veterinarian-selected applicator combination. Avoid bathing for two days, wear gloves, limit handling until dry and keep product or containers out of watercourses.
Assessment sources
  1. EU UPD Broadline 0.9 ml2026
  2. EC Broadline product information2021
  3. EMA Broadline EPAR2026
  4. Georgia NFA register 20262026
  5. Broadline European field study2014
  6. Broadline Brazil field study2022
  7. Broadline lungworm field study2015
  8. Broadline Thelazia field trial2021
  9. Broadline heartworm studies2014
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil74.7 mg (S)-Methoprene90 mg Eprinomectin3.6 mg Praziquantel74.7 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Registration
Georgia No
Not registered in Georgia
Veterinary (National Food Agency)
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Expired
Expired on 03 Jul 2026, not renewed yet
№ 61700/5084
Verified on: 22 Oct 2026
 US No
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 pipette
The recommended minimum doses are 10 mg/kg bodyweight for fipronil, 12 mg/kg for (S)-methoprene, 0.5 mg/kg for eprinomectin and 10 mg/kg for praziquantel. Do not use in sick or convalescent animals.
 Cat 2.49–7.5 kg On the skin once; flea and heartworm protection - one month Product label (SPC)
No dose for this species
This feline product is not intended for dogs. Prevent oral exposure, particularly in Collies, Old English Sheepdogs, and related breeds.
 Dog Any weight On the skin - Product label (SPC)
Active substance doses, with sources
Active substance Fipronil
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
6.7 mg/kg Dog Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 67.00 mg / 60.30 mg spot-on solution for dog S - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
7.5–15 mg/kg Dog, Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Spray 0.25% w/v cutaneous spray solution - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
5 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 50.00 mg / 60.00 mg spot-on solution for cat - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
8.3 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Effipro Duo 50 mg/60 mg Spot-on Solution for Cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
Active substance (S)-Methoprene
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
6 mg/kg Dog, Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 67.00 mg / 60.30 mg spot-on solution for dog S - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 50.00 mg / 60.00 mg spot-on solution for cat - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
Active substance Eprinomectin
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
0.48 mg/kg Cat Maintenance On the skin once
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
NexGard Combo spot-on solution for cats 2.5-7.5 kg - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
Active substance Praziquantel
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
5 mg/kg Dog, Cat Maintenance By mouth once
VMD SPC 2022
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Krka Multiwormer 50/144/150 mg tablets for dogs - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2022
VMD SPC 2024
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Krka Wormer 230 mg/20 mg film-coated tablets for cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2024

Known Contraindications

  • Critical (S)-Methoprene
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Eprinomectin
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Warning Eprinomectin (Cat)
    The safety of the veterinary medicinal product has not been tested in kittens under 8 weeks of age. The product is for use in cats weighing at least 0.8 kg and from 8 weeks of age.
    Sources: VMD SPC · VMD
  • Warning Eprinomectin (Cat)
    Target animal safety has not been evaluated beyond 6 consecutive monthly treatments and accumulation of esafoxolaner and eprinomectin was observed up to the 5th monthly administration (see also sections 3.10 and 4.3). Repeated treatments beyond 6 consecutive months should be restricted to limited individual situations (see section 3.9 for treatment guidance), with a minimum treatment interval of 4 weeks, according to a benefit-risk evaluation by the responsible veterinarian.
    Sources: VMD SPC · VMD
  • Caution Eprinomectin (Cat)
    Although the veterinary medicinal product may be safely administered to cats infected with adult heartworms, no therapeutic effect against adult Dirofilaria immitis has been established. It is, therefore, recommended that all cats 6 months of age or older, living in endemic areas for heartworm, should be tested for existing adult heartworm infection before being treated with the product for heartworm disease prevention.
    Sources: VMD SPC · VMD
  • Critical Fipronil
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Fipronil
    Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
    Sources: VMD SPC · VMD
  • Warning Fipronil (Dog)
    In the absence of available data, the veterinary medicinal product should not be used on puppies less than 8 weeks old and/or weighing less than 2 kg. Puppies and kittens from 2 days of age may be safely treated. Nepoužívat u štěňat do 3 dnů stáří.
    Sources: VMD SPC · VMD
  • Warning Fipronil (Cat)
    In the absence of available data, the veterinary medicinal product should not be used on kittens less than 8 weeks old and/or weighing less than 1 kg. Nepoužívat u koťat do 8 týdnů stáří. Puppies and kittens from 2 days of age may be safely treated.
    Sources: VMD SPC · VMD
  • Caution Fipronil (Cat)
    The potential toxicity of the veterinary medicinal product for kittens of less than 8 weeks of age in contact with a treated queen is not documented. Special care should be taken in this case. Data are not available on treatment of pregnant queens or nursing queens. Přípravek může být podán chovným, březím i laktujícím kočkám.
    Sources: VMD SPC · VMD
  • Critical Praziquantel
    Do not use in cases of known hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD

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