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Active substance

Torasemide

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Loop diuretic. Registered in Georgia: 2 human medicines. Forms: scored tablet, solution.

Dose and use

Doses

Each dose comes with its source. Check the label of the product you use.

Active substance Torasemide
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
0.1–0.6 mg/kg Dog Congestive Heart Failure By mouth once daily
UpCard dog oral SPC
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
UpCard 0.75 mg Tablets for Dogs (torasemide) - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
0.1–0.2 mg/kg
off-label
 Dog Congestive Heart Failure By mouth every 12-24 hours
ACVIM canine MMVD
Guideline or consensus statement
Recommendations agreed by a panel of veterinary specialists after reviewing the evidence. They guide practice and do not authorise a product.
ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs
Journal of Veterinary Internal Medicine, 2019
0.1–0.2 mg/kg
off-label
 Cat Congestive Heart Failure By mouth once daily
ACVIM feline cardiomyopathy
Guideline or consensus statement
Recommendations agreed by a panel of veterinary specialists after reviewing the evidence. They guide practice and do not authorise a product.
ACVIM consensus statement guidelines for the classification, diagnosis, and management of cardiomyopathies in cats
Journal of Veterinary Internal Medicine, 2020
Before use

Safety information

Known Contraindications

  • Critical
    Do not use in cases of renal failure.
    Sources: VMD SPC · VMD
  • Critical
    Do not use in cases of severe dehydration, hypovolaemia or hypotension.
    Sources: VMD SPC · VMD
  • Critical
    Known hypersensitivity to torasemide is a contraindication.
    Sources: VMD SPC · VMD

Known Drug Interactions

  • Contraindicated Furosemide + Torasemide
    Do not use concomitantly with other loop diuretics.
    Recommendation: Substitute one for the other rather than adding them. A single torasemide dose is approximately 20 times as potent as a single furosemide dose in the pharmacodynamic model, so milligrams are not directly interchangeable.
    Sources: VMD SPC · VMD
  • Minor warning Dexamethasone + Torasemide
    The risk of hypokalaemia may be increased if dexamethasone is administered together with potassium depleting diuretics.
    Recommendation: Monitor serum potassium.
    Sources: VMD SPC · VMD
  • Minor warning Robenacoxib + Torasemide
    When robenacoxib is used with drugs that affect renal blood flow, such as diuretics or angiotensin-converting enzyme inhibitors, monitor the patient clinically.
    Recommendation: Monitor the patient clinically and check renal parameters.
Latin name
Torasemide
Georgian name
ტორასემიდი
Authorisation status
Authorised veterinary medicine
An authorised veterinary medicine containing this substance exists. Whether a particular use is on-label depends on the species and the indication - see each dose rule.
Registered in Georgia
2 of 2 forms
Products
Trifas
Human medicines in Georgia
Toragamma, Torventa, Trifas
Human medicines with this substance in the Georgian register of medicines (Ministry of Health), checked on 18 Oct 2026. They are human medicines, not veterinary products; strengths and forms differ.
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
All forms and registration2

Registration in Georgia and abroad: the register, number, validity and source are behind (i).

Trifas 5 mg/ml, Solution

solution for injection, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Potential parenteral loop-diuretic treatment of confirmed cardiogenic congestion when an injectable route is required
Not rateable
No numerical score assigned
vetman assessment

Trifas

5 mg/ml, solution for injection, human medicine
Assessed clinical scopeDog · Potential parenteral loop-diuretic treatment of confirmed cardiogenic congestion when an injectable route is required · Intravenous
Care settingPotential veterinarian-administered inpatient/emergency use with continuous clinical assessment and rapid renal, electrolyte, perfusion and urine-output monitoring.
vetman score Not rateable No numerical score assigned
Evidence confidence: Low Georgia: Yes, human · № რ-039414 · Verified on 15 Oct 2026 Off-label use
Not rateable

A numerical exact-product score cannot responsibly be assigned. Trifas identity, human authorisation, 5 mg/ml composition and slow-IV handling are transparent, and oral torasemide has strong canine evidence. However, no dog IV dose, target-animal pharmacokinetic bridge, safety study, clinical-outcome study or guideline regimen was found. Scoring efficacy, safety or practicality would convert oral evidence and adult-human fixed doses into unsupported parenteral assumptions.

Oral torasemide is a credible canine CHF medicine, but that does not validate Trifas IV. Keep this presentation unscored and without a calculator dose until a dog parenteral regimen and safety bridge are supported.

Important safety and use flags

  • Human IV medicine. Georgian and EU human authorisation does not establish veterinary approval; exact dog/cat intravenous use is off-label by species and indication.
  • No dog/cat IV torasemide dose is established. Do not copy the adult-human 10–100 mg schedule, authorised dog oral 0.1–0.6 mg/kg schedule or feline oral rescue dose into this presentation.
  • Official route is slow intravenous injection only. Do not give IM or intra-arterially; the previous catalogue IV/IM route was incorrect.
  • Use only clear solution, do not mix with another medicine in the same injection or infusion, use immediately after opening and discard the remainder. Store below 30°C.
  • The authorised oral canine torasemide label prohibits combination with another loop diuretic such as furosemide. For this unsupported IV use, any switch requires deliberate potency, timing, response and monitoring decisions; milligrams are not interchangeable.
  • The human SPC contraindicates torasemide/related-sulfonylurea hypersensitivity and hepatic coma or precoma. Also avoid anuria, hypovolaemia, hypotension, important hyponatraemia/hypokalaemia and major urinary outflow obstruction.
  • Monitor respiratory effort, perfusion, blood pressure, urine output, body weight, hydration, creatinine/urea, sodium, potassium, chloride and acid-base status; reassess promptly after each treatment decision.
  • Review ACE inhibitors and other hypotensives, NSAIDs, digitalis, aminoglycosides, cephalosporins, platinum drugs, corticosteroids/mineralocorticoids, laxatives and other nephrotoxic or potassium-altering treatment.
  • Acute hypersensitivity including anaphylactic shock can occur after IV administration. Use only where immediate recognition and emergency treatment are possible.
  • The human label favours early conversion to oral treatment and no more than one week IV; these are handling boundaries, not a veterinary regimen. Exact reproductive and juvenile safety is unestablished.
Assessment sources
  1. Trifas 5 mg/ml IV SPC2023
  2. GE Trifas 20 IV audit2026
  3. Oral torasemide diuresis2003
  4. UpCard dog oral SPC2025
  5. ACVIM canine MMVD2019
  6. CARPODIEM oral dog trial2020
Assessed: 22 Oct 2026No axis or overall score is shown when the available evidence does not support a responsible numerical assessment.
Cat Potential parenteral loop-diuretic treatment of confirmed cardiogenic congestion when an injectable route is required
Not rateable
No numerical score assigned
vetman assessment

Trifas

5 mg/ml, solution for injection, human medicine
Assessed clinical scopeCat · Potential parenteral loop-diuretic treatment of confirmed cardiogenic congestion when an injectable route is required · Intravenous
Care settingPotential veterinarian-administered inpatient/emergency use with continuous clinical assessment and rapid renal, electrolyte, perfusion and urine-output monitoring.
vetman score Not rateable No numerical score assigned
Evidence confidence: Low Georgia: Yes, human · № რ-039414 · Verified on 15 Oct 2026 Off-label use
Not rateable

A numerical exact-product score cannot responsibly be assigned. Trifas identity, human authorisation, 5 mg/ml composition and slow-IV handling are transparent, but feline torasemide evidence is already limited and entirely oral. No cat IV dose, pharmacokinetic bridge, safety study, clinical-outcome study or guideline regimen was found; dog and adult-human doses are not transferable.

Available feline torasemide use is low-evidence and oral. Trifas IV remains unscored and without a calculator dose until a feline parenteral regimen and safety bridge are supported.

Important safety and use flags

  • Human IV medicine. Georgian and EU human authorisation does not establish veterinary approval; exact dog/cat intravenous use is off-label by species and indication.
  • No dog/cat IV torasemide dose is established. Do not copy the adult-human 10–100 mg schedule, authorised dog oral 0.1–0.6 mg/kg schedule or feline oral rescue dose into this presentation.
  • Official route is slow intravenous injection only. Do not give IM or intra-arterially; the previous catalogue IV/IM route was incorrect.
  • Use only clear solution, do not mix with another medicine in the same injection or infusion, use immediately after opening and discard the remainder. Store below 30°C.
  • No exact feline Trifas label establishes a combination rule. Avoid concurrent loop diuretics because additive diuresis, electrolyte loss and hypotension are plausible; any specialist-directed switch or overlap requires deliberate timing and close monitoring.
  • The human SPC contraindicates torasemide/related-sulfonylurea hypersensitivity and hepatic coma or precoma. Also avoid anuria, hypovolaemia, hypotension, important hyponatraemia/hypokalaemia and major urinary outflow obstruction.
  • Monitor respiratory effort, perfusion, blood pressure, urine output, body weight, hydration, creatinine/urea, sodium, potassium, chloride and acid-base status; reassess promptly after each treatment decision.
  • Review ACE inhibitors and other hypotensives, NSAIDs, digitalis, aminoglycosides, cephalosporins, platinum drugs, corticosteroids/mineralocorticoids, laxatives and other nephrotoxic or potassium-altering treatment.
  • Acute hypersensitivity including anaphylactic shock can occur after IV administration. Use only where immediate recognition and emergency treatment are possible.
  • The human label favours early conversion to oral treatment and no more than one week IV; these are handling boundaries, not a veterinary regimen. Exact reproductive and juvenile safety is unestablished.
Assessment sources
  1. Trifas 5 mg/ml IV SPC2023
  2. GE Trifas 20 IV audit2026
  3. Oral torasemide diuresis2003
  4. ACVIM feline cardiomyopathy2020
  5. Feline oral torasemide cohort2020
Assessed: 22 Oct 2026No axis or overall score is shown when the available evidence does not support a responsible numerical assessment.
Composition / strength
Torasemide5 mg/ml
Formulation Type
Solution
Administration route
Intravenous
Manufacturer
Berlin-Chemie / Menarini · Germany
Registration
Georgia Yes, human
In force until 24 Oct 2028
Human (Ministry of Health, RAMA)
№ რ-039414
Verified on: 15 Oct 2026
 EU Yes, human
Verified on: 16 Oct 2026
 UK No
Verified on: 16 Oct 2026
 US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
Information not fully verified No dog/cat intravenous dose is established. The exact adult-human label requires slow IV injection only; never IM or intra-arterial. Human fixed doses and veterinary oral torasemide regimens must not be converted into an IV animal dose. Use only clear solution, do not mix with another medicine in the same injection/infusion, use immediately after opening and discard the remainder.

Trifas 10 mg, Scored tablet

tablet, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Veterinarian-directed oral loop-diuretic treatment of objectively diagnosed cardiogenic congestion/congestive heart failure, with response-guided titration and renal/electrolyte monitoring
4.7/10
Weak evidence support
vetman assessment

Trifas

10 mg, tablet, human medicine
Assessed clinical scopeDog · Veterinarian-directed oral loop-diuretic treatment of objectively diagnosed cardiogenic congestion/congestive heart failure, with response-guided titration and renal/electrolyte monitoring · By mouth
Care settingLong-term veterinary-managed home CHF treatment after stabilisation, with prompt clinic reassessment after initiation/escalation and whenever congestion, hydration, perfusion or renal function changes
vetman score 4.7/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, human · № რ-039238 · Verified on 23 Oct 2026 Off-label use

A situational off-label human tablet for selected larger dogs when a prescribed oral torasemide dose can be delivered exactly as a whole or half and authorised veterinary strengths are unavailable. Canine torasemide efficacy is strong, but exact Trifas equivalence and coarse dose fit are limitations.

Regulatory and scientific credibility4.0/10

Exact 10 mg identity, equal-half divisibility and current Georgian/EU human authorisations are transparent. However, Trifas has no veterinary authorisation, target-animal bioequivalence or outcome study; the applicable canine evidence concerns different veterinary formulations and is partly sponsor-linked, so the evidence gate caps this axis at 4.0.

Clinical efficacy4.0/10

Two large prospective randomised studies found once-daily oral torasemide noninferior to furosemide for canine DMVD CHF and suggested longer time to cardiac endpoints. Both were sponsor-linked and tested veterinary regimens/products, so they strongly support the molecule/route but not exact Trifas equivalence.

Safety and tolerability6.0/10

Canine veterinary labels and trials characterise the major risks and monitoring, but potent long diuresis can cause dehydration, hypotension, azotaemia and sodium/potassium/chloride disturbance. Exact Trifas target-animal repeated safety and dose-uniformity after division are untested; coarse rounding can materially change exposure.

Clinical practicality5.0/10

Once-daily oral use is convenient and the tablet has validated equal halves, but the smallest 5 mg step is coarse for many dogs, cannot reproduce fine mg/kg titration and lacks veterinary flavour/palatability data. Frequent early renal/electrolyte reassessment is appropriate treatment burden, not a defect.

Full-course cost-effectiveness-

A current comparable Georgian full-course price and exact veterinary regimen were not verified; cost is excluded from the denominator.

Important safety and use flags

  • Human scored tablet; all dog/cat use is off-label. Authorised canine torasemide tablets are separate products and do not prove exact Trifas bioequivalence.
  • The score line validates equal 5 mg halves only. Do not quarter or crush by assumption. For cats and many dogs, use a dose-accurate alternative rather than rounding a narrow diuretic plan to this tablet.
  • Avoid anuria/renal failure, severe dehydration, hypovolaemia or hypotension, clinically important hyponatraemia/hypokalaemia and major urinary outflow obstruction. Correct perfusion/electrolyte deficits before further diuresis.
  • Do not routinely combine with another loop diuretic such as furosemide. Switching is a deliberate potency, timing, response and monitoring decision; milligrams are not interchangeable.
  • Track resting respiratory rate/effort, congestion, body weight, hydration, perfusion, blood pressure and urine output. Reassess promptly if dyspnoea, weakness, syncope, anorexia, vomiting, oliguria or excessive weight loss occurs.
  • Check creatinine/urea, sodium, potassium, chloride and acid-base status soon after initiation or escalation and periodically thereafter. Titrate to the lowest dose that controls congestion, not to urine volume alone.
  • Review ACE inhibitors and other hypotensives, NSAIDs, digoxin when potassium is low, aminoglycosides, cephalosporins, platinum drugs, corticosteroids/mineralocorticoids, laxatives and other nephrotoxic or electrolyte-altering treatment.
  • Do not use a human fixed daily dose or infer a universal dog/cat tablet count. The ingredient-level veterinary ranges require patient-specific diagnosis, prior loop-diuretic exposure, response and monitoring.
  • For a typical 5 kg cat, the ACVIM 0.1–0.2 mg/kg starting range is about 0.5–1 mg; the validated 5 mg half is five to ten times that amount. Do not administer a half tablet or approximate tiny fragments.
  • Exact juvenile, pregnancy/lactation, breeding, severe hepatic-disease and long-term Trifas safety in dogs/cats is not established. Prevent accidental exposure; a single tablet can be a major dose for a small animal.
Assessment sources
  1. Trifas 10 exact SPC2022
  2. Trifas 10 GE register2026
  3. Trifas 10 EU audit2026
  4. Isemid dog torasemide EPAR2025
  5. UpCard dog oral SPC2025
  6. ACVIM canine MMVD2019
  7. TEST canine torasemide trial2017
  8. CARPODIEM oral dog trial2020
  9. Oral torasemide diuresis2003
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Veterinarian-directed oral loop-diuretic treatment of objectively diagnosed cardiogenic congestion/congestive heart failure, with response-guided titration and renal/electrolyte monitoring
3.6/10
Poor / unconvincing
vetman assessment

Trifas

10 mg, tablet, human medicine
Assessed clinical scopeCat · Veterinarian-directed oral loop-diuretic treatment of objectively diagnosed cardiogenic congestion/congestive heart failure, with response-guided titration and renal/electrolyte monitoring · By mouth
Care settingLong-term veterinary-managed home CHF treatment after stabilisation, with prompt clinic reassessment after initiation/escalation and whenever congestion, hydration, perfusion or renal function changes
vetman score 3.6/10 Poor / unconvincing
Evidence confidence: Low Georgia: Yes, human · № რ-039238 · Verified on 23 Oct 2026 Off-label use

A weak and generally impractical feline presentation. Oral torasemide has limited rescue evidence in cats, but the smallest validated 5 mg half is several-fold above ordinary feline starting doses; use a dose-accurate alternative rather than visually subdividing Trifas.

Regulatory and scientific credibility4.0/10

Exact tablet identity and human market status are transparent, but no authorised feline torasemide product, exact Trifas pharmacokinetics, dose-accuracy study, target-animal safety study or feline outcome trial exists. Evidence is indirect and formulation-mismatched, so the evidence gate caps this axis at 4.0.

Clinical efficacy4.0/10

A 21-cat retrospective cohort reported early improvement in 20/21 cats but no survival difference from a contemporary furosemide group; treatment was confounded and prospective confirmation is absent. Experimental diuresis supports pharmacology, not durable spontaneous-CHF benefit.

Safety and tolerability4.5/10

Feline target-animal safety is limited to a small retrospective cohort and class evidence. Renal perfusion and electrolyte injury are clinically important, exact Trifas exposure is untested, and the 5 mg minimum half creates a major overdose risk at ordinary feline mg/kg doses.

Clinical practicality1.0/10

The exact tablet is practically unsuitable for ordinary cats: a 5 kg cat commonly needs about 0.5–1 mg at the guideline starting range, while the smallest validated half is 5 mg. Quartering is neither accurate nor sufficient; a dose-accurate alternative is required.

Full-course cost-effectiveness-

A current comparable Georgian full-course price and exact veterinary regimen were not verified; cost is excluded from the denominator.

Important safety and use flags

  • Human scored tablet; all dog/cat use is off-label. Authorised canine torasemide tablets are separate products and do not prove exact Trifas bioequivalence.
  • The score line validates equal 5 mg halves only. Do not quarter or crush by assumption. For cats and many dogs, use a dose-accurate alternative rather than rounding a narrow diuretic plan to this tablet.
  • Avoid anuria/renal failure, severe dehydration, hypovolaemia or hypotension, clinically important hyponatraemia/hypokalaemia and major urinary outflow obstruction. Correct perfusion/electrolyte deficits before further diuresis.
  • Do not routinely combine with another loop diuretic such as furosemide. Switching is a deliberate potency, timing, response and monitoring decision; milligrams are not interchangeable.
  • Track resting respiratory rate/effort, congestion, body weight, hydration, perfusion, blood pressure and urine output. Reassess promptly if dyspnoea, weakness, syncope, anorexia, vomiting, oliguria or excessive weight loss occurs.
  • Check creatinine/urea, sodium, potassium, chloride and acid-base status soon after initiation or escalation and periodically thereafter. Titrate to the lowest dose that controls congestion, not to urine volume alone.
  • Review ACE inhibitors and other hypotensives, NSAIDs, digoxin when potassium is low, aminoglycosides, cephalosporins, platinum drugs, corticosteroids/mineralocorticoids, laxatives and other nephrotoxic or electrolyte-altering treatment.
  • Do not use a human fixed daily dose or infer a universal dog/cat tablet count. The ingredient-level veterinary ranges require patient-specific diagnosis, prior loop-diuretic exposure, response and monitoring.
  • For a typical 5 kg cat, the ACVIM 0.1–0.2 mg/kg starting range is about 0.5–1 mg; the validated 5 mg half is five to ten times that amount. Do not administer a half tablet or approximate tiny fragments.
  • Exact juvenile, pregnancy/lactation, breeding, severe hepatic-disease and long-term Trifas safety in dogs/cats is not established. Prevent accidental exposure; a single tablet can be a major dose for a small animal.
Assessment sources
  1. Trifas 10 exact SPC2022
  2. Trifas 10 GE register2026
  3. Trifas 10 EU audit2026
  4. Isemid dog torasemide EPAR2025
  5. UpCard dog oral SPC2025
  6. ACVIM feline cardiomyopathy2020
  7. Feline oral torasemide cohort2020
  8. Oral torasemide diuresis2003
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Torasemide10 mg
Formulation Type
Scored tablet
Administration route
By mouth
Manufacturer
Berlin-Chemie · Germany
Registration
Georgia Yes, human
In force until 03 Oct 2028
Human (Ministry of Health, RAMA)
In the register: ტრიფასი 10 მგ, ტაბლეტი
№ რ-039238
Verified on: 23 Oct 2026
 EU Yes, human
Verified on: 23 Oct 2026
 UK No
Verified on: 23 Oct 2026
 US No
Verified on: 23 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
Information not fully verified Human tablet; all dog/cat use is off-label. The exact tablet contains 10 mg torasemide and is validated to divide into equal 5 mg halves only; quartering or crushing is not established. Oral torasemide has authorised canine alternatives and guideline doses, but no universal exact-Trifas calculator dose is published because a 5 mg step is too coarse for many dogs and ordinary feline doses. Use a dose-accurate alternative whenever the prescribed amount is not a whole or equal half.

Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

For veterinary professionals only. It does not replace clinical judgement or the product label; check the dose in the official label (SPC). vetman is not liable for harm caused by using this information.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 23 Oct 2026

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