KA/EN
Register
Medicines reference
Search
Search
Active substance

Phenobarbital

Favourites

Barbiturate.

Controlled substance. For use only by a veterinarian, as the law prescribes.
Dose and use

Doses

We have no dose with a cited source for this substance yet.

Before use

Safety information

Known Drug Interactions

  • Major warning Phenobarbital + Aminophylline
    induced by rifampin and phenobarbital
    Recommendation: Monitor the bronchodilator response; a dose increase may be necessary.
    Sources: MSD Vet Manual
  • Major warning Doxycycline + Phenobarbital
    Phenobarbital, phenytoin, carbamazepine, and other enzyme-inducing antiepileptic drugs can shorten the half-life of doxycycline and reduce its antibacterial exposure. Standard doxycycline dosing may therefore be subtherapeutic.
    Recommendation: If the patient receives phenobarbital and doxycycline is essential, the standard 10 mg/kg dose may be inadequate; monitor clinical response closely. Alternatively, choose an antibiotic from another class based on susceptibility testing.
    Sources: VMD SPC · VMD
  • Major warning Metronidazole + Phenobarbital
    Phenobarbital may increase hepatic metabolism of metronidazole resulting in decreased serum concentration of metronidazole.
    Recommendation: Metronidazole may be less effective than expected in a patient receiving phenobarbital. Monitor clinical response.
    Sources: VMD SPC · VMD
  • Major warning Phenobarbital + Theophylline
    Plasma theophylline levels may... decrease in patients receiving phenobarbitone or phenytoin. is induced by rifampin and phenobarbital
    Recommendation: Reduced theophylline effect is expected during concomitant use. Assess clinical response and increase the dose if needed without exceeding 20 mg/kg in dogs. Theophylline levels rise when phenobarbital is stopped; reassess the dose.
    Sources: VMD SPC · VMD · MSD Vet Manual
  • Minor warning Phenobarbital + Methimazole
    Phenobarbital can reduce the clinical efficacy of thiamazole when the drugs are used together.
    Recommendation: Recheck T4 and clinical response.
  • Minor warning Levothyroxine + Phenobarbital
    Several drugs, including barbiturates, antacids, anabolic steroids, diazepam, and furosemide, can alter thyroid-hormone binding or metabolism and may affect the response to levothyroxine.
    Recommendation: Recheck T4 and adjust the dose as needed.
Latin name
Phenobarbital
Georgian name
ფენობარბიტალი
Controlled in Georgia
Yes
Listed under the Georgian narcotics law (Annex 1) or the Minister's Order No. 22/n. The legal text is in Georgian.
Verified on: 16 Oct 2026

Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

For veterinary professionals only. It does not replace clinical judgement or the product label; check the dose in the official label (SPC). vetman is not liable for harm caused by using this information.

Trademarks belong to their owners; vetman is not affiliated with the manufacturers and receives no payment from them.

The database is protected under Chapter VII of the Law of Georgia on Copyright and Related Rights; automated or bulk copying is prohibited.

This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 16 Oct 2026

All of this shows in vetman as you prescribe

The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

Register Demo ↗