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Metronidazole
Nitroimidazole. Registered in Georgia: 3 veterinary products and 18 human medicines. Forms: coated tablet, solution, tablet.
Overdose
Used in veterinary practice at veterinary doses; human tablets and gels are much stronger and cannot be dosed accurately for an animal. The table shows where harm has been described after a single ingestion, mg per kg of body weight: overdose thresholds, not treatment doses.
| Species | Signs begin | Severe | Deaths reported | Source |
|---|---|---|---|---|
| Cat | not established | not established | not established |
Caylor & Cassimatis 2001 · Olson et al. 2005
Low confidence
Case reports (Caylor & Cassimatis 2001; Olson et al. 2005). Scientific article A study or review published in a scientific journal. Its findings apply to the animals and conditions it studied. Journal of the American Animal Hospital Association, J Am Anim Hosp Assoc 2001;37(3):258-262, 2001 two cats: 58 mg/kg/day for 6 months; 111 then 222 mg/kg/day; signs resolved after withdrawal Scientific article A study or review published in a scientific journal. Its findings apply to the animals and conditions it studied. Veterinary Pathology, Vet Pathol 2005;42(5):665-669, 2005 73.5-147 mg/kg/day for ~40 days; brainstem necrosis |
Cat
Signs: Ataxia, altered mentation, tremors, tetraparesis, seizures.
Neurotoxicity is reported in cats on high doses or long courses: 58 mg/kg a day for 6 months, 111 then 222 mg/kg a day, and 73.5-147 mg/kg a day for about 40 days (that cat had brainstem necrosis). In two cats the signs went within days of stopping the drug. Keep to the label dose and duration.
Doses
Each dose comes with its source. Check the label of the product you use.
| Dose | Species | Indication | Route | Frequency | Source |
|---|---|---|---|---|---|
| 25 mg/kg | Dog, Cat | Bacterial Infection | By mouth | 2 times daily |
VMD SPC 2025
Official product label (SPC), VMD, UK Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there. UK Veterinary Medicines Directorate, 2025 |
Safety information
Known Contraindications
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Critical
Do not use in cases of hepatic disorders.Sources: VMD SPC · VMD
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Critical
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.Sources: VMD SPC · VMD
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Critical
In dogs, high doses can cause neurotoxicity: tremor, muscle spasms, ataxia and even seizures, especially after a long course. The risk rises when the recommended dose or treatment length is exceeded. If neurological signs appear, stop metronidazole and treat the signs.Sources: VMD SPC · VMD · MSD Vet Manual
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Warning
Studies in laboratory animals have shown inconsistent results with regard to teratogenic/embryotoxic effects of metronidazole. Therefore, use of this veterinary medicinal product during pregnancy is not recommended.Sources: VMD SPC · VMD
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Warning
Metronidazole is excreted in milk and use during lactation is therefore not recommended.Sources: VMD SPC · VMD
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Warning
tremors, muscle spasms, ataxia, and even convulsionsSources: MSD Vet Manual
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Warning
(Cat) Metronidazole in cats: neurotoxicity (ataxia, altered mentation, tremors, seizures) is reported with high doses and long courses (58 mg/kg a day for 6 months; 111-222 mg/kg a day; 73.5-147 mg/kg a day). Keep to the label dose and duration; stop the drug at the first neurological sign.
Known Drug Interactions
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Major warning
Metronidazole + Phenobarbital
Phenobarbital may increase hepatic metabolism of metronidazole resulting in decreased serum concentration of metronidazole.Recommendation: Metronidazole may be less effective than expected in a patient receiving phenobarbital. Monitor clinical response.Sources: VMD SPC · VMD
All forms and registration21
Registration in Georgia and abroad: the register, number, validity and source are behind (i).
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Metrid 5 mg/ml (0.5%), Solution
Metrol 5 mg/ml, Solution
Metrolag 500 mg, Tablet
Metronidazole Belmedpreparaty 5 mg/ml, Solution
Metronidazole Borisov 250 mg, Tablet
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Neofleks Metronidazole 5 mg/ml (0.5%), Solution
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Rilebi 500 mg, Coated tablet
Stomorgyl 2, Tablet
Stomorgyl 10, Tablet
Stomorgyl 20, Tablet
Trichopol 250 mg, Tablet
Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.
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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 22 Oct 2026