Register
Medicines reference
Active substance

Metronidazole

Nitroimidazole. Registered in Georgia: 3 veterinary products and 18 human medicines. Forms: coated tablet, solution, tablet.

Safety

Overdose

Used in veterinary practice at veterinary doses; human tablets and gels are much stronger and cannot be dosed accurately for an animal. The table shows where harm has been described after a single ingestion, mg per kg of body weight: overdose thresholds, not treatment doses.

Species Signs begin Severe Deaths reported Source
Cat not established not established not established
Caylor & Cassimatis 2001 · Olson et al. 2005
Low confidence
Case reports (Caylor & Cassimatis 2001; Olson et al. 2005).
Scientific article
A study or review published in a scientific journal. Its findings apply to the animals and conditions it studied.
Metronidazole neurotoxicosis in two cats
Journal of the American Animal Hospital Association, J Am Anim Hosp Assoc 2001;37(3):258-262, 2001
two cats: 58 mg/kg/day for 6 months; 111 then 222 mg/kg/day; signs resolved after withdrawal
Scientific article
A study or review published in a scientific journal. Its findings apply to the animals and conditions it studied.
Putative metronidazole neurotoxicosis in a cat
Veterinary Pathology, Vet Pathol 2005;42(5):665-669, 2005
73.5-147 mg/kg/day for ~40 days; brainstem necrosis

Cat

Signs: Ataxia, altered mentation, tremors, tetraparesis, seizures.

Neurotoxicity is reported in cats on high doses or long courses: 58 mg/kg a day for 6 months, 111 then 222 mg/kg a day, and 73.5-147 mg/kg a day for about 40 days (that cat had brainstem necrosis). In two cats the signs went within days of stopping the drug. Keep to the label dose and duration.

Dose and use

Doses

Each dose comes with its source. Check the label of the product you use.

Active substance Metronidazole
Before use

Safety information

Known Contraindications

  • Critical
    Do not use in cases of hepatic disorders.
    Sources: VMD SPC · VMD
  • Critical
    Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical
    In dogs, high doses can cause neurotoxicity: tremor, muscle spasms, ataxia and even seizures, especially after a long course. The risk rises when the recommended dose or treatment length is exceeded. If neurological signs appear, stop metronidazole and treat the signs.
    Sources: VMD SPC · VMD · MSD Vet Manual
  • Warning
    Studies in laboratory animals have shown inconsistent results with regard to teratogenic/embryotoxic effects of metronidazole. Therefore, use of this veterinary medicinal product during pregnancy is not recommended.
    Sources: VMD SPC · VMD
  • Warning
    Metronidazole is excreted in milk and use during lactation is therefore not recommended.
    Sources: VMD SPC · VMD
  • Warning
    tremors, muscle spasms, ataxia, and even convulsions
    Sources: MSD Vet Manual
  • Warning (Cat)
    Metronidazole in cats: neurotoxicity (ataxia, altered mentation, tremors, seizures) is reported with high doses and long courses (58 mg/kg a day for 6 months; 111-222 mg/kg a day; 73.5-147 mg/kg a day). Keep to the label dose and duration; stop the drug at the first neurological sign.

Known Drug Interactions

  • Major warning Metronidazole + Phenobarbital
    Phenobarbital may increase hepatic metabolism of metronidazole resulting in decreased serum concentration of metronidazole.
    Recommendation: Metronidazole may be less effective than expected in a patient receiving phenobarbital. Monitor clinical response.
    Sources: VMD SPC · VMD
Latin name
Metronidazole
Georgian name
მეტრონიდაზოლი
Authorisation status
Authorised veterinary medicine
An authorised veterinary medicine containing this substance exists. Whether a particular use is on-label depends on the species and the indication - see each dose rule.
Registered in Georgia
21 of 21 forms
Human medicines in Georgia
Anaerobex, Efloran, Flagyl, Flagymet, Klont, Metrid, Metrolag, Neofleks, Polgyl, Rileb, Rozamet, Trichopol
Human medicines with this substance in the Georgian register of medicines (Ministry of Health), checked on 18 Oct 2026. They are human medicines, not veterinary products; strengths and forms differ.
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
All forms and registration21

Registration in Georgia and abroad: the register, number, validity and source are behind (i).

Acumet 5 mg/ml, Solution

solution for infusion 100 ml, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.5/10
Situational / acceptable
vetman assessment

Acumet

5 mg/ml, solution for infusion 100 ml, human medicine
Assessed clinical scopeDog · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.5/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-035711 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.5/10

Metronidazole has reliable activity and tissue penetration against susceptible obligate anaerobes, and human IV formulations have an established veterinary role in serious canine anaerobic infection. Outcome evidence for these exact bags is indirect and source control or broader therapy can remain essential.

Safety and tolerability6.0/10

Gastrointestinal adverse effects and marked microbiome disruption are relevant, and cumulative exposure can cause vestibulocerebellar neurotoxicity at lower doses than historically assumed. Reduce exposure in hepatic dysfunction and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.2/10
Situational / acceptable
vetman assessment

Acumet

5 mg/ml, solution for infusion 100 ml, human medicine
Assessed clinical scopeCat · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.2/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-035711 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.0/10

Activity against susceptible obligate anaerobes and direct feline IV pharmacokinetics support a hospital role, but feline clinical-outcome evidence for human infusion bags is sparse; source control and broader therapy may remain essential.

Safety and tolerability5.5/10

Feline PK is documented, but direct safety data are limited; in-vitro genotoxicity and a severe neurotoxicosis case add uncertainty. Avoid unnecessary or prolonged exposure, account for hepatic disease and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Metronidazole5 mg/ml
Formulation Type
Solution
Administration route
Intravenous
Manufacturer
Registration
Georgia Yes, human
In force until 30 Jun 2027
Human (Ministry of Health, RAMA)
In the register: აკუმეტი 5 მგ/მლ, საინფუზიო ხსნარი 100 მლ
№ რ-035711
Verified on: 16 Oct 2026
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Amorob 500 mg/100 ml, Solution

solution for infusion, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.5/10
Situational / acceptable
vetman assessment

Amorob

500 mg/100 ml, solution for infusion, human medicine
Assessed clinical scopeDog · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.5/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-036151 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.5/10

Metronidazole has reliable activity and tissue penetration against susceptible obligate anaerobes, and human IV formulations have an established veterinary role in serious canine anaerobic infection. Outcome evidence for these exact bags is indirect and source control or broader therapy can remain essential.

Safety and tolerability6.0/10

Gastrointestinal adverse effects and marked microbiome disruption are relevant, and cumulative exposure can cause vestibulocerebellar neurotoxicity at lower doses than historically assumed. Reduce exposure in hepatic dysfunction and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.2/10
Situational / acceptable
vetman assessment

Amorob

500 mg/100 ml, solution for infusion, human medicine
Assessed clinical scopeCat · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.2/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-036151 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.0/10

Activity against susceptible obligate anaerobes and direct feline IV pharmacokinetics support a hospital role, but feline clinical-outcome evidence for human infusion bags is sparse; source control and broader therapy may remain essential.

Safety and tolerability5.5/10

Feline PK is documented, but direct safety data are limited; in-vitro genotoxicity and a severe neurotoxicosis case add uncertainty. Avoid unnecessary or prolonged exposure, account for hepatic disease and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Metronidazole5 mg/ml
Formulation Type
Solution
Administration route
Intravenous
Manufacturer
Saffron · Pakistan
Registration
Georgia Yes, human
In force until 10 Aug 2027
Human (Ministry of Health, RAMA)
In the register: ამორობი 500 მგ/100 მლ, საინფუზიო ხსნარი
№ რ-036151
Verified on: 16 Oct 2026
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Anaerobex 500 mg, Coated tablet

film-coated tablet, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy
6.0/10
Situational / acceptable
vetman assessment

Anaerobex

500 mg, film-coated tablet, human medicine
Assessed clinical scopeDog · Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy · By mouth
Care settingVeterinary-directed inpatient or outpatient course after diagnosis and antimicrobial review, with a measured patient-specific dose and reassessment rather than automatic repeat courses
vetman score 6.0/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-034655 · Verified on 16 Oct 2026 Off-label use

A clinically credible but stewardship-limited drug for susceptible anaerobes or selected giardiasis, not routine diarrhoea care. This whole 500 mg human tablet is useful only when it matches the calculated canine dose; otherwise a veterinary or validated compounded form is preferable.

Regulatory and scientific credibility6.5/10

The exact human presentation has sourced current registrations in Georgia and EU/EEA with identifiable strength, route and manufacturer. It is not a veterinary-authorised presentation and this animal use is off-label.

Clinical efficacy7.0/10

Veterinary labels and EMA review support susceptible anaerobic infections and selected giardiasis, but controlled studies do not support routine metronidazole for uncomplicated acute diarrhoea and Giardia cure depends on reinfection control.

Safety and tolerability6.0/10

Gastrointestinal adverse effects and marked microbiome disruption are relevant, and cumulative exposure can cause vestibulocerebellar neurotoxicity at lower doses than historically assumed. Reduce exposure in hepatic dysfunction and stop promptly for neurologic signs.

Clinical practicality3.5/10

The whole 500 mg tablet is workable only for a limited range of large dogs at the calculated dose. It cannot accurately serve most dogs without a validated compounded preparation.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This intensely bitter human tablet is recorded as a whole dosing unit. Do not call an unmeasured crushed-powder fraction an accurate veterinary dose; when the calculated dose does not match the unit, select a suitable veterinary strength or validated compounded liquid.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy
5.1/10
Weak evidence support
vetman assessment

Anaerobex

500 mg, film-coated tablet, human medicine
Assessed clinical scopeCat · Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy · By mouth
Care settingVeterinary-directed inpatient or outpatient course after diagnosis and antimicrobial review, with a measured patient-specific dose and reassessment rather than automatic repeat courses
vetman score 5.1/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, human · № რ-034655 · Verified on 16 Oct 2026 Off-label use

Metronidazole retains a narrow role for susceptible anaerobic infection or selected symptomatic giardiasis, but this whole 500 mg human tablet cannot accurately deliver a typical feline dose. The low score is mainly presentation-specific and reinforced by variable Giardia efficacy and safety uncertainty.

Regulatory and scientific credibility6.5/10

The exact human presentation has sourced current registrations in Georgia and EU/EEA with identifiable strength, route and manufacturer. It is not a veterinary-authorised presentation and this animal use is off-label.

Clinical efficacy6.5/10

Veterinary labels support susceptible anaerobic infections, while feline Giardia studies and CAPC show variable roughly 50-60% efficacy and safety limitations; this does not support routine use for nonspecific diarrhoea.

Safety and tolerability5.5/10

Feline PK is documented, but direct safety data are limited; in-vitro genotoxicity and a severe neurotoxicosis case add uncertainty. Avoid unnecessary or prolonged exposure, account for hepatic disease and stop promptly for neurologic signs.

Clinical practicality0.0/10

This 500 mg whole-unit human tablet is far above the usual feline dose and metronidazole is intensely bitter. Crushing does not make an unmeasured powder fraction accurate; use a validated lower-strength or compounded veterinary form.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This intensely bitter human tablet is recorded as a whole dosing unit. Do not call an unmeasured crushed-powder fraction an accurate veterinary dose; when the calculated dose does not match the unit, select a suitable veterinary strength or validated compounded liquid.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Formulation Type
Coated tablet
Administration route
By mouth
Manufacturer
G.L. Pharma · Austria
Registration
Georgia Yes, human
In force until 15 Mar 2027
Human (Ministry of Health, RAMA)
In the register: ანაერობექსი 500 მგ, აბი
№ რ-034655
Verified on: 16 Oct 2026
EU Yes, human
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Efloran 5 mg/ml, Solution

solution for infusion 100 ml, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.6/10
Situational / acceptable
vetman assessment

Efloran

5 mg/ml, solution for infusion 100 ml, human medicine
Assessed clinical scopeDog · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.6/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-036875 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.5/10

The exact human presentation has sourced current registrations in Georgia and EU/EEA with identifiable strength, route and manufacturer. It is not a veterinary-authorised presentation and this animal use is off-label.

Clinical efficacy6.5/10

Metronidazole has reliable activity and tissue penetration against susceptible obligate anaerobes, and human IV formulations have an established veterinary role in serious canine anaerobic infection. Outcome evidence for these exact bags is indirect and source control or broader therapy can remain essential.

Safety and tolerability6.0/10

Gastrointestinal adverse effects and marked microbiome disruption are relevant, and cumulative exposure can cause vestibulocerebellar neurotoxicity at lower doses than historically assumed. Reduce exposure in hepatic dysfunction and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.3/10
Situational / acceptable
vetman assessment

Efloran

5 mg/ml, solution for infusion 100 ml, human medicine
Assessed clinical scopeCat · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.3/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-036875 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.5/10

The exact human presentation has sourced current registrations in Georgia and EU/EEA with identifiable strength, route and manufacturer. It is not a veterinary-authorised presentation and this animal use is off-label.

Clinical efficacy6.0/10

Activity against susceptible obligate anaerobes and direct feline IV pharmacokinetics support a hospital role, but feline clinical-outcome evidence for human infusion bags is sparse; source control and broader therapy may remain essential.

Safety and tolerability5.5/10

Feline PK is documented, but direct safety data are limited; in-vitro genotoxicity and a severe neurotoxicosis case add uncertainty. Avoid unnecessary or prolonged exposure, account for hepatic disease and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Metronidazole5 mg/ml
Formulation Type
Solution
Administration route
Intravenous
Manufacturer
Krka · Slovenia
Registration
Georgia Yes, human
In force until 17 Nov 2027
Human (Ministry of Health, RAMA)
In the register: ეფლორანი 5 მგ/მლ, საინფუზიო ხსნარი 100 მლ
№ რ-036875
Verified on: 16 Oct 2026
EU Yes, human
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Flagyl 500 mg, Coated tablet

film-coated tablet, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy
6.1/10
Situational / acceptable
vetman assessment

Flagyl

500 mg, film-coated tablet, human medicine
Assessed clinical scopeDog · Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy · By mouth
Care settingVeterinary-directed inpatient or outpatient course after diagnosis and antimicrobial review, with a measured patient-specific dose and reassessment rather than automatic repeat courses
vetman score 6.1/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ/ა-P-0597 · Verified on 16 Oct 2026 Off-label use

A clinically credible but stewardship-limited drug for susceptible anaerobes or selected giardiasis, not routine diarrhoea care. This whole 500 mg human tablet is useful only when it matches the calculated canine dose; otherwise a veterinary or validated compounded form is preferable.

Regulatory and scientific credibility7.0/10

The exact human tablet has sourced current registrations in Georgia, EU/EEA and the UK and a transparent strength and form. It is not a veterinary-authorised presentation and this animal use is off-label.

Clinical efficacy7.0/10

Veterinary labels and EMA review support susceptible anaerobic infections and selected giardiasis, but controlled studies do not support routine metronidazole for uncomplicated acute diarrhoea and Giardia cure depends on reinfection control.

Safety and tolerability6.0/10

Gastrointestinal adverse effects and marked microbiome disruption are relevant, and cumulative exposure can cause vestibulocerebellar neurotoxicity at lower doses than historically assumed. Reduce exposure in hepatic dysfunction and stop promptly for neurologic signs.

Clinical practicality3.5/10

The whole 500 mg tablet is workable only for a limited range of large dogs at the calculated dose. It cannot accurately serve most dogs without a validated compounded preparation.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This intensely bitter human tablet is recorded as a whole dosing unit. Do not call an unmeasured crushed-powder fraction an accurate veterinary dose; when the calculated dose does not match the unit, select a suitable veterinary strength or validated compounded liquid.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy
5.3/10
Weak evidence support
vetman assessment

Flagyl

500 mg, film-coated tablet, human medicine
Assessed clinical scopeCat · Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy · By mouth
Care settingVeterinary-directed inpatient or outpatient course after diagnosis and antimicrobial review, with a measured patient-specific dose and reassessment rather than automatic repeat courses
vetman score 5.3/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, human · № რ/ა-P-0597 · Verified on 16 Oct 2026 Off-label use

Metronidazole retains a narrow role for susceptible anaerobic infection or selected symptomatic giardiasis, but this whole 500 mg human tablet cannot accurately deliver a typical feline dose. The low score is mainly presentation-specific and reinforced by variable Giardia efficacy and safety uncertainty.

Regulatory and scientific credibility7.0/10

The exact human tablet has sourced current registrations in Georgia, EU/EEA and the UK and a transparent strength and form. It is not a veterinary-authorised presentation and this animal use is off-label.

Clinical efficacy6.5/10

Veterinary labels support susceptible anaerobic infections, while feline Giardia studies and CAPC show variable roughly 50-60% efficacy and safety limitations; this does not support routine use for nonspecific diarrhoea.

Safety and tolerability5.5/10

Feline PK is documented, but direct safety data are limited; in-vitro genotoxicity and a severe neurotoxicosis case add uncertainty. Avoid unnecessary or prolonged exposure, account for hepatic disease and stop promptly for neurologic signs.

Clinical practicality0.0/10

This 500 mg whole-unit human tablet is far above the usual feline dose and metronidazole is intensely bitter. Crushing does not make an unmeasured powder fraction accurate; use a validated lower-strength or compounded veterinary form.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This intensely bitter human tablet is recorded as a whole dosing unit. Do not call an unmeasured crushed-powder fraction an accurate veterinary dose; when the calculated dose does not match the unit, select a suitable veterinary strength or validated compounded liquid.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Formulation Type
Coated tablet
Administration route
By mouth
Manufacturer
Sanofi · France
Registration
Georgia Yes, human
In force until 09 Jul 2028
Human (Ministry of Health, RAMA)
In the register: ფლაგილი 500 მგ, აბი
№ რ/ა-P-0597
Verified on: 16 Oct 2026
EU Yes, human
UK Yes, human
№ PL044250745, PL564850004, PLPI151841855, PLPI158141065
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Metrid 5 mg/ml (0.5%), Solution

solution for infusion 100 ml, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.5/10
Situational / acceptable
vetman assessment

Metrid

5 mg/ml (0.5%), solution for infusion 100 ml, human medicine
Assessed clinical scopeDog · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.5/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-036071 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.5/10

Metronidazole has reliable activity and tissue penetration against susceptible obligate anaerobes, and human IV formulations have an established veterinary role in serious canine anaerobic infection. Outcome evidence for these exact bags is indirect and source control or broader therapy can remain essential.

Safety and tolerability6.0/10

Gastrointestinal adverse effects and marked microbiome disruption are relevant, and cumulative exposure can cause vestibulocerebellar neurotoxicity at lower doses than historically assumed. Reduce exposure in hepatic dysfunction and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.2/10
Situational / acceptable
vetman assessment

Metrid

5 mg/ml (0.5%), solution for infusion 100 ml, human medicine
Assessed clinical scopeCat · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.2/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-036071 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.0/10

Activity against susceptible obligate anaerobes and direct feline IV pharmacokinetics support a hospital role, but feline clinical-outcome evidence for human infusion bags is sparse; source control and broader therapy may remain essential.

Safety and tolerability5.5/10

Feline PK is documented, but direct safety data are limited; in-vitro genotoxicity and a severe neurotoxicosis case add uncertainty. Avoid unnecessary or prolonged exposure, account for hepatic disease and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Metronidazole5 mg/ml
Formulation Type
Solution
Administration route
Intravenous
Manufacturer
Registration
Georgia Yes, human
In force until 03 Aug 2027
Human (Ministry of Health, RAMA)
In the register: მეტრიდი 5 მგ/მლ (0.5%), საინფუზიო ხსნარი 100 მლ
№ რ-036071
Verified on: 16 Oct 2026
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Metrol 5 mg/ml, Solution

solution for infusion 100 ml, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.5/10
Situational / acceptable
vetman assessment

Metrol

5 mg/ml, solution for infusion 100 ml, human medicine
Assessed clinical scopeDog · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.5/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-038781 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.5/10

Metronidazole has reliable activity and tissue penetration against susceptible obligate anaerobes, and human IV formulations have an established veterinary role in serious canine anaerobic infection. Outcome evidence for these exact bags is indirect and source control or broader therapy can remain essential.

Safety and tolerability6.0/10

Gastrointestinal adverse effects and marked microbiome disruption are relevant, and cumulative exposure can cause vestibulocerebellar neurotoxicity at lower doses than historically assumed. Reduce exposure in hepatic dysfunction and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.2/10
Situational / acceptable
vetman assessment

Metrol

5 mg/ml, solution for infusion 100 ml, human medicine
Assessed clinical scopeCat · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.2/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-038781 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.0/10

Activity against susceptible obligate anaerobes and direct feline IV pharmacokinetics support a hospital role, but feline clinical-outcome evidence for human infusion bags is sparse; source control and broader therapy may remain essential.

Safety and tolerability5.5/10

Feline PK is documented, but direct safety data are limited; in-vitro genotoxicity and a severe neurotoxicosis case add uncertainty. Avoid unnecessary or prolonged exposure, account for hepatic disease and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Metronidazole5 mg/ml
Formulation Type
Solution
Administration route
Intravenous
Manufacturer
Registration
Georgia Yes, human
In force until 03 Aug 2028
Human (Ministry of Health, RAMA)
In the register: მეტროლი 5 მგ/მლ, საინფუზიო ხსნარი 100 მლ
№ რ-038781
Verified on: 16 Oct 2026
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Metrolag 500 mg, Tablet

tablet, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy
5.9/10
Weak evidence support
vetman assessment

Metrolag

500 mg, tablet, human medicine
Assessed clinical scopeDog · Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy · By mouth
Care settingVeterinary-directed inpatient or outpatient course after diagnosis and antimicrobial review, with a measured patient-specific dose and reassessment rather than automatic repeat courses
vetman score 5.9/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, human · № რ-037536 · Verified on 16 Oct 2026 Off-label use

A clinically credible but stewardship-limited drug for susceptible anaerobes or selected giardiasis, not routine diarrhoea care. This whole 500 mg human tablet is useful only when it matches the calculated canine dose; otherwise a veterinary or validated compounded form is preferable.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy7.0/10

Veterinary labels and EMA review support susceptible anaerobic infections and selected giardiasis, but controlled studies do not support routine metronidazole for uncomplicated acute diarrhoea and Giardia cure depends on reinfection control.

Safety and tolerability6.0/10

Gastrointestinal adverse effects and marked microbiome disruption are relevant, and cumulative exposure can cause vestibulocerebellar neurotoxicity at lower doses than historically assumed. Reduce exposure in hepatic dysfunction and stop promptly for neurologic signs.

Clinical practicality3.5/10

The whole 500 mg tablet is workable only for a limited range of large dogs at the calculated dose. It cannot accurately serve most dogs without a validated compounded preparation.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This intensely bitter human tablet is recorded as a whole dosing unit. Do not call an unmeasured crushed-powder fraction an accurate veterinary dose; when the calculated dose does not match the unit, select a suitable veterinary strength or validated compounded liquid.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy
5.0/10
Weak evidence support
vetman assessment

Metrolag

500 mg, tablet, human medicine
Assessed clinical scopeCat · Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy · By mouth
Care settingVeterinary-directed inpatient or outpatient course after diagnosis and antimicrobial review, with a measured patient-specific dose and reassessment rather than automatic repeat courses
vetman score 5.0/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, human · № რ-037536 · Verified on 16 Oct 2026 Off-label use

Metronidazole retains a narrow role for susceptible anaerobic infection or selected symptomatic giardiasis, but this whole 500 mg human tablet cannot accurately deliver a typical feline dose. The low score is mainly presentation-specific and reinforced by variable Giardia efficacy and safety uncertainty.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.5/10

Veterinary labels support susceptible anaerobic infections, while feline Giardia studies and CAPC show variable roughly 50-60% efficacy and safety limitations; this does not support routine use for nonspecific diarrhoea.

Safety and tolerability5.5/10

Feline PK is documented, but direct safety data are limited; in-vitro genotoxicity and a severe neurotoxicosis case add uncertainty. Avoid unnecessary or prolonged exposure, account for hepatic disease and stop promptly for neurologic signs.

Clinical practicality0.0/10

This 500 mg whole-unit human tablet is far above the usual feline dose and metronidazole is intensely bitter. Crushing does not make an unmeasured powder fraction accurate; use a validated lower-strength or compounded veterinary form.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This intensely bitter human tablet is recorded as a whole dosing unit. Do not call an unmeasured crushed-powder fraction an accurate veterinary dose; when the calculated dose does not match the unit, select a suitable veterinary strength or validated compounded liquid.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Formulation Type
Tablet
Administration route
By mouth
Manufacturer
Lagap · Switzerland
Registration
Georgia Yes, human
In force until 13 Mar 2028
Human (Ministry of Health, RAMA)
In the register: მეტროლაგი 500 მგ, აბი
№ რ-037536
Verified on: 16 Oct 2026
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Metronidazole Belmedpreparaty 5 mg/ml, Solution

solution for infusion 100 ml, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.5/10
Situational / acceptable
vetman assessment

Metronidazole Belmedpreparaty

5 mg/ml, solution for infusion 100 ml, human medicine
Assessed clinical scopeDog · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.5/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-035616 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.5/10

Metronidazole has reliable activity and tissue penetration against susceptible obligate anaerobes, and human IV formulations have an established veterinary role in serious canine anaerobic infection. Outcome evidence for these exact bags is indirect and source control or broader therapy can remain essential.

Safety and tolerability6.0/10

Gastrointestinal adverse effects and marked microbiome disruption are relevant, and cumulative exposure can cause vestibulocerebellar neurotoxicity at lower doses than historically assumed. Reduce exposure in hepatic dysfunction and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.2/10
Situational / acceptable
vetman assessment

Metronidazole Belmedpreparaty

5 mg/ml, solution for infusion 100 ml, human medicine
Assessed clinical scopeCat · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.2/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-035616 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.0/10

Activity against susceptible obligate anaerobes and direct feline IV pharmacokinetics support a hospital role, but feline clinical-outcome evidence for human infusion bags is sparse; source control and broader therapy may remain essential.

Safety and tolerability5.5/10

Feline PK is documented, but direct safety data are limited; in-vitro genotoxicity and a severe neurotoxicosis case add uncertainty. Avoid unnecessary or prolonged exposure, account for hepatic disease and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Metronidazole5 mg/ml
Formulation Type
Solution
Administration route
Intravenous
Manufacturer
Belmedpreparaty · Belarus
Registration
Georgia Yes, human
In force until 22 Jun 2027
Human (Ministry of Health, RAMA)
In the register: მეტრონიდაზოლი ბელმედპრეპარატი 5 მგ/მლ, საინფუზიო ხსნარი 100 მლ
№ რ-035616
Verified on: 16 Oct 2026
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Metronidazole Borisov 250 mg, Tablet

tablet, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy
6.1/10
Situational / acceptable
vetman assessment

Metronidazole Borisov

250 mg, tablet, human medicine
Assessed clinical scopeDog · Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy · By mouth
Care settingVeterinary-directed inpatient or outpatient course after diagnosis and antimicrobial review, with a measured patient-specific dose and reassessment rather than automatic repeat courses
vetman score 6.1/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-036003, რ-036004 · Verified on 16 Oct 2026 Off-label use

A clinically credible but stewardship-limited drug for susceptible anaerobes or selected giardiasis, not routine diarrhoea care. This whole 250 mg human tablet is useful only when it matches the calculated canine dose; otherwise a veterinary or validated compounded form is preferable.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy7.0/10

Veterinary labels and EMA review support susceptible anaerobic infections and selected giardiasis, but controlled studies do not support routine metronidazole for uncomplicated acute diarrhoea and Giardia cure depends on reinfection control.

Safety and tolerability6.0/10

Gastrointestinal adverse effects and marked microbiome disruption are relevant, and cumulative exposure can cause vestibulocerebellar neurotoxicity at lower doses than historically assumed. Reduce exposure in hepatic dysfunction and stop promptly for neurologic signs.

Clinical practicality5.0/10

The whole 250 mg tablet can match a limited medium-to-large-dog weight range, but it cannot accurately deliver many patient-specific doses; use a suitable veterinary strength or validated compound outside that range.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This intensely bitter human tablet is recorded as a whole dosing unit. Do not call an unmeasured crushed-powder fraction an accurate veterinary dose; when the calculated dose does not match the unit, select a suitable veterinary strength or validated compounded liquid.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy
5.2/10
Weak evidence support
vetman assessment

Metronidazole Borisov

250 mg, tablet, human medicine
Assessed clinical scopeCat · Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy · By mouth
Care settingVeterinary-directed inpatient or outpatient course after diagnosis and antimicrobial review, with a measured patient-specific dose and reassessment rather than automatic repeat courses
vetman score 5.2/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, human · № რ-036003, რ-036004 · Verified on 16 Oct 2026 Off-label use

Metronidazole retains a narrow role for susceptible anaerobic infection or selected symptomatic giardiasis, but this whole 250 mg human tablet cannot accurately deliver a typical feline dose. The low score is mainly presentation-specific and reinforced by variable Giardia efficacy and safety uncertainty.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.5/10

Veterinary labels support susceptible anaerobic infections, while feline Giardia studies and CAPC show variable roughly 50-60% efficacy and safety limitations; this does not support routine use for nonspecific diarrhoea.

Safety and tolerability5.5/10

Feline PK is documented, but direct safety data are limited; in-vitro genotoxicity and a severe neurotoxicosis case add uncertainty. Avoid unnecessary or prolonged exposure, account for hepatic disease and stop promptly for neurologic signs.

Clinical practicality1.0/10

This 250 mg whole-unit human tablet is far above the usual feline dose and metronidazole is intensely bitter. Crushing does not make an unmeasured powder fraction accurate; use a validated lower-strength or compounded veterinary form.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This intensely bitter human tablet is recorded as a whole dosing unit. Do not call an unmeasured crushed-powder fraction an accurate veterinary dose; when the calculated dose does not match the unit, select a suitable veterinary strength or validated compounded liquid.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Formulation Type
Tablet
Administration route
By mouth
Registration
Georgia Yes, human
In force until 29 Jul 2027
Human (Ministry of Health, RAMA)
In the register: მეტრონიდაზოლი ბორისოვი 250 მგ, აბი
№ რ-036003, რ-036004
Verified on: 16 Oct 2026
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Metronidazole Dentafill Plus 5 mg/ml (0.5%), Solution

solution for infusion 100 ml, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.5/10
Situational / acceptable
vetman assessment

Metronidazole Dentafill Plus

5 mg/ml (0.5%), solution for infusion 100 ml, human medicine
Assessed clinical scopeDog · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.5/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-036180 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.5/10

Metronidazole has reliable activity and tissue penetration against susceptible obligate anaerobes, and human IV formulations have an established veterinary role in serious canine anaerobic infection. Outcome evidence for these exact bags is indirect and source control or broader therapy can remain essential.

Safety and tolerability6.0/10

Gastrointestinal adverse effects and marked microbiome disruption are relevant, and cumulative exposure can cause vestibulocerebellar neurotoxicity at lower doses than historically assumed. Reduce exposure in hepatic dysfunction and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.2/10
Situational / acceptable
vetman assessment

Metronidazole Dentafill Plus

5 mg/ml (0.5%), solution for infusion 100 ml, human medicine
Assessed clinical scopeCat · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.2/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-036180 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.0/10

Activity against susceptible obligate anaerobes and direct feline IV pharmacokinetics support a hospital role, but feline clinical-outcome evidence for human infusion bags is sparse; source control and broader therapy may remain essential.

Safety and tolerability5.5/10

Feline PK is documented, but direct safety data are limited; in-vitro genotoxicity and a severe neurotoxicosis case add uncertainty. Avoid unnecessary or prolonged exposure, account for hepatic disease and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Metronidazole5 mg/ml
Formulation Type
Solution
Administration route
Intravenous
Manufacturer
Dentafill Plus · Uzbekistan
Registration
Georgia Yes, human
In force until 12 Aug 2027
Human (Ministry of Health, RAMA)
In the register: მეტრონიდაზოლი დენტაფილ პლუსი 5 მგ/მლ (0.5%), საინფუზიო ხსნარი 100 მლ
№ რ-036180
Verified on: 16 Oct 2026
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Metronidazole Irbit 250 mg, Tablet

tablet, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy
6.1/10
Situational / acceptable
vetman assessment

Metronidazole Irbit

250 mg, tablet, human medicine
Assessed clinical scopeDog · Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy · By mouth
Care settingVeterinary-directed inpatient or outpatient course after diagnosis and antimicrobial review, with a measured patient-specific dose and reassessment rather than automatic repeat courses
vetman score 6.1/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-034426 · Verified on 16 Oct 2026 Off-label use

A clinically credible but stewardship-limited drug for susceptible anaerobes or selected giardiasis, not routine diarrhoea care. This whole 250 mg human tablet is useful only when it matches the calculated canine dose; otherwise a veterinary or validated compounded form is preferable.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy7.0/10

Veterinary labels and EMA review support susceptible anaerobic infections and selected giardiasis, but controlled studies do not support routine metronidazole for uncomplicated acute diarrhoea and Giardia cure depends on reinfection control.

Safety and tolerability6.0/10

Gastrointestinal adverse effects and marked microbiome disruption are relevant, and cumulative exposure can cause vestibulocerebellar neurotoxicity at lower doses than historically assumed. Reduce exposure in hepatic dysfunction and stop promptly for neurologic signs.

Clinical practicality5.0/10

The whole 250 mg tablet can match a limited medium-to-large-dog weight range, but it cannot accurately deliver many patient-specific doses; use a suitable veterinary strength or validated compound outside that range.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This intensely bitter human tablet is recorded as a whole dosing unit. Do not call an unmeasured crushed-powder fraction an accurate veterinary dose; when the calculated dose does not match the unit, select a suitable veterinary strength or validated compounded liquid.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy
5.2/10
Weak evidence support
vetman assessment

Metronidazole Irbit

250 mg, tablet, human medicine
Assessed clinical scopeCat · Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy · By mouth
Care settingVeterinary-directed inpatient or outpatient course after diagnosis and antimicrobial review, with a measured patient-specific dose and reassessment rather than automatic repeat courses
vetman score 5.2/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, human · № რ-034426 · Verified on 16 Oct 2026 Off-label use

Metronidazole retains a narrow role for susceptible anaerobic infection or selected symptomatic giardiasis, but this whole 250 mg human tablet cannot accurately deliver a typical feline dose. The low score is mainly presentation-specific and reinforced by variable Giardia efficacy and safety uncertainty.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.5/10

Veterinary labels support susceptible anaerobic infections, while feline Giardia studies and CAPC show variable roughly 50-60% efficacy and safety limitations; this does not support routine use for nonspecific diarrhoea.

Safety and tolerability5.5/10

Feline PK is documented, but direct safety data are limited; in-vitro genotoxicity and a severe neurotoxicosis case add uncertainty. Avoid unnecessary or prolonged exposure, account for hepatic disease and stop promptly for neurologic signs.

Clinical practicality1.0/10

This 250 mg whole-unit human tablet is far above the usual feline dose and metronidazole is intensely bitter. Crushing does not make an unmeasured powder fraction accurate; use a validated lower-strength or compounded veterinary form.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This intensely bitter human tablet is recorded as a whole dosing unit. Do not call an unmeasured crushed-powder fraction an accurate veterinary dose; when the calculated dose does not match the unit, select a suitable veterinary strength or validated compounded liquid.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Formulation Type
Tablet
Administration route
By mouth
Registration
Georgia Yes, human
In force until 16 Feb 2027
Human (Ministry of Health, RAMA)
In the register: მეტრონიდაზოლი ირბიტი 250 მგ, აბი
№ რ-034426
Verified on: 16 Oct 2026
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Metronidazole Ozon 500 mg, Tablet

tablet, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy
5.9/10
Weak evidence support
vetman assessment

Metronidazole Ozon

500 mg, tablet, human medicine
Assessed clinical scopeDog · Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy · By mouth
Care settingVeterinary-directed inpatient or outpatient course after diagnosis and antimicrobial review, with a measured patient-specific dose and reassessment rather than automatic repeat courses
vetman score 5.9/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, human · № რ-037899 · Verified on 16 Oct 2026 Off-label use

A clinically credible but stewardship-limited drug for susceptible anaerobes or selected giardiasis, not routine diarrhoea care. This whole 500 mg human tablet is useful only when it matches the calculated canine dose; otherwise a veterinary or validated compounded form is preferable.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy7.0/10

Veterinary labels and EMA review support susceptible anaerobic infections and selected giardiasis, but controlled studies do not support routine metronidazole for uncomplicated acute diarrhoea and Giardia cure depends on reinfection control.

Safety and tolerability6.0/10

Gastrointestinal adverse effects and marked microbiome disruption are relevant, and cumulative exposure can cause vestibulocerebellar neurotoxicity at lower doses than historically assumed. Reduce exposure in hepatic dysfunction and stop promptly for neurologic signs.

Clinical practicality3.5/10

The whole 500 mg tablet is workable only for a limited range of large dogs at the calculated dose. It cannot accurately serve most dogs without a validated compounded preparation.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This intensely bitter human tablet is recorded as a whole dosing unit. Do not call an unmeasured crushed-powder fraction an accurate veterinary dose; when the calculated dose does not match the unit, select a suitable veterinary strength or validated compounded liquid.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy
5.0/10
Weak evidence support
vetman assessment

Metronidazole Ozon

500 mg, tablet, human medicine
Assessed clinical scopeCat · Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy · By mouth
Care settingVeterinary-directed inpatient or outpatient course after diagnosis and antimicrobial review, with a measured patient-specific dose and reassessment rather than automatic repeat courses
vetman score 5.0/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, human · № რ-037899 · Verified on 16 Oct 2026 Off-label use

Metronidazole retains a narrow role for susceptible anaerobic infection or selected symptomatic giardiasis, but this whole 500 mg human tablet cannot accurately deliver a typical feline dose. The low score is mainly presentation-specific and reinforced by variable Giardia efficacy and safety uncertainty.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.5/10

Veterinary labels support susceptible anaerobic infections, while feline Giardia studies and CAPC show variable roughly 50-60% efficacy and safety limitations; this does not support routine use for nonspecific diarrhoea.

Safety and tolerability5.5/10

Feline PK is documented, but direct safety data are limited; in-vitro genotoxicity and a severe neurotoxicosis case add uncertainty. Avoid unnecessary or prolonged exposure, account for hepatic disease and stop promptly for neurologic signs.

Clinical practicality0.0/10

This 500 mg whole-unit human tablet is far above the usual feline dose and metronidazole is intensely bitter. Crushing does not make an unmeasured powder fraction accurate; use a validated lower-strength or compounded veterinary form.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This intensely bitter human tablet is recorded as a whole dosing unit. Do not call an unmeasured crushed-powder fraction an accurate veterinary dose; when the calculated dose does not match the unit, select a suitable veterinary strength or validated compounded liquid.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Formulation Type
Tablet
Administration route
By mouth
Manufacturer
Ozon · Russia
Registration
Georgia Yes, human
In force until 20 Apr 2028
Human (Ministry of Health, RAMA)
In the register: მეტრონიდაზოლი ოზონი 500 მგ, აბი
№ რ-037899
Verified on: 16 Oct 2026
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Metronidazole Pharmatech 5 mg/ml, Solution

solution for infusion 100 ml, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.5/10
Situational / acceptable
vetman assessment

Metronidazole Pharmatech

5 mg/ml, solution for infusion 100 ml, human medicine
Assessed clinical scopeDog · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.5/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-035449 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.5/10

Metronidazole has reliable activity and tissue penetration against susceptible obligate anaerobes, and human IV formulations have an established veterinary role in serious canine anaerobic infection. Outcome evidence for these exact bags is indirect and source control or broader therapy can remain essential.

Safety and tolerability6.0/10

Gastrointestinal adverse effects and marked microbiome disruption are relevant, and cumulative exposure can cause vestibulocerebellar neurotoxicity at lower doses than historically assumed. Reduce exposure in hepatic dysfunction and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.2/10
Situational / acceptable
vetman assessment

Metronidazole Pharmatech

5 mg/ml, solution for infusion 100 ml, human medicine
Assessed clinical scopeCat · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.2/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-035449 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.0/10

Activity against susceptible obligate anaerobes and direct feline IV pharmacokinetics support a hospital role, but feline clinical-outcome evidence for human infusion bags is sparse; source control and broader therapy may remain essential.

Safety and tolerability5.5/10

Feline PK is documented, but direct safety data are limited; in-vitro genotoxicity and a severe neurotoxicosis case add uncertainty. Avoid unnecessary or prolonged exposure, account for hepatic disease and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Metronidazole5 mg/ml
Formulation Type
Solution
Administration route
Intravenous
Manufacturer
Registration
Georgia Yes, human
In force until 03 Jun 2027
Human (Ministry of Health, RAMA)
In the register: მეტრონიდაზოლი ფარმატექი 5 მგ/მლ, საინფუზიო ხსნარი 100 მლ
№ რ-035449
Verified on: 16 Oct 2026
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Neofleks Metronidazole 5 mg/ml (0.5%), Solution

solution for infusion 100 ml, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.5/10
Situational / acceptable
vetman assessment

Neofleks Metronidazole

5 mg/ml (0.5%), solution for infusion 100 ml, human medicine
Assessed clinical scopeDog · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.5/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-036750 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.5/10

Metronidazole has reliable activity and tissue penetration against susceptible obligate anaerobes, and human IV formulations have an established veterinary role in serious canine anaerobic infection. Outcome evidence for these exact bags is indirect and source control or broader therapy can remain essential.

Safety and tolerability6.0/10

Gastrointestinal adverse effects and marked microbiome disruption are relevant, and cumulative exposure can cause vestibulocerebellar neurotoxicity at lower doses than historically assumed. Reduce exposure in hepatic dysfunction and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.2/10
Situational / acceptable
vetman assessment

Neofleks Metronidazole

5 mg/ml (0.5%), solution for infusion 100 ml, human medicine
Assessed clinical scopeCat · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.2/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-036750 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.0/10

Activity against susceptible obligate anaerobes and direct feline IV pharmacokinetics support a hospital role, but feline clinical-outcome evidence for human infusion bags is sparse; source control and broader therapy may remain essential.

Safety and tolerability5.5/10

Feline PK is documented, but direct safety data are limited; in-vitro genotoxicity and a severe neurotoxicosis case add uncertainty. Avoid unnecessary or prolonged exposure, account for hepatic disease and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Metronidazole5 mg/ml
Formulation Type
Solution
Administration route
Intravenous
Manufacturer
Turktipsan · Türkiye
Registration
Georgia Yes, human
In force until 02 Nov 2027
Human (Ministry of Health, RAMA)
In the register: ნეოფლექსი მეტრონიდაზოლი 5 მგ/მლ (0.5%), საინფუზიო ხსნარი 100 მლ
№ რ-036750
Verified on: 16 Oct 2026
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Polgil 5 mg/ml (0.5%), Solution

solution for infusion 100 ml, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.5/10
Situational / acceptable
vetman assessment

Polgil

5 mg/ml (0.5%), solution for infusion 100 ml, human medicine
Assessed clinical scopeDog · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.5/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-036548 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.5/10

Metronidazole has reliable activity and tissue penetration against susceptible obligate anaerobes, and human IV formulations have an established veterinary role in serious canine anaerobic infection. Outcome evidence for these exact bags is indirect and source control or broader therapy can remain essential.

Safety and tolerability6.0/10

Gastrointestinal adverse effects and marked microbiome disruption are relevant, and cumulative exposure can cause vestibulocerebellar neurotoxicity at lower doses than historically assumed. Reduce exposure in hepatic dysfunction and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea
6.2/10
Situational / acceptable
vetman assessment

Polgil

5 mg/ml (0.5%), solution for infusion 100 ml, human medicine
Assessed clinical scopeCat · Temporary intravenous metronidazole for a hospitalised patient with a proven or strongly suspected susceptible obligate-anaerobic infection when enteral treatment is not feasible; not routine treatment of diarrhoea · Intravenous
Care settingHospital treatment with aseptic single-patient withdrawal, light protection, controlled infusion, neurologic monitoring and early conversion to a suitable oral veterinary presentation when possible
vetman score 6.2/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-036548 · Verified on 16 Oct 2026 Off-label use

A credible hospital option for selected serious anaerobic infection when oral treatment is impossible, but not a default diarrhoea infusion. The score reflects precise 5 mg/mL dosing alongside off-label use, limited exact-product veterinary evidence and antimicrobial stewardship.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.0/10

Activity against susceptible obligate anaerobes and direct feline IV pharmacokinetics support a hospital role, but feline clinical-outcome evidence for human infusion bags is sparse; source control and broader therapy may remain essential.

Safety and tolerability5.5/10

Feline PK is documented, but direct safety data are limited; in-vitro genotoxicity and a severe neurotoxicosis case add uncertainty. Avoid unnecessary or prolonged exposure, account for hepatic disease and stop promptly for neurologic signs.

Clinical practicality8.0/10

The ready-to-use 5 mg/mL infusion permits accurate small-animal dosing in hospital, but the 100 mL single-use bag creates aseptic handling and wastage constraints; infusion compatibility and exact-product instructions must be verified.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This 5 mg/mL human infusion is a single-dose 100 mL container. Verify the exact product insert, solution integrity, light protection, infusion rate and compatibility; do not add unverified medicines, and discard unused solution rather than sharing a breached bag between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Metronidazole5 mg/ml
Formulation Type
Solution
Administration route
Intravenous
Manufacturer
Polifarma Ilac · Türkiye
Registration
Georgia Yes, human
In force until 03 Oct 2027
Human (Ministry of Health, RAMA)
In the register: პოლგილი 5 მგ/მლ (0.5%), საინფუზიო ხსნარი 100 მლ
№ რ-036548
Verified on: 16 Oct 2026
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Rilebi 500 mg, Coated tablet

film-coated tablet, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy
5.9/10
Weak evidence support
vetman assessment

Rilebi

500 mg, film-coated tablet, human medicine
Assessed clinical scopeDog · Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy · By mouth
Care settingVeterinary-directed inpatient or outpatient course after diagnosis and antimicrobial review, with a measured patient-specific dose and reassessment rather than automatic repeat courses
vetman score 5.9/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, human · № რ-040344 · Verified on 16 Oct 2026 Off-label use

A clinically credible but stewardship-limited drug for susceptible anaerobes or selected giardiasis, not routine diarrhoea care. This whole 500 mg human tablet is useful only when it matches the calculated canine dose; otherwise a veterinary or validated compounded form is preferable.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy7.0/10

Veterinary labels and EMA review support susceptible anaerobic infections and selected giardiasis, but controlled studies do not support routine metronidazole for uncomplicated acute diarrhoea and Giardia cure depends on reinfection control.

Safety and tolerability6.0/10

Gastrointestinal adverse effects and marked microbiome disruption are relevant, and cumulative exposure can cause vestibulocerebellar neurotoxicity at lower doses than historically assumed. Reduce exposure in hepatic dysfunction and stop promptly for neurologic signs.

Clinical practicality3.5/10

The whole 500 mg tablet is workable only for a limited range of large dogs at the calculated dose. It cannot accurately serve most dogs without a validated compounded preparation.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This intensely bitter human tablet is recorded as a whole dosing unit. Do not call an unmeasured crushed-powder fraction an accurate veterinary dose; when the calculated dose does not match the unit, select a suitable veterinary strength or validated compounded liquid.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy
5.0/10
Weak evidence support
vetman assessment

Rilebi

500 mg, film-coated tablet, human medicine
Assessed clinical scopeCat · Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy · By mouth
Care settingVeterinary-directed inpatient or outpatient course after diagnosis and antimicrobial review, with a measured patient-specific dose and reassessment rather than automatic repeat courses
vetman score 5.0/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, human · № რ-040344 · Verified on 16 Oct 2026 Off-label use

Metronidazole retains a narrow role for susceptible anaerobic infection or selected symptomatic giardiasis, but this whole 500 mg human tablet cannot accurately deliver a typical feline dose. The low score is mainly presentation-specific and reinforced by variable Giardia efficacy and safety uncertainty.

Regulatory and scientific credibility6.0/10

The exact human presentation has a sourced current Georgian registration and identifiable strength, route and manufacturer; exhaustive checked EU/EEA, UK and US registers contained no exact trade-name match. It is not veterinary-authorised.

Clinical efficacy6.5/10

Veterinary labels support susceptible anaerobic infections, while feline Giardia studies and CAPC show variable roughly 50-60% efficacy and safety limitations; this does not support routine use for nonspecific diarrhoea.

Safety and tolerability5.5/10

Feline PK is documented, but direct safety data are limited; in-vitro genotoxicity and a severe neurotoxicosis case add uncertainty. Avoid unnecessary or prolonged exposure, account for hepatic disease and stop promptly for neurologic signs.

Clinical practicality0.0/10

This 500 mg whole-unit human tablet is far above the usual feline dose and metronidazole is intensely bitter. Crushing does not make an unmeasured powder fraction accurate; use a validated lower-strength or compounded veterinary form.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This intensely bitter human tablet is recorded as a whole dosing unit. Do not call an unmeasured crushed-powder fraction an accurate veterinary dose; when the calculated dose does not match the unit, select a suitable veterinary strength or validated compounded liquid.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Formulation Type
Coated tablet
Administration route
By mouth
Manufacturer
World Medicine · Türkiye
Registration
Georgia Yes, human
In force until 27 Feb 2029
Human (Ministry of Health, RAMA)
In the register: რილები 500 მგ, აბი
№ რ-040344
Verified on: 16 Oct 2026
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Stomorgyl 2, Tablet

Spiramycin 150000 IU + metronidazole 25 mg tablet for dogs and cats
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Adjunct oral spiramycin/metronidazole for diagnosed susceptible periodontal or related oral infection, with indicated professional dental or surgical source control; not routine prophylaxis or first-line empirical treatment
6.7/10
Situational / acceptable
vetman assessment

Stomorgyl 2

Spiramycin 150000 IU + metronidazole 25 mg tablet for dogs and cats
Assessed clinical scopeDog · Adjunct oral spiramycin/metronidazole for diagnosed susceptible periodontal or related oral infection, with indicated professional dental or surgical source control; not routine prophylaxis or first-line empirical treatment · By mouth
Care settingVeterinary-directed course after oral examination and treatment planning, with professional cleaning, endodontic treatment, extraction or surgery when indicated and reassessment if response is inadequate
vetman score 6.7/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, veterinary · № 215-11 · Verified on 19 Oct 2026

A well-identified veterinary strength for selected susceptible oral infection in small dogs, with convenient once-daily whole-unit dosing. Its role is adjunctive: dental source control comes first, direct clinical outcome evidence is limited and antimicrobial/neurotoxicity precautions remain material.

Regulatory and scientific credibility8.0/10

The exact veterinary presentation has a sourced current Georgian registration and independently verified EU/EEA product information defining its strength, species, oral route and regimen. The dossier is transparent, although independent exact-product clinical outcome evidence remains limited.

Clinical efficacy5.5/10

The authorised spectrum fits mixed susceptible periodontal flora, and a six-dog study found a treatment-time reduction in selected dental-biofilm taxa. It did not test clinical cure, recurrence or superiority, while current dental and stewardship guidance makes source control primary and systemic antibiotics selective rather than routine.

Safety and tolerability6.0/10

The labelled 5-10-day course has a useful safety margin and gastrointestinal reactions are very rare, but metronidazole adds dose- and duration-related neurologic and genotoxic uncertainty, reproductive safety is not established, and concurrent macrolides are prohibited. Hepatic disease requires particular caution and is contraindicated by the bound Stomorgyl 20 label.

Clinical practicality7.5/10

Once-daily dosing for 5-10 days and the 1-tablet/2-kg strength are workable for many cats and small dogs. The tablet must remain whole, so patients whose calculated dose is not a whole 2-kg unit need another authorised strength or presentation.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use this combination as routine dental prophylaxis or first-line empirical periodontal treatment. Examine and stage the mouth; professional cleaning, endodontic treatment, extraction or surgery is primary source control and must not be replaced by tablets.
  • Reserve treatment for a diagnosed susceptible aerobic/anaerobic oral infection when systemic antimicrobial benefit is expected. Obtain culture and susceptibility when feasible, follow local antimicrobial policy, use the shortest justified label course and reassess treatment failure rather than repeating empirically.
  • Do not administer concurrently with another macrolide antibiotic. Review the full medication list for additive antimicrobial exposure and avoid combining products that duplicate metronidazole.
  • Stop and assess promptly for ataxia, tremor, nystagmus, spasm, seizure, weakness or altered mentation. Metronidazole neurotoxicity is related to exposure and duration and cannot be dismissed because the planned course is short.
  • Safety in pregnancy and lactation is not established consistently across national Stomorgyl information. Verify the exact current Georgian leaflet and use only after an individual veterinary benefit-risk assessment; avoid unnecessary exposure.
  • Hepatic dysfunction can increase metronidazole exposure. Assess liver disease before use, limit duration and monitor closely; the bound Stomorgyl 20 label contraindicates use in hepatic disease.
  • Vomiting, diarrhoea or anorexia may occur. Record response and adverse effects, and remember that broad combination therapy alters oral and intestinal microbial ecology and selects resistance even when short-term tolerance appears good.
  • Give whole tablets only: one tablet corresponds to 2 kg. Do not divide or crush; if the calculated dose is not a whole 2-kg unit, choose another authorised strength or accurately deliverable presentation.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Adjunct oral spiramycin/metronidazole for diagnosed susceptible periodontal or related oral infection, with indicated professional dental or surgical source control; not routine prophylaxis or first-line empirical treatment
6.5/10
Situational / acceptable
vetman assessment

Stomorgyl 2

Spiramycin 150000 IU + metronidazole 25 mg tablet for dogs and cats
Assessed clinical scopeCat · Adjunct oral spiramycin/metronidazole for diagnosed susceptible periodontal or related oral infection, with indicated professional dental or surgical source control; not routine prophylaxis or first-line empirical treatment · By mouth
Care settingVeterinary-directed course after oral examination and treatment planning, with professional cleaning, endodontic treatment, extraction or surgery when indicated and reassessment if response is inadequate
vetman score 6.5/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, veterinary · № 215-11 · Verified on 19 Oct 2026

A well-identified feline-authorised strength whose 2-kg whole-unit step is workable for many cats. Use only for selected susceptible oral infection alongside dental source control; direct feline outcome evidence is absent and antimicrobial/neurotoxicity precautions remain material.

Regulatory and scientific credibility8.0/10

The exact veterinary presentation has a sourced current Georgian registration and independently verified EU/EEA product information defining its strength, species, oral route and regimen. The dossier is transparent, although independent exact-product clinical outcome evidence remains limited.

Clinical efficacy5.0/10

The product is authorised for cats and its spectrum plausibly covers susceptible mixed oral flora, but no applicable independent feline clinical outcome trial was found. Dental and stewardship guidance makes source control primary and systemic antibiotics selective, so efficacy confidence is lower than in dogs.

Safety and tolerability6.0/10

The labelled 5-10-day course has a useful safety margin and gastrointestinal reactions are very rare, but metronidazole adds dose- and duration-related neurologic and genotoxic uncertainty, reproductive safety is not established, and concurrent macrolides are prohibited. Hepatic disease requires particular caution and is contraindicated by the bound Stomorgyl 20 label.

Clinical practicality7.5/10

Once-daily dosing for 5-10 days and the 1-tablet/2-kg strength are workable for many cats and small dogs. The tablet must remain whole, so patients whose calculated dose is not a whole 2-kg unit need another authorised strength or presentation.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use this combination as routine dental prophylaxis or first-line empirical periodontal treatment. Examine and stage the mouth; professional cleaning, endodontic treatment, extraction or surgery is primary source control and must not be replaced by tablets.
  • Reserve treatment for a diagnosed susceptible aerobic/anaerobic oral infection when systemic antimicrobial benefit is expected. Obtain culture and susceptibility when feasible, follow local antimicrobial policy, use the shortest justified label course and reassess treatment failure rather than repeating empirically.
  • Do not administer concurrently with another macrolide antibiotic. Review the full medication list for additive antimicrobial exposure and avoid combining products that duplicate metronidazole.
  • Stop and assess promptly for ataxia, tremor, nystagmus, spasm, seizure, weakness or altered mentation. Metronidazole neurotoxicity is related to exposure and duration and cannot be dismissed because the planned course is short.
  • Safety in pregnancy and lactation is not established consistently across national Stomorgyl information. Verify the exact current Georgian leaflet and use only after an individual veterinary benefit-risk assessment; avoid unnecessary exposure.
  • Hepatic dysfunction can increase metronidazole exposure. Assess liver disease before use, limit duration and monitor closely; the bound Stomorgyl 20 label contraindicates use in hepatic disease.
  • Vomiting, diarrhoea or anorexia may occur. Record response and adverse effects, and remember that broad combination therapy alters oral and intestinal microbial ecology and selects resistance even when short-term tolerance appears good.
  • Give whole tablets only: one tablet corresponds to 2 kg. Do not divide or crush; if the calculated dose is not a whole 2-kg unit, choose another authorised strength or accurately deliverable presentation.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Spiramycin150000 IU Metronidazole25 mg
Formulation Type
Tablet
Administration route
By mouth
Manufacturer
Manufacturer (register)
Merial, France
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 152, 19 Oct 2026.
Registration
Georgia Yes, veterinary
Controlled in Georgia
Unknown

Stomorgyl 10, Tablet

spiramycin 750, 000 IU / metronidazole 125 mg tablets, N20
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Adjunct oral spiramycin/metronidazole for diagnosed susceptible periodontal or related oral infection, with indicated professional dental or surgical source control; not routine prophylaxis or first-line empirical treatment
6.5/10
Situational / acceptable
vetman assessment

Stomorgyl 10

spiramycin 750, 000 IU / metronidazole 125 mg tablets, N20
Assessed clinical scopeDog · Adjunct oral spiramycin/metronidazole for diagnosed susceptible periodontal or related oral infection, with indicated professional dental or surgical source control; not routine prophylaxis or first-line empirical treatment · By mouth
Care settingVeterinary-directed course after oral examination and treatment planning, with professional cleaning, endodontic treatment, extraction or surgery when indicated and reassessment if response is inadequate
vetman score 6.5/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, veterinary · № 213-11 · Verified on 21 Oct 2026

A transparent veterinary product for selected susceptible canine oral infection, but only where the whole 10-kg dosing unit matches the patient. It is an adjunct to dental source control, with limited direct outcome evidence and important antimicrobial/neurotoxicity precautions.

Regulatory and scientific credibility8.0/10

The exact veterinary presentation has a sourced current Georgian registration and independently verified EU/EEA product information defining its strength, species, oral route and regimen. The dossier is transparent, although independent exact-product clinical outcome evidence remains limited.

Clinical efficacy5.5/10

The authorised spectrum fits mixed susceptible periodontal flora, and a six-dog study found a treatment-time reduction in selected dental-biofilm taxa. It did not test clinical cure, recurrence or superiority, while current dental and stewardship guidance makes source control primary and systemic antibiotics selective rather than routine.

Safety and tolerability6.0/10

The labelled 5-10-day course has a useful safety margin and gastrointestinal reactions are very rare, but metronidazole adds dose- and duration-related neurologic and genotoxic uncertainty, reproductive safety is not established, and concurrent macrolides are prohibited. Hepatic disease requires particular caution and is contraindicated by the bound Stomorgyl 20 label.

Clinical practicality6.5/10

Once-daily dosing for 5-10 days is simple, but the whole-only 1-tablet/10-kg unit cannot accurately fit many dogs between weight steps. Stomorgyl 2 or 20 should be selected when an authorised whole-unit strength matches better.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use this combination as routine dental prophylaxis or first-line empirical periodontal treatment. Examine and stage the mouth; professional cleaning, endodontic treatment, extraction or surgery is primary source control and must not be replaced by tablets.
  • Reserve treatment for a diagnosed susceptible aerobic/anaerobic oral infection when systemic antimicrobial benefit is expected. Obtain culture and susceptibility when feasible, follow local antimicrobial policy, use the shortest justified label course and reassess treatment failure rather than repeating empirically.
  • Do not administer concurrently with another macrolide antibiotic. Review the full medication list for additive antimicrobial exposure and avoid combining products that duplicate metronidazole.
  • Stop and assess promptly for ataxia, tremor, nystagmus, spasm, seizure, weakness or altered mentation. Metronidazole neurotoxicity is related to exposure and duration and cannot be dismissed because the planned course is short.
  • Safety in pregnancy and lactation is not established consistently across national Stomorgyl information. Verify the exact current Georgian leaflet and use only after an individual veterinary benefit-risk assessment; avoid unnecessary exposure.
  • Hepatic dysfunction can increase metronidazole exposure. Assess liver disease before use, limit duration and monitor closely; the bound Stomorgyl 20 label contraindicates use in hepatic disease.
  • Vomiting, diarrhoea or anorexia may occur. Record response and adverse effects, and remember that broad combination therapy alters oral and intestinal microbial ecology and selects resistance even when short-term tolerance appears good.
  • Give whole tablets only: one tablet corresponds to 10 kg. Do not divide or crush; choose Stomorgyl 2 or 20 when another authorised whole-unit strength matches the dog more accurately.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Adjunct oral spiramycin/metronidazole for diagnosed susceptible periodontal or related oral infection, with indicated professional dental or surgical source control; not routine prophylaxis or first-line empirical treatment
5.5/10
Weak evidence support
vetman assessment

Stomorgyl 10

spiramycin 750, 000 IU / metronidazole 125 mg tablets, N20
Assessed clinical scopeCat · Adjunct oral spiramycin/metronidazole for diagnosed susceptible periodontal or related oral infection, with indicated professional dental or surgical source control; not routine prophylaxis or first-line empirical treatment · By mouth
Care settingVeterinary-directed course after oral examination and treatment planning, with professional cleaning, endodontic treatment, extraction or surgery when indicated and reassessment if response is inadequate
vetman score 5.5/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, veterinary · № 213-11 · Verified on 21 Oct 2026

Although authorised for cats, the whole-only 10-kg tablet is a poor practical match for most feline doses. Prefer Stomorgyl 2 or another accurately deliverable authorised option when this combination is justified, always alongside dental source control.

Regulatory and scientific credibility8.0/10

The exact veterinary presentation has a sourced current Georgian registration and independently verified EU/EEA product information defining its strength, species, oral route and regimen. The dossier is transparent, although independent exact-product clinical outcome evidence remains limited.

Clinical efficacy5.0/10

The product is authorised for cats and its spectrum plausibly covers susceptible mixed oral flora, but no applicable independent feline clinical outcome trial was found. Dental and stewardship guidance makes source control primary and systemic antibiotics selective, so efficacy confidence is lower than in dogs.

Safety and tolerability6.0/10

The labelled 5-10-day course has a useful safety margin and gastrointestinal reactions are very rare, but metronidazole adds dose- and duration-related neurologic and genotoxic uncertainty, reproductive safety is not established, and concurrent macrolides are prohibited. Hepatic disease requires particular caution and is contraindicated by the bound Stomorgyl 20 label.

Clinical practicality1.5/10

The tablet must not be divided or crushed and one whole tablet corresponds to 10 kg. That is a poor dose-delivery match for most cats; the exact label itself directs clinicians toward Stomorgyl 2 for feline patients.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use this combination as routine dental prophylaxis or first-line empirical periodontal treatment. Examine and stage the mouth; professional cleaning, endodontic treatment, extraction or surgery is primary source control and must not be replaced by tablets.
  • Reserve treatment for a diagnosed susceptible aerobic/anaerobic oral infection when systemic antimicrobial benefit is expected. Obtain culture and susceptibility when feasible, follow local antimicrobial policy, use the shortest justified label course and reassess treatment failure rather than repeating empirically.
  • Do not administer concurrently with another macrolide antibiotic. Review the full medication list for additive antimicrobial exposure and avoid combining products that duplicate metronidazole.
  • Stop and assess promptly for ataxia, tremor, nystagmus, spasm, seizure, weakness or altered mentation. Metronidazole neurotoxicity is related to exposure and duration and cannot be dismissed because the planned course is short.
  • Safety in pregnancy and lactation is not established consistently across national Stomorgyl information. Verify the exact current Georgian leaflet and use only after an individual veterinary benefit-risk assessment; avoid unnecessary exposure.
  • Hepatic dysfunction can increase metronidazole exposure. Assess liver disease before use, limit duration and monitor closely; the bound Stomorgyl 20 label contraindicates use in hepatic disease.
  • Vomiting, diarrhoea or anorexia may occur. Record response and adverse effects, and remember that broad combination therapy alters oral and intestinal microbial ecology and selects resistance even when short-term tolerance appears good.
  • This whole-only tablet corresponds to 10 kg and is unsuitable for accurate dosing in most cats. Do not divide or crush; Stomorgyl 2 is the label-directed smaller-patient strength.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Spiramycin750000 IU/tablet Metronidazole125 mg/tablet
Formulation Type
Tablet
Administration route
By mouth
Manufacturer
Registration
Georgia Yes, veterinary
Controlled in Georgia
Unknown

Stomorgyl 20, Tablet

spiramycin 1, 500, 000 IU / metronidazole 250 mg tablets, N10 for dogs
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
6.3/10
Situational / acceptable
vetman assessment

Stomorgyl 20

spiramycin 1, 500, 000 IU / metronidazole 250 mg tablets, N10 for dogs
Assessed clinical scopeDog · Adjunct oral spiramycin/metronidazole for diagnosed susceptible periodontal or related oral infection, with indicated professional dental or surgical source control; not routine prophylaxis or first-line empirical treatment · By mouth
Care settingVeterinary-directed course after oral examination and treatment planning, with professional cleaning, endodontic treatment, extraction or surgery when indicated and reassessment if response is inadequate
vetman score 6.3/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, veterinary · № 214-11 · Verified on 21 Oct 2026

A transparent dog-only veterinary product for selected susceptible oral infection in a dog that matches the whole 20-kg unit. Its narrow practicality, limited direct outcome evidence and adjunctive—not first-line empirical—role keep the overall value situational.

Regulatory and scientific credibility8.0/10

The exact veterinary presentation has a sourced current Georgian registration and independently verified EU/EEA product information defining its strength, species, oral route and regimen. The dossier is transparent, although independent exact-product clinical outcome evidence remains limited.

Clinical efficacy5.5/10

The authorised spectrum fits mixed susceptible periodontal flora, and a six-dog study found a treatment-time reduction in selected dental-biofilm taxa. It did not test clinical cure, recurrence or superiority, while current dental and stewardship guidance makes source control primary and systemic antibiotics selective rather than routine.

Safety and tolerability6.0/10

The labelled 5-10-day course has a useful safety margin and gastrointestinal reactions are very rare, but metronidazole adds dose- and duration-related neurologic and genotoxic uncertainty, reproductive safety is not established, and concurrent macrolides are prohibited. Hepatic disease requires particular caution and is contraindicated by the bound Stomorgyl 20 label.

Clinical practicality5.5/10

Once-daily dosing for 5-10 days is simple for an appropriately sized dog, but this dog-only whole tablet corresponds to 20 kg and cannot accurately fit many patients. The bound label also excludes dogs below 5 kg.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use this combination as routine dental prophylaxis or first-line empirical periodontal treatment. Examine and stage the mouth; professional cleaning, endodontic treatment, extraction or surgery is primary source control and must not be replaced by tablets.
  • Reserve treatment for a diagnosed susceptible aerobic/anaerobic oral infection when systemic antimicrobial benefit is expected. Obtain culture and susceptibility when feasible, follow local antimicrobial policy, use the shortest justified label course and reassess treatment failure rather than repeating empirically.
  • Do not administer concurrently with another macrolide antibiotic. Review the full medication list for additive antimicrobial exposure and avoid combining products that duplicate metronidazole.
  • Stop and assess promptly for ataxia, tremor, nystagmus, spasm, seizure, weakness or altered mentation. Metronidazole neurotoxicity is related to exposure and duration and cannot be dismissed because the planned course is short.
  • Safety in pregnancy and lactation is not established consistently across national Stomorgyl information. Verify the exact current Georgian leaflet and use only after an individual veterinary benefit-risk assessment; avoid unnecessary exposure.
  • Hepatic dysfunction can increase metronidazole exposure. Assess liver disease before use, limit duration and monitor closely; the bound Stomorgyl 20 label contraindicates use in hepatic disease.
  • Vomiting, diarrhoea or anorexia may occur. Record response and adverse effects, and remember that broad combination therapy alters oral and intestinal microbial ecology and selects resistance even when short-term tolerance appears good.
  • Dog only: one whole tablet corresponds to 20 kg and the bound label excludes dogs below 5 kg. Do not infer a feline use or an unverified tablet fraction; choose another authorised strength when the whole unit does not match.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Spiramycin1500000 IU/tablet Metronidazole250 mg/tablet
Formulation Type
Tablet
Administration route
By mouth
Manufacturer
Manufacturer (register)
Merial, France
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 151, 19 Oct 2026.
Registration
Georgia Yes, veterinary
Controlled in Georgia
Unknown

Trichopol 250 mg, Tablet

tablet, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy
6.3/10
Situational / acceptable
vetman assessment

Trichopol

250 mg, tablet, human medicine
Assessed clinical scopeDog · Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy · By mouth
Care settingVeterinary-directed inpatient or outpatient course after diagnosis and antimicrobial review, with a measured patient-specific dose and reassessment rather than automatic repeat courses
vetman score 6.3/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-040538 · Verified on 15 Oct 2026 Off-label use

A clinically credible but stewardship-limited drug for susceptible anaerobes or selected giardiasis, not routine diarrhoea care. This whole 250 mg human tablet is useful only when it matches the calculated canine dose; otherwise a veterinary or validated compounded form is preferable.

Regulatory and scientific credibility6.5/10

The exact human presentation has sourced current registrations in Georgia and EU/EEA with identifiable strength, route and manufacturer. It is not a veterinary-authorised presentation and this animal use is off-label.

Clinical efficacy7.0/10

Veterinary labels and EMA review support susceptible anaerobic infections and selected giardiasis, but controlled studies do not support routine metronidazole for uncomplicated acute diarrhoea and Giardia cure depends on reinfection control.

Safety and tolerability6.0/10

Gastrointestinal adverse effects and marked microbiome disruption are relevant, and cumulative exposure can cause vestibulocerebellar neurotoxicity at lower doses than historically assumed. Reduce exposure in hepatic dysfunction and stop promptly for neurologic signs.

Clinical practicality5.0/10

The whole 250 mg tablet can match a limited medium-to-large-dog weight range, but it cannot accurately deliver many patient-specific doses; use a suitable veterinary strength or validated compound outside that range.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This intensely bitter human tablet is recorded as a whole dosing unit. Do not call an unmeasured crushed-powder fraction an accurate veterinary dose; when the calculated dose does not match the unit, select a suitable veterinary strength or validated compounded liquid.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy
5.3/10
Weak evidence support
vetman assessment

Trichopol

250 mg, tablet, human medicine
Assessed clinical scopeCat · Oral metronidazole for a proven or strongly suspected susceptible obligate-anaerobic infection or selected symptomatic giardiasis with environmental control; not routine empirical treatment of uncomplicated diarrhoea or chronic enteropathy · By mouth
Care settingVeterinary-directed inpatient or outpatient course after diagnosis and antimicrobial review, with a measured patient-specific dose and reassessment rather than automatic repeat courses
vetman score 5.3/10 Weak evidence support
Evidence confidence: Medium Georgia: Yes, human · № რ-040538 · Verified on 15 Oct 2026 Off-label use

Metronidazole retains a narrow role for susceptible anaerobic infection or selected symptomatic giardiasis, but this whole 250 mg human tablet cannot accurately deliver a typical feline dose. The low score is mainly presentation-specific and reinforced by variable Giardia efficacy and safety uncertainty.

Regulatory and scientific credibility6.5/10

The exact human presentation has sourced current registrations in Georgia and EU/EEA with identifiable strength, route and manufacturer. It is not a veterinary-authorised presentation and this animal use is off-label.

Clinical efficacy6.5/10

Veterinary labels support susceptible anaerobic infections, while feline Giardia studies and CAPC show variable roughly 50-60% efficacy and safety limitations; this does not support routine use for nonspecific diarrhoea.

Safety and tolerability5.5/10

Feline PK is documented, but direct safety data are limited; in-vitro genotoxicity and a severe neurotoxicosis case add uncertainty. Avoid unnecessary or prolonged exposure, account for hepatic disease and stop promptly for neurologic signs.

Clinical practicality1.0/10

This 250 mg whole-unit human tablet is far above the usual feline dose and metronidazole is intensely bitter. Crushing does not make an unmeasured powder fraction accurate; use a validated lower-strength or compounded veterinary form.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not use metronidazole routinely for uncomplicated acute diarrhoea, haemorrhagic diarrhoea that responds to fluids, nonspecific dysbiosis or chronic enteropathy. Establish a defensible anaerobic/protozoal target and reassess the need for any antimicrobial.
  • Do not use after hypersensitivity to metronidazole, another nitroimidazole or an excipient. Stop and treat urgently for facial swelling, bronchospasm, collapse or anaphylaxis.
  • Stop metronidazole promptly for ataxia, nystagmus, tremor, seizure, altered mentation, weakness or peripheral neuropathy. Neurotoxicity can follow cumulative or prolonged exposure and has occurred in dogs at lower doses than historically assumed.
  • Severe hepatic dysfunction can reduce clearance and increase neurotoxicity. Adjust the regimen, avoid unnecessary duration and monitor clinical status; renal failure can permit metabolite accumulation.
  • Avoid unnecessary exposure during pregnancy or lactation and use only after an individual benefit-risk assessment. Human labels carry mutagenicity/carcinogenicity concerns, and feline in-vitro genotoxicity adds uncertainty rather than proving clinical cancer risk.
  • Review warfarin or other coumarins, phenobarbital, phenytoin, cimetidine, lithium, ciclosporin, busulfan and alcohol-containing preparations. Exposure or effect can change and targeted monitoring may be required.
  • Vomiting, nausea, anorexia, diarrhoea or hypersalivation can occur. Metronidazole can markedly disrupt the canine intestinal microbiome for weeks, so repeated empirical courses are not microbiota-sparing treatment.
  • This intensely bitter human tablet is recorded as a whole dosing unit. Do not call an unmeasured crushed-powder fraction an accurate veterinary dose; when the calculated dose does not match the unit, select a suitable veterinary strength or validated compounded liquid.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Formulation Type
Tablet
Administration route
By mouth
Manufacturer
Polpharma · Poland
Registration
Georgia Yes, human
EU Yes, human
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

All of this shows in vetman as you prescribe

The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.