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Active substance

Doxycycline

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Tetracycline. Registered in Georgia: 2 veterinary products and 2 human medicines. Forms: chewable tablet, scored tablet, tablet.

Dose and use

Doses

Each dose comes with its source. Check the label of the product you use.

Active substance Doxycycline
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
10 mg/kg Dog, Cat Respiratory Tract Infection; Canine Ehrlichiosis; Leptospirosis; Bacterial Infection; Feline Chlamydiosis By mouth once daily
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Ronaxan 20 mg tablets for dogs and cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, Product Information Database, 2025
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Doxybactin 50 mg tablets for dogs and cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, Product Information Database, 2025
5 mg/kg
off-label
 Dog, Cat Leptospirosis; Respiratory Tract Infection By mouth 2 times daily
ACVIM 2023
Guideline or consensus statement
Recommendations agreed by a panel of veterinary specialists after reviewing the evidence. They guide practice and do not authorise a product.
Updated ACVIM consensus statement on leptospirosis in dogs
Journal of Veterinary Internal Medicine, 2023
ISCAID 2017
Guideline or consensus statement
Recommendations agreed by a panel of veterinary specialists after reviewing the evidence. They guide practice and do not authorise a product.
Antimicrobial Use Guidelines for Treatment of Respiratory Tract Disease in Dogs and Cats
Journal of Veterinary Internal Medicine, 2017
Before use

Safety information

Known Contraindications

  • Critical
    administration of doxycycline hyclate tablets has been associated with oesophageal erosion.
    Sources: VMD SPC · VMD · ISCAID · JVIM
  • Critical
    Do not use in animals with renal or hepatic insufficiency. Special warnings: None.
    Sources: VMD SPC · VMD
  • Critical
    Product labels differ: some contraindicate doxycycline in hepatic insufficiency, while others advise special caution and monitoring because liver-enzyme increases have been reported. Follow the label of the selected product and monitor hepatic function.
    Sources: Product label
  • Critical
    Do not use doxycycline tablets in animals with vomiting or dysphagia when the product label lists these conditions as contraindications. Other labels advise caution because impaired swallowing or vomiting increases the risk of a tablet lodging in the oesophagus.
    Sources: VMD SPC · VMD
  • Critical
    Do not use doxycycline in puppies or kittens before tooth-enamel formation is complete when the product label lists this as a contraindication. Doxycycline is less likely than other tetracyclines to cause tooth abnormalities because it binds calcium less strongly, but the labelled restriction still applies.
    Sources: VMD SPC · VMD
  • Warning
    Tetracyclines as a class can retard foetal skeletal development (fully reversible) The safety of the veterinary medicinal product has not been established during pregnancy
    Sources: VMD
  • Warning
    The safety of the veterinary medicinal product has not been established during pregnancy and lactation.
    Sources: VMD
  • Warning
    Do not use in animals with known photosensitivity. During treatment, avoid prolonged intense sunlight, particularly in light-coloured or sparsely haired animals, because photosensitivity and photodermatitis may occur.
    Sources: VMD SPC · VMD
  • Warning (Cat)
    Doxycycline tablets and capsules can lodge in the cat oesophagus and cause oesophagitis and stricture (regurgitation, at varying times after the course). Follow every tablet or capsule with a water bolus or food.

Known Drug Interactions

  • Major warning Enrofloxacin + Doxycycline
    Do not combine enrofloxacin with antimicrobials that act antagonistically to quinolones, including macrolides, tetracyclines such as doxycycline, and phenicols such as chloramphenicol.
    Recommendation: Do not administer concurrently. Based on susceptibility testing, choose either a bactericidal fluoroquinolone or a bacteriostatic tetracycline.
    Sources: VMD SPC · VMD
  • Major warning Ampicillin + Doxycycline
    It is not recommended to administer bactericidal and bacteriostatic antibiotics concomitantly.
    Recommendation: If both are required, support the choice with culture and susceptibility results. Otherwise, choose one mechanism.
    Sources: VMD SPC · VMD
  • Major warning Amoxicillin + Doxycycline
    The bactericidal effect of amoxicillin may be inhibited by the concomitant use of bacteriostatic antimicrobials.
    Recommendation: If both are required, support the choice with culture and susceptibility results. Otherwise, choose one mechanism.
    Sources: VMD SPC · VMD
  • Major warning Doxycycline + Phenobarbital
    Phenobarbital, phenytoin, carbamazepine, and other enzyme-inducing antiepileptic drugs can shorten the half-life of doxycycline and reduce its antibacterial exposure. Standard doxycycline dosing may therefore be subtherapeutic.
    Recommendation: If the patient receives phenobarbital and doxycycline is essential, the standard 10 mg/kg dose may be inadequate; monitor clinical response closely. Alternatively, choose an antibiotic from another class based on susceptibility testing.
    Sources: VMD SPC · VMD
  • Major warning Doxycycline + Procaine Benzylpenicillin
    Tetracyclines, chloramphenicol, macrolides, and lincosamides may antagonise the bactericidal action of benzylpenicillin.
    Recommendation: Do not administer concurrently. Choose one mechanism based on susceptibility testing.
    Sources: VMD SPC · VMD
  • Major warning Doxycycline + Sucralfate
    In dogs, concurrent administration of sucralfate suspension reduced doxycycline AUC from 36.0 to 7.2 h·mcg/mL (relative bioavailability 20%). No interaction was detected with sucralfate tablets because tablet fragments were visible in faeces, indicating that the tablets did not disintegrate and were not effective.
    Recommendation: Separate administration by 2 hours: give doxycycline first and sucralfate 2 hours later. With this schedule, bioavailability is 74% and is not statistically different from doxycycline alone.
    Sources: JVPT
Latin name
Doxycycline
Georgian name
დოქსიციკლინი
Authorisation status
Authorised veterinary medicine
An authorised veterinary medicine containing this substance exists. Whether a particular use is on-label depends on the species and the indication - see each dose rule.
Registered in Georgia
4 of 5 forms
Products
Doxy-Denk, Doxytron, Medaox, Unidox Solutab
Human medicines in Georgia
Devadox, Doxy-Denk, Doxylan, Ksemin, Medaox, Monodoks
Human medicines with this substance in the Georgian register of medicines (Ministry of Health), checked on 18 Oct 2026. They are human medicines, not veterinary products; strengths and forms differ.
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
All forms and registration5

Registration in Georgia and abroad: the register, number, validity and source are behind (i).

Doxy-Denk 100 mg, Scored tablet

tablet, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Veterinary-directed treatment of doxycycline-susceptible bacterial infections in dogs when doxycycline is indicated and this human tablet is selected extra-label
7.1/10
Good
vetman assessment

Doxy-Denk

100 mg, tablet, human medicine
Assessed clinical scopeDog · Veterinary-directed treatment of doxycycline-susceptible bacterial infections in dogs when doxycycline is indicated and this human tablet is selected extra-label · By mouth
Care settingPrimarily veterinary-directed outpatient treatment, with diagnosis and susceptibility testing where indicated
vetman score 7.1/10 Good
Evidence confidence: Medium Georgia: Yes, human · № რ-043572 · Verified on 15 Oct 2026 Off-label use

A clinically useful doxycycline option with strong ingredient-level evidence, but it is a human extra-label 100 mg tablet rather than a veterinary formulation; patient selection, susceptibility and dose accuracy still matter.

Regulatory and scientific credibility6.5/10

The exact 100 mg doxycycline-hyclate tablet has a transparent manufacturer leaflet and active Georgian human registration (R-043572), while canine use is extra-label and lacks an exact-product veterinary dossier; licensed veterinary doxycycline products and strong independent ingredient guidance are available.

Clinical efficacy8.0/10

Doxycycline is a well-established guideline-supported option for appropriate susceptible canine respiratory, vector-borne and selected skin infections, but organism identification, local resistance and antimicrobial stewardship determine whether it is the right choice.

Safety and tolerability7.0/10

At appropriate doses it is generally well tolerated in dogs, with gastrointestinal adverse effects, photosensitivity and restrictions around tooth development, pregnancy and significant hepatic or renal disease requiring patient selection and monitoring.

Clinical practicality7.0/10

Once-daily oral treatment is workable at home for many dogs, but the 100 mg strength is coarse for small patients and the locally observed quartering is not validated as equal-dose subdivision by the accessible manufacturer leaflet.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use for a clinically supported, doxycycline-susceptible infection; culture and susceptibility testing are required where the disease context or prior antimicrobial exposure warrants them.
  • Calcium, magnesium, aluminium, iron and other polyvalent cations can reduce oral absorption; separate administration according to the applicable label or protocol.
  • Monitor gastrointestinal tolerance and use additional caution in significant hepatic or renal disease, during pregnancy or lactation, and before tooth development is complete.
Assessment sources
  1. Doxy-Denk leaflet2019
  2. Doxycare SPC2026
  3. ISCAID 20172017
  4. ACVIM 20232023
  5. ISCAID pyoderma 20252025
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Veterinary-directed treatment of doxycycline-susceptible bacterial infections in cats when doxycycline is indicated and this human tablet is selected extra-label
6.3/10
Situational / acceptable
vetman assessment

Doxy-Denk

100 mg, tablet, human medicine
Assessed clinical scopeCat · Veterinary-directed treatment of doxycycline-susceptible bacterial infections in cats when doxycycline is indicated and this human tablet is selected extra-label · By mouth
Care settingVeterinary-directed outpatient treatment only when reliable food-or-water follow-through can be ensured
vetman score 6.3/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-043572 · Verified on 15 Oct 2026 Off-label use

The active ingredient is strongly supported, but this exact human 100 mg hyclate tablet is only a situational feline choice because preventable oesophageal injury and dose-form limitations make better formulations preferable.

Regulatory and scientific credibility6.5/10

The exact 100 mg doxycycline-hyclate tablet has a transparent manufacturer leaflet and active Georgian human registration (R-043572), while feline use is extra-label and lacks an exact-product veterinary dossier; licensed veterinary doxycycline formulations are available.

Clinical efficacy8.0/10

Doxycycline is a well-established guideline-supported option for appropriate susceptible feline respiratory and other bacterial infections; this score does not imply empirical use without diagnosis, susceptibility context or stewardship.

Safety and tolerability5.5/10

Doxycycline can be effective and otherwise tolerable in cats, but a dry tablet may lodge in the oesophagus and cause severe oesophagitis or stricture; this preventable, formulation-relevant harm materially limits the exact product.

Clinical practicality4.5/10

The 100 mg non-dispersible tablet is poorly matched to many cats: dose subdivision is coarse and every dose must be followed immediately by food or water; smaller veterinary or reliably dispersible/liquid alternatives are usually more practical.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Never give this tablet dry. Follow it immediately with food or water; avoid the presentation when swallowing or reliable follow-through is uncertain.
  • Prefer a smaller veterinary, liquid or reliably dispersible formulation when available, especially in small cats or patients with oesophageal disease.
  • Calcium, magnesium, aluminium, iron and other polyvalent cations can reduce oral absorption; separate administration according to the applicable label or protocol.
  • Use for a clinically supported, doxycycline-susceptible infection; culture and susceptibility testing are required where indicated.
Assessment sources
  1. Doxy-Denk leaflet2019
  2. Doxycare SPC2026
  3. ISCAID 20172017
  4. Westfall et al. 20012001
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Doxycycline100 mg
Formulation Type
Scored tablet
Administration route
By mouth
Manufacturer
Denk Pharma · Germany
Registration
Georgia Yes, human
In force until 10 Jul 2030
Human (Ministry of Health, RAMA)
№ რ-043572
Verified on: 15 Oct 2026
 EU No
Verified on: 16 Oct 2026
 UK No
Verified on: 16 Oct 2026
 US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Doxytron 20 mg chewable tablets, Chewable tablet

N20 for dogs and cats
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Full dog label: doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections, 10 mg/kg once daily with food (one tablet per 2 kg)
6.2/10
Situational / acceptable
vetman assessment

Doxytron

20 mg chewable tablets, N20 for dogs and cats
Assessed clinical scopeDog · Full dog label: doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections, 10 mg/kg once daily with food (one tablet per 2 kg) · By mouth
Care settingVeterinary prescription after diagnosis for oral treatment at home
vetman score 6.2/10 Situational / acceptable
Evidence confidence: Low Georgia: Yes, veterinary · № 000831 · Verified on 21 Oct 2026

A situational, guideline-aligned first-line antimicrobial for small dogs at a standard doxycycline dose. Extend the course to what the diagnosis needs rather than the label's 3-5 days.

Regulatory and scientific credibility5.0/10

The exact product is registered in Georgia (000831, valid to 2030) with an AVZ instruction (2023 Russian edition); it has no EU, UK or US authorisation documented in the reviewed evidence or product study, but 10 mg/kg once daily is a well-established authorised doxycycline dose.

Clinical efficacy6.5/10

Doxycycline is first-line in ISCAID respiratory guidance and a WSAVA essential medicine, covering Mycoplasma, Bordetella and tick-borne rickettsial agents; bioequivalence is unproven and the 3-5 day acute course is shorter than guideline courses.

Safety and tolerability7.0/10

Generally well tolerated; nausea is reduced by giving with food. The label excludes marked hepatic or renal dysfunction and tooth development, and asks for supervision in pregnancy and lactation.

Clinical practicality6.5/10

One chewable tablet per 2 kg once daily suits small dogs, but the tablet may be unscored, giving coarse 2 kg steps, and larger dogs need many tablets.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Do not use with tetracycline hypersensitivity, marked hepatic or renal dysfunction, or in puppies during tooth development.
  • Give apart from calcium, magnesium, iron or aluminium products and antacids; the label also lists barbiturates, phenytoin and avoidance with penicillins or cephalosporins.
  • Guideline courses are usually 7-10 days for acute bacterial respiratory infection and longer for Mycoplasma or tick-borne disease; the label's 3-5 days may be too short.
  • Give during or right after a meal to reduce nausea and oesophageal irritation; recheck if vomiting persists.
  • Doxycycline is EU AMEG Category D (Prudence) and a WSAVA essential medicine: a sound first choice when indicated.
Assessment sources
  1. Doxytron label2023
  2. Georgia NFA register 20262026
  3. ISCAID 20172017
  4. WSAVA essential medicines 20232023
  5. MSD tetracyclines2026
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Full cat label: doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections, 10 mg/kg once daily with food (one tablet per 2 kg)
5.9/10
Weak evidence support
vetman assessment

Doxytron

20 mg chewable tablets, N20 for dogs and cats
Assessed clinical scopeCat · Full cat label: doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections, 10 mg/kg once daily with food (one tablet per 2 kg) · By mouth
Care settingVeterinary prescription after diagnosis for oral treatment at home, each dose followed by food or water
vetman score 5.9/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000831 · Verified on 21 Oct 2026

A situational, guideline-aligned first-line antimicrobial for cats in a cat-sized strength. Follow every dose with water or food and run courses to guideline length, not the label's 3-5 days.

Regulatory and scientific credibility5.0/10

The exact product is registered in Georgia (000831, valid to 2030) with an AVZ instruction (2023 Russian edition); it has no EU, UK or US authorisation documented in the reviewed evidence or product study, but 10 mg/kg once daily is a well-established doxycycline dose.

Clinical efficacy6.5/10

Doxycycline is the first-line drug for feline bacterial upper respiratory infection, Mycoplasma and Chlamydia felis in ISCAID and ABCD guidance; bioequivalence is unproven and the label's 3-5 day course is much shorter than the 4 weeks needed for Chlamydia felis.

Safety and tolerability6.0/10

Doxycycline tablets can lodge in the feline oesophagus and cause oesophagitis and stricture unless followed by food or water; the label also excludes marked hepatic or renal dysfunction and tooth development.

Clinical practicality6.5/10

One small chewable tablet per 2 kg once daily fits cats well, although an unscored tablet gives coarse steps between body weights.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • In cats, follow every tablet with food or about 5 ml of water to prevent oesophageal stricture; watch for drooling, gagging or difficulty swallowing.
  • Do not use with tetracycline hypersensitivity, marked hepatic or renal dysfunction, or in kittens during tooth development.
  • Chlamydia felis needs about 4 weeks of doxycycline for all cats in the household, and acute bacterial upper respiratory infection usually 7-10 days.
  • Give apart from calcium, magnesium, iron or aluminium products and antacids; the label also lists barbiturates and phenytoin.
  • Doxycycline is EU AMEG Category D (Prudence) and a WSAVA essential medicine: a sound first choice when indicated.
Assessment sources
  1. Doxytron label2023
  2. Georgia NFA register 20262026
  3. ISCAID 20172017
  4. ABCD Chlamydia felis guideline2026
  5. MSD tetracyclines2026
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Doxycycline20 mg/tablet
Formulation Type
Chewable tablet
Administration route
By mouth
Manufacturer
AVZ S-P Ltd · Russia
Manufacturer (register)
AVZ S-P Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1362, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 10 Apr 2030
Veterinary (National Food Agency)
In the register: დოქსიტრონი საღეჭი ტაბლეტები
№ 000831
Verified on: 21 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Doxytron 100 mg chewable tablets, Chewable tablet

N12 for dogs and cats
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Full dog label: doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections, 10 mg/kg once daily with food (one tablet per 10 kg)
6.3/10
Situational / acceptable
vetman assessment

Doxytron

100 mg chewable tablets, N12 for dogs and cats
Assessed clinical scopeDog · Full dog label: doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections, 10 mg/kg once daily with food (one tablet per 10 kg) · By mouth
Care settingVeterinary prescription after diagnosis for oral treatment at home
vetman score 6.3/10 Situational / acceptable
Evidence confidence: Low Georgia: Yes, veterinary · № 000830 · Verified on 21 Oct 2026

A situational, guideline-aligned first-line antimicrobial for dogs at a standard doxycycline dose. Extend the course to what the diagnosis needs rather than the label's 3-5 days.

Regulatory and scientific credibility5.0/10

The exact product is registered in Georgia (000830, valid to 2030) with an AVZ instruction (2023 Russian edition); it has no EU, UK or US authorisation documented in the reviewed evidence or product study, but 10 mg/kg once daily is a well-established authorised doxycycline dose.

Clinical efficacy6.5/10

Doxycycline is first-line in ISCAID respiratory guidance and a WSAVA essential medicine, covering Mycoplasma, Bordetella and tick-borne rickettsial agents; bioequivalence is unproven and the 3-5 day acute course is shorter than guideline courses.

Safety and tolerability7.0/10

Generally well tolerated; nausea is reduced by giving with food. The label excludes marked hepatic or renal dysfunction and tooth development, and asks for supervision in pregnancy and lactation.

Clinical practicality7.0/10

A chewable tablet once daily with a half-tablet score suits dogs from about 5 kg and is easy for owners.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Do not use with tetracycline hypersensitivity, marked hepatic or renal dysfunction, or in puppies during tooth development.
  • Give apart from calcium, magnesium, iron or aluminium products and antacids; the label also lists barbiturates, phenytoin and avoidance with penicillins or cephalosporins.
  • Guideline courses are usually 7-10 days for acute bacterial respiratory infection and longer for Mycoplasma or tick-borne disease; the label's 3-5 days may be too short.
  • Give during or right after a meal to reduce nausea and oesophageal irritation; recheck if vomiting persists.
  • Doxycycline is EU AMEG Category D (Prudence) and a WSAVA essential medicine: a sound first choice when indicated.
Assessment sources
  1. Doxytron label2023
  2. Georgia NFA register 20262026
  3. ISCAID 20172017
  4. WSAVA essential medicines 20232023
  5. MSD tetracyclines2026
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Full cat label: doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections, 10 mg/kg once daily with food (one tablet per 10 kg)
5.8/10
Weak evidence support
vetman assessment

Doxytron

100 mg chewable tablets, N12 for dogs and cats
Assessed clinical scopeCat · Full cat label: doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections, 10 mg/kg once daily with food (one tablet per 10 kg) · By mouth
Care settingVeterinary prescription after diagnosis for oral treatment at home, each dose followed by food or water
vetman score 5.8/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000830 · Verified on 21 Oct 2026

A weak fit for cats despite a first-line active: the 100 mg tablet is too large for accurate feline dosing. Prefer the 20 mg strength, follow every dose with water or food and run courses to guideline length.

Regulatory and scientific credibility5.0/10

The exact product is registered in Georgia (000830, valid to 2030) with an AVZ instruction (2023 Russian edition); it has no EU, UK or US authorisation documented in the reviewed evidence or product study, but 10 mg/kg once daily is a well-established doxycycline dose.

Clinical efficacy6.5/10

Doxycycline is the first-line drug for feline bacterial upper respiratory infection, Mycoplasma and Chlamydia felis in ISCAID and ABCD guidance; bioequivalence is unproven and the label's 3-5 day course is much shorter than the 4 weeks needed for Chlamydia felis.

Safety and tolerability6.0/10

Doxycycline tablets can lodge in the feline oesophagus and cause oesophagitis and stricture unless followed by food or water; the label also excludes marked hepatic or renal dysfunction and tooth development.

Clinical practicality5.5/10

For most cats a half 100 mg tablet is the smallest step, which gives well above 10 mg/kg below 5 kg; the 20 mg strength fits cats better.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • In cats, follow every tablet with food or about 5 ml of water to prevent oesophageal stricture; watch for drooling, gagging or difficulty swallowing.
  • Do not use with tetracycline hypersensitivity, marked hepatic or renal dysfunction, or in kittens during tooth development.
  • Chlamydia felis needs about 4 weeks of doxycycline for all cats in the household, and acute bacterial upper respiratory infection usually 7-10 days.
  • Give apart from calcium, magnesium, iron or aluminium products and antacids; the label also lists barbiturates and phenytoin.
  • Below 5 kg a half tablet overdoses; use the 20 mg strength for most cats.
Assessment sources
  1. Doxytron label2023
  2. Georgia NFA register 20262026
  3. ISCAID 20172017
  4. ABCD Chlamydia felis guideline2026
  5. MSD tetracyclines2026
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Doxycycline100 mg/tablet
Formulation Type
Chewable tablet
Administration route
By mouth
Manufacturer
AVZ S-P Ltd · Russia
Manufacturer (register)
AVZ S-P Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1361, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 10 Apr 2030
Veterinary (National Food Agency)
In the register: დოქსიტრონი საღეჭი ტაბლეტები
№ 000830
Verified on: 21 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Medaox 100 mg, Tablet

dispersible tablet, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Veterinarian-directed treatment of doxycycline-susceptible bacterial infections when oral doxycycline is appropriate and the whole 100 mg dose unit fits the patient
6.7/10
Situational / acceptable
vetman assessment

Medaox

100 mg, dispersible tablet, human medicine
Assessed clinical scopeDog · Veterinarian-directed treatment of doxycycline-susceptible bacterial infections when oral doxycycline is appropriate and the whole 100 mg dose unit fits the patient · By mouth
Care settingVeterinarian-directed outpatient treatment after patient, infection and dose-form selection; use a different presentation when the required dose is below or materially different from 100 mg.
vetman score 6.7/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-035618 · Verified on 15 Oct 2026 Off-label use

Strong doxycycline evidence does not make this exact 100 mg human unit broadly practical. It is a reasonable extra-label option only when infection and susceptibility support doxycycline and a whole tablet fits the calculated dose.

Regulatory and scientific credibility6.0/10

The exact World Medicine product, 100 mg dispersible form, 10-tablet pack, manufacturer and current Kazakhstan registration are independently verifiable from official sources. The full current regulator-hosted dossier was not publicly retrievable, and dog/cat use is extra-label with no exact-product veterinary efficacy study.

Clinical efficacy8.0/10

Doxycycline is a well-established guideline-supported treatment for appropriate susceptible canine respiratory, vector-borne and selected skin or systemic infections. The score depends on diagnosis, organism and stewardship and does not transfer the human label infection list to dogs.

Safety and tolerability7.0/10

Appropriately selected doxycycline is generally well tolerated, but gastrointestinal effects, oesophageal injury, photosensitivity and restrictions around pregnancy, immature dentition and significant hepatic disease require selection and monitoring. Exact-product dog safety data are absent.

Clinical practicality5.0/10

Once-daily oral treatment can be workable when a whole 100 mg unit reasonably matches the calculated dose. The score line is not an equal-dose divider and the labelled suspension cannot provide a validated dose below 100 mg, making this form poorly matched to many small and medium dogs.

Full-course cost-effectiveness-

Current comparable full-course local prices were not verified.

Important safety and use flags

  • Use only for a clinically supported doxycycline-susceptible infection. Obtain culture and susceptibility testing whenever the disease site, severity, prior antimicrobial exposure or response makes it appropriate.
  • The 100 mg unit is not divisible for dose purposes. The score line is aesthetic and dispersion does not validate withdrawal of a fractional dose; use another product when the calculated dose does not reasonably match a whole tablet.
  • The human instructions disperse the whole tablet in at least 50 ml water and administer the complete suspension immediately with food. A veterinarian must choose a safer veterinary presentation when that volume or whole dose is unsuitable.
  • Administer with food and adequate fluid according to the selected protocol. Reassess vomiting, dysphagia, regurgitation or another sign of oesophageal or gastrointestinal intolerance.
  • Calcium, magnesium, aluminium, iron, bismuth, antacids, sucralfate and other polyvalent cation sources can reduce doxycycline absorption; separate them according to the applicable protocol.
  • Phenobarbital, phenytoin, carbamazepine, primidone, rifampicin and other enzyme inducers may shorten doxycycline exposure. Review the antimicrobial plan rather than assuming the standard regimen remains adequate.
  • Avoid routine use during pregnancy, lactation and active tooth development unless a veterinarian judges the indication-specific benefit to outweigh the risk and no safer effective option exists.
  • Monitor gastrointestinal tolerance, hydration, clinical response and, for prolonged treatment or relevant comorbidity, liver, renal and haematologic parameters. Stop and reassess severe diarrhoea, dysphagia, jaundice or hypersensitivity.
  • Review concurrent antimicrobials, retinoids, anticoagulants, ciclosporin and methoxyflurane. Product information identifies clinically important combinations, and an interaction check is required before treatment.
Assessment sources
  1. Medaox official page2026
  2. World Medicine portfolio2023
  3. Medaox Kazakhstan listing2026
  4. Doxycare SPC2026
  5. ISCAID 20172017
  6. ACVIM 20232023
  7. ISCAID pyoderma 20252025
  8. Westfall et al. 20012001
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Veterinarian-directed treatment of doxycycline-susceptible bacterial infections when oral doxycycline is appropriate and the whole 100 mg dose unit fits the patient
6.0/10
Situational / acceptable
vetman assessment

Medaox

100 mg, dispersible tablet, human medicine
Assessed clinical scopeCat · Veterinarian-directed treatment of doxycycline-susceptible bacterial infections when oral doxycycline is appropriate and the whole 100 mg dose unit fits the patient · By mouth
Care settingVeterinarian-directed outpatient treatment after patient, infection and dose-form selection; use a different presentation when the required dose is below or materially different from 100 mg.
vetman score 6.0/10 Situational / acceptable
Evidence confidence: Low Georgia: Yes, human · № რ-035618 · Verified on 15 Oct 2026 Off-label use

The active ingredient is well supported, but the indivisible 100 mg human unit is poorly matched to most cats. Prefer a validated smaller veterinary or liquid presentation rather than inventing a fractional dose from the dispersion.

Regulatory and scientific credibility6.0/10

The exact World Medicine product, 100 mg dispersible form, 10-tablet pack, manufacturer and current Kazakhstan registration are independently verifiable from official sources. The full current regulator-hosted dossier was not publicly retrievable, and dog/cat use is extra-label with no exact-product veterinary efficacy study.

Clinical efficacy8.0/10

Doxycycline is a well-established guideline-supported treatment for appropriate susceptible feline respiratory and selected other bacterial infections. Benefit depends on diagnosis, likely organism and stewardship; the score does not authorise indiscriminate empirical use.

Safety and tolerability6.5/10

Dispersion reduces the dry-tablet transit hazard but does not eliminate doxycycline-associated oesophagitis or systemic adverse effects. Feline use still requires reliable fluid or food follow-through, reproductive and dentition caution, and clinical monitoring; exact-product feline safety data are absent.

Clinical practicality2.0/10

Most cats require far below 100 mg at established veterinary regimens. Although dispersion avoids dry-pilling, the exact label forbids treating the score or suspension as a validated fractional dose, so this presentation is generally impractical for feline dose accuracy.

Full-course cost-effectiveness-

Current comparable full-course local prices were not verified.

Important safety and use flags

  • Use only for a clinically supported doxycycline-susceptible infection. Obtain culture and susceptibility testing whenever the disease site, severity, prior antimicrobial exposure or response makes it appropriate.
  • The 100 mg unit is not divisible for dose purposes. The score line is aesthetic and dispersion does not validate withdrawal of a fractional dose; use another product when the calculated dose does not reasonably match a whole tablet.
  • The human instructions disperse the whole tablet in at least 50 ml water and administer the complete suspension immediately with food. A veterinarian must choose a safer veterinary presentation when that volume or whole dose is unsuitable.
  • Never administer this product dry to a cat. Even a dispersed dose requires reliable swallowing and food or fluid follow-through; avoid it in oesophageal disease or when follow-through cannot be assured.
  • Calcium, magnesium, aluminium, iron, bismuth, antacids, sucralfate and other polyvalent cation sources can reduce doxycycline absorption; separate them according to the applicable protocol.
  • Phenobarbital, phenytoin, carbamazepine, primidone, rifampicin and other enzyme inducers may shorten doxycycline exposure. Review the antimicrobial plan rather than assuming the standard regimen remains adequate.
  • Avoid routine use during pregnancy, lactation and active tooth development unless a veterinarian judges the indication-specific benefit to outweigh the risk and no safer effective option exists.
  • Monitor gastrointestinal tolerance, hydration, clinical response and, for prolonged treatment or relevant comorbidity, liver, renal and haematologic parameters. Stop and reassess severe diarrhoea, dysphagia, jaundice or hypersensitivity.
  • Review concurrent antimicrobials, retinoids, anticoagulants, ciclosporin and methoxyflurane. Product information identifies clinically important combinations, and an interaction check is required before treatment.
Assessment sources
  1. Medaox official page2026
  2. World Medicine portfolio2023
  3. Medaox Kazakhstan listing2026
  4. Doxycare SPC2026
  5. ISCAID 20172017
  6. ACVIM 20232023
  7. ISCAID pyoderma 20252025
  8. Westfall et al. 20012001
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Doxycycline100 mg
Formulation Type
Tablet
Administration route
By mouth
Manufacturer
World Medicine · Türkiye
Registration
Georgia Yes, human
In force until 22 Jun 2027
Human (Ministry of Health, RAMA)
№ რ-035618
Verified on: 15 Oct 2026
 EU No
Verified on: 16 Oct 2026
 UK No
Verified on: 16 Oct 2026
 US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Unidox Solutab 100 mg, Tablet

dispersible tablet, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Veterinarian-directed treatment of doxycycline-susceptible bacterial infections when oral doxycycline is appropriate and the whole 100 mg dose unit fits the patient
6.9/10
Situational / acceptable
vetman assessment

Unidox Solutab

100 mg, dispersible tablet, human medicine
Assessed clinical scopeDog · Veterinarian-directed treatment of doxycycline-susceptible bacterial infections when oral doxycycline is appropriate and the whole 100 mg dose unit fits the patient · By mouth
Care settingVeterinarian-directed outpatient treatment after patient, infection and dose-form selection; use a different presentation when the required dose is below or materially different from 100 mg.
vetman score 6.9/10 Situational / acceptable
Evidence confidence: Medium Georgia: Expired · № რ-019803 · Verified on 15 Oct 2026 Off-label use

Strong doxycycline evidence does not make this exact 100 mg human unit broadly practical. It is a reasonable extra-label option only when infection and susceptibility support doxycycline and a whole tablet fits the calculated dose.

Regulatory and scientific credibility7.0/10

The exact monohydrate product has a current official regulator-hosted SmPC, package record and authorisation number. It is transparent but authorised for humans, not dogs or cats; the catalogue attribution has been updated to the current holder and exact-product veterinary efficacy is not established.

Clinical efficacy8.0/10

Doxycycline is a well-established guideline-supported treatment for appropriate susceptible canine respiratory, vector-borne and selected skin or systemic infections. The score depends on diagnosis, organism and stewardship and does not transfer the human label infection list to dogs.

Safety and tolerability7.0/10

Appropriately selected doxycycline is generally well tolerated, but gastrointestinal effects, oesophageal injury, photosensitivity and restrictions around pregnancy, immature dentition and significant hepatic disease require selection and monitoring. Exact-product dog safety data are absent.

Clinical practicality5.0/10

Once-daily oral treatment can be workable when a whole 100 mg unit reasonably matches the calculated dose. The score line is not an equal-dose divider and the labelled suspension cannot provide a validated dose below 100 mg, making this form poorly matched to many small and medium dogs.

Full-course cost-effectiveness-

Current comparable full-course local prices were not verified.

Important safety and use flags

  • Use only for a clinically supported doxycycline-susceptible infection. Obtain culture and susceptibility testing whenever the disease site, severity, prior antimicrobial exposure or response makes it appropriate.
  • The 100 mg unit is not divisible for dose purposes. The score line is aesthetic and dispersion does not validate withdrawal of a fractional dose; use another product when the calculated dose does not reasonably match a whole tablet.
  • The human instructions disperse the whole tablet in at least 50 ml water and administer the complete suspension immediately with food. A veterinarian must choose a safer veterinary presentation when that volume or whole dose is unsuitable.
  • Administer with food and adequate fluid according to the selected protocol. Reassess vomiting, dysphagia, regurgitation or another sign of oesophageal or gastrointestinal intolerance.
  • Calcium, magnesium, aluminium, iron, bismuth, antacids, sucralfate and other polyvalent cation sources can reduce doxycycline absorption; separate them according to the applicable protocol.
  • Phenobarbital, phenytoin, carbamazepine, primidone, rifampicin and other enzyme inducers may shorten doxycycline exposure. Review the antimicrobial plan rather than assuming the standard regimen remains adequate.
  • Avoid routine use during pregnancy, lactation and active tooth development unless a veterinarian judges the indication-specific benefit to outweigh the risk and no safer effective option exists.
  • Monitor gastrointestinal tolerance, hydration, clinical response and, for prolonged treatment or relevant comorbidity, liver, renal and haematologic parameters. Stop and reassess severe diarrhoea, dysphagia, jaundice or hypersensitivity.
  • Review concurrent antimicrobials, retinoids, anticoagulants, ciclosporin and methoxyflurane. Product information identifies clinically important combinations, and an interaction check is required before treatment.
Assessment sources
  1. Unidox official SmPC2026
  2. Unidox package record2026
  3. World Medicine portfolio2023
  4. Doxycare SPC2026
  5. ISCAID 20172017
  6. ACVIM 20232023
  7. ISCAID pyoderma 20252025
  8. Westfall et al. 20012001
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Veterinarian-directed treatment of doxycycline-susceptible bacterial infections when oral doxycycline is appropriate and the whole 100 mg dose unit fits the patient
6.3/10
Situational / acceptable
vetman assessment

Unidox Solutab

100 mg, dispersible tablet, human medicine
Assessed clinical scopeCat · Veterinarian-directed treatment of doxycycline-susceptible bacterial infections when oral doxycycline is appropriate and the whole 100 mg dose unit fits the patient · By mouth
Care settingVeterinarian-directed outpatient treatment after patient, infection and dose-form selection; use a different presentation when the required dose is below or materially different from 100 mg.
vetman score 6.3/10 Situational / acceptable
Evidence confidence: Medium Georgia: Expired · № რ-019803 · Verified on 15 Oct 2026 Off-label use

The active ingredient is well supported, but the indivisible 100 mg human unit is poorly matched to most cats. Prefer a validated smaller veterinary or liquid presentation rather than inventing a fractional dose from the dispersion.

Regulatory and scientific credibility7.0/10

The exact monohydrate product has a current official regulator-hosted SmPC, package record and authorisation number. It is transparent but authorised for humans, not dogs or cats; the catalogue attribution has been updated to the current holder and exact-product veterinary efficacy is not established.

Clinical efficacy8.0/10

Doxycycline is a well-established guideline-supported treatment for appropriate susceptible feline respiratory and selected other bacterial infections. Benefit depends on diagnosis, likely organism and stewardship; the score does not authorise indiscriminate empirical use.

Safety and tolerability6.5/10

Dispersion reduces the dry-tablet transit hazard but does not eliminate doxycycline-associated oesophagitis or systemic adverse effects. Feline use still requires reliable fluid or food follow-through, reproductive and dentition caution, and clinical monitoring; exact-product feline safety data are absent.

Clinical practicality2.0/10

Most cats require far below 100 mg at established veterinary regimens. Although dispersion avoids dry-pilling, the exact label forbids treating the score or suspension as a validated fractional dose, so this presentation is generally impractical for feline dose accuracy.

Full-course cost-effectiveness-

Current comparable full-course local prices were not verified.

Important safety and use flags

  • Use only for a clinically supported doxycycline-susceptible infection. Obtain culture and susceptibility testing whenever the disease site, severity, prior antimicrobial exposure or response makes it appropriate.
  • The 100 mg unit is not divisible for dose purposes. The score line is aesthetic and dispersion does not validate withdrawal of a fractional dose; use another product when the calculated dose does not reasonably match a whole tablet.
  • The human instructions disperse the whole tablet in at least 50 ml water and administer the complete suspension immediately with food. A veterinarian must choose a safer veterinary presentation when that volume or whole dose is unsuitable.
  • Never administer this product dry to a cat. Even a dispersed dose requires reliable swallowing and food or fluid follow-through; avoid it in oesophageal disease or when follow-through cannot be assured.
  • Calcium, magnesium, aluminium, iron, bismuth, antacids, sucralfate and other polyvalent cation sources can reduce doxycycline absorption; separate them according to the applicable protocol.
  • Phenobarbital, phenytoin, carbamazepine, primidone, rifampicin and other enzyme inducers may shorten doxycycline exposure. Review the antimicrobial plan rather than assuming the standard regimen remains adequate.
  • Avoid routine use during pregnancy, lactation and active tooth development unless a veterinarian judges the indication-specific benefit to outweigh the risk and no safer effective option exists.
  • Monitor gastrointestinal tolerance, hydration, clinical response and, for prolonged treatment or relevant comorbidity, liver, renal and haematologic parameters. Stop and reassess severe diarrhoea, dysphagia, jaundice or hypersensitivity.
  • Review concurrent antimicrobials, retinoids, anticoagulants, ciclosporin and methoxyflurane. Product information identifies clinically important combinations, and an interaction check is required before treatment.
Assessment sources
  1. Unidox official SmPC2026
  2. Unidox package record2026
  3. World Medicine portfolio2023
  4. Doxycare SPC2026
  5. ISCAID 20172017
  6. ACVIM 20232023
  7. ISCAID pyoderma 20252025
  8. Westfall et al. 20012001
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Doxycycline100 mg
Formulation Type
Tablet
Administration route
By mouth
Manufacturer
CHEPLAPHARM Arzneimittel GmbH · Germany
Registration
Georgia Expired
Expired on 18 Jul 2026, not renewed yet
Human (Ministry of Health, RAMA)
№ რ-019803
Verified on: 15 Oct 2026
 EU Yes, human
Verified on: 16 Oct 2026
 UK No
Verified on: 16 Oct 2026
 US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

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