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Sucralfate
Mucosal protectant. Registered in Georgia: 1 human medicine. Forms: scored tablet, suspension.
Doses
Each dose comes with its source. Check the label of the product you use.
| Dose | Species | Indication | Route | Frequency | Source |
|---|---|---|---|---|---|
|
500–1000 mg per animal
off-label |
Dog | Gastric Ulceration | By mouth | every 6-8 hours |
Merck GI-ulcer pharmacology
Reference book A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose. MSD/Merck Veterinary Manual, 2025 |
|
500–1000 mg per animal
off-label |
Dog | Gastric Ulceration | By mouth | every 8-12 hours |
Merck small-animal GI ulcers
Reference book A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose. MSD/Merck Veterinary Manual, 2025 |
|
250–500 mg per animal
off-label |
Cat | Gastric Ulceration | By mouth | every 8-12 hours |
Merck GI-ulcer pharmacology
Reference book A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose. MSD/Merck Veterinary Manual, 2025 |
|
250 mg per animal
off-label |
Cat | Gastric Ulceration | By mouth | every 8-12 hours |
Merck small-animal GI ulcers
Reference book A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose. MSD/Merck Veterinary Manual, 2025 |
Safety information
Known Contraindications
-
Critical
(Cat) In a small study of cats with chronic kidney disease and normal phosphate, three of five cats given sucralfate deteriorated (vomiting, loss of appetite, constipation, worsening azotaemia). The study was stopped because of these effects and the lack of benefit, which contradicts the usual claim that sucralfate has almost no adverse effects.Sources: MSD Vet Manual
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Warning
In renal failure, aluminium absorption from sucralfate may increase. Prolonged treatment can therefore increase the risk of aluminium toxicity and requires caution.Sources: ACVIM · MSD Vet Manual
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Warning
Contraindicated in known hypersensitivity to sucralfate or any excipient. Reported hypersensitivity reactions include dyspnoea, rash, urticaria, anaphylaxis, and bronchospasm.Sources: FDA
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Warning
No pregnancy data are available in dogs or cats. Sucralfate is minimally absorbed, making systemic exposure less likely, but this is a pharmacological inference rather than evidence of safety.Sources: MSD Vet Manual
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Warning
No lactation data are available in dogs or cats. Minimal absorption makes systemic exposure less likely, but this remains a pharmacological inference rather than evidence of safety.Sources: Product label
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Caution
Sucralfate is less effective than a proton pump inhibitor for gastrointestinal ulceration and erosion, and there is no evidence that adding it to a proton pump inhibitor or an H2 blocker brings extra benefit. If a proton pump inhibitor is already given, adding sucralfate is not justified.Sources: ACVIM · MSD Vet Manual
Known Drug Interactions
-
Major warning
Marbofloxacin + Sucralfate
Sucralfate, antacids, and mineral supplements containing iron, aluminium, calcium, magnesium, zinc, or other divalent or trivalent cations can reduce quinolone absorption and bioavailability. The magnitude is drug-specific; marbofloxacin is covered by a direct product warning.Recommendation: Avoid concurrent oral administration. If both medicines are necessary, separate sucralfate or the cation-containing product from the quinolone by at least 2 hours and monitor clinical response.Sources: VMD SPC · VMD · FDA · ACVIM · JVIM
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Major warning
Doxycycline + Sucralfate
In dogs, concurrent administration of sucralfate suspension reduced doxycycline AUC from 36.0 to 7.2 h·mcg/mL (relative bioavailability 20%). No interaction was detected with sucralfate tablets because tablet fragments were visible in faeces, indicating that the tablets did not disintegrate and were not effective.Recommendation: Separate administration by 2 hours: give doxycycline first and sucralfate 2 hours later. With this schedule, bioavailability is 74% and is not statistically different from doxycycline alone.Sources: JVPT
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Minor warning
Sucralfate + Levothyroxine
Antacids containing aluminium, magnesium, or calcium, as well as ferrous sulfate and sucralfate, can reduce levothyroxine absorption.Recommendation: Separate levothyroxine from antacids, iron, or sucralfate by at least 2 hours.
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Minor warning
Enrofloxacin + Sucralfate
The concomitant administration of substances containing magnesium or aluminium may reduce the absorption of enrofloxacin. These drugs should be administered two hours apart.Recommendation: Separation is not critical in dogs, but a 2-hour interval is safe and label-consistent. No comparable measurement exists in cats; use a 2-hour interval in cats.Sources: VMD SPC · VMD · JVIM
-
Minor warning
Oxytetracycline + Sucralfate
Divalent and trivalent cations, including magnesium, iron, aluminium, and calcium, can chelate oxytetracycline and reduce its absorption. Do not give it at the same time as milk or antacids.Recommendation: Separate this medicine from oral oxytetracycline in time.
All forms and registration2
Registration in Georgia and abroad: the register, number, validity and source are behind (i).
Venter 1 g tablet, Scored tablet
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