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Rycarfa

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Carprofen · KRKA, d.d., Novo mesto

1 form: scored tablet. In force in Georgia: 1 of 1 (veterinary register).

Forms and doses1 of 1 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Form Species Dose Frequency Georgia
Scored tablet · Dog Dog 2–4 mg/kg
Initial dose is 4 mg/kg/day as one dose or two equal doses. After 7 days it may be reduced to 2 mg/kg once daily according to clinical response. After parenteral preoperative analgesia, 4 mg/kg/day may be continued for up to 5 days. Tablets divide into equal halves. Do not use in cats, pregnant or lactating bitches, dogs under 4 months, or animals with cardiac, hepatic or renal disease, gastrointestinal ulceration/bleeding risk or blood dyscrasia. Do not combine with another NSAID or a glucocorticoid; allow at least 24 hours and account for the previous drug.
 · once daily; the initial 4 mg/kg daily amount may instead be divided into two equal doses		 once daily; the initial 4 mg/kg daily amount may instead be divided into two equal doses Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: რიკარფა 50 მგ
№ 145-11; 232-11
Verified on: 19 Oct 2026
Details: pack, label wording, sources, registration

Rycarfa, Scored tablet

Carprofen 50 mg, meat-flavoured divisible tablet for dogs
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.0/10
Very good
vetman assessment

Rycarfa

Carprofen 50 mg, meat-flavoured divisible tablet for dogs
Assessed clinical scopeDog · Reduction of canine musculoskeletal and degenerative-joint pain and inflammation, plus up to five days of oral follow-up after parenteral preoperative analgesia · By mouth
Care settingVeterinary-directed home treatment after diagnosis and patient selection, with accurate weighing, response-guided dose reduction, toxicity counselling and periodic reassessment/monitoring
vetman score 8.0/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 145-11; 232-11 · Verified on 19 Oct 2026

A well-documented, evidence-supported oral canine NSAID and a very good standard option for appropriately selected osteoarthritis patients, with useful short postoperative follow-up use. Its value depends on diagnosis, the lowest effective response-guided dose, multimodal care, baseline risk assessment and prompt withdrawal if intolerance appears; it is not for cats and not a harmless routine analgesic.

Regulatory and scientific credibility9.0/10

Exact Rycarfa 50 mg has current regulator-hosted EU/UK product information, a named MA holder, authorisation number, dog-only indications, complete dosing and safety text, and two current Georgian registrations. FDA-authorised oral carprofen products provide an additional mature regulatory and pharmacovigilance comparator.

Clinical efficacy8.5/10

Multiple placebo-controlled and active-comparator canine studies consistently support oral carprofen for osteoarthritis pain and function, and current pain guidelines place NSAIDs among core high-impact options. The evidence is strongest for OA; product-label postoperative follow-up is useful but is not a stand-alone multimodal perioperative plan or a disease-modifying claim.

Safety and tolerability6.5/10

Correctly selected dogs often tolerate carprofen well and controlled trials did not show a large routine toxicity signal, but the therapeutic margin is not trivial. Gastrointestinal ulceration/bleeding, renal injury, idiosyncratic hepatic injury and rare serious or fatal reactions remain clinically important; organ disease, dehydration, pregnancy/lactation, young age and interacting anti-inflammatory drugs materially narrow safe use.

Clinical practicality8.0/10

Meat flavour, once-daily use, optional division of the initial daily amount and equal half-tablets make home treatment workable. Accurate weight-based selection is still limited by 25 mg half-tablet increments; the unused half must return to the blister and be used within 24 hours, and long-term treatment requires regular clinical and laboratory review.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Verify exact Rycarfa 50 mg tablets for dogs. Do not transfer this score, half-tablet handling or dose to another carprofen brand, strength, chewable tablet, capsule or injection.
  • Weigh accurately. Give 2-4 mg/kg/day; the initial 4 mg/kg daily amount may be given once or split into two equal doses and may be reduced after 7 days to 2 mg/kg once daily according to response. Use the lowest effective dose.
  • Dog only. Do not use oral carprofen tablets in cats; feline clearance and therapeutic margin differ, and current Rycarfa/Rimadyl tablet labels explicitly prohibit feline use.
  • Before treatment, obtain a thorough history and examination and consider baseline CBC, serum biochemistry and urinalysis. Reassess pain, function, hydration, blood pressure and renal/hepatic variables periodically, especially in older dogs or long courses.
  • Stop treatment and assess promptly for appetite loss, vomiting, diarrhoea, melena or hematemesis, lethargy, behaviour change, PU/PD, pallor, jaundice, ataxia, seizure, oedema or other suspected intolerance; rare serious or fatal reactions can occur without warning.
  • Do not combine with another NSAID or a glucocorticoid and do not give either within at least 24 hours of Rycarfa. Select any longer washout from the previous drug’s pharmacokinetics and the patient’s condition; use non-NSAID rescue analgesia if needed.
  • Avoid in dehydration, hypovolaemia or hypotension and in cardiac, hepatic or renal disease, gastrointestinal ulceration/bleeding risk or blood dyscrasia. Avoid potentially nephrotoxic drugs and closely review highly protein-bound or similarly metabolised medicines.
  • Do not use in pregnant or lactating bitches, dogs under 4 months, or patients hypersensitive to carprofen/NSAIDs or excipients. Use in aged dogs adds risk and requires careful management.
  • The 50 mg tablet divides only into equal halves. Return the unused half to the opened blister, use it within 24 hours, protect from light/moisture and prevent accidental ingestion of the flavoured tablets.
  • For chronic osteoarthritis, combine medicine with weight management, appropriate exercise/rehabilitation and other case-specific modalities. Reassess benefit regularly; carprofen controls pain and inflammation but does not modify the underlying joint disease.
Assessment sources
  1. Rycarfa 50 mg, VMD SPC 20252025
  2. EU SPC2026
  3. Rycarfa 50 mg GE register2026
  4. FDA 20192019
  5. Canine OA carprofen RCT1995
  6. Canine hip OA placebo RCT2023
  7. Carprofen two-month safety RCT2006
  8. AAHA Pain Guidelines 20222022
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Carprofen50 mg
Formulation Type
Scored tablet
Administration route
By mouth
Manufacturer
KRKA, d.d., Novo mesto · Slovenia
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: რიკარფა 50 მგ
№ 145-11; 232-11
Verified on: 19 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
2–4 mg/kg
Initial dose is 4 mg/kg/day as one dose or two equal doses. After 7 days it may be reduced to 2 mg/kg once daily according to clinical response. After parenteral preoperative analgesia, 4 mg/kg/day may be continued for up to 5 days. Tablets divide into equal halves. Do not use in cats, pregnant or lactating bitches, dogs under 4 months, or animals with cardiac, hepatic or renal disease, gastrointestinal ulceration/bleeding risk or blood dyscrasia. Do not combine with another NSAID or a glucocorticoid; allow at least 24 hours and account for the previous drug.
 Dog Any weight By mouth once daily; the initial 4 mg/kg daily amount may instead be divided into two equal doses
EU SPC
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
Rycarfa 50 mg tablets with meat flavour for dogs - Product Information
EU Union Product Database, 2026
Active substance doses, with sources
Active substance Carprofen
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
2–4 mg/kg Dog Musculoskeletal Pain and Inflammation By mouth total daily dose, given once or divided into 2 doses
Rycarfa 50 mg, VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Rycarfa 50 mg tablets for dogs - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
4.4 mg/kg Dog Musculoskeletal Pain and Inflammation By mouth once daily
FDA 2019
Official product label (SPC), FDA, US
Approved by the US Food and Drug Administration (FDA) as part of the product's authorisation. It applies to that product as authorised there.
Rimadyl (carprofen) Caplets - package insert
FDA (NADA 141-053), DailyMed, 2019
2.2 mg/kg Dog Musculoskeletal Pain and Inflammation By mouth 2 times daily
FDA 2019
Official product label (SPC), FDA, US
Approved by the US Food and Drug Administration (FDA) as part of the product's authorisation. It applies to that product as authorised there.
Rimadyl (carprofen) Caplets - package insert
FDA (NADA 141-053), DailyMed, 2019
4 mg/kg Dog Postoperative Pain
Analgesia
 Intravenous / Subcutaneous once before surgery
Rycarfa 50 mg/ml, VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Rycarfa 50 mg/ml solution for injection for dogs and cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
4.4 mg/kg Dog Postoperative Pain
Analgesia
 Subcutaneous once daily
FDA 2020
Official product label (SPC), FDA, US
Approved by the US Food and Drug Administration (FDA) as part of the product's authorisation. It applies to that product as authorised there.
Rimadyl (carprofen) Sterile Injectable Solution - package insert
FDA (NADA 141-199), DailyMed, 2020
4 mg/kg Cat Postoperative Pain
Analgesia
 Intravenous / Subcutaneous single dose; do not repeat
Rycarfa 50 mg/ml, VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Rycarfa 50 mg/ml solution for injection for dogs and cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025

Known Contraindications

  • Critical
    Do not use carprofen in dogs with renal disease. Dehydration, hypovolaemia, or hypotension further increases the risk of renal toxicity.
    Sources: FDA
  • Critical
    Do not use carprofen in dogs with hepatic disease. Cyclooxygenase-inhibiting non-steroidal anti-inflammatory drugs can cause hepatic, renal, and gastrointestinal toxicity.
    Sources: FDA
  • Critical
    Do not use carprofen in animals with significant cardiac disease because haemodynamic compromise can increase renal and gastrointestinal risk.
  • Critical
    Do not use carprofen when gastrointestinal ulceration or bleeding is present or likely.
    Sources: FDA
  • Critical
    Do not use carprofen in patients with blood dyscrasia or a bleeding disorder.
    Sources: FDA
  • Critical
    Do not use carprofen during pregnancy or lactation. Fetotoxic effects occurred in laboratory animals at doses close to the therapeutic range.
    Sources: FDA
  • Critical
    Do not use carprofen during lactation. The injectable product is contraindicated during pregnancy and lactation in dogs and cats.
  • Critical
    Rimadyl should not be used in dogs exhibiting previous hypersensitivity to carprofen.
    Sources: FDA
  • Warning
    Avoid carprofen in dehydrated, hypovolaemic, or hypotensive dogs because renal toxicity may be increased.
  • Warning
    Do not use carprofen tablets in dogs younger than 4 months. Do not use the injectable product in dogs younger than 10 weeks or cats younger than 5 months.
    Sources: FDA

Known Drug Interactions

  • Contraindicated Carprofen + Robenacoxib
    Do not give robenacoxib together with other non-steroidal anti-inflammatory drugs or glucocorticoids because adverse gastrointestinal and renal effects may increase.
    Recommendation: Do not use these drugs together. Allow a treatment-free interval of at least 24 hours after the previous anti-inflammatory drug, extending it when required by that drug’s pharmacokinetics.
  • Major warning Meloxicam + Carprofen
    Do not give other non-steroidal anti-inflammatory drugs or glucocorticoids concurrently with carprofen or within 24 hours of treatment because gastrointestinal ulceration or perforation may occur.
    Recommendation: Consider appropriate washout times when switching from one NSAID to another or when switching from corticosteroid use to NSAID use.
    Sources: FDA
  • Major warning Carprofen + Dexamethasone
    Do not give other non-steroidal anti-inflammatory drugs or glucocorticoids concurrently with carprofen or within 24 hours of treatment because gastrointestinal ulceration or perforation may occur.
    Recommendation: Consider appropriate washout times when switching from one NSAID to another or when switching from corticosteroid use to NSAID use.
    Sources: FDA
  • Major warning Carprofen + Dihydrostreptomycin
    Avoid giving carprofen with potentially nephrotoxic drugs because renal toxicity may increase.
    Recommendation: Avoid concomitant use; if unavoidable, monitor renal function.
  • Major warning Carprofen + Prednisolone
    Do not give other non-steroidal anti-inflammatory drugs or glucocorticoids concurrently with carprofen or within 24 hours of treatment because gastrointestinal ulceration or perforation may occur.
    Recommendation: Consider appropriate washout times when switching from one NSAID to another or when switching from corticosteroid use to NSAID use.
    Sources: FDA

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