spiramycin 1, 500, 000 IU / metronidazole 250 mg tablets, N10 for dogs
Assessed clinical scopeDog · Adjunct oral spiramycin/metronidazole for diagnosed susceptible periodontal or related oral infection, with indicated professional dental or surgical source control; not routine prophylaxis or first-line empirical treatment · By mouth
Care settingVeterinary-directed course after oral examination and treatment planning, with professional cleaning, endodontic treatment, extraction or surgery when indicated and reassessment if response is inadequate
vetman score
6.3/10
Situational / acceptable
Evidence confidence: Medium
Georgia: Yes, veterinary · № 214-11 · Verified on 21 Oct 2026
A transparent dog-only veterinary product for selected susceptible oral infection in a dog that matches the whole 20-kg unit. Its narrow practicality, limited direct outcome evidence and adjunctive—not first-line empirical—role keep the overall value situational.
Regulatory and scientific credibility8.0/10
The exact veterinary presentation has a sourced current Georgian registration and independently verified EU/EEA product information defining its strength, species, oral route and regimen. The dossier is transparent, although independent exact-product clinical outcome evidence remains limited.
Clinical efficacy5.5/10
The authorised spectrum fits mixed susceptible periodontal flora, and a six-dog study found a treatment-time reduction in selected dental-biofilm taxa. It did not test clinical cure, recurrence or superiority, while current dental and stewardship guidance makes source control primary and systemic antibiotics selective rather than routine.
Safety and tolerability6.0/10
The labelled 5-10-day course has a useful safety margin and gastrointestinal reactions are very rare, but metronidazole adds dose- and duration-related neurologic and genotoxic uncertainty, reproductive safety is not established, and concurrent macrolides are prohibited. Hepatic disease requires particular caution and is contraindicated by the bound Stomorgyl 20 label.
Clinical practicality5.5/10
Once-daily dosing for 5-10 days is simple for an appropriately sized dog, but this dog-only whole tablet corresponds to 20 kg and cannot accurately fit many patients. The bound label also excludes dogs below 5 kg.
Full-course cost-effectiveness-
Price was not assessed and is excluded from the overall score.
Important safety and use flags
- Do not use this combination as routine dental prophylaxis or first-line empirical periodontal treatment. Examine and stage the mouth; professional cleaning, endodontic treatment, extraction or surgery is primary source control and must not be replaced by tablets.
- Reserve treatment for a diagnosed susceptible aerobic/anaerobic oral infection when systemic antimicrobial benefit is expected. Obtain culture and susceptibility when feasible, follow local antimicrobial policy, use the shortest justified label course and reassess treatment failure rather than repeating empirically.
- Do not administer concurrently with another macrolide antibiotic. Review the full medication list for additive antimicrobial exposure and avoid combining products that duplicate metronidazole.
- Stop and assess promptly for ataxia, tremor, nystagmus, spasm, seizure, weakness or altered mentation. Metronidazole neurotoxicity is related to exposure and duration and cannot be dismissed because the planned course is short.
- Safety in pregnancy and lactation is not established consistently across national Stomorgyl information. Verify the exact current Georgian leaflet and use only after an individual veterinary benefit-risk assessment; avoid unnecessary exposure.
- Hepatic dysfunction can increase metronidazole exposure. Assess liver disease before use, limit duration and monitor closely; the bound Stomorgyl 20 label contraindicates use in hepatic disease.
- Vomiting, diarrhoea or anorexia may occur. Record response and adverse effects, and remember that broad combination therapy alters oral and intestinal microbial ecology and selects resistance even when short-term tolerance appears good.
- Dog only: one whole tablet corresponds to 20 kg and the bound label excludes dogs below 5 kg. Do not infer a feline use or an unverified tablet fraction; choose another authorised strength when the whole unit does not match.
Assessment sources+
