solution for injection, 3 ml ampoule, human medicine
Assessed clinical scopeDog · Proposed deep-IM use of the exact Benevron B human ampoule for a diagnosed vitamin deficiency or adjunctive neurologic role · Intramuscular
Care settingVeterinarian-directed use only after diagnosis and selection of a source-backed, deliverable regimen
vetman score
Not rateable
No numerical score assigned
Evidence confidence: Low
Georgia: Yes, human · № რ-045603, რ-038060 · Verified on 15 Oct 2026
Off-label use
Not rateable
A numerical canine score cannot be assigned responsibly. AEM DV 22-01101 and Kazakhstan SPC ҚР-ДЗ-5№121984 verify the exact 3 ml human ampoule, four-vitamin composition and deep-IM human route. They provide no dog/cat dose, veterinary PK, target-animal safety margin or clinical outcome evidence. The human schedule and an isolated clinic-chart volume are not transferable, and the ampoule also contains 60 mg benzyl alcohol.
Exact human identity and deep-IM route are verified; a veterinary dose and benefit-risk are not. Do not transfer the human schedule or infer “slow injection.”
Important safety and use flags
- Use only for a defined deficiency or other explicit clinical rationale. A nonspecific neurologic sign, anorexia, fatigue or routine supplementation is not a diagnosis.
- No dog or cat dose is established for this exact ampoule. Do not scale the human schedule, copy an isolated clinic-chart volume or derive a mixture dose from one component.
- The exact official route is deep IM. “Slowly” is not stated in the audited primary documents; do not add it or extrapolate IV, SC or oral use.
- AEM and the Kazakhstan SPC describe a human medicine; this is not a veterinary authorisation. Exact dog/cat PK, efficacy and repeated-dose safety remain absent.
- Do not infer that all B vitamins are required because one deficiency is plausible. Ingredient or comparator evidence cannot validate this fixed high-dose ratio or transfer another product’s dose.
- Each 3 ml ampoule contains 250 mg pyridoxine and 60 mg benzyl alcohol with the other vitamins. Dog/cat local tolerance, repeated-dose safety and therapeutic margin are not established.
- High experimental pyridoxine exposure caused sensory-neuron injury in dogs. Those studies do not define a safe lower Benevron regimen, but they rule out assuming that water solubility makes chronic high-dose exposure harmless.
- Parenteral thiamine can cause serious hypersensitivity. Use aseptic technique, review excipients and ensure readiness to manage an acute reaction.
- Review the full medication plan, especially levodopa without a peripheral decarboxylase inhibitor and other vitamin-containing products. Avoid unexamined cumulative exposure.
- Set a diagnosis-specific response point and stop date. If response is absent, reassess diet, malabsorption, antagonists, primary disease and the actual deficient nutrient rather than continuing empirical B-complex treatment.
Assessment sources+