Register
Medicines reference
Active substance

Cyanocobalamin

B vitamin. Registered in Georgia: 8 human medicines. Forms: coated tablet, solution.

Dose and use

Doses

Each dose comes with its source. Check the label of the product you use.

Active substance Cyanocobalamin
Before use

Safety information

Known Contraindications

  • Warning
    Tumours: according to the product label, vitamin B12 may stimulate the growth of malignant tumours, so it should not be given to patients with a tumour.
    Sources: Product label
Latin name
Cyanocobalamin
Georgian name
ციანოკობალამინი
Authorisation status
Authorised veterinary medicine
An authorised veterinary medicine containing this substance exists. Whether a particular use is on-label depends on the species and the indication - see each dose rule.
Registered in Georgia
8 of 8 forms
Human medicines in Georgia
B12 Ankermann, Cobaleksin, Optovite B12, Vitamin B12 Sopharma
Human medicines with this substance in the Georgian register of medicines (Ministry of Health), checked on 18 Oct 2026. They are human medicines, not veterinary products; strengths and forms differ.
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
All forms and registration8

Registration in Georgia and abroad: the register, number, validity and source are behind (i).

Benevron B, Solution

solution for injection, 3 ml ampoule, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Proposed deep-IM use of the exact Benevron B human ampoule for a diagnosed vitamin deficiency or adjunctive neurologic role
Not rateable
No numerical score assigned
vetman assessment

Benevron B

solution for injection, 3 ml ampoule, human medicine
Assessed clinical scopeDog · Proposed deep-IM use of the exact Benevron B human ampoule for a diagnosed vitamin deficiency or adjunctive neurologic role · Intramuscular
Care settingVeterinarian-directed use only after diagnosis and selection of a source-backed, deliverable regimen
vetman score Not rateable No numerical score assigned
Evidence confidence: Low Georgia: Yes, human · № რ-045603, რ-038060 · Verified on 15 Oct 2026 Off-label use
Not rateable

A numerical canine score cannot be assigned responsibly. AEM DV 22-01101 and Kazakhstan SPC ҚР-ДЗ-5№121984 verify the exact 3 ml human ampoule, four-vitamin composition and deep-IM human route. They provide no dog/cat dose, veterinary PK, target-animal safety margin or clinical outcome evidence. The human schedule and an isolated clinic-chart volume are not transferable, and the ampoule also contains 60 mg benzyl alcohol.

Exact human identity and deep-IM route are verified; a veterinary dose and benefit-risk are not. Do not transfer the human schedule or infer “slow injection.”

Important safety and use flags

  • Use only for a defined deficiency or other explicit clinical rationale. A nonspecific neurologic sign, anorexia, fatigue or routine supplementation is not a diagnosis.
  • No dog or cat dose is established for this exact ampoule. Do not scale the human schedule, copy an isolated clinic-chart volume or derive a mixture dose from one component.
  • The exact official route is deep IM. “Slowly” is not stated in the audited primary documents; do not add it or extrapolate IV, SC or oral use.
  • AEM and the Kazakhstan SPC describe a human medicine; this is not a veterinary authorisation. Exact dog/cat PK, efficacy and repeated-dose safety remain absent.
  • Do not infer that all B vitamins are required because one deficiency is plausible. Ingredient or comparator evidence cannot validate this fixed high-dose ratio or transfer another product’s dose.
  • Each 3 ml ampoule contains 250 mg pyridoxine and 60 mg benzyl alcohol with the other vitamins. Dog/cat local tolerance, repeated-dose safety and therapeutic margin are not established.
  • High experimental pyridoxine exposure caused sensory-neuron injury in dogs. Those studies do not define a safe lower Benevron regimen, but they rule out assuming that water solubility makes chronic high-dose exposure harmless.
  • Parenteral thiamine can cause serious hypersensitivity. Use aseptic technique, review excipients and ensure readiness to manage an acute reaction.
  • Review the full medication plan, especially levodopa without a peripheral decarboxylase inhibitor and other vitamin-containing products. Avoid unexamined cumulative exposure.
  • Set a diagnosis-specific response point and stop date. If response is absent, reassess diet, malabsorption, antagonists, primary disease and the actual deficient nutrient rather than continuing empirical B-complex treatment.
Assessment sources
Assessed: 23 Oct 2026No axis or overall score is shown when the available evidence does not support a responsible numerical assessment.
Cat Proposed deep-IM use of the exact Benevron B human ampoule for a diagnosed vitamin deficiency or adjunctive neurologic role
Not rateable
No numerical score assigned
vetman assessment

Benevron B

solution for injection, 3 ml ampoule, human medicine
Assessed clinical scopeCat · Proposed deep-IM use of the exact Benevron B human ampoule for a diagnosed vitamin deficiency or adjunctive neurologic role · Intramuscular
Care settingVeterinarian-directed use only after diagnosis and selection of a source-backed, deliverable regimen
vetman score Not rateable No numerical score assigned
Evidence confidence: Low Georgia: Yes, human · № რ-045603, რ-038060 · Verified on 15 Oct 2026 Off-label use
Not rateable

A numerical feline score cannot be assigned responsibly. AEM DV 22-01101 and Kazakhstan SPC ҚР-ДЗ-5№121984 verify the exact 3 ml human ampoule, four-vitamin composition and deep-IM human route. They provide no dog/cat dose, veterinary PK, target-animal safety margin or clinical outcome evidence. The human schedule and an isolated clinic-chart volume are not transferable, and the ampoule also contains 60 mg benzyl alcohol.

Exact human identity and deep-IM route are verified; a veterinary dose and benefit-risk are not. Do not transfer the human schedule or infer “slow injection.”

Important safety and use flags

  • Use only for a defined deficiency or other explicit clinical rationale. A nonspecific neurologic sign, anorexia, fatigue or routine supplementation is not a diagnosis.
  • No dog or cat dose is established for this exact ampoule. Do not scale the human schedule, copy an isolated clinic-chart volume or derive a mixture dose from one component.
  • The exact official route is deep IM. “Slowly” is not stated in the audited primary documents; do not add it or extrapolate IV, SC or oral use.
  • AEM and the Kazakhstan SPC describe a human medicine; this is not a veterinary authorisation. Exact dog/cat PK, efficacy and repeated-dose safety remain absent.
  • Do not infer that all B vitamins are required because one deficiency is plausible. Ingredient or comparator evidence cannot validate this fixed high-dose ratio or transfer another product’s dose.
  • Each 3 ml ampoule contains 250 mg pyridoxine and 60 mg benzyl alcohol with the other vitamins. Dog/cat local tolerance, repeated-dose safety and therapeutic margin are not established.
  • High experimental pyridoxine exposure caused sensory-neuron injury in dogs. Those studies do not define a safe lower Benevron regimen, but they rule out assuming that water solubility makes chronic high-dose exposure harmless.
  • Parenteral thiamine can cause serious hypersensitivity. Use aseptic technique, review excipients and ensure readiness to manage an acute reaction.
  • Review the full medication plan, especially levodopa without a peripheral decarboxylase inhibitor and other vitamin-containing products. Avoid unexamined cumulative exposure.
  • Set a diagnosis-specific response point and stop date. If response is absent, reassess diet, malabsorption, antagonists, primary disease and the actual deficient nutrient rather than continuing empirical B-complex treatment.
Assessment sources
Assessed: 23 Oct 2026No axis or overall score is shown when the available evidence does not support a responsible numerical assessment.
Composition / strength
Thiamine83.33 mg/ml Pyridoxine83.33 mg/ml Cyanocobalamin0.5 mg/ml Riboflavin1.333 mg/ml
Formulation Type
Solution
Administration route
Intramuscular
Registration
Georgia Yes, human
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
Information not fully verified No dog or cat dose was identified for this exact high-dose four-vitamin ampoule. The official human information specifies deep intramuscular administration; it does not say slowly and its human schedule cannot establish a veterinary ml/kg regimen.
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Proposed oral use of the exact Benevron BF human gastro-resistant product for a diagnosed vitamin deficiency or adjunctive neurologic role
Not rateable
No numerical score assigned
vetman assessment

Benevron BF

20 gastro-resistant tablets, human medicine
Assessed clinical scopeDog · Proposed oral use of the exact Benevron BF human gastro-resistant product for a diagnosed vitamin deficiency or adjunctive neurologic role · By mouth
Care settingVeterinarian-directed use only after diagnosis and selection of a source-backed, deliverable regimen
vetman score Not rateable No numerical score assigned
Evidence confidence: Low Georgia: Yes, human · № რ-046262, რ-044386 · Verified on 15 Oct 2026 Off-label use
Not rateable

A numerical canine score cannot be assigned responsibly. AEM DV 25-00460 verifies the Azerbaijani gastro-resistant medicine, while the exact World Medicine Kazakhstan document describes the same name, composition and 20-tablet presentation as a food supplement. Neither source establishes a dog/cat regimen, veterinary PK, target-animal safety or outcomes; neither establishes a validated veterinary fraction.

Exact identity is documented, but the regulatory category differs by jurisdiction and no veterinary dose or validated tablet fraction is established.

Important safety and use flags

  • Use only for a defined deficiency or other explicit clinical rationale. A nonspecific neurologic sign, anorexia, fatigue or routine supplementation is not a diagnosis.
  • No dog or cat dose is established for this exact product. Do not restore a quarter-tablet practice or derive a fraction by arithmetic.
  • The exact presentation is gastro-resistant, but the audited primary documents do not establish scoring, equal-dose subdivision, whole-only administration or crushing instructions. Do not invent any of them.
  • AEM records a human medicine in Azerbaijan; the exact World Medicine Kazakhstan document calls the same name/composition/presentation a food supplement. Keep the jurisdiction-specific categories distinct.
  • Do not infer that all B vitamins are required because one deficiency is plausible. Ingredient or comparator evidence cannot validate this fixed high-dose ratio or transfer another product’s dose.
  • Each tablet contains 200 mg pyridoxine with four other vitamins. No product-specific dog/cat exposure threshold, safe duration or therapeutic margin is established.
  • High experimental pyridoxine exposure caused sensory-neuron injury in dogs. Those studies do not define a safe lower Benevron regimen, but they rule out assuming that water solubility makes chronic high-dose exposure harmless.
  • Review hypersensitivity to active ingredients and excipients. The exact product document lists sulfite and paraben excipients; target-animal tolerability is not established.
  • Review the full medication plan, especially levodopa without a peripheral decarboxylase inhibitor and other vitamin-containing products. Avoid unexamined cumulative exposure.
  • Set a diagnosis-specific response point and stop date. If response is absent, reassess diet, malabsorption, antagonists, primary disease and the actual deficient nutrient rather than continuing empirical B-complex treatment.
Assessment sources
Assessed: 23 Oct 2026No axis or overall score is shown when the available evidence does not support a responsible numerical assessment.
Cat Proposed oral use of the exact Benevron BF human gastro-resistant product for a diagnosed vitamin deficiency or adjunctive neurologic role
Not rateable
No numerical score assigned
vetman assessment

Benevron BF

20 gastro-resistant tablets, human medicine
Assessed clinical scopeCat · Proposed oral use of the exact Benevron BF human gastro-resistant product for a diagnosed vitamin deficiency or adjunctive neurologic role · By mouth
Care settingVeterinarian-directed use only after diagnosis and selection of a source-backed, deliverable regimen
vetman score Not rateable No numerical score assigned
Evidence confidence: Low Georgia: Yes, human · № რ-046262, რ-044386 · Verified on 15 Oct 2026 Off-label use
Not rateable

A numerical feline score cannot be assigned responsibly. AEM DV 25-00460 verifies the Azerbaijani gastro-resistant medicine, while the exact World Medicine Kazakhstan document describes the same name, composition and 20-tablet presentation as a food supplement. Neither source establishes a dog/cat regimen, veterinary PK, target-animal safety or outcomes; neither establishes a validated veterinary fraction.

Exact identity is documented, but the regulatory category differs by jurisdiction and no veterinary dose or validated tablet fraction is established.

Important safety and use flags

  • Use only for a defined deficiency or other explicit clinical rationale. A nonspecific neurologic sign, anorexia, fatigue or routine supplementation is not a diagnosis.
  • No dog or cat dose is established for this exact product. Do not restore a quarter-tablet practice or derive a fraction by arithmetic.
  • The exact presentation is gastro-resistant, but the audited primary documents do not establish scoring, equal-dose subdivision, whole-only administration or crushing instructions. Do not invent any of them.
  • AEM records a human medicine in Azerbaijan; the exact World Medicine Kazakhstan document calls the same name/composition/presentation a food supplement. Keep the jurisdiction-specific categories distinct.
  • Do not infer that all B vitamins are required because one deficiency is plausible. Ingredient or comparator evidence cannot validate this fixed high-dose ratio or transfer another product’s dose.
  • Each tablet contains 200 mg pyridoxine with four other vitamins. No product-specific dog/cat exposure threshold, safe duration or therapeutic margin is established.
  • High experimental pyridoxine exposure caused sensory-neuron injury in dogs. Those studies do not define a safe lower Benevron regimen, but they rule out assuming that water solubility makes chronic high-dose exposure harmless.
  • Review hypersensitivity to active ingredients and excipients. The exact product document lists sulfite and paraben excipients; target-animal tolerability is not established.
  • Review the full medication plan, especially levodopa without a peripheral decarboxylase inhibitor and other vitamin-containing products. Avoid unexamined cumulative exposure.
  • Set a diagnosis-specific response point and stop date. If response is absent, reassess diet, malabsorption, antagonists, primary disease and the actual deficient nutrient rather than continuing empirical B-complex treatment.
Assessment sources
Assessed: 23 Oct 2026No axis or overall score is shown when the available evidence does not support a responsible numerical assessment.
Composition / strength
Thiamine250 mg Pyridoxine200 mg Riboflavin15 mg Folic acid0.5 mg Cyanocobalamin0.25 mg
Formulation Type
Coated tablet
Administration route
By mouth
Registration
Georgia Yes, human
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
Information not fully verified No dog or cat dose was identified for this exact high-dose five-vitamin gastro-resistant product. The exact public documents contain human directions only and do not establish tablet subdivision, crushing, veterinary exposure or a treatment course.

Kobalexin 1000 mcg/ml, Solution

1 ml ampoule, solution for injection, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder
7.2/10
Good
vetman assessment

Kobalexin

1000 mcg/ml, 1 ml ampoule, solution for injection, human medicine
Assessed clinical scopeDog · SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder · SC,IM
Care settingVeterinary clinic or a trained home-treatment plan after deficiency and cause assessment, with exact small-volume measurement, injection-site rotation, follow-up cobalamin or methylmalonic-acid testing and treatment of the underlying disease
vetman score 7.2/10 Good
Evidence confidence: Medium Georgia: Yes, human · № რ-037560 · Verified on 16 Oct 2026 Off-label use

A useful, generally safe parenteral replacement when true cobalamin deficiency is documented or strongly supported and injection is preferred for severity, adherence or clinical context. It should accompany cause-directed care and follow-up testing; oral supplementation is a credible less-invasive alternative for many stable dogs and cats.

Regulatory and scientific credibility5.5/10

The exact human cyanocobalamin ampoule has a sourced current Georgian registration and identifiable strength, route and manufacturer, while exhaustive current checks record it as not registered in EU/EEA, GB or US. Veterinary use is off-label and exact-product animal evidence is absent.

Clinical efficacy7.5/10

Parenteral cobalamin reliably raises cobalamin and lowers methylmalonic acid in deficient dogs and cats, with feline clinical improvement reported and randomized canine evidence supporting biochemical normalization. It remains adjunctive to diagnosis and treatment of enteropathy, exocrine pancreatic insufficiency or another cause; oral cobalamin is often similarly effective, so injections are not inherently superior for every stable patient.

Safety and tolerability8.0/10

Cyanocobalamin has a wide therapeutic margin and serious toxicity is uncommon. Relevant risks are injection pain, local inflammation, rare cobalt/cobalamin or excipient hypersensitivity including anaphylaxis, and potassium decline during brisk correction of severe deficiency; the exact human ampoule excipients and neonatal suitability require verification.

Clinical practicality8.0/10

The sterile 1000 mcg/ml single-use ampoule supplies common feline and canine replacement amounts in a small SC or IM volume; a 250 mcg feline dose is 0.25 ml, so a precise low-dead-space syringe is required. Repeated injections and visits remain a burden compared with effective daily oral supplementation, and the ampoule remainder must be discarded.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not administer to a patient with known cobalt, cobalamin or product-excipient hypersensitivity. Parenteral vitamin B12 has rarely caused anaphylaxis; have observation and emergency treatment available, especially after a previous unexplained injection reaction.
  • Confirm deficiency with an appropriate cobalamin assay and, when results or clinical response are equivocal, methylmalonic acid or other diagnostic context. Do not use cyanocobalamin as an empirical tonic, nonspecific appetite stimulant or substitute for investigating weight loss, anaemia, neuropathy or chronic gastrointestinal signs.
  • Treat the cause of deficiency, including chronic enteropathy, ileal disease, exocrine pancreatic insufficiency, altered intestinal anatomy or an inadequate diet. Cobalamin can correct a deficiency marker but cannot by itself control inflammation, infection, pancreatic failure, neoplasia or malnutrition.
  • Recheck clinical response and serum cobalamin after the replacement course and consider methylmalonic acid when functional deficiency remains uncertain. Draw planned baseline samples before supplementation and interpret very high post-treatment concentrations in light of timing rather than escalating automatically.
  • During brisk correction of severe deficiency or megaloblastic anaemia, monitor potassium and the haematologic response; hypokalaemia and arrhythmia have been reported with intensive parenteral replacement. Investigate concurrent folate, iron or other deficiencies rather than assuming nonresponse means a higher B12 dose.
  • Oral cobalamin normalized biochemical markers similarly to injections in randomized canine studies and has supportive feline evidence. Reassess whether repeated SC/IM visits, restraint and injection discomfort add value for a stable patient who can reliably receive an appropriate oral product.
  • Verify the exact ampoule excipients before neonatal, very small, renal-impaired or repeated use; human cyanocobalamin products may contain benzyl alcohol or trace aluminum, and formulations are not interchangeable by appearance. Use only the labelled SC/IM routes and concentration.
  • Protect the ampoule from light according to its insert, inspect the solution and container, use an accurate low-dead-space syringe and aseptic technique, rotate injection sites, and discard the unused remainder of a breached single-use ampoule rather than sharing it between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder
7.2/10
Good
vetman assessment

Kobalexin

1000 mcg/ml, 1 ml ampoule, solution for injection, human medicine
Assessed clinical scopeCat · SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder · SC,IM
Care settingVeterinary clinic or a trained home-treatment plan after deficiency and cause assessment, with exact small-volume measurement, injection-site rotation, follow-up cobalamin or methylmalonic-acid testing and treatment of the underlying disease
vetman score 7.2/10 Good
Evidence confidence: Medium Georgia: Yes, human · № რ-037560 · Verified on 16 Oct 2026 Off-label use

A useful, generally safe parenteral replacement when true cobalamin deficiency is documented or strongly supported and injection is preferred for severity, adherence or clinical context. It should accompany cause-directed care and follow-up testing; oral supplementation is a credible less-invasive alternative for many stable dogs and cats.

Regulatory and scientific credibility5.5/10

The exact human cyanocobalamin ampoule has a sourced current Georgian registration and identifiable strength, route and manufacturer, while exhaustive current checks record it as not registered in EU/EEA, GB or US. Veterinary use is off-label and exact-product animal evidence is absent.

Clinical efficacy7.5/10

Parenteral cobalamin reliably raises cobalamin and lowers methylmalonic acid in deficient dogs and cats, with feline clinical improvement reported and randomized canine evidence supporting biochemical normalization. It remains adjunctive to diagnosis and treatment of enteropathy, exocrine pancreatic insufficiency or another cause; oral cobalamin is often similarly effective, so injections are not inherently superior for every stable patient.

Safety and tolerability8.0/10

Cyanocobalamin has a wide therapeutic margin and serious toxicity is uncommon. Relevant risks are injection pain, local inflammation, rare cobalt/cobalamin or excipient hypersensitivity including anaphylaxis, and potassium decline during brisk correction of severe deficiency; the exact human ampoule excipients and neonatal suitability require verification.

Clinical practicality8.0/10

The sterile 1000 mcg/ml single-use ampoule supplies common feline and canine replacement amounts in a small SC or IM volume; a 250 mcg feline dose is 0.25 ml, so a precise low-dead-space syringe is required. Repeated injections and visits remain a burden compared with effective daily oral supplementation, and the ampoule remainder must be discarded.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not administer to a patient with known cobalt, cobalamin or product-excipient hypersensitivity. Parenteral vitamin B12 has rarely caused anaphylaxis; have observation and emergency treatment available, especially after a previous unexplained injection reaction.
  • Confirm deficiency with an appropriate cobalamin assay and, when results or clinical response are equivocal, methylmalonic acid or other diagnostic context. Do not use cyanocobalamin as an empirical tonic, nonspecific appetite stimulant or substitute for investigating weight loss, anaemia, neuropathy or chronic gastrointestinal signs.
  • Treat the cause of deficiency, including chronic enteropathy, ileal disease, exocrine pancreatic insufficiency, altered intestinal anatomy or an inadequate diet. Cobalamin can correct a deficiency marker but cannot by itself control inflammation, infection, pancreatic failure, neoplasia or malnutrition.
  • Recheck clinical response and serum cobalamin after the replacement course and consider methylmalonic acid when functional deficiency remains uncertain. Draw planned baseline samples before supplementation and interpret very high post-treatment concentrations in light of timing rather than escalating automatically.
  • During brisk correction of severe deficiency or megaloblastic anaemia, monitor potassium and the haematologic response; hypokalaemia and arrhythmia have been reported with intensive parenteral replacement. Investigate concurrent folate, iron or other deficiencies rather than assuming nonresponse means a higher B12 dose.
  • Oral cobalamin normalized biochemical markers similarly to injections in randomized canine studies and has supportive feline evidence. Reassess whether repeated SC/IM visits, restraint and injection discomfort add value for a stable patient who can reliably receive an appropriate oral product.
  • Verify the exact ampoule excipients before neonatal, very small, renal-impaired or repeated use; human cyanocobalamin products may contain benzyl alcohol or trace aluminum, and formulations are not interchangeable by appearance. Use only the labelled SC/IM routes and concentration.
  • Protect the ampoule from light according to its insert, inspect the solution and container, use an accurate low-dead-space syringe and aseptic technique, rotate injection sites, and discard the unused remainder of a breached single-use ampoule rather than sharing it between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Formulation Type
Solution
Administration route
Subcutaneous, Intramuscular
Manufacturer
Registration
Georgia Yes, human
In force until 14 Mar 2028
Human (Ministry of Health, RAMA)
In the register: კობალექსინი 1000 მკგ/მლ, 1 მლ ამპულა, საინექციო ხსნარი
№ რ-037560
Verified on: 16 Oct 2026
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Optovit B12 1000 mcg/2 ml, Solution

2 ml ampoule, solution for injection, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder
7.1/10
Good
vetman assessment

Optovit B12

1000 mcg/2 ml, 2 ml ampoule, solution for injection, human medicine
Assessed clinical scopeDog · SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder · SC,IM
Care settingVeterinary clinic or a trained home-treatment plan after deficiency and cause assessment, with exact small-volume measurement, injection-site rotation, follow-up cobalamin or methylmalonic-acid testing and treatment of the underlying disease
vetman score 7.1/10 Good
Evidence confidence: Medium Georgia: Yes, human · № რ-044999 · Verified on 16 Oct 2026 Off-label use

A useful, generally safe parenteral replacement when true cobalamin deficiency is documented or strongly supported and injection is preferred for severity, adherence or clinical context. It should accompany cause-directed care and follow-up testing; oral supplementation is a credible less-invasive alternative for many stable dogs and cats.

Regulatory and scientific credibility5.5/10

The exact human cyanocobalamin ampoule has a sourced current Georgian registration and identifiable strength, route and manufacturer, while exhaustive current checks record it as not registered in EU/EEA, GB or US. Veterinary use is off-label and exact-product animal evidence is absent.

Clinical efficacy7.5/10

Parenteral cobalamin reliably raises cobalamin and lowers methylmalonic acid in deficient dogs and cats, with feline clinical improvement reported and randomized canine evidence supporting biochemical normalization. It remains adjunctive to diagnosis and treatment of enteropathy, exocrine pancreatic insufficiency or another cause; oral cobalamin is often similarly effective, so injections are not inherently superior for every stable patient.

Safety and tolerability8.0/10

Cyanocobalamin has a wide therapeutic margin and serious toxicity is uncommon. Relevant risks are injection pain, local inflammation, rare cobalt/cobalamin or excipient hypersensitivity including anaphylaxis, and potassium decline during brisk correction of severe deficiency; the exact human ampoule excipients and neonatal suitability require verification.

Clinical practicality7.5/10

The sterile 500 mcg/ml single-use ampoule is straightforward for SC or IM replacement; a 250 mcg feline dose is 0.5 ml and published canine weight-band amounts fit practical volumes. Repeated injections and visits remain a burden compared with effective daily oral supplementation, and the ampoule remainder must be discarded.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not administer to a patient with known cobalt, cobalamin or product-excipient hypersensitivity. Parenteral vitamin B12 has rarely caused anaphylaxis; have observation and emergency treatment available, especially after a previous unexplained injection reaction.
  • Confirm deficiency with an appropriate cobalamin assay and, when results or clinical response are equivocal, methylmalonic acid or other diagnostic context. Do not use cyanocobalamin as an empirical tonic, nonspecific appetite stimulant or substitute for investigating weight loss, anaemia, neuropathy or chronic gastrointestinal signs.
  • Treat the cause of deficiency, including chronic enteropathy, ileal disease, exocrine pancreatic insufficiency, altered intestinal anatomy or an inadequate diet. Cobalamin can correct a deficiency marker but cannot by itself control inflammation, infection, pancreatic failure, neoplasia or malnutrition.
  • Recheck clinical response and serum cobalamin after the replacement course and consider methylmalonic acid when functional deficiency remains uncertain. Draw planned baseline samples before supplementation and interpret very high post-treatment concentrations in light of timing rather than escalating automatically.
  • During brisk correction of severe deficiency or megaloblastic anaemia, monitor potassium and the haematologic response; hypokalaemia and arrhythmia have been reported with intensive parenteral replacement. Investigate concurrent folate, iron or other deficiencies rather than assuming nonresponse means a higher B12 dose.
  • Oral cobalamin normalized biochemical markers similarly to injections in randomized canine studies and has supportive feline evidence. Reassess whether repeated SC/IM visits, restraint and injection discomfort add value for a stable patient who can reliably receive an appropriate oral product.
  • Verify the exact ampoule excipients before neonatal, very small, renal-impaired or repeated use; human cyanocobalamin products may contain benzyl alcohol or trace aluminum, and formulations are not interchangeable by appearance. Use only the labelled SC/IM routes and concentration.
  • Protect the ampoule from light according to its insert, inspect the solution and container, use an accurate low-dead-space syringe and aseptic technique, rotate injection sites, and discard the unused remainder of a breached single-use ampoule rather than sharing it between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder
7.1/10
Good
vetman assessment

Optovit B12

1000 mcg/2 ml, 2 ml ampoule, solution for injection, human medicine
Assessed clinical scopeCat · SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder · SC,IM
Care settingVeterinary clinic or a trained home-treatment plan after deficiency and cause assessment, with exact small-volume measurement, injection-site rotation, follow-up cobalamin or methylmalonic-acid testing and treatment of the underlying disease
vetman score 7.1/10 Good
Evidence confidence: Medium Georgia: Yes, human · № რ-044999 · Verified on 16 Oct 2026 Off-label use

A useful, generally safe parenteral replacement when true cobalamin deficiency is documented or strongly supported and injection is preferred for severity, adherence or clinical context. It should accompany cause-directed care and follow-up testing; oral supplementation is a credible less-invasive alternative for many stable dogs and cats.

Regulatory and scientific credibility5.5/10

The exact human cyanocobalamin ampoule has a sourced current Georgian registration and identifiable strength, route and manufacturer, while exhaustive current checks record it as not registered in EU/EEA, GB or US. Veterinary use is off-label and exact-product animal evidence is absent.

Clinical efficacy7.5/10

Parenteral cobalamin reliably raises cobalamin and lowers methylmalonic acid in deficient dogs and cats, with feline clinical improvement reported and randomized canine evidence supporting biochemical normalization. It remains adjunctive to diagnosis and treatment of enteropathy, exocrine pancreatic insufficiency or another cause; oral cobalamin is often similarly effective, so injections are not inherently superior for every stable patient.

Safety and tolerability8.0/10

Cyanocobalamin has a wide therapeutic margin and serious toxicity is uncommon. Relevant risks are injection pain, local inflammation, rare cobalt/cobalamin or excipient hypersensitivity including anaphylaxis, and potassium decline during brisk correction of severe deficiency; the exact human ampoule excipients and neonatal suitability require verification.

Clinical practicality7.5/10

The sterile 500 mcg/ml single-use ampoule is straightforward for SC or IM replacement; a 250 mcg feline dose is 0.5 ml and published canine weight-band amounts fit practical volumes. Repeated injections and visits remain a burden compared with effective daily oral supplementation, and the ampoule remainder must be discarded.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not administer to a patient with known cobalt, cobalamin or product-excipient hypersensitivity. Parenteral vitamin B12 has rarely caused anaphylaxis; have observation and emergency treatment available, especially after a previous unexplained injection reaction.
  • Confirm deficiency with an appropriate cobalamin assay and, when results or clinical response are equivocal, methylmalonic acid or other diagnostic context. Do not use cyanocobalamin as an empirical tonic, nonspecific appetite stimulant or substitute for investigating weight loss, anaemia, neuropathy or chronic gastrointestinal signs.
  • Treat the cause of deficiency, including chronic enteropathy, ileal disease, exocrine pancreatic insufficiency, altered intestinal anatomy or an inadequate diet. Cobalamin can correct a deficiency marker but cannot by itself control inflammation, infection, pancreatic failure, neoplasia or malnutrition.
  • Recheck clinical response and serum cobalamin after the replacement course and consider methylmalonic acid when functional deficiency remains uncertain. Draw planned baseline samples before supplementation and interpret very high post-treatment concentrations in light of timing rather than escalating automatically.
  • During brisk correction of severe deficiency or megaloblastic anaemia, monitor potassium and the haematologic response; hypokalaemia and arrhythmia have been reported with intensive parenteral replacement. Investigate concurrent folate, iron or other deficiencies rather than assuming nonresponse means a higher B12 dose.
  • Oral cobalamin normalized biochemical markers similarly to injections in randomized canine studies and has supportive feline evidence. Reassess whether repeated SC/IM visits, restraint and injection discomfort add value for a stable patient who can reliably receive an appropriate oral product.
  • Verify the exact ampoule excipients before neonatal, very small, renal-impaired or repeated use; human cyanocobalamin products may contain benzyl alcohol or trace aluminum, and formulations are not interchangeable by appearance. Use only the labelled SC/IM routes and concentration.
  • Protect the ampoule from light according to its insert, inspect the solution and container, use an accurate low-dead-space syringe and aseptic technique, rotate injection sites, and discard the unused remainder of a breached single-use ampoule rather than sharing it between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Cyanocobalamin0.5 mg/ml
Formulation Type
Solution
Administration route
Subcutaneous, Intramuscular
Manufacturer
Normon · Spain
Registration
Georgia Yes, human
In force until 16 Mar 2031
Human (Ministry of Health, RAMA)
In the register: ოპტოვიტი B12 1000 მკგ/2 მლ, 2 მლ ამპულა, საინექციო ხსნარი
№ რ-044999
Verified on: 16 Oct 2026
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Vitamin B12 Biopolus 500 mcg/ml (0.05%), Solution

1 ml ampoule, solution for injection, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder
7.1/10
Good
vetman assessment

Vitamin B12 Biopolus

500 mcg/ml (0.05%), 1 ml ampoule, solution for injection, human medicine
Assessed clinical scopeDog · SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder · SC,IM
Care settingVeterinary clinic or a trained home-treatment plan after deficiency and cause assessment, with exact small-volume measurement, injection-site rotation, follow-up cobalamin or methylmalonic-acid testing and treatment of the underlying disease
vetman score 7.1/10 Good
Evidence confidence: Medium Georgia: Yes, human · № რ-035391 · Verified on 16 Oct 2026 Off-label use

A useful, generally safe parenteral replacement when true cobalamin deficiency is documented or strongly supported and injection is preferred for severity, adherence or clinical context. It should accompany cause-directed care and follow-up testing; oral supplementation is a credible less-invasive alternative for many stable dogs and cats.

Regulatory and scientific credibility5.5/10

The exact human cyanocobalamin ampoule has a sourced current Georgian registration and identifiable strength, route and manufacturer, while exhaustive current checks record it as not registered in EU/EEA, GB or US. Veterinary use is off-label and exact-product animal evidence is absent.

Clinical efficacy7.5/10

Parenteral cobalamin reliably raises cobalamin and lowers methylmalonic acid in deficient dogs and cats, with feline clinical improvement reported and randomized canine evidence supporting biochemical normalization. It remains adjunctive to diagnosis and treatment of enteropathy, exocrine pancreatic insufficiency or another cause; oral cobalamin is often similarly effective, so injections are not inherently superior for every stable patient.

Safety and tolerability8.0/10

Cyanocobalamin has a wide therapeutic margin and serious toxicity is uncommon. Relevant risks are injection pain, local inflammation, rare cobalt/cobalamin or excipient hypersensitivity including anaphylaxis, and potassium decline during brisk correction of severe deficiency; the exact human ampoule excipients and neonatal suitability require verification.

Clinical practicality7.5/10

The sterile 500 mcg/ml single-use ampoule is straightforward for SC or IM replacement; a 250 mcg feline dose is 0.5 ml and published canine weight-band amounts fit practical volumes. Repeated injections and visits remain a burden compared with effective daily oral supplementation, and the ampoule remainder must be discarded.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not administer to a patient with known cobalt, cobalamin or product-excipient hypersensitivity. Parenteral vitamin B12 has rarely caused anaphylaxis; have observation and emergency treatment available, especially after a previous unexplained injection reaction.
  • Confirm deficiency with an appropriate cobalamin assay and, when results or clinical response are equivocal, methylmalonic acid or other diagnostic context. Do not use cyanocobalamin as an empirical tonic, nonspecific appetite stimulant or substitute for investigating weight loss, anaemia, neuropathy or chronic gastrointestinal signs.
  • Treat the cause of deficiency, including chronic enteropathy, ileal disease, exocrine pancreatic insufficiency, altered intestinal anatomy or an inadequate diet. Cobalamin can correct a deficiency marker but cannot by itself control inflammation, infection, pancreatic failure, neoplasia or malnutrition.
  • Recheck clinical response and serum cobalamin after the replacement course and consider methylmalonic acid when functional deficiency remains uncertain. Draw planned baseline samples before supplementation and interpret very high post-treatment concentrations in light of timing rather than escalating automatically.
  • During brisk correction of severe deficiency or megaloblastic anaemia, monitor potassium and the haematologic response; hypokalaemia and arrhythmia have been reported with intensive parenteral replacement. Investigate concurrent folate, iron or other deficiencies rather than assuming nonresponse means a higher B12 dose.
  • Oral cobalamin normalized biochemical markers similarly to injections in randomized canine studies and has supportive feline evidence. Reassess whether repeated SC/IM visits, restraint and injection discomfort add value for a stable patient who can reliably receive an appropriate oral product.
  • Verify the exact ampoule excipients before neonatal, very small, renal-impaired or repeated use; human cyanocobalamin products may contain benzyl alcohol or trace aluminum, and formulations are not interchangeable by appearance. Use only the labelled SC/IM routes and concentration.
  • Protect the ampoule from light according to its insert, inspect the solution and container, use an accurate low-dead-space syringe and aseptic technique, rotate injection sites, and discard the unused remainder of a breached single-use ampoule rather than sharing it between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder
7.1/10
Good
vetman assessment

Vitamin B12 Biopolus

500 mcg/ml (0.05%), 1 ml ampoule, solution for injection, human medicine
Assessed clinical scopeCat · SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder · SC,IM
Care settingVeterinary clinic or a trained home-treatment plan after deficiency and cause assessment, with exact small-volume measurement, injection-site rotation, follow-up cobalamin or methylmalonic-acid testing and treatment of the underlying disease
vetman score 7.1/10 Good
Evidence confidence: Medium Georgia: Yes, human · № რ-035391 · Verified on 16 Oct 2026 Off-label use

A useful, generally safe parenteral replacement when true cobalamin deficiency is documented or strongly supported and injection is preferred for severity, adherence or clinical context. It should accompany cause-directed care and follow-up testing; oral supplementation is a credible less-invasive alternative for many stable dogs and cats.

Regulatory and scientific credibility5.5/10

The exact human cyanocobalamin ampoule has a sourced current Georgian registration and identifiable strength, route and manufacturer, while exhaustive current checks record it as not registered in EU/EEA, GB or US. Veterinary use is off-label and exact-product animal evidence is absent.

Clinical efficacy7.5/10

Parenteral cobalamin reliably raises cobalamin and lowers methylmalonic acid in deficient dogs and cats, with feline clinical improvement reported and randomized canine evidence supporting biochemical normalization. It remains adjunctive to diagnosis and treatment of enteropathy, exocrine pancreatic insufficiency or another cause; oral cobalamin is often similarly effective, so injections are not inherently superior for every stable patient.

Safety and tolerability8.0/10

Cyanocobalamin has a wide therapeutic margin and serious toxicity is uncommon. Relevant risks are injection pain, local inflammation, rare cobalt/cobalamin or excipient hypersensitivity including anaphylaxis, and potassium decline during brisk correction of severe deficiency; the exact human ampoule excipients and neonatal suitability require verification.

Clinical practicality7.5/10

The sterile 500 mcg/ml single-use ampoule is straightforward for SC or IM replacement; a 250 mcg feline dose is 0.5 ml and published canine weight-band amounts fit practical volumes. Repeated injections and visits remain a burden compared with effective daily oral supplementation, and the ampoule remainder must be discarded.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not administer to a patient with known cobalt, cobalamin or product-excipient hypersensitivity. Parenteral vitamin B12 has rarely caused anaphylaxis; have observation and emergency treatment available, especially after a previous unexplained injection reaction.
  • Confirm deficiency with an appropriate cobalamin assay and, when results or clinical response are equivocal, methylmalonic acid or other diagnostic context. Do not use cyanocobalamin as an empirical tonic, nonspecific appetite stimulant or substitute for investigating weight loss, anaemia, neuropathy or chronic gastrointestinal signs.
  • Treat the cause of deficiency, including chronic enteropathy, ileal disease, exocrine pancreatic insufficiency, altered intestinal anatomy or an inadequate diet. Cobalamin can correct a deficiency marker but cannot by itself control inflammation, infection, pancreatic failure, neoplasia or malnutrition.
  • Recheck clinical response and serum cobalamin after the replacement course and consider methylmalonic acid when functional deficiency remains uncertain. Draw planned baseline samples before supplementation and interpret very high post-treatment concentrations in light of timing rather than escalating automatically.
  • During brisk correction of severe deficiency or megaloblastic anaemia, monitor potassium and the haematologic response; hypokalaemia and arrhythmia have been reported with intensive parenteral replacement. Investigate concurrent folate, iron or other deficiencies rather than assuming nonresponse means a higher B12 dose.
  • Oral cobalamin normalized biochemical markers similarly to injections in randomized canine studies and has supportive feline evidence. Reassess whether repeated SC/IM visits, restraint and injection discomfort add value for a stable patient who can reliably receive an appropriate oral product.
  • Verify the exact ampoule excipients before neonatal, very small, renal-impaired or repeated use; human cyanocobalamin products may contain benzyl alcohol or trace aluminum, and formulations are not interchangeable by appearance. Use only the labelled SC/IM routes and concentration.
  • Protect the ampoule from light according to its insert, inspect the solution and container, use an accurate low-dead-space syringe and aseptic technique, rotate injection sites, and discard the unused remainder of a breached single-use ampoule rather than sharing it between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Cyanocobalamin0.5 mg/ml
Formulation Type
Solution
Administration route
Subcutaneous, Intramuscular
Manufacturer
Registration
Georgia Yes, human
In force until 31 May 2027
Human (Ministry of Health, RAMA)
In the register: ვიტამინი B12 ბიოპოლუსი 500 მკგ/მლ (0.05%), 1 მლ ამპულა, საინექციო ხსნარი
№ რ-035391
Verified on: 16 Oct 2026
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Vitamin B12 Sopharma 500 mcg/ml, Solution

1 ml ampoule, solution for injection, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder
7.4/10
Good
vetman assessment

Vitamin B12 Sopharma

500 mcg/ml, 1 ml ampoule, solution for injection, human medicine
Assessed clinical scopeDog · SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder · SC,IM
Care settingVeterinary clinic or a trained home-treatment plan after deficiency and cause assessment, with exact small-volume measurement, injection-site rotation, follow-up cobalamin or methylmalonic-acid testing and treatment of the underlying disease
vetman score 7.4/10 Good
Evidence confidence: Medium Georgia: Yes, human · № რ-044521 · Verified on 16 Oct 2026 Off-label use

A useful, generally safe parenteral replacement when true cobalamin deficiency is documented or strongly supported and injection is preferred for severity, adherence or clinical context. It should accompany cause-directed care and follow-up testing; oral supplementation is a credible less-invasive alternative for many stable dogs and cats.

Regulatory and scientific credibility6.5/10

This exact Sopharma cyanocobalamin ampoule has sourced current registrations in Georgia and EU/EEA with identifiable strength, route and manufacturer, while current checks record no exact GB or US registration. Veterinary use is off-label and exact-product animal evidence is absent.

Clinical efficacy7.5/10

Parenteral cobalamin reliably raises cobalamin and lowers methylmalonic acid in deficient dogs and cats, with feline clinical improvement reported and randomized canine evidence supporting biochemical normalization. It remains adjunctive to diagnosis and treatment of enteropathy, exocrine pancreatic insufficiency or another cause; oral cobalamin is often similarly effective, so injections are not inherently superior for every stable patient.

Safety and tolerability8.0/10

Cyanocobalamin has a wide therapeutic margin and serious toxicity is uncommon. Relevant risks are injection pain, local inflammation, rare cobalt/cobalamin or excipient hypersensitivity including anaphylaxis, and potassium decline during brisk correction of severe deficiency; the exact human ampoule excipients and neonatal suitability require verification.

Clinical practicality7.5/10

The sterile 500 mcg/ml single-use ampoule is straightforward for SC or IM replacement; a 250 mcg feline dose is 0.5 ml and published canine weight-band amounts fit practical volumes. Repeated injections and visits remain a burden compared with effective daily oral supplementation, and the ampoule remainder must be discarded.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not administer to a patient with known cobalt, cobalamin or product-excipient hypersensitivity. Parenteral vitamin B12 has rarely caused anaphylaxis; have observation and emergency treatment available, especially after a previous unexplained injection reaction.
  • Confirm deficiency with an appropriate cobalamin assay and, when results or clinical response are equivocal, methylmalonic acid or other diagnostic context. Do not use cyanocobalamin as an empirical tonic, nonspecific appetite stimulant or substitute for investigating weight loss, anaemia, neuropathy or chronic gastrointestinal signs.
  • Treat the cause of deficiency, including chronic enteropathy, ileal disease, exocrine pancreatic insufficiency, altered intestinal anatomy or an inadequate diet. Cobalamin can correct a deficiency marker but cannot by itself control inflammation, infection, pancreatic failure, neoplasia or malnutrition.
  • Recheck clinical response and serum cobalamin after the replacement course and consider methylmalonic acid when functional deficiency remains uncertain. Draw planned baseline samples before supplementation and interpret very high post-treatment concentrations in light of timing rather than escalating automatically.
  • During brisk correction of severe deficiency or megaloblastic anaemia, monitor potassium and the haematologic response; hypokalaemia and arrhythmia have been reported with intensive parenteral replacement. Investigate concurrent folate, iron or other deficiencies rather than assuming nonresponse means a higher B12 dose.
  • Oral cobalamin normalized biochemical markers similarly to injections in randomized canine studies and has supportive feline evidence. Reassess whether repeated SC/IM visits, restraint and injection discomfort add value for a stable patient who can reliably receive an appropriate oral product.
  • Verify the exact ampoule excipients before neonatal, very small, renal-impaired or repeated use; human cyanocobalamin products may contain benzyl alcohol or trace aluminum, and formulations are not interchangeable by appearance. Use only the labelled SC/IM routes and concentration.
  • Protect the ampoule from light according to its insert, inspect the solution and container, use an accurate low-dead-space syringe and aseptic technique, rotate injection sites, and discard the unused remainder of a breached single-use ampoule rather than sharing it between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder
7.4/10
Good
vetman assessment

Vitamin B12 Sopharma

500 mcg/ml, 1 ml ampoule, solution for injection, human medicine
Assessed clinical scopeCat · SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder · SC,IM
Care settingVeterinary clinic or a trained home-treatment plan after deficiency and cause assessment, with exact small-volume measurement, injection-site rotation, follow-up cobalamin or methylmalonic-acid testing and treatment of the underlying disease
vetman score 7.4/10 Good
Evidence confidence: Medium Georgia: Yes, human · № რ-044521 · Verified on 16 Oct 2026 Off-label use

A useful, generally safe parenteral replacement when true cobalamin deficiency is documented or strongly supported and injection is preferred for severity, adherence or clinical context. It should accompany cause-directed care and follow-up testing; oral supplementation is a credible less-invasive alternative for many stable dogs and cats.

Regulatory and scientific credibility6.5/10

This exact Sopharma cyanocobalamin ampoule has sourced current registrations in Georgia and EU/EEA with identifiable strength, route and manufacturer, while current checks record no exact GB or US registration. Veterinary use is off-label and exact-product animal evidence is absent.

Clinical efficacy7.5/10

Parenteral cobalamin reliably raises cobalamin and lowers methylmalonic acid in deficient dogs and cats, with feline clinical improvement reported and randomized canine evidence supporting biochemical normalization. It remains adjunctive to diagnosis and treatment of enteropathy, exocrine pancreatic insufficiency or another cause; oral cobalamin is often similarly effective, so injections are not inherently superior for every stable patient.

Safety and tolerability8.0/10

Cyanocobalamin has a wide therapeutic margin and serious toxicity is uncommon. Relevant risks are injection pain, local inflammation, rare cobalt/cobalamin or excipient hypersensitivity including anaphylaxis, and potassium decline during brisk correction of severe deficiency; the exact human ampoule excipients and neonatal suitability require verification.

Clinical practicality7.5/10

The sterile 500 mcg/ml single-use ampoule is straightforward for SC or IM replacement; a 250 mcg feline dose is 0.5 ml and published canine weight-band amounts fit practical volumes. Repeated injections and visits remain a burden compared with effective daily oral supplementation, and the ampoule remainder must be discarded.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not administer to a patient with known cobalt, cobalamin or product-excipient hypersensitivity. Parenteral vitamin B12 has rarely caused anaphylaxis; have observation and emergency treatment available, especially after a previous unexplained injection reaction.
  • Confirm deficiency with an appropriate cobalamin assay and, when results or clinical response are equivocal, methylmalonic acid or other diagnostic context. Do not use cyanocobalamin as an empirical tonic, nonspecific appetite stimulant or substitute for investigating weight loss, anaemia, neuropathy or chronic gastrointestinal signs.
  • Treat the cause of deficiency, including chronic enteropathy, ileal disease, exocrine pancreatic insufficiency, altered intestinal anatomy or an inadequate diet. Cobalamin can correct a deficiency marker but cannot by itself control inflammation, infection, pancreatic failure, neoplasia or malnutrition.
  • Recheck clinical response and serum cobalamin after the replacement course and consider methylmalonic acid when functional deficiency remains uncertain. Draw planned baseline samples before supplementation and interpret very high post-treatment concentrations in light of timing rather than escalating automatically.
  • During brisk correction of severe deficiency or megaloblastic anaemia, monitor potassium and the haematologic response; hypokalaemia and arrhythmia have been reported with intensive parenteral replacement. Investigate concurrent folate, iron or other deficiencies rather than assuming nonresponse means a higher B12 dose.
  • Oral cobalamin normalized biochemical markers similarly to injections in randomized canine studies and has supportive feline evidence. Reassess whether repeated SC/IM visits, restraint and injection discomfort add value for a stable patient who can reliably receive an appropriate oral product.
  • Verify the exact ampoule excipients before neonatal, very small, renal-impaired or repeated use; human cyanocobalamin products may contain benzyl alcohol or trace aluminum, and formulations are not interchangeable by appearance. Use only the labelled SC/IM routes and concentration.
  • Protect the ampoule from light according to its insert, inspect the solution and container, use an accurate low-dead-space syringe and aseptic technique, rotate injection sites, and discard the unused remainder of a breached single-use ampoule rather than sharing it between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Cyanocobalamin0.5 mg/ml
Formulation Type
Solution
Administration route
Subcutaneous, Intramuscular
Manufacturer
Sopharma · Bulgaria
Registration
Georgia Yes, human
In force until 19 Dec 2030
Human (Ministry of Health, RAMA)
In the register: ვიტამინი B12 სოფარმა 500 მკგ/მლ, 1 მლ ამპულა, საინექციო ხსნარი
№ რ-044521
Verified on: 16 Oct 2026
EU Yes, human
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Vitamin B12 Sopharma 1000 mcg/ml, Solution

1 ml ampoule, solution for injection, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder
7.4/10
Good
vetman assessment

Vitamin B12 Sopharma

1000 mcg/ml, 1 ml ampoule, solution for injection, human medicine
Assessed clinical scopeDog · SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder · SC,IM
Care settingVeterinary clinic or a trained home-treatment plan after deficiency and cause assessment, with exact small-volume measurement, injection-site rotation, follow-up cobalamin or methylmalonic-acid testing and treatment of the underlying disease
vetman score 7.4/10 Good
Evidence confidence: Medium Georgia: Yes, human · № რ-044522 · Verified on 16 Oct 2026 Off-label use

A useful, generally safe parenteral replacement when true cobalamin deficiency is documented or strongly supported and injection is preferred for severity, adherence or clinical context. It should accompany cause-directed care and follow-up testing; oral supplementation is a credible less-invasive alternative for many stable dogs and cats.

Regulatory and scientific credibility6.5/10

This exact Sopharma cyanocobalamin ampoule has sourced current registrations in Georgia and EU/EEA with identifiable strength, route and manufacturer, while current checks record no exact GB or US registration. Veterinary use is off-label and exact-product animal evidence is absent.

Clinical efficacy7.5/10

Parenteral cobalamin reliably raises cobalamin and lowers methylmalonic acid in deficient dogs and cats, with feline clinical improvement reported and randomized canine evidence supporting biochemical normalization. It remains adjunctive to diagnosis and treatment of enteropathy, exocrine pancreatic insufficiency or another cause; oral cobalamin is often similarly effective, so injections are not inherently superior for every stable patient.

Safety and tolerability8.0/10

Cyanocobalamin has a wide therapeutic margin and serious toxicity is uncommon. Relevant risks are injection pain, local inflammation, rare cobalt/cobalamin or excipient hypersensitivity including anaphylaxis, and potassium decline during brisk correction of severe deficiency; the exact human ampoule excipients and neonatal suitability require verification.

Clinical practicality8.0/10

The sterile 1000 mcg/ml single-use ampoule supplies common feline and canine replacement amounts in a small SC or IM volume; a 250 mcg feline dose is 0.25 ml, so a precise low-dead-space syringe is required. Repeated injections and visits remain a burden compared with effective daily oral supplementation, and the ampoule remainder must be discarded.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not administer to a patient with known cobalt, cobalamin or product-excipient hypersensitivity. Parenteral vitamin B12 has rarely caused anaphylaxis; have observation and emergency treatment available, especially after a previous unexplained injection reaction.
  • Confirm deficiency with an appropriate cobalamin assay and, when results or clinical response are equivocal, methylmalonic acid or other diagnostic context. Do not use cyanocobalamin as an empirical tonic, nonspecific appetite stimulant or substitute for investigating weight loss, anaemia, neuropathy or chronic gastrointestinal signs.
  • Treat the cause of deficiency, including chronic enteropathy, ileal disease, exocrine pancreatic insufficiency, altered intestinal anatomy or an inadequate diet. Cobalamin can correct a deficiency marker but cannot by itself control inflammation, infection, pancreatic failure, neoplasia or malnutrition.
  • Recheck clinical response and serum cobalamin after the replacement course and consider methylmalonic acid when functional deficiency remains uncertain. Draw planned baseline samples before supplementation and interpret very high post-treatment concentrations in light of timing rather than escalating automatically.
  • During brisk correction of severe deficiency or megaloblastic anaemia, monitor potassium and the haematologic response; hypokalaemia and arrhythmia have been reported with intensive parenteral replacement. Investigate concurrent folate, iron or other deficiencies rather than assuming nonresponse means a higher B12 dose.
  • Oral cobalamin normalized biochemical markers similarly to injections in randomized canine studies and has supportive feline evidence. Reassess whether repeated SC/IM visits, restraint and injection discomfort add value for a stable patient who can reliably receive an appropriate oral product.
  • Verify the exact ampoule excipients before neonatal, very small, renal-impaired or repeated use; human cyanocobalamin products may contain benzyl alcohol or trace aluminum, and formulations are not interchangeable by appearance. Use only the labelled SC/IM routes and concentration.
  • Protect the ampoule from light according to its insert, inspect the solution and container, use an accurate low-dead-space syringe and aseptic technique, rotate injection sites, and discard the unused remainder of a breached single-use ampoule rather than sharing it between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder
7.4/10
Good
vetman assessment

Vitamin B12 Sopharma

1000 mcg/ml, 1 ml ampoule, solution for injection, human medicine
Assessed clinical scopeCat · SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder · SC,IM
Care settingVeterinary clinic or a trained home-treatment plan after deficiency and cause assessment, with exact small-volume measurement, injection-site rotation, follow-up cobalamin or methylmalonic-acid testing and treatment of the underlying disease
vetman score 7.4/10 Good
Evidence confidence: Medium Georgia: Yes, human · № რ-044522 · Verified on 16 Oct 2026 Off-label use

A useful, generally safe parenteral replacement when true cobalamin deficiency is documented or strongly supported and injection is preferred for severity, adherence or clinical context. It should accompany cause-directed care and follow-up testing; oral supplementation is a credible less-invasive alternative for many stable dogs and cats.

Regulatory and scientific credibility6.5/10

This exact Sopharma cyanocobalamin ampoule has sourced current registrations in Georgia and EU/EEA with identifiable strength, route and manufacturer, while current checks record no exact GB or US registration. Veterinary use is off-label and exact-product animal evidence is absent.

Clinical efficacy7.5/10

Parenteral cobalamin reliably raises cobalamin and lowers methylmalonic acid in deficient dogs and cats, with feline clinical improvement reported and randomized canine evidence supporting biochemical normalization. It remains adjunctive to diagnosis and treatment of enteropathy, exocrine pancreatic insufficiency or another cause; oral cobalamin is often similarly effective, so injections are not inherently superior for every stable patient.

Safety and tolerability8.0/10

Cyanocobalamin has a wide therapeutic margin and serious toxicity is uncommon. Relevant risks are injection pain, local inflammation, rare cobalt/cobalamin or excipient hypersensitivity including anaphylaxis, and potassium decline during brisk correction of severe deficiency; the exact human ampoule excipients and neonatal suitability require verification.

Clinical practicality8.0/10

The sterile 1000 mcg/ml single-use ampoule supplies common feline and canine replacement amounts in a small SC or IM volume; a 250 mcg feline dose is 0.25 ml, so a precise low-dead-space syringe is required. Repeated injections and visits remain a burden compared with effective daily oral supplementation, and the ampoule remainder must be discarded.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not administer to a patient with known cobalt, cobalamin or product-excipient hypersensitivity. Parenteral vitamin B12 has rarely caused anaphylaxis; have observation and emergency treatment available, especially after a previous unexplained injection reaction.
  • Confirm deficiency with an appropriate cobalamin assay and, when results or clinical response are equivocal, methylmalonic acid or other diagnostic context. Do not use cyanocobalamin as an empirical tonic, nonspecific appetite stimulant or substitute for investigating weight loss, anaemia, neuropathy or chronic gastrointestinal signs.
  • Treat the cause of deficiency, including chronic enteropathy, ileal disease, exocrine pancreatic insufficiency, altered intestinal anatomy or an inadequate diet. Cobalamin can correct a deficiency marker but cannot by itself control inflammation, infection, pancreatic failure, neoplasia or malnutrition.
  • Recheck clinical response and serum cobalamin after the replacement course and consider methylmalonic acid when functional deficiency remains uncertain. Draw planned baseline samples before supplementation and interpret very high post-treatment concentrations in light of timing rather than escalating automatically.
  • During brisk correction of severe deficiency or megaloblastic anaemia, monitor potassium and the haematologic response; hypokalaemia and arrhythmia have been reported with intensive parenteral replacement. Investigate concurrent folate, iron or other deficiencies rather than assuming nonresponse means a higher B12 dose.
  • Oral cobalamin normalized biochemical markers similarly to injections in randomized canine studies and has supportive feline evidence. Reassess whether repeated SC/IM visits, restraint and injection discomfort add value for a stable patient who can reliably receive an appropriate oral product.
  • Verify the exact ampoule excipients before neonatal, very small, renal-impaired or repeated use; human cyanocobalamin products may contain benzyl alcohol or trace aluminum, and formulations are not interchangeable by appearance. Use only the labelled SC/IM routes and concentration.
  • Protect the ampoule from light according to its insert, inspect the solution and container, use an accurate low-dead-space syringe and aseptic technique, rotate injection sites, and discard the unused remainder of a breached single-use ampoule rather than sharing it between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Formulation Type
Solution
Administration route
Subcutaneous, Intramuscular
Manufacturer
Sopharma · Bulgaria
Registration
Georgia Yes, human
In force until 19 Dec 2030
Human (Ministry of Health, RAMA)
In the register: ვიტამინი B12 სოფარმა 1000 მკგ/მლ, 1 მლ ამპულა, საინექციო ხსნარი
№ რ-044522
Verified on: 16 Oct 2026
EU Yes, human
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Vitamin B12 Tbilkimpharm 500 mcg/ml, Solution

1 ml ampoule, solution for injection, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder
7.1/10
Good
vetman assessment

Vitamin B12 Tbilkimpharm

500 mcg/ml, 1 ml ampoule, solution for injection, human medicine
Assessed clinical scopeDog · SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder · SC,IM
Care settingVeterinary clinic or a trained home-treatment plan after deficiency and cause assessment, with exact small-volume measurement, injection-site rotation, follow-up cobalamin or methylmalonic-acid testing and treatment of the underlying disease
vetman score 7.1/10 Good
Evidence confidence: Medium Georgia: Yes, human · № რ-035012 · Verified on 16 Oct 2026 Off-label use

A useful, generally safe parenteral replacement when true cobalamin deficiency is documented or strongly supported and injection is preferred for severity, adherence or clinical context. It should accompany cause-directed care and follow-up testing; oral supplementation is a credible less-invasive alternative for many stable dogs and cats.

Regulatory and scientific credibility5.5/10

The exact human cyanocobalamin ampoule has a sourced current Georgian registration and identifiable strength, route and manufacturer, while exhaustive current checks record it as not registered in EU/EEA, GB or US. Veterinary use is off-label and exact-product animal evidence is absent.

Clinical efficacy7.5/10

Parenteral cobalamin reliably raises cobalamin and lowers methylmalonic acid in deficient dogs and cats, with feline clinical improvement reported and randomized canine evidence supporting biochemical normalization. It remains adjunctive to diagnosis and treatment of enteropathy, exocrine pancreatic insufficiency or another cause; oral cobalamin is often similarly effective, so injections are not inherently superior for every stable patient.

Safety and tolerability8.0/10

Cyanocobalamin has a wide therapeutic margin and serious toxicity is uncommon. Relevant risks are injection pain, local inflammation, rare cobalt/cobalamin or excipient hypersensitivity including anaphylaxis, and potassium decline during brisk correction of severe deficiency; the exact human ampoule excipients and neonatal suitability require verification.

Clinical practicality7.5/10

The sterile 500 mcg/ml single-use ampoule is straightforward for SC or IM replacement; a 250 mcg feline dose is 0.5 ml and published canine weight-band amounts fit practical volumes. Repeated injections and visits remain a burden compared with effective daily oral supplementation, and the ampoule remainder must be discarded.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not administer to a patient with known cobalt, cobalamin or product-excipient hypersensitivity. Parenteral vitamin B12 has rarely caused anaphylaxis; have observation and emergency treatment available, especially after a previous unexplained injection reaction.
  • Confirm deficiency with an appropriate cobalamin assay and, when results or clinical response are equivocal, methylmalonic acid or other diagnostic context. Do not use cyanocobalamin as an empirical tonic, nonspecific appetite stimulant or substitute for investigating weight loss, anaemia, neuropathy or chronic gastrointestinal signs.
  • Treat the cause of deficiency, including chronic enteropathy, ileal disease, exocrine pancreatic insufficiency, altered intestinal anatomy or an inadequate diet. Cobalamin can correct a deficiency marker but cannot by itself control inflammation, infection, pancreatic failure, neoplasia or malnutrition.
  • Recheck clinical response and serum cobalamin after the replacement course and consider methylmalonic acid when functional deficiency remains uncertain. Draw planned baseline samples before supplementation and interpret very high post-treatment concentrations in light of timing rather than escalating automatically.
  • During brisk correction of severe deficiency or megaloblastic anaemia, monitor potassium and the haematologic response; hypokalaemia and arrhythmia have been reported with intensive parenteral replacement. Investigate concurrent folate, iron or other deficiencies rather than assuming nonresponse means a higher B12 dose.
  • Oral cobalamin normalized biochemical markers similarly to injections in randomized canine studies and has supportive feline evidence. Reassess whether repeated SC/IM visits, restraint and injection discomfort add value for a stable patient who can reliably receive an appropriate oral product.
  • Verify the exact ampoule excipients before neonatal, very small, renal-impaired or repeated use; human cyanocobalamin products may contain benzyl alcohol or trace aluminum, and formulations are not interchangeable by appearance. Use only the labelled SC/IM routes and concentration.
  • Protect the ampoule from light according to its insert, inspect the solution and container, use an accurate low-dead-space syringe and aseptic technique, rotate injection sites, and discard the unused remainder of a breached single-use ampoule rather than sharing it between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder
7.1/10
Good
vetman assessment

Vitamin B12 Tbilkimpharm

500 mcg/ml, 1 ml ampoule, solution for injection, human medicine
Assessed clinical scopeCat · SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder · SC,IM
Care settingVeterinary clinic or a trained home-treatment plan after deficiency and cause assessment, with exact small-volume measurement, injection-site rotation, follow-up cobalamin or methylmalonic-acid testing and treatment of the underlying disease
vetman score 7.1/10 Good
Evidence confidence: Medium Georgia: Yes, human · № რ-035012 · Verified on 16 Oct 2026 Off-label use

A useful, generally safe parenteral replacement when true cobalamin deficiency is documented or strongly supported and injection is preferred for severity, adherence or clinical context. It should accompany cause-directed care and follow-up testing; oral supplementation is a credible less-invasive alternative for many stable dogs and cats.

Regulatory and scientific credibility5.5/10

The exact human cyanocobalamin ampoule has a sourced current Georgian registration and identifiable strength, route and manufacturer, while exhaustive current checks record it as not registered in EU/EEA, GB or US. Veterinary use is off-label and exact-product animal evidence is absent.

Clinical efficacy7.5/10

Parenteral cobalamin reliably raises cobalamin and lowers methylmalonic acid in deficient dogs and cats, with feline clinical improvement reported and randomized canine evidence supporting biochemical normalization. It remains adjunctive to diagnosis and treatment of enteropathy, exocrine pancreatic insufficiency or another cause; oral cobalamin is often similarly effective, so injections are not inherently superior for every stable patient.

Safety and tolerability8.0/10

Cyanocobalamin has a wide therapeutic margin and serious toxicity is uncommon. Relevant risks are injection pain, local inflammation, rare cobalt/cobalamin or excipient hypersensitivity including anaphylaxis, and potassium decline during brisk correction of severe deficiency; the exact human ampoule excipients and neonatal suitability require verification.

Clinical practicality7.5/10

The sterile 500 mcg/ml single-use ampoule is straightforward for SC or IM replacement; a 250 mcg feline dose is 0.5 ml and published canine weight-band amounts fit practical volumes. Repeated injections and visits remain a burden compared with effective daily oral supplementation, and the ampoule remainder must be discarded.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not administer to a patient with known cobalt, cobalamin or product-excipient hypersensitivity. Parenteral vitamin B12 has rarely caused anaphylaxis; have observation and emergency treatment available, especially after a previous unexplained injection reaction.
  • Confirm deficiency with an appropriate cobalamin assay and, when results or clinical response are equivocal, methylmalonic acid or other diagnostic context. Do not use cyanocobalamin as an empirical tonic, nonspecific appetite stimulant or substitute for investigating weight loss, anaemia, neuropathy or chronic gastrointestinal signs.
  • Treat the cause of deficiency, including chronic enteropathy, ileal disease, exocrine pancreatic insufficiency, altered intestinal anatomy or an inadequate diet. Cobalamin can correct a deficiency marker but cannot by itself control inflammation, infection, pancreatic failure, neoplasia or malnutrition.
  • Recheck clinical response and serum cobalamin after the replacement course and consider methylmalonic acid when functional deficiency remains uncertain. Draw planned baseline samples before supplementation and interpret very high post-treatment concentrations in light of timing rather than escalating automatically.
  • During brisk correction of severe deficiency or megaloblastic anaemia, monitor potassium and the haematologic response; hypokalaemia and arrhythmia have been reported with intensive parenteral replacement. Investigate concurrent folate, iron or other deficiencies rather than assuming nonresponse means a higher B12 dose.
  • Oral cobalamin normalized biochemical markers similarly to injections in randomized canine studies and has supportive feline evidence. Reassess whether repeated SC/IM visits, restraint and injection discomfort add value for a stable patient who can reliably receive an appropriate oral product.
  • Verify the exact ampoule excipients before neonatal, very small, renal-impaired or repeated use; human cyanocobalamin products may contain benzyl alcohol or trace aluminum, and formulations are not interchangeable by appearance. Use only the labelled SC/IM routes and concentration.
  • Protect the ampoule from light according to its insert, inspect the solution and container, use an accurate low-dead-space syringe and aseptic technique, rotate injection sites, and discard the unused remainder of a breached single-use ampoule rather than sharing it between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Cyanocobalamin0.5 mg/ml
Formulation Type
Solution
Administration route
Subcutaneous, Intramuscular
Manufacturer
Registration
Georgia Yes, human
In force until 20 Apr 2027
Human (Ministry of Health, RAMA)
In the register: ვიტამინი B12 თბილქიმფარმი 500 მკგ/მლ, 1 მლ ამპულა, საინექციო ხსნარი
№ რ-035012
Verified on: 16 Oct 2026
EU No
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

All of this shows in vetman as you prescribe

The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.