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Benevron B

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Thiamine + Pyridoxine + Cyanocobalamin + Riboflavin · World Medicine İlaç San. ve Tic. A.Ş.

1 form: solution. In force in Georgia: 1 of 1 (human register).

Forms and doses1 of 1 in force in Georgia

Form Dose Frequency Georgia
Solution No label dose in the reference yet - Georgia Yes, human
In force until 02 Jun 2031
Human (Ministry of Health, RAMA)
№ რ-045603, რ-038060
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Benevron B, Solution

solution for injection, 3 ml ampoule, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Proposed deep-IM use of the exact Benevron B human ampoule for a diagnosed vitamin deficiency or adjunctive neurologic role
Not rateable
No numerical score assigned
vetman assessment

Benevron B

solution for injection, 3 ml ampoule, human medicine
Assessed clinical scopeDog · Proposed deep-IM use of the exact Benevron B human ampoule for a diagnosed vitamin deficiency or adjunctive neurologic role · Intramuscular
Care settingVeterinarian-directed use only after diagnosis and selection of a source-backed, deliverable regimen
vetman score Not rateable No numerical score assigned
Evidence confidence: Low Georgia: Yes, human · № რ-045603, რ-038060 · Verified on 15 Oct 2026 Off-label use
Not rateable

A numerical canine score cannot be assigned responsibly. AEM DV 22-01101 and Kazakhstan SPC ҚР-ДЗ-5№121984 verify the exact 3 ml human ampoule, four-vitamin composition and deep-IM human route. They provide no dog/cat dose, veterinary PK, target-animal safety margin or clinical outcome evidence. The human schedule and an isolated clinic-chart volume are not transferable, and the ampoule also contains 60 mg benzyl alcohol.

Exact human identity and deep-IM route are verified; a veterinary dose and benefit-risk are not. Do not transfer the human schedule or infer “slow injection.”

Important safety and use flags

  • Use only for a defined deficiency or other explicit clinical rationale. A nonspecific neurologic sign, anorexia, fatigue or routine supplementation is not a diagnosis.
  • No dog or cat dose is established for this exact ampoule. Do not scale the human schedule, copy an isolated clinic-chart volume or derive a mixture dose from one component.
  • The exact official route is deep IM. “Slowly” is not stated in the audited primary documents; do not add it or extrapolate IV, SC or oral use.
  • AEM and the Kazakhstan SPC describe a human medicine; this is not a veterinary authorisation. Exact dog/cat PK, efficacy and repeated-dose safety remain absent.
  • Do not infer that all B vitamins are required because one deficiency is plausible. Ingredient or comparator evidence cannot validate this fixed high-dose ratio or transfer another product’s dose.
  • Each 3 ml ampoule contains 250 mg pyridoxine and 60 mg benzyl alcohol with the other vitamins. Dog/cat local tolerance, repeated-dose safety and therapeutic margin are not established.
  • High experimental pyridoxine exposure caused sensory-neuron injury in dogs. Those studies do not define a safe lower Benevron regimen, but they rule out assuming that water solubility makes chronic high-dose exposure harmless.
  • Parenteral thiamine can cause serious hypersensitivity. Use aseptic technique, review excipients and ensure readiness to manage an acute reaction.
  • Review the full medication plan, especially levodopa without a peripheral decarboxylase inhibitor and other vitamin-containing products. Avoid unexamined cumulative exposure.
  • Set a diagnosis-specific response point and stop date. If response is absent, reassess diet, malabsorption, antagonists, primary disease and the actual deficient nutrient rather than continuing empirical B-complex treatment.
Assessment sources
  1. Benevron B Azerbaijan register2022
  2. Benevron B Kazakhstan SPC2026
  3. Small-animal nutrition2026
  4. Feline thiamine case2010
  5. Veterinary B12 comparator2025
  6. Canine oral pyridoxine toxicity1981
  7. Canine parenteral pyridoxine toxicity2008
Assessed: 23 Oct 2026No axis or overall score is shown when the available evidence does not support a responsible numerical assessment.
Cat Proposed deep-IM use of the exact Benevron B human ampoule for a diagnosed vitamin deficiency or adjunctive neurologic role
Not rateable
No numerical score assigned
vetman assessment

Benevron B

solution for injection, 3 ml ampoule, human medicine
Assessed clinical scopeCat · Proposed deep-IM use of the exact Benevron B human ampoule for a diagnosed vitamin deficiency or adjunctive neurologic role · Intramuscular
Care settingVeterinarian-directed use only after diagnosis and selection of a source-backed, deliverable regimen
vetman score Not rateable No numerical score assigned
Evidence confidence: Low Georgia: Yes, human · № რ-045603, რ-038060 · Verified on 15 Oct 2026 Off-label use
Not rateable

A numerical feline score cannot be assigned responsibly. AEM DV 22-01101 and Kazakhstan SPC ҚР-ДЗ-5№121984 verify the exact 3 ml human ampoule, four-vitamin composition and deep-IM human route. They provide no dog/cat dose, veterinary PK, target-animal safety margin or clinical outcome evidence. The human schedule and an isolated clinic-chart volume are not transferable, and the ampoule also contains 60 mg benzyl alcohol.

Exact human identity and deep-IM route are verified; a veterinary dose and benefit-risk are not. Do not transfer the human schedule or infer “slow injection.”

Important safety and use flags

  • Use only for a defined deficiency or other explicit clinical rationale. A nonspecific neurologic sign, anorexia, fatigue or routine supplementation is not a diagnosis.
  • No dog or cat dose is established for this exact ampoule. Do not scale the human schedule, copy an isolated clinic-chart volume or derive a mixture dose from one component.
  • The exact official route is deep IM. “Slowly” is not stated in the audited primary documents; do not add it or extrapolate IV, SC or oral use.
  • AEM and the Kazakhstan SPC describe a human medicine; this is not a veterinary authorisation. Exact dog/cat PK, efficacy and repeated-dose safety remain absent.
  • Do not infer that all B vitamins are required because one deficiency is plausible. Ingredient or comparator evidence cannot validate this fixed high-dose ratio or transfer another product’s dose.
  • Each 3 ml ampoule contains 250 mg pyridoxine and 60 mg benzyl alcohol with the other vitamins. Dog/cat local tolerance, repeated-dose safety and therapeutic margin are not established.
  • High experimental pyridoxine exposure caused sensory-neuron injury in dogs. Those studies do not define a safe lower Benevron regimen, but they rule out assuming that water solubility makes chronic high-dose exposure harmless.
  • Parenteral thiamine can cause serious hypersensitivity. Use aseptic technique, review excipients and ensure readiness to manage an acute reaction.
  • Review the full medication plan, especially levodopa without a peripheral decarboxylase inhibitor and other vitamin-containing products. Avoid unexamined cumulative exposure.
  • Set a diagnosis-specific response point and stop date. If response is absent, reassess diet, malabsorption, antagonists, primary disease and the actual deficient nutrient rather than continuing empirical B-complex treatment.
Assessment sources
  1. Benevron B Azerbaijan register2022
  2. Benevron B Kazakhstan SPC2026
  3. Small-animal nutrition2026
  4. Feline thiamine case2010
  5. Veterinary B12 comparator2025
  6. Canine oral pyridoxine toxicity1981
  7. Canine parenteral pyridoxine toxicity2008
Assessed: 23 Oct 2026No axis or overall score is shown when the available evidence does not support a responsible numerical assessment.
Composition / strength
Thiamine83.33 mg/ml Pyridoxine83.33 mg/ml Cyanocobalamin0.5 mg/ml Riboflavin1.333 mg/ml
Formulation Type
Solution
Administration route
Intramuscular
Registration
Georgia Yes, human
In force until 02 Jun 2031
Human (Ministry of Health, RAMA)
№ რ-045603, რ-038060
Verified on: 15 Oct 2026
 EU No
Verified on: 16 Oct 2026
 UK No
Verified on: 16 Oct 2026
 US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
Information not fully verified No dog or cat dose was identified for this exact high-dose four-vitamin ampoule. The official human information specifies deep intramuscular administration; it does not say slowly and its human schedule cannot establish a veterinary ml/kg regimen.

The dose of a combination product is determined by its own product information. The doses below apply to the individual active substances and should not be used as the dose of this product.

Active substance doses, with sources
Active substance Cyanocobalamin
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
25 mcg/kg
off-label
 Dog Maintenance By mouth once daily
MSD Vet Manual 2025
Reference book
A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose.
Exocrine Pancreatic Insufficiency in Dogs and Cats
MSD/Merck Veterinary Manual, 2025
25 mcg/kg
off-label
 Dog Maintenance Subcutaneous once weekly
MSD Vet Manual 2025
Reference book
A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose.
Exocrine Pancreatic Insufficiency in Dogs and Cats
MSD/Merck Veterinary Manual, 2025
0.25 mg per animal
off-label
 Cat Maintenance By mouth once daily
MSD Vet Manual 2025
Reference book
A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose.
Exocrine Pancreatic Insufficiency in Dogs and Cats
MSD/Merck Veterinary Manual, 2025
0.25 mg per animal
off-label
 Cat Maintenance Subcutaneous once weekly
MSD Vet Manual 2025
Reference book
A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose.
Exocrine Pancreatic Insufficiency in Dogs and Cats
MSD/Merck Veterinary Manual, 2025

Thiamine: No dose supported by a publicly verifiable source yet

Pyridoxine: No dose supported by a publicly verifiable source yet

Riboflavin: No dose supported by a publicly verifiable source yet

Known Contraindications

  • Warning Cyanocobalamin
    Tumours: according to the product label, vitamin B12 may stimulate the growth of malignant tumours, so it should not be given to patients with a tumour.
    Sources: Product label
  • Critical Pyridoxine
    A whole tablet is a large dose for a small animal: one tablet contains 200 mg pyridoxine, which is 50 mg/kg for a 4 kg cat. The label's overdose section describes pyridoxine neuropathy in people after months or years of chronic intake of 200 to 6000 mg a day (roughly 3 to 100 mg/kg a day). In practice an adult cat is given a quarter of a tablet (see the product note): 12.5 mg/kg pyridoxine for a 4 kg cat, in the lower third of that range. A short course and a long one are different questions. No source gives a veterinary dose for this combination.
    Sources: Product label
  • Critical Pyridoxine
    Kidney failure: the human product label makes kidney or liver failure an absolute contraindication. This is a pharmacological restriction and does not depend on the species.
    Sources: Product label
  • Critical Pyridoxine
    Hepatic impairment is listed as an absolute contraindication on the human product label, alongside renal impairment.
    Sources: Product label
  • Warning Pyridoxine
    Pregnancy and lactation are contraindications on the human product label because of the high vitamin doses rather than the vitamins themselves. This restriction cannot be transferred directly to animals, but it applies to the doses contained in this tablet.
    Sources: Product label
  • Warning Thiamine
    Sodium metabisulfite (E223) can rarely cause severe hypersensitivity reactions and bronchospasm. The tablet also contains the azo dyes Ponceau 4R (E124) and Sunset Yellow (E110). Riboflavin can turn urine yellow; this is expected and is not an adverse effect.
    Sources: Product label

Products are connected by name, active ingredients, or therapeutic group. They are not direct substitutes for one another.

Show all related products (19 more) Hide additional products

Same therapeutic group 19

Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

For veterinary professionals only. It does not replace clinical judgement or the product label; check the dose in the official label (SPC). vetman is not liable for harm caused by using this information.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 16 Oct 2026

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The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

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