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Vitamin B12 Sopharma

Cyanocobalamin · Sopharma

2 forms: solution. In force in Georgia: 2 of 2 (human register).

Forms and doses2 of 2 in force in Georgia

Form Dose Frequency Georgia
500 mcg/ml, Solution No label dose in the reference yet - Georgia Yes, human
In force until 19 Dec 2030
Human (Ministry of Health, RAMA)
In the register: ვიტამინი B12 სოფარმა 500 მკგ/მლ, 1 მლ ამპულა, საინექციო ხსნარი
№ რ-044521
Verified on: 16 Oct 2026
Details: pack, label wording, sources, registration

Vitamin B12 Sopharma 500 mcg/ml, Solution

1 ml ampoule, solution for injection, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder
7.4/10
Good
vetman assessment

Vitamin B12 Sopharma

500 mcg/ml, 1 ml ampoule, solution for injection, human medicine
Assessed clinical scopeDog · SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder · SC,IM
Care settingVeterinary clinic or a trained home-treatment plan after deficiency and cause assessment, with exact small-volume measurement, injection-site rotation, follow-up cobalamin or methylmalonic-acid testing and treatment of the underlying disease
vetman score 7.4/10 Good
Evidence confidence: Medium Georgia: Yes, human · № რ-044521 · Verified on 16 Oct 2026 Off-label use

A useful, generally safe parenteral replacement when true cobalamin deficiency is documented or strongly supported and injection is preferred for severity, adherence or clinical context. It should accompany cause-directed care and follow-up testing; oral supplementation is a credible less-invasive alternative for many stable dogs and cats.

Regulatory and scientific credibility6.5/10

This exact Sopharma cyanocobalamin ampoule has sourced current registrations in Georgia and EU/EEA with identifiable strength, route and manufacturer, while current checks record no exact GB or US registration. Veterinary use is off-label and exact-product animal evidence is absent.

Clinical efficacy7.5/10

Parenteral cobalamin reliably raises cobalamin and lowers methylmalonic acid in deficient dogs and cats, with feline clinical improvement reported and randomized canine evidence supporting biochemical normalization. It remains adjunctive to diagnosis and treatment of enteropathy, exocrine pancreatic insufficiency or another cause; oral cobalamin is often similarly effective, so injections are not inherently superior for every stable patient.

Safety and tolerability8.0/10

Cyanocobalamin has a wide therapeutic margin and serious toxicity is uncommon. Relevant risks are injection pain, local inflammation, rare cobalt/cobalamin or excipient hypersensitivity including anaphylaxis, and potassium decline during brisk correction of severe deficiency; the exact human ampoule excipients and neonatal suitability require verification.

Clinical practicality7.5/10

The sterile 500 mcg/ml single-use ampoule is straightforward for SC or IM replacement; a 250 mcg feline dose is 0.5 ml and published canine weight-band amounts fit practical volumes. Repeated injections and visits remain a burden compared with effective daily oral supplementation, and the ampoule remainder must be discarded.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not administer to a patient with known cobalt, cobalamin or product-excipient hypersensitivity. Parenteral vitamin B12 has rarely caused anaphylaxis; have observation and emergency treatment available, especially after a previous unexplained injection reaction.
  • Confirm deficiency with an appropriate cobalamin assay and, when results or clinical response are equivocal, methylmalonic acid or other diagnostic context. Do not use cyanocobalamin as an empirical tonic, nonspecific appetite stimulant or substitute for investigating weight loss, anaemia, neuropathy or chronic gastrointestinal signs.
  • Treat the cause of deficiency, including chronic enteropathy, ileal disease, exocrine pancreatic insufficiency, altered intestinal anatomy or an inadequate diet. Cobalamin can correct a deficiency marker but cannot by itself control inflammation, infection, pancreatic failure, neoplasia or malnutrition.
  • Recheck clinical response and serum cobalamin after the replacement course and consider methylmalonic acid when functional deficiency remains uncertain. Draw planned baseline samples before supplementation and interpret very high post-treatment concentrations in light of timing rather than escalating automatically.
  • During brisk correction of severe deficiency or megaloblastic anaemia, monitor potassium and the haematologic response; hypokalaemia and arrhythmia have been reported with intensive parenteral replacement. Investigate concurrent folate, iron or other deficiencies rather than assuming nonresponse means a higher B12 dose.
  • Oral cobalamin normalized biochemical markers similarly to injections in randomized canine studies and has supportive feline evidence. Reassess whether repeated SC/IM visits, restraint and injection discomfort add value for a stable patient who can reliably receive an appropriate oral product.
  • Verify the exact ampoule excipients before neonatal, very small, renal-impaired or repeated use; human cyanocobalamin products may contain benzyl alcohol or trace aluminum, and formulations are not interchangeable by appearance. Use only the labelled SC/IM routes and concentration.
  • Protect the ampoule from light according to its insert, inspect the solution and container, use an accurate low-dead-space syringe and aseptic technique, rotate injection sites, and discard the unused remainder of a breached single-use ampoule rather than sharing it between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder
7.4/10
Good
vetman assessment

Vitamin B12 Sopharma

500 mcg/ml, 1 ml ampoule, solution for injection, human medicine
Assessed clinical scopeCat · SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder · SC,IM
Care settingVeterinary clinic or a trained home-treatment plan after deficiency and cause assessment, with exact small-volume measurement, injection-site rotation, follow-up cobalamin or methylmalonic-acid testing and treatment of the underlying disease
vetman score 7.4/10 Good
Evidence confidence: Medium Georgia: Yes, human · № რ-044521 · Verified on 16 Oct 2026 Off-label use

A useful, generally safe parenteral replacement when true cobalamin deficiency is documented or strongly supported and injection is preferred for severity, adherence or clinical context. It should accompany cause-directed care and follow-up testing; oral supplementation is a credible less-invasive alternative for many stable dogs and cats.

Regulatory and scientific credibility6.5/10

This exact Sopharma cyanocobalamin ampoule has sourced current registrations in Georgia and EU/EEA with identifiable strength, route and manufacturer, while current checks record no exact GB or US registration. Veterinary use is off-label and exact-product animal evidence is absent.

Clinical efficacy7.5/10

Parenteral cobalamin reliably raises cobalamin and lowers methylmalonic acid in deficient dogs and cats, with feline clinical improvement reported and randomized canine evidence supporting biochemical normalization. It remains adjunctive to diagnosis and treatment of enteropathy, exocrine pancreatic insufficiency or another cause; oral cobalamin is often similarly effective, so injections are not inherently superior for every stable patient.

Safety and tolerability8.0/10

Cyanocobalamin has a wide therapeutic margin and serious toxicity is uncommon. Relevant risks are injection pain, local inflammation, rare cobalt/cobalamin or excipient hypersensitivity including anaphylaxis, and potassium decline during brisk correction of severe deficiency; the exact human ampoule excipients and neonatal suitability require verification.

Clinical practicality7.5/10

The sterile 500 mcg/ml single-use ampoule is straightforward for SC or IM replacement; a 250 mcg feline dose is 0.5 ml and published canine weight-band amounts fit practical volumes. Repeated injections and visits remain a burden compared with effective daily oral supplementation, and the ampoule remainder must be discarded.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not administer to a patient with known cobalt, cobalamin or product-excipient hypersensitivity. Parenteral vitamin B12 has rarely caused anaphylaxis; have observation and emergency treatment available, especially after a previous unexplained injection reaction.
  • Confirm deficiency with an appropriate cobalamin assay and, when results or clinical response are equivocal, methylmalonic acid or other diagnostic context. Do not use cyanocobalamin as an empirical tonic, nonspecific appetite stimulant or substitute for investigating weight loss, anaemia, neuropathy or chronic gastrointestinal signs.
  • Treat the cause of deficiency, including chronic enteropathy, ileal disease, exocrine pancreatic insufficiency, altered intestinal anatomy or an inadequate diet. Cobalamin can correct a deficiency marker but cannot by itself control inflammation, infection, pancreatic failure, neoplasia or malnutrition.
  • Recheck clinical response and serum cobalamin after the replacement course and consider methylmalonic acid when functional deficiency remains uncertain. Draw planned baseline samples before supplementation and interpret very high post-treatment concentrations in light of timing rather than escalating automatically.
  • During brisk correction of severe deficiency or megaloblastic anaemia, monitor potassium and the haematologic response; hypokalaemia and arrhythmia have been reported with intensive parenteral replacement. Investigate concurrent folate, iron or other deficiencies rather than assuming nonresponse means a higher B12 dose.
  • Oral cobalamin normalized biochemical markers similarly to injections in randomized canine studies and has supportive feline evidence. Reassess whether repeated SC/IM visits, restraint and injection discomfort add value for a stable patient who can reliably receive an appropriate oral product.
  • Verify the exact ampoule excipients before neonatal, very small, renal-impaired or repeated use; human cyanocobalamin products may contain benzyl alcohol or trace aluminum, and formulations are not interchangeable by appearance. Use only the labelled SC/IM routes and concentration.
  • Protect the ampoule from light according to its insert, inspect the solution and container, use an accurate low-dead-space syringe and aseptic technique, rotate injection sites, and discard the unused remainder of a breached single-use ampoule rather than sharing it between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Cyanocobalamin0.5 mg/ml
Formulation Type
Solution
Administration route
Subcutaneous, Intramuscular
Manufacturer
Sopharma · Bulgaria
Registration
Georgia Yes, human
In force until 19 Dec 2030
Human (Ministry of Health, RAMA)
In the register: ვიტამინი B12 სოფარმა 500 მკგ/მლ, 1 მლ ამპულა, საინექციო ხსნარი
№ რ-044521
Verified on: 16 Oct 2026
EU Yes, human
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
1000 mcg/ml, Solution No label dose in the reference yet - Georgia Yes, human
In force until 19 Dec 2030
Human (Ministry of Health, RAMA)
In the register: ვიტამინი B12 სოფარმა 1000 მკგ/მლ, 1 მლ ამპულა, საინექციო ხსნარი
№ რ-044522
Verified on: 16 Oct 2026
Details: pack, label wording, sources, registration

Vitamin B12 Sopharma 1000 mcg/ml, Solution

1 ml ampoule, solution for injection, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder
7.4/10
Good
vetman assessment

Vitamin B12 Sopharma

1000 mcg/ml, 1 ml ampoule, solution for injection, human medicine
Assessed clinical scopeDog · SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder · SC,IM
Care settingVeterinary clinic or a trained home-treatment plan after deficiency and cause assessment, with exact small-volume measurement, injection-site rotation, follow-up cobalamin or methylmalonic-acid testing and treatment of the underlying disease
vetman score 7.4/10 Good
Evidence confidence: Medium Georgia: Yes, human · № რ-044522 · Verified on 16 Oct 2026 Off-label use

A useful, generally safe parenteral replacement when true cobalamin deficiency is documented or strongly supported and injection is preferred for severity, adherence or clinical context. It should accompany cause-directed care and follow-up testing; oral supplementation is a credible less-invasive alternative for many stable dogs and cats.

Regulatory and scientific credibility6.5/10

This exact Sopharma cyanocobalamin ampoule has sourced current registrations in Georgia and EU/EEA with identifiable strength, route and manufacturer, while current checks record no exact GB or US registration. Veterinary use is off-label and exact-product animal evidence is absent.

Clinical efficacy7.5/10

Parenteral cobalamin reliably raises cobalamin and lowers methylmalonic acid in deficient dogs and cats, with feline clinical improvement reported and randomized canine evidence supporting biochemical normalization. It remains adjunctive to diagnosis and treatment of enteropathy, exocrine pancreatic insufficiency or another cause; oral cobalamin is often similarly effective, so injections are not inherently superior for every stable patient.

Safety and tolerability8.0/10

Cyanocobalamin has a wide therapeutic margin and serious toxicity is uncommon. Relevant risks are injection pain, local inflammation, rare cobalt/cobalamin or excipient hypersensitivity including anaphylaxis, and potassium decline during brisk correction of severe deficiency; the exact human ampoule excipients and neonatal suitability require verification.

Clinical practicality8.0/10

The sterile 1000 mcg/ml single-use ampoule supplies common feline and canine replacement amounts in a small SC or IM volume; a 250 mcg feline dose is 0.25 ml, so a precise low-dead-space syringe is required. Repeated injections and visits remain a burden compared with effective daily oral supplementation, and the ampoule remainder must be discarded.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not administer to a patient with known cobalt, cobalamin or product-excipient hypersensitivity. Parenteral vitamin B12 has rarely caused anaphylaxis; have observation and emergency treatment available, especially after a previous unexplained injection reaction.
  • Confirm deficiency with an appropriate cobalamin assay and, when results or clinical response are equivocal, methylmalonic acid or other diagnostic context. Do not use cyanocobalamin as an empirical tonic, nonspecific appetite stimulant or substitute for investigating weight loss, anaemia, neuropathy or chronic gastrointestinal signs.
  • Treat the cause of deficiency, including chronic enteropathy, ileal disease, exocrine pancreatic insufficiency, altered intestinal anatomy or an inadequate diet. Cobalamin can correct a deficiency marker but cannot by itself control inflammation, infection, pancreatic failure, neoplasia or malnutrition.
  • Recheck clinical response and serum cobalamin after the replacement course and consider methylmalonic acid when functional deficiency remains uncertain. Draw planned baseline samples before supplementation and interpret very high post-treatment concentrations in light of timing rather than escalating automatically.
  • During brisk correction of severe deficiency or megaloblastic anaemia, monitor potassium and the haematologic response; hypokalaemia and arrhythmia have been reported with intensive parenteral replacement. Investigate concurrent folate, iron or other deficiencies rather than assuming nonresponse means a higher B12 dose.
  • Oral cobalamin normalized biochemical markers similarly to injections in randomized canine studies and has supportive feline evidence. Reassess whether repeated SC/IM visits, restraint and injection discomfort add value for a stable patient who can reliably receive an appropriate oral product.
  • Verify the exact ampoule excipients before neonatal, very small, renal-impaired or repeated use; human cyanocobalamin products may contain benzyl alcohol or trace aluminum, and formulations are not interchangeable by appearance. Use only the labelled SC/IM routes and concentration.
  • Protect the ampoule from light according to its insert, inspect the solution and container, use an accurate low-dead-space syringe and aseptic technique, rotate injection sites, and discard the unused remainder of a breached single-use ampoule rather than sharing it between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder
7.4/10
Good
vetman assessment

Vitamin B12 Sopharma

1000 mcg/ml, 1 ml ampoule, solution for injection, human medicine
Assessed clinical scopeCat · SC or IM cyanocobalamin replacement for documented or strongly supported cobalamin deficiency when parenteral treatment is clinically preferred; not nonspecific appetite support, a tonic or automatic treatment of every gastrointestinal disorder · SC,IM
Care settingVeterinary clinic or a trained home-treatment plan after deficiency and cause assessment, with exact small-volume measurement, injection-site rotation, follow-up cobalamin or methylmalonic-acid testing and treatment of the underlying disease
vetman score 7.4/10 Good
Evidence confidence: Medium Georgia: Yes, human · № რ-044522 · Verified on 16 Oct 2026 Off-label use

A useful, generally safe parenteral replacement when true cobalamin deficiency is documented or strongly supported and injection is preferred for severity, adherence or clinical context. It should accompany cause-directed care and follow-up testing; oral supplementation is a credible less-invasive alternative for many stable dogs and cats.

Regulatory and scientific credibility6.5/10

This exact Sopharma cyanocobalamin ampoule has sourced current registrations in Georgia and EU/EEA with identifiable strength, route and manufacturer, while current checks record no exact GB or US registration. Veterinary use is off-label and exact-product animal evidence is absent.

Clinical efficacy7.5/10

Parenteral cobalamin reliably raises cobalamin and lowers methylmalonic acid in deficient dogs and cats, with feline clinical improvement reported and randomized canine evidence supporting biochemical normalization. It remains adjunctive to diagnosis and treatment of enteropathy, exocrine pancreatic insufficiency or another cause; oral cobalamin is often similarly effective, so injections are not inherently superior for every stable patient.

Safety and tolerability8.0/10

Cyanocobalamin has a wide therapeutic margin and serious toxicity is uncommon. Relevant risks are injection pain, local inflammation, rare cobalt/cobalamin or excipient hypersensitivity including anaphylaxis, and potassium decline during brisk correction of severe deficiency; the exact human ampoule excipients and neonatal suitability require verification.

Clinical practicality8.0/10

The sterile 1000 mcg/ml single-use ampoule supplies common feline and canine replacement amounts in a small SC or IM volume; a 250 mcg feline dose is 0.25 ml, so a precise low-dead-space syringe is required. Repeated injections and visits remain a burden compared with effective daily oral supplementation, and the ampoule remainder must be discarded.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Do not administer to a patient with known cobalt, cobalamin or product-excipient hypersensitivity. Parenteral vitamin B12 has rarely caused anaphylaxis; have observation and emergency treatment available, especially after a previous unexplained injection reaction.
  • Confirm deficiency with an appropriate cobalamin assay and, when results or clinical response are equivocal, methylmalonic acid or other diagnostic context. Do not use cyanocobalamin as an empirical tonic, nonspecific appetite stimulant or substitute for investigating weight loss, anaemia, neuropathy or chronic gastrointestinal signs.
  • Treat the cause of deficiency, including chronic enteropathy, ileal disease, exocrine pancreatic insufficiency, altered intestinal anatomy or an inadequate diet. Cobalamin can correct a deficiency marker but cannot by itself control inflammation, infection, pancreatic failure, neoplasia or malnutrition.
  • Recheck clinical response and serum cobalamin after the replacement course and consider methylmalonic acid when functional deficiency remains uncertain. Draw planned baseline samples before supplementation and interpret very high post-treatment concentrations in light of timing rather than escalating automatically.
  • During brisk correction of severe deficiency or megaloblastic anaemia, monitor potassium and the haematologic response; hypokalaemia and arrhythmia have been reported with intensive parenteral replacement. Investigate concurrent folate, iron or other deficiencies rather than assuming nonresponse means a higher B12 dose.
  • Oral cobalamin normalized biochemical markers similarly to injections in randomized canine studies and has supportive feline evidence. Reassess whether repeated SC/IM visits, restraint and injection discomfort add value for a stable patient who can reliably receive an appropriate oral product.
  • Verify the exact ampoule excipients before neonatal, very small, renal-impaired or repeated use; human cyanocobalamin products may contain benzyl alcohol or trace aluminum, and formulations are not interchangeable by appearance. Use only the labelled SC/IM routes and concentration.
  • Protect the ampoule from light according to its insert, inspect the solution and container, use an accurate low-dead-space syringe and aseptic technique, rotate injection sites, and discard the unused remainder of a breached single-use ampoule rather than sharing it between patients.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Formulation Type
Solution
Administration route
Subcutaneous, Intramuscular
Manufacturer
Sopharma · Bulgaria
Registration
Georgia Yes, human
In force until 19 Dec 2030
Human (Ministry of Health, RAMA)
In the register: ვიტამინი B12 სოფარმა 1000 მკგ/მლ, 1 მლ ამპულა, საინექციო ხსნარი
№ რ-044522
Verified on: 16 Oct 2026
EU Yes, human
UK No
Verified on: 16 Oct 2026
US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026

Active substance doses, with sources

Each dose comes with its source. Check the label of the product you use.

Active substance Cyanocobalamin
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
25 mcg/kg
off-label
Dog Maintenance By mouth once daily
MSD Vet Manual 2025
Reference book
A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose.
Exocrine Pancreatic Insufficiency in Dogs and Cats
MSD/Merck Veterinary Manual, 2025
25 mcg/kg
off-label
Dog Maintenance Subcutaneous once weekly
MSD Vet Manual 2025
Reference book
A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose.
Exocrine Pancreatic Insufficiency in Dogs and Cats
MSD/Merck Veterinary Manual, 2025
0.25 mg per animal
off-label
Cat Maintenance By mouth once daily
MSD Vet Manual 2025
Reference book
A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose.
Exocrine Pancreatic Insufficiency in Dogs and Cats
MSD/Merck Veterinary Manual, 2025
0.25 mg per animal
off-label
Cat Maintenance Subcutaneous once weekly
MSD Vet Manual 2025
Reference book
A veterinary reference written and reviewed by specialists, summarising accepted practice. The product label gives the authorised dose.
Exocrine Pancreatic Insufficiency in Dogs and Cats
MSD/Merck Veterinary Manual, 2025

Known Contraindications

  • Warning
    Tumours: according to the product label, vitamin B12 may stimulate the growth of malignant tumours, so it should not be given to patients with a tumour.
    Sources: Product label

All of this shows in vetman as you prescribe

The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.