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Doxytron

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Doxycycline · AVZ S-P Ltd

2 forms: chewable tablet. In force in Georgia: 2 of 2 (veterinary register).

Forms and doses2 of 2 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Dose Frequency Georgia
20 mg chewable tablets, Chewable tablet · Cat Cat Bacterial Infection · By mouth: 1 tablet per 2 kg - Georgia Yes, veterinary
In force until 10 Apr 2030
Veterinary (National Food Agency)
In the register: დოქსიტრონი საღეჭი ტაბლეტები
№ 000831
Verified on: 21 Oct 2026
20 mg chewable tablets, Chewable tablet · Dog Dog Bacterial Infection · By mouth: 1 tablet per 2 kg - Georgia Yes, veterinary
In force until 10 Apr 2030
Veterinary (National Food Agency)
In the register: დოქსიტრონი საღეჭი ტაბლეტები
№ 000831
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Doxytron 20 mg chewable tablets, Chewable tablet

N20 for dogs and cats
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Full dog label: doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections, 10 mg/kg once daily with food (one tablet per 2 kg)
6.2/10
Situational / acceptable
vetman assessment

Doxytron

20 mg chewable tablets, N20 for dogs and cats
Assessed clinical scopeDog · Full dog label: doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections, 10 mg/kg once daily with food (one tablet per 2 kg) · By mouth
Care settingVeterinary prescription after diagnosis for oral treatment at home
vetman score 6.2/10 Situational / acceptable
Evidence confidence: Low Georgia: Yes, veterinary · № 000831 · Verified on 21 Oct 2026

A situational, guideline-aligned first-line antimicrobial for small dogs at a standard doxycycline dose. Extend the course to what the diagnosis needs rather than the label's 3-5 days.

Regulatory and scientific credibility5.0/10

The exact product is registered in Georgia (000831, valid to 2030) with an AVZ instruction (2023 Russian edition); it has no EU, UK or US authorisation documented in the reviewed evidence or product study, but 10 mg/kg once daily is a well-established authorised doxycycline dose.

Clinical efficacy6.5/10

Doxycycline is first-line in ISCAID respiratory guidance and a WSAVA essential medicine, covering Mycoplasma, Bordetella and tick-borne rickettsial agents; bioequivalence is unproven and the 3-5 day acute course is shorter than guideline courses.

Safety and tolerability7.0/10

Generally well tolerated; nausea is reduced by giving with food. The label excludes marked hepatic or renal dysfunction and tooth development, and asks for supervision in pregnancy and lactation.

Clinical practicality6.5/10

One chewable tablet per 2 kg once daily suits small dogs, but the tablet may be unscored, giving coarse 2 kg steps, and larger dogs need many tablets.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Do not use with tetracycline hypersensitivity, marked hepatic or renal dysfunction, or in puppies during tooth development.
  • Give apart from calcium, magnesium, iron or aluminium products and antacids; the label also lists barbiturates, phenytoin and avoidance with penicillins or cephalosporins.
  • Guideline courses are usually 7-10 days for acute bacterial respiratory infection and longer for Mycoplasma or tick-borne disease; the label's 3-5 days may be too short.
  • Give during or right after a meal to reduce nausea and oesophageal irritation; recheck if vomiting persists.
  • Doxycycline is EU AMEG Category D (Prudence) and a WSAVA essential medicine: a sound first choice when indicated.
Assessment sources
  1. Doxytron label2023
  2. Georgia NFA register 20262026
  3. ISCAID 20172017
  4. WSAVA essential medicines 20232023
  5. MSD tetracyclines2026
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Full cat label: doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections, 10 mg/kg once daily with food (one tablet per 2 kg)
5.9/10
Weak evidence support
vetman assessment

Doxytron

20 mg chewable tablets, N20 for dogs and cats
Assessed clinical scopeCat · Full cat label: doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections, 10 mg/kg once daily with food (one tablet per 2 kg) · By mouth
Care settingVeterinary prescription after diagnosis for oral treatment at home, each dose followed by food or water
vetman score 5.9/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000831 · Verified on 21 Oct 2026

A situational, guideline-aligned first-line antimicrobial for cats in a cat-sized strength. Follow every dose with water or food and run courses to guideline length, not the label's 3-5 days.

Regulatory and scientific credibility5.0/10

The exact product is registered in Georgia (000831, valid to 2030) with an AVZ instruction (2023 Russian edition); it has no EU, UK or US authorisation documented in the reviewed evidence or product study, but 10 mg/kg once daily is a well-established doxycycline dose.

Clinical efficacy6.5/10

Doxycycline is the first-line drug for feline bacterial upper respiratory infection, Mycoplasma and Chlamydia felis in ISCAID and ABCD guidance; bioequivalence is unproven and the label's 3-5 day course is much shorter than the 4 weeks needed for Chlamydia felis.

Safety and tolerability6.0/10

Doxycycline tablets can lodge in the feline oesophagus and cause oesophagitis and stricture unless followed by food or water; the label also excludes marked hepatic or renal dysfunction and tooth development.

Clinical practicality6.5/10

One small chewable tablet per 2 kg once daily fits cats well, although an unscored tablet gives coarse steps between body weights.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • In cats, follow every tablet with food or about 5 ml of water to prevent oesophageal stricture; watch for drooling, gagging or difficulty swallowing.
  • Do not use with tetracycline hypersensitivity, marked hepatic or renal dysfunction, or in kittens during tooth development.
  • Chlamydia felis needs about 4 weeks of doxycycline for all cats in the household, and acute bacterial upper respiratory infection usually 7-10 days.
  • Give apart from calcium, magnesium, iron or aluminium products and antacids; the label also lists barbiturates and phenytoin.
  • Doxycycline is EU AMEG Category D (Prudence) and a WSAVA essential medicine: a sound first choice when indicated.
Assessment sources
  1. Doxytron label2023
  2. Georgia NFA register 20262026
  3. ISCAID 20172017
  4. ABCD Chlamydia felis guideline2026
  5. MSD tetracyclines2026
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Doxycycline20 mg/tablet
Formulation Type
Chewable tablet
Administration route
By mouth
Manufacturer
AVZ S-P Ltd · Russia
Manufacturer (register)
AVZ S-P Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1362, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 10 Apr 2030
Veterinary (National Food Agency)
In the register: დოქსიტრონი საღეჭი ტაბლეტები
№ 000831
Verified on: 21 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
Cat
WeightBacterial Infection · By mouth
Any weight 1 tablet per 2 kg
  • Bacterial Infection · By mouth (once daily): Give 1 tablet per 2 kg (doxycycline 10 mg/kg) once daily during or immediately after feeding. Treat acute disease for 3-5 days and chronic disease for 8-10 days; a veterinarian may increase the dose or duration. Indications are doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections. Do not use with tetracycline hypersensitivity, marked hepatic or renal dysfunction, or during tooth development in puppies and kittens. Pregnancy and lactation require veterinary supervision. Do not combine with penicillins or cephalosporins, calcium/magnesium/iron/aluminium products, barbiturates or phenytoin. The 20 mg tablet may be manufactured without a score, so the calculator does not promise fractional tablet delivery.
Source:
Doxytron label
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
Doxytron chewable tablets - regulator-approved veterinary instruction
Rosselkhoznadzor-approved veterinary instruction, 2023
Dog
WeightBacterial Infection · By mouth
Any weight 1 tablet per 2 kg
  • Bacterial Infection · By mouth (once daily): Give 1 tablet per 2 kg (doxycycline 10 mg/kg) once daily during or immediately after feeding. Treat acute disease for 3-5 days and chronic disease for 8-10 days; a veterinarian may increase the dose or duration. Indications are doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections. Do not use with tetracycline hypersensitivity, marked hepatic or renal dysfunction, or during tooth development in puppies and kittens. Pregnancy and lactation require veterinary supervision. Do not combine with penicillins or cephalosporins, calcium/magnesium/iron/aluminium products, barbiturates or phenytoin. The 20 mg tablet may be manufactured without a score, so the calculator does not promise fractional tablet delivery.
Source:
Doxytron label
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
Doxytron chewable tablets - regulator-approved veterinary instruction
Rosselkhoznadzor-approved veterinary instruction, 2023
100 mg chewable tablets, Chewable tablet · Cat Cat Bacterial Infection · By mouth: 1 tablet per 10 kg - Georgia Yes, veterinary
In force until 10 Apr 2030
Veterinary (National Food Agency)
In the register: დოქსიტრონი საღეჭი ტაბლეტები
№ 000830
Verified on: 21 Oct 2026
100 mg chewable tablets, Chewable tablet · Dog Dog Bacterial Infection · By mouth: 1 tablet per 10 kg - Georgia Yes, veterinary
In force until 10 Apr 2030
Veterinary (National Food Agency)
In the register: დოქსიტრონი საღეჭი ტაბლეტები
№ 000830
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Doxytron 100 mg chewable tablets, Chewable tablet

N12 for dogs and cats
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Full dog label: doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections, 10 mg/kg once daily with food (one tablet per 10 kg)
6.3/10
Situational / acceptable
vetman assessment

Doxytron

100 mg chewable tablets, N12 for dogs and cats
Assessed clinical scopeDog · Full dog label: doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections, 10 mg/kg once daily with food (one tablet per 10 kg) · By mouth
Care settingVeterinary prescription after diagnosis for oral treatment at home
vetman score 6.3/10 Situational / acceptable
Evidence confidence: Low Georgia: Yes, veterinary · № 000830 · Verified on 21 Oct 2026

A situational, guideline-aligned first-line antimicrobial for dogs at a standard doxycycline dose. Extend the course to what the diagnosis needs rather than the label's 3-5 days.

Regulatory and scientific credibility5.0/10

The exact product is registered in Georgia (000830, valid to 2030) with an AVZ instruction (2023 Russian edition); it has no EU, UK or US authorisation documented in the reviewed evidence or product study, but 10 mg/kg once daily is a well-established authorised doxycycline dose.

Clinical efficacy6.5/10

Doxycycline is first-line in ISCAID respiratory guidance and a WSAVA essential medicine, covering Mycoplasma, Bordetella and tick-borne rickettsial agents; bioequivalence is unproven and the 3-5 day acute course is shorter than guideline courses.

Safety and tolerability7.0/10

Generally well tolerated; nausea is reduced by giving with food. The label excludes marked hepatic or renal dysfunction and tooth development, and asks for supervision in pregnancy and lactation.

Clinical practicality7.0/10

A chewable tablet once daily with a half-tablet score suits dogs from about 5 kg and is easy for owners.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Do not use with tetracycline hypersensitivity, marked hepatic or renal dysfunction, or in puppies during tooth development.
  • Give apart from calcium, magnesium, iron or aluminium products and antacids; the label also lists barbiturates, phenytoin and avoidance with penicillins or cephalosporins.
  • Guideline courses are usually 7-10 days for acute bacterial respiratory infection and longer for Mycoplasma or tick-borne disease; the label's 3-5 days may be too short.
  • Give during or right after a meal to reduce nausea and oesophageal irritation; recheck if vomiting persists.
  • Doxycycline is EU AMEG Category D (Prudence) and a WSAVA essential medicine: a sound first choice when indicated.
Assessment sources
  1. Doxytron label2023
  2. Georgia NFA register 20262026
  3. ISCAID 20172017
  4. WSAVA essential medicines 20232023
  5. MSD tetracyclines2026
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Full cat label: doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections, 10 mg/kg once daily with food (one tablet per 10 kg)
5.8/10
Weak evidence support
vetman assessment

Doxytron

100 mg chewable tablets, N12 for dogs and cats
Assessed clinical scopeCat · Full cat label: doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections, 10 mg/kg once daily with food (one tablet per 10 kg) · By mouth
Care settingVeterinary prescription after diagnosis for oral treatment at home, each dose followed by food or water
vetman score 5.8/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000830 · Verified on 21 Oct 2026

A weak fit for cats despite a first-line active: the 100 mg tablet is too large for accurate feline dosing. Prefer the 20 mg strength, follow every dose with water or food and run courses to guideline length.

Regulatory and scientific credibility5.0/10

The exact product is registered in Georgia (000830, valid to 2030) with an AVZ instruction (2023 Russian edition); it has no EU, UK or US authorisation documented in the reviewed evidence or product study, but 10 mg/kg once daily is a well-established doxycycline dose.

Clinical efficacy6.5/10

Doxycycline is the first-line drug for feline bacterial upper respiratory infection, Mycoplasma and Chlamydia felis in ISCAID and ABCD guidance; bioequivalence is unproven and the label's 3-5 day course is much shorter than the 4 weeks needed for Chlamydia felis.

Safety and tolerability6.0/10

Doxycycline tablets can lodge in the feline oesophagus and cause oesophagitis and stricture unless followed by food or water; the label also excludes marked hepatic or renal dysfunction and tooth development.

Clinical practicality5.5/10

For most cats a half 100 mg tablet is the smallest step, which gives well above 10 mg/kg below 5 kg; the 20 mg strength fits cats better.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • In cats, follow every tablet with food or about 5 ml of water to prevent oesophageal stricture; watch for drooling, gagging or difficulty swallowing.
  • Do not use with tetracycline hypersensitivity, marked hepatic or renal dysfunction, or in kittens during tooth development.
  • Chlamydia felis needs about 4 weeks of doxycycline for all cats in the household, and acute bacterial upper respiratory infection usually 7-10 days.
  • Give apart from calcium, magnesium, iron or aluminium products and antacids; the label also lists barbiturates and phenytoin.
  • Below 5 kg a half tablet overdoses; use the 20 mg strength for most cats.
Assessment sources
  1. Doxytron label2023
  2. Georgia NFA register 20262026
  3. ISCAID 20172017
  4. ABCD Chlamydia felis guideline2026
  5. MSD tetracyclines2026
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Doxycycline100 mg/tablet
Formulation Type
Chewable tablet
Administration route
By mouth
Manufacturer
AVZ S-P Ltd · Russia
Manufacturer (register)
AVZ S-P Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1361, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 10 Apr 2030
Veterinary (National Food Agency)
In the register: დოქსიტრონი საღეჭი ტაბლეტები
№ 000830
Verified on: 21 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
Cat
WeightBacterial Infection · By mouth
Any weight 1 tablet per 10 kg
  • Bacterial Infection · By mouth (once daily): Give 1 tablet per 10 kg (doxycycline 10 mg/kg) once daily during or immediately after feeding. Treat acute disease for 3-5 days and chronic disease for 8-10 days; a veterinarian may increase the dose or duration. Indications are doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections. Do not use with tetracycline hypersensitivity, marked hepatic or renal dysfunction, or during tooth development in puppies and kittens. Pregnancy and lactation require veterinary supervision. Do not combine with penicillins or cephalosporins, calcium/magnesium/iron/aluminium products, barbiturates or phenytoin. The official description identifies a score line; the calculator allows half-tablet delivery, not smaller fractions.
Source:
Doxytron label
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
Doxytron chewable tablets - regulator-approved veterinary instruction
Rosselkhoznadzor-approved veterinary instruction, 2023
Dog
WeightBacterial Infection · By mouth
Any weight 1 tablet per 10 kg
  • Bacterial Infection · By mouth (once daily): Give 1 tablet per 10 kg (doxycycline 10 mg/kg) once daily during or immediately after feeding. Treat acute disease for 3-5 days and chronic disease for 8-10 days; a veterinarian may increase the dose or duration. Indications are doxycycline-sensitive respiratory, genitourinary, skin and associated bacterial infections. Do not use with tetracycline hypersensitivity, marked hepatic or renal dysfunction, or during tooth development in puppies and kittens. Pregnancy and lactation require veterinary supervision. Do not combine with penicillins or cephalosporins, calcium/magnesium/iron/aluminium products, barbiturates or phenytoin. The official description identifies a score line; the calculator allows half-tablet delivery, not smaller fractions.
Source:
Doxytron label
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
Doxytron chewable tablets - regulator-approved veterinary instruction
Rosselkhoznadzor-approved veterinary instruction, 2023
Active substance doses, with sources
Active substance Doxycycline
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
10 mg/kg Dog, Cat Respiratory Tract Infection; Canine Ehrlichiosis; Leptospirosis; Bacterial Infection; Feline Chlamydiosis By mouth once daily
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Ronaxan 20 mg tablets for dogs and cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, Product Information Database, 2025
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Doxybactin 50 mg tablets for dogs and cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, Product Information Database, 2025
5 mg/kg
off-label
 Dog, Cat Leptospirosis; Respiratory Tract Infection By mouth 2 times daily
ACVIM 2023
Guideline or consensus statement
Recommendations agreed by a panel of veterinary specialists after reviewing the evidence. They guide practice and do not authorise a product.
Updated ACVIM consensus statement on leptospirosis in dogs
Journal of Veterinary Internal Medicine, 2023
ISCAID 2017
Guideline or consensus statement
Recommendations agreed by a panel of veterinary specialists after reviewing the evidence. They guide practice and do not authorise a product.
Antimicrobial Use Guidelines for Treatment of Respiratory Tract Disease in Dogs and Cats
Journal of Veterinary Internal Medicine, 2017

Known Contraindications

  • Critical
    administration of doxycycline hyclate tablets has been associated with oesophageal erosion.
    Sources: VMD SPC · VMD · ISCAID · JVIM
  • Critical
    Do not use in animals with renal or hepatic insufficiency. Special warnings: None.
    Sources: VMD SPC · VMD
  • Critical
    Product labels differ: some contraindicate doxycycline in hepatic insufficiency, while others advise special caution and monitoring because liver-enzyme increases have been reported. Follow the label of the selected product and monitor hepatic function.
    Sources: Product label
  • Critical
    Do not use doxycycline tablets in animals with vomiting or dysphagia when the product label lists these conditions as contraindications. Other labels advise caution because impaired swallowing or vomiting increases the risk of a tablet lodging in the oesophagus.
    Sources: VMD SPC · VMD
  • Critical
    Do not use doxycycline in puppies or kittens before tooth-enamel formation is complete when the product label lists this as a contraindication. Doxycycline is less likely than other tetracyclines to cause tooth abnormalities because it binds calcium less strongly, but the labelled restriction still applies.
    Sources: VMD SPC · VMD
  • Warning
    Tetracyclines as a class can retard foetal skeletal development (fully reversible) The safety of the veterinary medicinal product has not been established during pregnancy
    Sources: VMD
  • Warning
    The safety of the veterinary medicinal product has not been established during pregnancy and lactation.
    Sources: VMD
  • Warning
    Do not use in animals with known photosensitivity. During treatment, avoid prolonged intense sunlight, particularly in light-coloured or sparsely haired animals, because photosensitivity and photodermatitis may occur.
    Sources: VMD SPC · VMD
  • Warning (Cat)
    Doxycycline tablets and capsules can lodge in the cat oesophagus and cause oesophagitis and stricture (regurgitation, at varying times after the course). Follow every tablet or capsule with a water bolus or food.

Known Drug Interactions

  • Major warning Enrofloxacin + Doxycycline
    Do not combine enrofloxacin with antimicrobials that act antagonistically to quinolones, including macrolides, tetracyclines such as doxycycline, and phenicols such as chloramphenicol.
    Recommendation: Do not administer concurrently. Based on susceptibility testing, choose either a bactericidal fluoroquinolone or a bacteriostatic tetracycline.
    Sources: VMD SPC · VMD
  • Major warning Ampicillin + Doxycycline
    It is not recommended to administer bactericidal and bacteriostatic antibiotics concomitantly.
    Recommendation: If both are required, support the choice with culture and susceptibility results. Otherwise, choose one mechanism.
    Sources: VMD SPC · VMD
  • Major warning Amoxicillin + Doxycycline
    The bactericidal effect of amoxicillin may be inhibited by the concomitant use of bacteriostatic antimicrobials.
    Recommendation: If both are required, support the choice with culture and susceptibility results. Otherwise, choose one mechanism.
    Sources: VMD SPC · VMD
  • Major warning Doxycycline + Phenobarbital
    Phenobarbital, phenytoin, carbamazepine, and other enzyme-inducing antiepileptic drugs can shorten the half-life of doxycycline and reduce its antibacterial exposure. Standard doxycycline dosing may therefore be subtherapeutic.
    Recommendation: If the patient receives phenobarbital and doxycycline is essential, the standard 10 mg/kg dose may be inadequate; monitor clinical response closely. Alternatively, choose an antibiotic from another class based on susceptibility testing.
    Sources: VMD SPC · VMD
  • Major warning Doxycycline + Procaine Benzylpenicillin
    Tetracyclines, chloramphenicol, macrolides, and lincosamides may antagonise the bactericidal action of benzylpenicillin.
    Recommendation: Do not administer concurrently. Choose one mechanism based on susceptibility testing.
    Sources: VMD SPC · VMD
  • Major warning Doxycycline + Sucralfate
    In dogs, concurrent administration of sucralfate suspension reduced doxycycline AUC from 36.0 to 7.2 h·mcg/mL (relative bioavailability 20%). No interaction was detected with sucralfate tablets because tablet fragments were visible in faeces, indicating that the tablets did not disintegrate and were not effective.
    Recommendation: Separate administration by 2 hours: give doxycycline first and sucralfate 2 hours later. With this schedule, bioavailability is 74% and is not statistically different from doxycycline alone.
    Sources: JVPT

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 21 Oct 2026

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