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Doxy-Denk

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Doxycycline · Denk Pharma

1 form: scored tablet. In force in Georgia: 1 of 1 (human register).

Forms and doses1 of 1 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Form Dose Frequency Georgia
100 mg, Scored tablet 10 mg/kg
Human medicine; extra-label in dogs and cats. Each tablet contains 100 mg doxycycline as doxycycline hyclate. The locally observed tablet can be divided into quarters, but the accessible 2019 manufacturer leaflet describes it as unscored and does not validate equal-dose subdivision. Never administer dry to cats; immediately follow with food or water. Prefer a smaller veterinary, liquid or reliably dispersible formulation when dose accuracy or swallowing is uncertain.
 · once daily		 once daily Georgia Yes, human
In force until 10 Jul 2030
Human (Ministry of Health, RAMA)
№ რ-043572
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Doxy-Denk 100 mg, Scored tablet

tablet, human medicine
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Veterinary-directed treatment of doxycycline-susceptible bacterial infections in dogs when doxycycline is indicated and this human tablet is selected extra-label
7.1/10
Good
vetman assessment

Doxy-Denk

100 mg, tablet, human medicine
Assessed clinical scopeDog · Veterinary-directed treatment of doxycycline-susceptible bacterial infections in dogs when doxycycline is indicated and this human tablet is selected extra-label · By mouth
Care settingPrimarily veterinary-directed outpatient treatment, with diagnosis and susceptibility testing where indicated
vetman score 7.1/10 Good
Evidence confidence: Medium Georgia: Yes, human · № რ-043572 · Verified on 15 Oct 2026 Off-label use

A clinically useful doxycycline option with strong ingredient-level evidence, but it is a human extra-label 100 mg tablet rather than a veterinary formulation; patient selection, susceptibility and dose accuracy still matter.

Regulatory and scientific credibility6.5/10

The exact 100 mg doxycycline-hyclate tablet has a transparent manufacturer leaflet and active Georgian human registration (R-043572), while canine use is extra-label and lacks an exact-product veterinary dossier; licensed veterinary doxycycline products and strong independent ingredient guidance are available.

Clinical efficacy8.0/10

Doxycycline is a well-established guideline-supported option for appropriate susceptible canine respiratory, vector-borne and selected skin infections, but organism identification, local resistance and antimicrobial stewardship determine whether it is the right choice.

Safety and tolerability7.0/10

At appropriate doses it is generally well tolerated in dogs, with gastrointestinal adverse effects, photosensitivity and restrictions around tooth development, pregnancy and significant hepatic or renal disease requiring patient selection and monitoring.

Clinical practicality7.0/10

Once-daily oral treatment is workable at home for many dogs, but the 100 mg strength is coarse for small patients and the locally observed quartering is not validated as equal-dose subdivision by the accessible manufacturer leaflet.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use for a clinically supported, doxycycline-susceptible infection; culture and susceptibility testing are required where the disease context or prior antimicrobial exposure warrants them.
  • Calcium, magnesium, aluminium, iron and other polyvalent cations can reduce oral absorption; separate administration according to the applicable label or protocol.
  • Monitor gastrointestinal tolerance and use additional caution in significant hepatic or renal disease, during pregnancy or lactation, and before tooth development is complete.
Assessment sources
  1. Doxy-Denk leaflet2019
  2. Doxycare SPC2026
  3. ISCAID 20172017
  4. ACVIM 20232023
  5. ISCAID pyoderma 20252025
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Veterinary-directed treatment of doxycycline-susceptible bacterial infections in cats when doxycycline is indicated and this human tablet is selected extra-label
6.3/10
Situational / acceptable
vetman assessment

Doxy-Denk

100 mg, tablet, human medicine
Assessed clinical scopeCat · Veterinary-directed treatment of doxycycline-susceptible bacterial infections in cats when doxycycline is indicated and this human tablet is selected extra-label · By mouth
Care settingVeterinary-directed outpatient treatment only when reliable food-or-water follow-through can be ensured
vetman score 6.3/10 Situational / acceptable
Evidence confidence: Medium Georgia: Yes, human · № რ-043572 · Verified on 15 Oct 2026 Off-label use

The active ingredient is strongly supported, but this exact human 100 mg hyclate tablet is only a situational feline choice because preventable oesophageal injury and dose-form limitations make better formulations preferable.

Regulatory and scientific credibility6.5/10

The exact 100 mg doxycycline-hyclate tablet has a transparent manufacturer leaflet and active Georgian human registration (R-043572), while feline use is extra-label and lacks an exact-product veterinary dossier; licensed veterinary doxycycline formulations are available.

Clinical efficacy8.0/10

Doxycycline is a well-established guideline-supported option for appropriate susceptible feline respiratory and other bacterial infections; this score does not imply empirical use without diagnosis, susceptibility context or stewardship.

Safety and tolerability5.5/10

Doxycycline can be effective and otherwise tolerable in cats, but a dry tablet may lodge in the oesophagus and cause severe oesophagitis or stricture; this preventable, formulation-relevant harm materially limits the exact product.

Clinical practicality4.5/10

The 100 mg non-dispersible tablet is poorly matched to many cats: dose subdivision is coarse and every dose must be followed immediately by food or water; smaller veterinary or reliably dispersible/liquid alternatives are usually more practical.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Never give this tablet dry. Follow it immediately with food or water; avoid the presentation when swallowing or reliable follow-through is uncertain.
  • Prefer a smaller veterinary, liquid or reliably dispersible formulation when available, especially in small cats or patients with oesophageal disease.
  • Calcium, magnesium, aluminium, iron and other polyvalent cations can reduce oral absorption; separate administration according to the applicable label or protocol.
  • Use for a clinically supported, doxycycline-susceptible infection; culture and susceptibility testing are required where indicated.
Assessment sources
  1. Doxy-Denk leaflet2019
  2. Doxycare SPC2026
  3. ISCAID 20172017
  4. Westfall et al. 20012001
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Doxycycline100 mg
Formulation Type
Scored tablet
Administration route
By mouth
Manufacturer
Denk Pharma · Germany
Registration
Georgia Yes, human
In force until 10 Jul 2030
Human (Ministry of Health, RAMA)
№ რ-043572
Verified on: 15 Oct 2026
 EU No
Verified on: 16 Oct 2026
 UK No
Verified on: 16 Oct 2026
 US No
Verified on: 16 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
10 mg/kg
Human medicine; extra-label in dogs and cats. Each tablet contains 100 mg doxycycline as doxycycline hyclate. The locally observed tablet can be divided into quarters, but the accessible 2019 manufacturer leaflet describes it as unscored and does not validate equal-dose subdivision. Never administer dry to cats; immediately follow with food or water. Prefer a smaller veterinary, liquid or reliably dispersible formulation when dose accuracy or swallowing is uncertain.
 All species Any weight By mouth once daily Product label (SPC)
Active substance doses, with sources
Active substance Doxycycline
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
10 mg/kg Dog, Cat Respiratory Tract Infection; Canine Ehrlichiosis; Leptospirosis; Bacterial Infection; Feline Chlamydiosis By mouth once daily
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Ronaxan 20 mg tablets for dogs and cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, Product Information Database, 2025
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Doxybactin 50 mg tablets for dogs and cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, Product Information Database, 2025
5 mg/kg
off-label
 Dog, Cat Leptospirosis; Respiratory Tract Infection By mouth 2 times daily
ACVIM 2023
Guideline or consensus statement
Recommendations agreed by a panel of veterinary specialists after reviewing the evidence. They guide practice and do not authorise a product.
Updated ACVIM consensus statement on leptospirosis in dogs
Journal of Veterinary Internal Medicine, 2023
ISCAID 2017
Guideline or consensus statement
Recommendations agreed by a panel of veterinary specialists after reviewing the evidence. They guide practice and do not authorise a product.
Antimicrobial Use Guidelines for Treatment of Respiratory Tract Disease in Dogs and Cats
Journal of Veterinary Internal Medicine, 2017

Known Contraindications

  • Critical
    administration of doxycycline hyclate tablets has been associated with oesophageal erosion.
    Sources: VMD SPC · VMD · ISCAID · JVIM
  • Critical
    Do not use in animals with renal or hepatic insufficiency. Special warnings: None.
    Sources: VMD SPC · VMD
  • Critical
    Product labels differ: some contraindicate doxycycline in hepatic insufficiency, while others advise special caution and monitoring because liver-enzyme increases have been reported. Follow the label of the selected product and monitor hepatic function.
    Sources: Product label
  • Critical
    Do not use doxycycline tablets in animals with vomiting or dysphagia when the product label lists these conditions as contraindications. Other labels advise caution because impaired swallowing or vomiting increases the risk of a tablet lodging in the oesophagus.
    Sources: VMD SPC · VMD
  • Critical
    Do not use doxycycline in puppies or kittens before tooth-enamel formation is complete when the product label lists this as a contraindication. Doxycycline is less likely than other tetracyclines to cause tooth abnormalities because it binds calcium less strongly, but the labelled restriction still applies.
    Sources: VMD SPC · VMD
  • Warning
    Tetracyclines as a class can retard foetal skeletal development (fully reversible) The safety of the veterinary medicinal product has not been established during pregnancy
    Sources: VMD
  • Warning
    The safety of the veterinary medicinal product has not been established during pregnancy and lactation.
    Sources: VMD
  • Warning
    Do not use in animals with known photosensitivity. During treatment, avoid prolonged intense sunlight, particularly in light-coloured or sparsely haired animals, because photosensitivity and photodermatitis may occur.
    Sources: VMD SPC · VMD
  • Warning (Cat)
    Doxycycline tablets and capsules can lodge in the cat oesophagus and cause oesophagitis and stricture (regurgitation, at varying times after the course). Follow every tablet or capsule with a water bolus or food.

Known Drug Interactions

  • Major warning Enrofloxacin + Doxycycline
    Do not combine enrofloxacin with antimicrobials that act antagonistically to quinolones, including macrolides, tetracyclines such as doxycycline, and phenicols such as chloramphenicol.
    Recommendation: Do not administer concurrently. Based on susceptibility testing, choose either a bactericidal fluoroquinolone or a bacteriostatic tetracycline.
    Sources: VMD SPC · VMD
  • Major warning Ampicillin + Doxycycline
    It is not recommended to administer bactericidal and bacteriostatic antibiotics concomitantly.
    Recommendation: If both are required, support the choice with culture and susceptibility results. Otherwise, choose one mechanism.
    Sources: VMD SPC · VMD
  • Major warning Amoxicillin + Doxycycline
    The bactericidal effect of amoxicillin may be inhibited by the concomitant use of bacteriostatic antimicrobials.
    Recommendation: If both are required, support the choice with culture and susceptibility results. Otherwise, choose one mechanism.
    Sources: VMD SPC · VMD
  • Major warning Doxycycline + Phenobarbital
    Phenobarbital, phenytoin, carbamazepine, and other enzyme-inducing antiepileptic drugs can shorten the half-life of doxycycline and reduce its antibacterial exposure. Standard doxycycline dosing may therefore be subtherapeutic.
    Recommendation: If the patient receives phenobarbital and doxycycline is essential, the standard 10 mg/kg dose may be inadequate; monitor clinical response closely. Alternatively, choose an antibiotic from another class based on susceptibility testing.
    Sources: VMD SPC · VMD
  • Major warning Doxycycline + Procaine Benzylpenicillin
    Tetracyclines, chloramphenicol, macrolides, and lincosamides may antagonise the bactericidal action of benzylpenicillin.
    Recommendation: Do not administer concurrently. Choose one mechanism based on susceptibility testing.
    Sources: VMD SPC · VMD
  • Major warning Doxycycline + Sucralfate
    In dogs, concurrent administration of sucralfate suspension reduced doxycycline AUC from 36.0 to 7.2 h·mcg/mL (relative bioavailability 20%). No interaction was detected with sucralfate tablets because tablet fragments were visible in faeces, indicating that the tablets did not disintegrate and were not effective.
    Recommendation: Separate administration by 2 hours: give doxycycline first and sucralfate 2 hours later. With this schedule, bioavailability is 74% and is not statistically different from doxycycline alone.
    Sources: JVPT

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 16 Oct 2026

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