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Biocan Novel DHPPi/L4R

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Canine distemper virus + Canine adenovirus + Canine parvovirus + Canine parainfluenza virus + Leptospira icterohaemorrhagiae + Leptospira canicola + Leptospira grippotyphosa + Leptospira australis + Rabies virus · Bioveta, a.s.

1 form: suspension. In force in Georgia: 1 of 1 (veterinary register).

Forms and doses1 of 1 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Form Species Dose Frequency Georgia
Suspension · Dog Dog 1 ml (1 ml)
Aseptically reconstitute and immediately inject the entire 1 ml dose SC. Give two doses 3-4 weeks apart from 8-9 weeks; the second not before 12 weeks. Rabies efficacy is proven after one dose from 12 weeks; travel/risk situations may require a two-dose rabies course or an extra dose after 12 weeks. Revaccinate DHPPi/L4R every 3 years and Pi/L4 annually. Vaccinate healthy dogs only; do not use with signs or suspicion of rabies. Maternal antibodies may delay response. Separate vaccinated dogs from susceptible non-dog carnivores and cats as a precaution. Not recommended in pregnancy/lactation. Common transient swelling; rare GI or hypersensitivity reactions require prompt treatment. Other medicines case by case; do not mix. Store 2-8 C, do not freeze, protect from light, use immediately.
 · two doses 3-4 weeks apart; every 3 years, with annual Pi/L4		 two doses 3-4 weeks apart; every 3 years, with annual Pi/L4 Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ბიოკან ნოველ DHPPi/L4R
№ 150-11
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Biocan Novel DHPPi/L4R, Suspension

lyophilisate and suspension, 1 ml dose for dogs
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.4/10
Very good
vetman assessment

Biocan Novel DHPPi/L4R

lyophilisate and suspension, 1 ml dose for dogs
Assessed clinical scopeDog · Full dog label from 8-9 weeks: core CDV, CAV-1/2 and CPV, CPiV, four-serogroup leptospirosis and rabies immunisation · Subcutaneous
Care settingPreventive veterinary vaccination of a healthy dog with examination, rabies certification where required, cold-chain control and emergency treatment available
vetman score 8.4/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 150-11 · Verified on 21 Oct 2026

A very good complete core, leptospirosis and rabies vaccine for dogs, convenient where rabies vaccination is required. Check rabies titres before travel because the label documents incomplete seroconversion after a single dose.

Regulatory and scientific credibility9.0/10

The exact presentation is registered in Georgia (150-11) and has a current EU authorisation and English SPC with transparent strains, potency, rabies potency and duration-of-immunity claims.

Clinical efficacy8.5/10

Core and rabies components carry a labelled three-year duration and four leptospiral serogroups are covered; the label itself reports that 10% of seronegative dogs did not seroconvert to rabies after one dose and 17% stayed below the 0.5 IU/ml travel threshold.

Safety and tolerability8.0/10

Benefit-risk is favourable in healthy dogs, with common transient swelling and rare gastrointestinal or hypersensitivity reactions; it must not be used in a dog suspected of rabies, and pregnancy use is not recommended.

Clinical practicality8.0/10

A single 1 ml dose covers the full core, leptospiral and rabies programme with three-yearly core and rabies boosting; the second dose cannot be given before 12 weeks and annual Pi/L4 is still needed.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Do not use with hypersensitivity to the adjuvant or an excipient, or in a dog showing signs of rabies or suspected of rabies infection. Vaccinate clinically healthy dogs only.
  • The rabies fraction is proven after one dose from 12 weeks: do not give this vaccine as the second dose before 12 weeks of age. Use Biocan Novel DHPPi/L4 for an earlier first dose.
  • In field studies 10% of seronegative dogs did not seroconvert to rabies and 17% stayed below 0.5 IU/ml after one dose. Before travel or in high-risk areas, consider a second rabies dose or a titre test.
  • Maternal antibody can delay the core response; finish the core series at 16 weeks or later when maternal antibody is likely. CPiV and Leptospira need annual boosting, for example with Biocan Novel Pi/L4.
  • Safety in pregnancy and lactation is not established and use is not recommended.
  • Vaccinated dogs can shed live CAV-2, CPiV and CPV-2b; keep them away from cats and other susceptible carnivores after vaccination. Common transient swelling and rare gastrointestinal or hypersensitivity reactions need observation.
  • No data support use with other veterinary medicines; decide timing case by case and do not mix.
  • Store at 2-8 C, do not freeze and inject the whole reconstituted 1 ml immediately.
Assessment sources
  1. EU UPD SPC 20262026
  2. Georgia NFA register 20262026
  3. WSAVA vaccination 20242024
  4. ACVIM leptospirosis consensus 20232023
  5. AAHA canine vaccination 20222022
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Canine distemper virus3.1 log10 TCID50/dose Canine adenovirus3.6 log10 TCID50/dose Canine parvovirus4.3 log10 TCID50/dose Canine parainfluenza virus3.1 log10 TCID50/dose Leptospira icterohaemorrhagiae51 GMT ALR/dose Leptospira canicola51 GMT ALR/dose Leptospira grippotyphosa40 GMT ALR/dose Leptospira australis51 GMT ALR/dose Rabies virus2 IU/dose
Formulation Type
Suspension
Administration route
Subcutaneous
Manufacturer
Bioveta, a.s. · Czechia
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ბიოკან ნოველ DHPPi/L4R
№ 150-11
Verified on: 21 Oct 2026
 EU Yes, veterinary
Verified on: 23 Oct 2026
Controlled in Georgia
Unknown
DoseSpeciesWeightRouteFrequencySource
1 ml (1 ml)
Aseptically reconstitute and immediately inject the entire 1 ml dose SC. Give two doses 3-4 weeks apart from 8-9 weeks; the second not before 12 weeks. Rabies efficacy is proven after one dose from 12 weeks; travel/risk situations may require a two-dose rabies course or an extra dose after 12 weeks. Revaccinate DHPPi/L4R every 3 years and Pi/L4 annually. Vaccinate healthy dogs only; do not use with signs or suspicion of rabies. Maternal antibodies may delay response. Separate vaccinated dogs from susceptible non-dog carnivores and cats as a precaution. Not recommended in pregnancy/lactation. Common transient swelling; rare GI or hypersensitivity reactions require prompt treatment. Other medicines case by case; do not mix. Store 2-8 C, do not freeze, protect from light, use immediately.
 Dog Any weight Subcutaneous two doses 3-4 weeks apart; every 3 years, with annual Pi/L4
EU UPD SPC 2026
Official product label (SPC)
Approved by a medicines regulator as part of the product's authorisation. It applies to that product as authorised there.
Biocan Novel DHPPi/L4R - official SPC
EU Union Product Database, 2026

Canine distemper virus: No dose supported by a publicly verifiable source yet

Canine adenovirus: No dose supported by a publicly verifiable source yet

Canine parvovirus: No dose supported by a publicly verifiable source yet

Canine parainfluenza virus: No dose supported by a publicly verifiable source yet

Leptospira icterohaemorrhagiae: No dose supported by a publicly verifiable source yet

Leptospira canicola: No dose supported by a publicly verifiable source yet

Leptospira grippotyphosa: No dose supported by a publicly verifiable source yet

Leptospira australis: No dose supported by a publicly verifiable source yet

Rabies virus: No dose supported by a publicly verifiable source yet

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Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

For veterinary professionals only. It does not replace clinical judgement or the product label; check the dose in the official label (SPC). vetman is not liable for harm caused by using this information.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 23 Oct 2026

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The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

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