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Imidacloprid + Moxidectin · Elanco

5 forms: spot-on. In force in Georgia: 5 of 5 (veterinary register).

Forms and doses5 of 5 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Weight Dose Frequency Georgia
40 mg/4 mg, Spot-on · Cat up to 4 kg Cat up to 4 kg 1 pipette
Apply 1 small-cat pipette containing 0.4 mL to a cat weighing up to 4 kg. Do not use in cats younger than 9 weeks or weighing less than 0.9 kg.
 · monthly		 monthly Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტეიჯ მულტი® კანზე დასაწვეთებელი ხსნარი ≤ 4კგ-მდე წონის კატებისთვის
№ 348-11
Verified on: 15 Oct 2026
40 mg/4 mg, Spot-on · Dog Any weight Dog Any weight No dose for this species
This 1% moxidectin pipette is for cats; no canine dose is provided on the label. For dogs, use an Advantage Multi canine pipette.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტეიჯ მულტი® კანზე დასაწვეთებელი ხსნარი ≤ 4კგ-მდე წონის კატებისთვის
№ 348-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Advantage Multi 40 mg/4 mg, Spot-on

imidacloprid 40 mg + moxidectin 4 mg, spot-on solution for cats up to 4 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
8.5/10
Very good
vetman assessment

Advantage Multi

40 mg/4 mg, imidacloprid 40 mg + moxidectin 4 mg, spot-on solution for cats up to 4 kg
Assessed clinical scopeCat · Full labelled species-specific scope for susceptible flea, mite, louse, gastrointestinal or cardiopulmonary nematode targets, including applicable heartworm prevention · On the skin
Care settingMonthly or indication-specific single-pipette spot-on treatment after exact species, weight, parasite, heartworm and macrocyclic-lactone risk assessment
vetman score 8.5/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 348-11 · Verified on 15 Oct 2026

A mature, broadly effective topical endectocide supported by FDA and the equivalent EU Advocate dossier; use the exact Georgian kilogram presentation rather than importing US pound-band assumptions.

Regulatory and scientific credibility9.0/10

The exact presentation is registered in Georgia and FDA-authorised under the same brand; its Georgian kilogram bands correspond to the EU Advocate line rather than the differently bounded US pound bands, which must not be interchanged.

Clinical efficacy9.0/10

A mature regulatory dossier and controlled laboratory and field programmes support the combination across its broad species-specific flea, mite, nematode and heartworm roles; exact target and repeat schedule remain indication-dependent.

Safety and tolerability7.5/10

The safety profile is extensively characterised, but the concentrated canine formulation can seriously harm cats; young, underweight, sick or debilitated patients, heartworm-positive animals, oral exposure, MDR1-sensitive dogs and concurrent macrocyclic lactones require strict precautions.

Clinical practicality8.5/10

A premeasured monthly pipette is practical and covers several parasite groups, but exact species/concentration selection, direct skin application, drying, licking prevention and indication-specific retreatment intervals are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use only the exact species, concentration and weight-band pipette. The canine 2.5% moxidectin formulation must never be used on cats, and EU/Georgian kilogram bands must not be replaced with US pound-band assumptions.
  • Do not combine with another antiparasitic macrocyclic lactone unless the exact label and a documented veterinarian-led benefit-risk decision support it.
  • Apply the complete pipette directly to exposed skin, prevent oral exposure and licking, keep animals apart until dry, and follow the indication-specific bathing and repeat-treatment interval.
  • Do not use below nine weeks of age. A cat below 1 kg, or a sick, debilitated or underweight cat, requires the strictest applicable label and a veterinarian-led benefit-risk decision.
  • Establish heartworm status and exact indication before use: applicable EU and FDA labels differ on heartworm-positive cats, and adult infection may carry severe risk.
Assessment sources
  1. VMD SPC 20252025
  2. FDA 20252025
  3. FDA Advantage Multi cat FOI2007
  4. EMA Advocate EPAR2024
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Imidacloprid40 mg Moxidectin4 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Elanco · United States
Manufacturer (register)
KVP Pharma + Veterinar Produkte GmbH, Germany
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1253, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტეიჯ მულტი® კანზე დასაწვეთებელი ხსნარი ≤ 4კგ-მდე წონის კატებისთვის
№ 348-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ NADA 141-251, 141-254
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 pipette
Apply 1 small-cat pipette containing 0.4 mL to a cat weighing up to 4 kg. Do not use in cats younger than 9 weeks or weighing less than 0.9 kg.
 Cat up to 4 kg On the skin monthly Product label (SPC)
No dose for this species
This 1% moxidectin pipette is for cats; no canine dose is provided on the label. For dogs, use an Advantage Multi canine pipette.
 Dog Any weight On the skin - Product label (SPC)
80 mg/8 mg, Spot-on · Cat 4–8 kg Cat 4–8 kg 1 pipette
Apply 1 large-cat pipette containing 0.8 mL to a cat weighing over 4 kg up to 8 kg. For cats above the labelled range, use the appropriate combination of feline pipettes according to the product label.
 · monthly		 monthly Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტეიჯ მულტი® კანზე დასაწვეთებელი ხსნარი > 4კგ-დან 8კგ-მდე წონის კატებისთვის
№ 345-11
Verified on: 15 Oct 2026
80 mg/8 mg, Spot-on · Dog Any weight Dog Any weight No dose for this species
This pipette is for cats; no canine dose is provided on the label.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტეიჯ მულტი® კანზე დასაწვეთებელი ხსნარი > 4კგ-დან 8კგ-მდე წონის კატებისთვის
№ 345-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Advantage Multi 80 mg/8 mg, Spot-on

imidacloprid 80 mg + moxidectin 8 mg, spot-on solution for cats 4-8 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Cat
8.5/10
Very good
vetman assessment

Advantage Multi

80 mg/8 mg, imidacloprid 80 mg + moxidectin 8 mg, spot-on solution for cats 4-8 kg
Assessed clinical scopeCat · Full labelled species-specific scope for susceptible flea, mite, louse, gastrointestinal or cardiopulmonary nematode targets, including applicable heartworm prevention · On the skin
Care settingMonthly or indication-specific single-pipette spot-on treatment after exact species, weight, parasite, heartworm and macrocyclic-lactone risk assessment
vetman score 8.5/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 345-11 · Verified on 15 Oct 2026

A mature, broadly effective topical endectocide supported by FDA and the equivalent EU Advocate dossier; use the exact Georgian kilogram presentation rather than importing US pound-band assumptions.

Regulatory and scientific credibility9.0/10

The exact presentation is registered in Georgia and FDA-authorised under the same brand; its Georgian kilogram bands correspond to the EU Advocate line rather than the differently bounded US pound bands, which must not be interchanged.

Clinical efficacy9.0/10

A mature regulatory dossier and controlled laboratory and field programmes support the combination across its broad species-specific flea, mite, nematode and heartworm roles; exact target and repeat schedule remain indication-dependent.

Safety and tolerability7.5/10

The safety profile is extensively characterised, but the concentrated canine formulation can seriously harm cats; young, underweight, sick or debilitated patients, heartworm-positive animals, oral exposure, MDR1-sensitive dogs and concurrent macrocyclic lactones require strict precautions.

Clinical practicality8.5/10

A premeasured monthly pipette is practical and covers several parasite groups, but exact species/concentration selection, direct skin application, drying, licking prevention and indication-specific retreatment intervals are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use only the exact species, concentration and weight-band pipette. The canine 2.5% moxidectin formulation must never be used on cats, and EU/Georgian kilogram bands must not be replaced with US pound-band assumptions.
  • Do not combine with another antiparasitic macrocyclic lactone unless the exact label and a documented veterinarian-led benefit-risk decision support it.
  • Apply the complete pipette directly to exposed skin, prevent oral exposure and licking, keep animals apart until dry, and follow the indication-specific bathing and repeat-treatment interval.
  • Do not use below nine weeks of age. A cat below 1 kg, or a sick, debilitated or underweight cat, requires the strictest applicable label and a veterinarian-led benefit-risk decision.
  • Establish heartworm status and exact indication before use: applicable EU and FDA labels differ on heartworm-positive cats, and adult infection may carry severe risk.
Assessment sources
  1. VMD SPC 20252025
  2. FDA 20252025
  3. FDA Advantage Multi cat FOI2007
  4. EMA Advocate EPAR2024
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Imidacloprid80 mg Moxidectin8 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Elanco · United States
Manufacturer (register)
KVP Pharma + Veterinar Produkte GmbH, Germany
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1250, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტეიჯ მულტი® კანზე დასაწვეთებელი ხსნარი > 4კგ-დან 8კგ-მდე წონის კატებისთვის
№ 345-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ NADA 141-251, 141-254
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
1 pipette
Apply 1 large-cat pipette containing 0.8 mL to a cat weighing over 4 kg up to 8 kg. For cats above the labelled range, use the appropriate combination of feline pipettes according to the product label.
 Cat 4–8 kg On the skin monthly Product label (SPC)
No dose for this species
This pipette is for cats; no canine dose is provided on the label.
 Dog Any weight On the skin - Product label (SPC)
100 mg/25 mg, Spot-on · Cat Any weight Cat Any weight No dose for this species
Do not use this canine product containing 2.5% moxidectin in cats. Oral or topical exposure in cats has caused serious reactions, including neurological signs and death.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტეიჯ მულტი® კანზე დასაწვეთებელი ხსნარი > 4კგ-დან 10კგ-მდე წონის ძაღლებისთვის
№ 347-11
Verified on: 15 Oct 2026
100 mg/25 mg, Spot-on · Dog 4–10 kg Dog 4–10 kg 1 pipette
Apply 1 medium-dog pipette containing 1 mL to a dog weighing over 4 kg up to 10 kg. This canine formulation contains 2.5% moxidectin and must not be used in cats.
 · monthly		 monthly Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტეიჯ მულტი® კანზე დასაწვეთებელი ხსნარი > 4კგ-დან 10კგ-მდე წონის ძაღლებისთვის
№ 347-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Advantage Multi 100 mg/25 mg, Spot-on

imidacloprid 100 mg + moxidectin 25 mg, spot-on solution for dogs 4-10 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.5/10
Very good
vetman assessment

Advantage Multi

100 mg/25 mg, imidacloprid 100 mg + moxidectin 25 mg, spot-on solution for dogs 4-10 kg
Assessed clinical scopeDog · Full labelled species-specific scope for susceptible flea, mite, louse, gastrointestinal or cardiopulmonary nematode targets, including applicable heartworm prevention · On the skin
Care settingMonthly or indication-specific single-pipette spot-on treatment after exact species, weight, parasite, heartworm and macrocyclic-lactone risk assessment
vetman score 8.5/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 347-11 · Verified on 15 Oct 2026

A mature, broadly effective topical endectocide supported by FDA and the equivalent EU Advocate dossier; use the exact Georgian kilogram presentation rather than importing US pound-band assumptions.

Regulatory and scientific credibility9.0/10

The exact presentation is registered in Georgia and FDA-authorised under the same brand; its Georgian kilogram bands correspond to the EU Advocate line rather than the differently bounded US pound bands, which must not be interchanged.

Clinical efficacy9.0/10

A mature regulatory dossier and controlled laboratory and field programmes support the combination across its broad species-specific flea, mite, nematode and heartworm roles; exact target and repeat schedule remain indication-dependent.

Safety and tolerability7.5/10

The safety profile is extensively characterised, but the concentrated canine formulation can seriously harm cats; young, underweight, sick or debilitated patients, heartworm-positive animals, oral exposure, MDR1-sensitive dogs and concurrent macrocyclic lactones require strict precautions.

Clinical practicality8.5/10

A premeasured monthly pipette is practical and covers several parasite groups, but exact species/concentration selection, direct skin application, drying, licking prevention and indication-specific retreatment intervals are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use only the exact species, concentration and weight-band pipette. The canine 2.5% moxidectin formulation must never be used on cats, and EU/Georgian kilogram bands must not be replaced with US pound-band assumptions.
  • Do not combine with another antiparasitic macrocyclic lactone unless the exact label and a documented veterinarian-led benefit-risk decision support it.
  • Apply the complete pipette directly to exposed skin, prevent oral exposure and licking, keep animals apart until dry, and follow the indication-specific bathing and repeat-treatment interval.
  • Do not use below seven weeks of age; animals below 1 kg, or sick, debilitated or underweight dogs, require the exact label and an explicit benefit-risk decision.
  • Before heartworm use, establish infection status and clinical class. Class 4 disease is contraindicated or unevaluated by the applicable labels; microfilariae treatment and MDR1-sensitive breeds require strict observation for neurologic or acute reactions.
Assessment sources
  1. VMD SPC 20252025
  2. FDA 20252025
  3. FDA Advantage Multi dog FOI2007
  4. EMA Advocate EPAR2024
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Imidacloprid100 mg Moxidectin25 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Elanco · United States
Manufacturer (register)
KVP Pharma + Veterinar Produkte GmbH, Germany
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1252, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტეიჯ მულტი® კანზე დასაწვეთებელი ხსნარი > 4კგ-დან 10კგ-მდე წონის ძაღლებისთვის
№ 347-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ NADA 141-251, 141-254
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
Do not use this canine product containing 2.5% moxidectin in cats. Oral or topical exposure in cats has caused serious reactions, including neurological signs and death.
 Cat Any weight On the skin - Product label (SPC)
1 pipette
Apply 1 medium-dog pipette containing 1 mL to a dog weighing over 4 kg up to 10 kg. This canine formulation contains 2.5% moxidectin and must not be used in cats.
 Dog 4–10 kg On the skin monthly Product label (SPC)
250 mg/62.5 mg, Spot-on · Cat Any weight Cat Any weight No dose for this species
Do not use this canine product containing 2.5% moxidectin in cats because severe neurological reactions and death can occur.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტეიჯ მულტი® კანზე დასაწვეთებელი ხსნარი > 10კგ-დან 25კგ-მდე წონის ძაღლებისთვის
№ 346-11
Verified on: 15 Oct 2026
250 mg/62.5 mg, Spot-on · Dog 10–25 kg Dog 10–25 kg 1 pipette
Apply 1 large-dog pipette containing 2.5 mL to a dog weighing over 10 kg up to 25 kg.
 · monthly		 monthly Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტეიჯ მულტი® კანზე დასაწვეთებელი ხსნარი > 10კგ-დან 25კგ-მდე წონის ძაღლებისთვის
№ 346-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Advantage Multi 250 mg/62.5 mg, Spot-on

imidacloprid 250 mg + moxidectin 62.5 mg, spot-on solution for dogs 10-25 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.5/10
Very good
vetman assessment

Advantage Multi

250 mg/62.5 mg, imidacloprid 250 mg + moxidectin 62.5 mg, spot-on solution for dogs 10-25 kg
Assessed clinical scopeDog · Full labelled species-specific scope for susceptible flea, mite, louse, gastrointestinal or cardiopulmonary nematode targets, including applicable heartworm prevention · On the skin
Care settingMonthly or indication-specific single-pipette spot-on treatment after exact species, weight, parasite, heartworm and macrocyclic-lactone risk assessment
vetman score 8.5/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 346-11 · Verified on 15 Oct 2026

A mature, broadly effective topical endectocide supported by FDA and the equivalent EU Advocate dossier; use the exact Georgian kilogram presentation rather than importing US pound-band assumptions.

Regulatory and scientific credibility9.0/10

The exact presentation is registered in Georgia and FDA-authorised under the same brand; its Georgian kilogram bands correspond to the EU Advocate line rather than the differently bounded US pound bands, which must not be interchanged.

Clinical efficacy9.0/10

A mature regulatory dossier and controlled laboratory and field programmes support the combination across its broad species-specific flea, mite, nematode and heartworm roles; exact target and repeat schedule remain indication-dependent.

Safety and tolerability7.5/10

The safety profile is extensively characterised, but the concentrated canine formulation can seriously harm cats; young, underweight, sick or debilitated patients, heartworm-positive animals, oral exposure, MDR1-sensitive dogs and concurrent macrocyclic lactones require strict precautions.

Clinical practicality8.5/10

A premeasured monthly pipette is practical and covers several parasite groups, but exact species/concentration selection, direct skin application, drying, licking prevention and indication-specific retreatment intervals are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use only the exact species, concentration and weight-band pipette. The canine 2.5% moxidectin formulation must never be used on cats, and EU/Georgian kilogram bands must not be replaced with US pound-band assumptions.
  • Do not combine with another antiparasitic macrocyclic lactone unless the exact label and a documented veterinarian-led benefit-risk decision support it.
  • Apply the complete pipette directly to exposed skin, prevent oral exposure and licking, keep animals apart until dry, and follow the indication-specific bathing and repeat-treatment interval.
  • Do not use below seven weeks of age; animals below 1 kg, or sick, debilitated or underweight dogs, require the exact label and an explicit benefit-risk decision.
  • Before heartworm use, establish infection status and clinical class. Class 4 disease is contraindicated or unevaluated by the applicable labels; microfilariae treatment and MDR1-sensitive breeds require strict observation for neurologic or acute reactions.
Assessment sources
  1. VMD SPC 20252025
  2. FDA 20252025
  3. FDA Advantage Multi dog FOI2007
  4. EMA Advocate EPAR2024
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Imidacloprid250 mg Moxidectin62.5 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Elanco · United States
Manufacturer (register)
KVP Pharma + Veterinar Produkte GmbH, Germany
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1251, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტეიჯ მულტი® კანზე დასაწვეთებელი ხსნარი > 10კგ-დან 25კგ-მდე წონის ძაღლებისთვის
№ 346-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ NADA 141-251, 141-254
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
Do not use this canine product containing 2.5% moxidectin in cats because severe neurological reactions and death can occur.
 Cat Any weight On the skin - Product label (SPC)
1 pipette
Apply 1 large-dog pipette containing 2.5 mL to a dog weighing over 10 kg up to 25 kg.
 Dog 10–25 kg On the skin monthly Product label (SPC)
400 mg/100 mg, Spot-on · Cat Any weight Cat Any weight No dose for this species
Do not use this canine product containing 2.5% moxidectin in cats because severe neurological reactions and death can occur.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტეიჯ მულტი® კანზე დასაწვეთებელი ხსნარი > 25კგ-დან 40კგ-მდე წონის ძაღლებისთვის
№ 349-11
Verified on: 15 Oct 2026
400 mg/100 mg, Spot-on · Dog 25–40 kg Dog 25–40 kg 1 pipette
For dogs weighing 25–40 kg, apply 1 pipette (4.0 mL) at 3–4 points along the back. Do not use in cats.
 · monthly		 monthly Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტეიჯ მულტი® კანზე დასაწვეთებელი ხსნარი > 25კგ-დან 40კგ-მდე წონის ძაღლებისთვის
№ 349-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Advantage Multi 400 mg/100 mg, Spot-on

imidacloprid 400 mg + moxidectin 100 mg, spot-on solution for dogs 25-40 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.5/10
Very good
vetman assessment

Advantage Multi

400 mg/100 mg, imidacloprid 400 mg + moxidectin 100 mg, spot-on solution for dogs 25-40 kg
Assessed clinical scopeDog · Full labelled species-specific scope for susceptible flea, mite, louse, gastrointestinal or cardiopulmonary nematode targets, including applicable heartworm prevention · On the skin
Care settingMonthly or indication-specific single-pipette spot-on treatment after exact species, weight, parasite, heartworm and macrocyclic-lactone risk assessment
vetman score 8.5/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 349-11 · Verified on 15 Oct 2026

A mature, broadly effective topical endectocide supported by FDA and the equivalent EU Advocate dossier; use the exact Georgian kilogram presentation rather than importing US pound-band assumptions.

Regulatory and scientific credibility9.0/10

The exact presentation is registered in Georgia and FDA-authorised under the same brand; its Georgian kilogram bands correspond to the EU Advocate line rather than the differently bounded US pound bands, which must not be interchanged.

Clinical efficacy9.0/10

A mature regulatory dossier and controlled laboratory and field programmes support the combination across its broad species-specific flea, mite, nematode and heartworm roles; exact target and repeat schedule remain indication-dependent.

Safety and tolerability7.5/10

The safety profile is extensively characterised, but the concentrated canine formulation can seriously harm cats; young, underweight, sick or debilitated patients, heartworm-positive animals, oral exposure, MDR1-sensitive dogs and concurrent macrocyclic lactones require strict precautions.

Clinical practicality8.5/10

A premeasured monthly pipette is practical and covers several parasite groups, but exact species/concentration selection, direct skin application, drying, licking prevention and indication-specific retreatment intervals are essential.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Use only the exact species, concentration and weight-band pipette. The canine 2.5% moxidectin formulation must never be used on cats, and EU/Georgian kilogram bands must not be replaced with US pound-band assumptions.
  • Do not combine with another antiparasitic macrocyclic lactone unless the exact label and a documented veterinarian-led benefit-risk decision support it.
  • Apply the complete pipette directly to exposed skin, prevent oral exposure and licking, keep animals apart until dry, and follow the indication-specific bathing and repeat-treatment interval.
  • Do not use below seven weeks of age; animals below 1 kg, or sick, debilitated or underweight dogs, require the exact label and an explicit benefit-risk decision.
  • Before heartworm use, establish infection status and clinical class. Class 4 disease is contraindicated or unevaluated by the applicable labels; microfilariae treatment and MDR1-sensitive breeds require strict observation for neurologic or acute reactions.
Assessment sources
  1. VMD SPC 20252025
  2. FDA 20252025
  3. FDA Advantage Multi dog FOI2007
  4. EMA Advocate EPAR2024
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Imidacloprid400 mg Moxidectin100 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Elanco · United States
Manufacturer (register)
KVP Pharma + Veterinar Produkte GmbH, Germany
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1254, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ადვანტეიჯ მულტი® კანზე დასაწვეთებელი ხსნარი > 25კგ-დან 40კგ-მდე წონის ძაღლებისთვის
№ 349-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ NADA 141-251, 141-254
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
Do not use this canine product containing 2.5% moxidectin in cats because severe neurological reactions and death can occur.
 Cat Any weight On the skin - Product label (SPC)
1 pipette
For dogs weighing 25–40 kg, apply 1 pipette (4.0 mL) at 3–4 points along the back. Do not use in cats.
 Dog 25–40 kg On the skin monthly Product label (SPC)
Active substance doses, with sources
Active substance Imidacloprid
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
10–25 mg/kg Dog Maintenance On the skin monthly
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Advocate 400 mg + 100 mg spot-on solution for extra-large dogs (> 25-40 kg) - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
10–20 mg/kg Cat Maintenance On the skin monthly
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Advocate 40 mg + 4 mg spot-on solution for small cats (<= 4 kg) and ferrets - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
Active substance Moxidectin
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
2.5–6.25 mg/kg Dog Maintenance On the skin monthly
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Advocate 400 mg + 100 mg spot-on solution for extra-large dogs (> 25-40 kg) - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
1–2 mg/kg Cat Maintenance On the skin monthly
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Advocate 40 mg + 4 mg spot-on solution for small cats (<= 4 kg) and ferrets - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025

Known Contraindications

  • Critical Imidacloprid
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Moxidectin
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Moxidectin (Dog)
    Do not use in puppies under 7 weeks of age. The safe use... has not been established in puppies and dogs less than 7 weeks of age or less than 3 lbs. body weight.
    Sources: VMD SPC · VMD · FDA
  • Critical Moxidectin (Cat)
    Do not use in kittens under 9 weeks of age. Do not use on cats less than 9 weeks of age or less than 2 lbs. body weight.
    Sources: VMD SPC · VMD · FDA
  • Warning Moxidectin
    The safety of the veterinary medicinal product has not been established during pregnancy and lactation in the target species.... The use is not recommended during pregnancy and lactation. Fertility: Do not use in breeding animals. The safety... has not been established in breeding, pregnant, or lactating
    Sources: VMD SPC · VMD · FDA
  • Warning Moxidectin
    The use is not recommended during pregnancy and lactation.
    Sources: VMD SPC · VMD · FDA
  • Warning Moxidectin (Dog)
    special care should be taken with Collie or Old English Sheep dogs and related breeds or crossbreeds... in particular, oral uptake by Collie or Old English Sheep dogs and related breeds or crossbreeds should be prevented. Dogs with this mutation may develop signs of severe avermectin toxicity if they ingest this product. The most common breeds associated with this mutation include Collies and Collie crosses.
    Sources: VMD SPC · VMD · FDA
  • Warning Moxidectin (Dog)
    Do not use in dogs classified as Class 4 for heartworm disease has not been evaluated in heartworm-positive dogs with Class 4 heartworm disease
    Sources: VMD SPC · VMD · FDA
  • Warning Moxidectin (Cat)
    use of the veterinary medicinal product on cats or ferrets which have adult heartworms may cause serious adverse effects, including death No adverse reactions were associated with the topical application... to experimentally heartworm-infected cats.
    Sources: VMD SPC · VMD · FDA
  • Warning Moxidectin (Cat)
    Do not use on sick, debilitated, or underweight cats Several otherwise healthy, thin geriatric cats experienced prolonged lethargy and sleepiness after using this drug.
    Sources: VMD SPC · VMD · FDA
  • Caution Moxidectin (Dog)
    Use with caution in sick, debilitated, or underweight animals.
    Sources: VMD SPC · VMD · FDA
  • Known Breed Sensitivities Moxidectin
    Collie, Collie (unspecified), Collie - Scottish Rough, Collie - Scottish Smooth, Sheepdog - Old English
    special care should be taken with Collie or Old English Sheep dogs and related breeds or crossbreeds... oral uptake... should be prevented.

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