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Fipronil + Permethrin · Virbac

5 forms: spot-on. In force in Georgia: 5 of 5 (veterinary register).

Do not use on cats. Prevent cats from contacting or grooming a treated dog; follow the exact label for the separation period. Species safety: cats →

Forms and doses5 of 5 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Weight Dose Frequency Georgia
26.8 mg/240 mg, Spot-on · Cat Any weight Cat Any weight No dose for this species
Do not use this permethrin-containing product in cats or rabbits because severe adverse reactions and death can occur.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფიტიქსი 26,8მგ/240მგ დასაწვეთებელი ხსნარი ძალიან პატარა ჯიშის ძაღლებისათვის (1.5-4კგ)
№ 313-11
Verified on: 15 Oct 2026
26.8 mg/240 mg, Spot-on · Dog 1.5–4 kg Dog 1.5–4 kg 1 pipette
The recommended minimum dose is 6.7 mg fipronil /kg b.w.and 60 mg permethrin/kg b.w. The interval between two treatments should be at least 4 weeks. Do not use on rabbits and cats as adverse reactions and even death can occur
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფიტიქსი 26,8მგ/240მგ დასაწვეთებელი ხსნარი ძალიან პატარა ჯიშის ძაღლებისათვის (1.5-4კგ)
№ 313-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Effitix 26.8 mg/240 mg, Spot-on

fipronil 26.84 mg + permethrin 239.8 mg, spot-on solution for dogs 1.5-4 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.2/10
Very good
vetman assessment

Effitix

26.8 mg/240 mg, fipronil 26.84 mg + permethrin 239.8 mg, spot-on solution for dogs 1.5-4 kg
Assessed clinical scopeDog · Full canine label: flea treatment/prevention and FAD strategy, tick treatment and four-week control, with four-week sand-fly and mosquito repellency when that combined role is clinically required · On the skin
Care settingExact weight-band pipette after weighing and parasite-risk assessment; apply to two to four skin sites, prevent licking, and separate treated dogs from cats until fully dry
vetman score 8.2/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 313-11 · Verified on 15 Oct 2026

A strongly supported four-week flea, tick and vector-repellency option for dogs when the combined role is actually needed. Its value is limited by strict cat-exposure precautions and a more involved application process, not by weak canine efficacy.

Regulatory and scientific credibility9.0/10

All five exact presentations are currently registered in Georgia, with a current regulator-hosted product-line leaflet, a transparent assessment dossier and exact-form evidence.

Clinical efficacy8.5/10

The regulatory dossier and several exact-product controlled or field studies consistently support four-week flea and tick activity plus anti-feeding activity against labelled sand flies and mosquitoes. Some studies are sponsor-linked and bites or attachment are not completely prevented.

Safety and tolerability7.5/10

Correctly selected dogs generally tolerate the label dose well and canine reactions are very rare, but neurologic signs are possible and permethrin exposure can be fatal to cats. Strict species separation, age, weight, illness and reproductive-use restrictions materially shape safe use.

Clinical practicality7.5/10

Monthly weight-band dosing is workable, but application to two to four skin sites, drying time, cat separation, licking prevention and swimming or shampoo restrictions create more handling burden than a simple single-site ectoparasiticide.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Never use on cats or rabbits. Permethrin exposure is extremely poisonous and may be fatal to cats; keep treated dogs away until the site is fully dry and urgently wash and seek veterinary help after accidental exposure.
  • Do not use in sick, febrile or convalescent dogs or in known hypersensitivity to either active substance or an excipient.
  • Use this fixed combination for confirmed or credible flea and/or tick risk when sand-fly or mosquito repellency is also needed; do not add the permethrin component without a coherent clinical purpose.
  • Do not use below 12 weeks of age or 1.5 kg. Weigh accurately and use the exact weight-band pipette; overdose can increase adverse reactions.
  • Very rare canine reactions include application-site pruritus, erythema or alopecia, vomiting, agitation and neurologic signs. Prevent licking; transient hypersalivation may follow oral exposure.
  • Single ticks or bites by sand flies or mosquitoes may still occur, so pathogen transmission cannot be excluded; some Dermacentor or Rhipicephalus present at application may remain alive for 48 hours.
  • Frequent swimming or shampooing may reduce persistence. Keep dogs out of watercourses for two days, minimise human contact for about 12 hours, and use in pregnancy or lactation only after veterinary benefit-risk assessment.
Assessment sources
  1. VMD Effitix leaflet2025
  2. VMD Effitix assessment2018
  3. Effitix European tick field study2016
  4. Effitix sand-fly study2015
  5. Effitix mosquito study2015
  6. Effitix speed-of-kill study2017
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil26.84 mg Permethrin239.8 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Virbac · France
Manufacturer (register)
Virbac, France
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 949, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფიტიქსი 26,8მგ/240მგ დასაწვეთებელი ხსნარი ძალიან პატარა ჯიშის ძაღლებისათვის (1.5-4კგ)
№ 313-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
Do not use this permethrin-containing product in cats or rabbits because severe adverse reactions and death can occur.
 Cat Any weight On the skin - Product label (SPC)
1 pipette
The recommended minimum dose is 6.7 mg fipronil /kg b.w.and 60 mg permethrin/kg b.w. The interval between two treatments should be at least 4 weeks. Do not use on rabbits and cats as adverse reactions and even death can occur
 Dog 1.5–4 kg On the skin not more often than every 4 weeks Product label (SPC)
67 mg/600 mg, Spot-on · Cat Any weight Cat Any weight No dose for this species
Never use in cats: permethrin can be fatal to cats.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფიტიქსი 67მგ/600მგ დასაწვეთებელი ხსნარი პატარა ჯიშის ძაღლებისათვის (4-10კგ)
№ 316-11
Verified on: 15 Oct 2026
67 mg/600 mg, Spot-on · Dog 4–10 kg Dog 4–10 kg 1 pipette
4-10 kg 67 [mg fipronil] 600 [mg permethrin]
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფიტიქსი 67მგ/600მგ დასაწვეთებელი ხსნარი პატარა ჯიშის ძაღლებისათვის (4-10კგ)
№ 316-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Effitix 67 mg/600 mg, Spot-on

fipronil 67.1 mg + permethrin 599.5 mg, spot-on solution for dogs 4-10 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.2/10
Very good
vetman assessment

Effitix

67 mg/600 mg, fipronil 67.1 mg + permethrin 599.5 mg, spot-on solution for dogs 4-10 kg
Assessed clinical scopeDog · Full canine label: flea treatment/prevention and FAD strategy, tick treatment and four-week control, with four-week sand-fly and mosquito repellency when that combined role is clinically required · On the skin
Care settingExact weight-band pipette after weighing and parasite-risk assessment; apply to two to four skin sites, prevent licking, and separate treated dogs from cats until fully dry
vetman score 8.2/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 316-11 · Verified on 15 Oct 2026

A strongly supported four-week flea, tick and vector-repellency option for dogs when the combined role is actually needed. Its value is limited by strict cat-exposure precautions and a more involved application process, not by weak canine efficacy.

Regulatory and scientific credibility9.0/10

All five exact presentations are currently registered in Georgia, with a current regulator-hosted product-line leaflet, a transparent assessment dossier and exact-form evidence.

Clinical efficacy8.5/10

The regulatory dossier and several exact-product controlled or field studies consistently support four-week flea and tick activity plus anti-feeding activity against labelled sand flies and mosquitoes. Some studies are sponsor-linked and bites or attachment are not completely prevented.

Safety and tolerability7.5/10

Correctly selected dogs generally tolerate the label dose well and canine reactions are very rare, but neurologic signs are possible and permethrin exposure can be fatal to cats. Strict species separation, age, weight, illness and reproductive-use restrictions materially shape safe use.

Clinical practicality7.5/10

Monthly weight-band dosing is workable, but application to two to four skin sites, drying time, cat separation, licking prevention and swimming or shampoo restrictions create more handling burden than a simple single-site ectoparasiticide.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Never use on cats or rabbits. Permethrin exposure is extremely poisonous and may be fatal to cats; keep treated dogs away until the site is fully dry and urgently wash and seek veterinary help after accidental exposure.
  • Do not use in sick, febrile or convalescent dogs or in known hypersensitivity to either active substance or an excipient.
  • Use this fixed combination for confirmed or credible flea and/or tick risk when sand-fly or mosquito repellency is also needed; do not add the permethrin component without a coherent clinical purpose.
  • Do not use below 12 weeks of age or 1.5 kg. Weigh accurately and use the exact weight-band pipette; overdose can increase adverse reactions.
  • Very rare canine reactions include application-site pruritus, erythema or alopecia, vomiting, agitation and neurologic signs. Prevent licking; transient hypersalivation may follow oral exposure.
  • Single ticks or bites by sand flies or mosquitoes may still occur, so pathogen transmission cannot be excluded; some Dermacentor or Rhipicephalus present at application may remain alive for 48 hours.
  • Frequent swimming or shampooing may reduce persistence. Keep dogs out of watercourses for two days, minimise human contact for about 12 hours, and use in pregnancy or lactation only after veterinary benefit-risk assessment.
Assessment sources
  1. VMD Effitix leaflet2025
  2. VMD Effitix assessment2018
  3. Effitix European tick field study2016
  4. Effitix sand-fly study2015
  5. Effitix mosquito study2015
  6. Effitix speed-of-kill study2017
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil67.1 mg Permethrin599.5 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Virbac · France
Manufacturer (register)
Virbac, France
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 952, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფიტიქსი 67მგ/600მგ დასაწვეთებელი ხსნარი პატარა ჯიშის ძაღლებისათვის (4-10კგ)
№ 316-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
Never use in cats: permethrin can be fatal to cats.
 Cat Any weight On the skin - Product label (SPC)
1 pipette
4-10 kg 67 [mg fipronil] 600 [mg permethrin]
 Dog 4–10 kg On the skin not more often than every 4 weeks Product label (SPC)
134 mg/1200 mg, Spot-on · Cat Any weight Cat Any weight No dose for this species
Never use in cats: permethrin can be fatal to cats.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფიტიქსი 134მგ/1200მგ დასაწვეთებელი ხსნარი საშუალო ჯიშის ძაღლებისათვის (10-20კგ)
№ 317-11
Verified on: 15 Oct 2026
134 mg/1200 mg, Spot-on · Dog 10–20 kg Dog 10–20 kg 1 pipette
10-20 kg 134 [mg fipronil] 1200 [mg permethrin]
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფიტიქსი 134მგ/1200მგ დასაწვეთებელი ხსნარი საშუალო ჯიშის ძაღლებისათვის (10-20კგ)
№ 317-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Effitix 134 mg/1200 mg, Spot-on

fipronil 134.2 mg + permethrin 1199 mg, spot-on solution for dogs 10-20 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.2/10
Very good
vetman assessment

Effitix

134 mg/1200 mg, fipronil 134.2 mg + permethrin 1199 mg, spot-on solution for dogs 10-20 kg
Assessed clinical scopeDog · Full canine label: flea treatment/prevention and FAD strategy, tick treatment and four-week control, with four-week sand-fly and mosquito repellency when that combined role is clinically required · On the skin
Care settingExact weight-band pipette after weighing and parasite-risk assessment; apply to two to four skin sites, prevent licking, and separate treated dogs from cats until fully dry
vetman score 8.2/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 317-11 · Verified on 15 Oct 2026

A strongly supported four-week flea, tick and vector-repellency option for dogs when the combined role is actually needed. Its value is limited by strict cat-exposure precautions and a more involved application process, not by weak canine efficacy.

Regulatory and scientific credibility9.0/10

All five exact presentations are currently registered in Georgia, with a current regulator-hosted product-line leaflet, a transparent assessment dossier and exact-form evidence.

Clinical efficacy8.5/10

The regulatory dossier and several exact-product controlled or field studies consistently support four-week flea and tick activity plus anti-feeding activity against labelled sand flies and mosquitoes. Some studies are sponsor-linked and bites or attachment are not completely prevented.

Safety and tolerability7.5/10

Correctly selected dogs generally tolerate the label dose well and canine reactions are very rare, but neurologic signs are possible and permethrin exposure can be fatal to cats. Strict species separation, age, weight, illness and reproductive-use restrictions materially shape safe use.

Clinical practicality7.5/10

Monthly weight-band dosing is workable, but application to two to four skin sites, drying time, cat separation, licking prevention and swimming or shampoo restrictions create more handling burden than a simple single-site ectoparasiticide.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Never use on cats or rabbits. Permethrin exposure is extremely poisonous and may be fatal to cats; keep treated dogs away until the site is fully dry and urgently wash and seek veterinary help after accidental exposure.
  • Do not use in sick, febrile or convalescent dogs or in known hypersensitivity to either active substance or an excipient.
  • Use this fixed combination for confirmed or credible flea and/or tick risk when sand-fly or mosquito repellency is also needed; do not add the permethrin component without a coherent clinical purpose.
  • Do not use below 12 weeks of age or 1.5 kg. Weigh accurately and use the exact weight-band pipette; overdose can increase adverse reactions.
  • Very rare canine reactions include application-site pruritus, erythema or alopecia, vomiting, agitation and neurologic signs. Prevent licking; transient hypersalivation may follow oral exposure.
  • Single ticks or bites by sand flies or mosquitoes may still occur, so pathogen transmission cannot be excluded; some Dermacentor or Rhipicephalus present at application may remain alive for 48 hours.
  • Frequent swimming or shampooing may reduce persistence. Keep dogs out of watercourses for two days, minimise human contact for about 12 hours, and use in pregnancy or lactation only after veterinary benefit-risk assessment.
Assessment sources
  1. VMD Effitix leaflet2025
  2. VMD Effitix assessment2018
  3. Effitix European tick field study2016
  4. Effitix sand-fly study2015
  5. Effitix mosquito study2015
  6. Effitix speed-of-kill study2017
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil134.2 mg Permethrin1199 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Virbac · France
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფიტიქსი 134მგ/1200მგ დასაწვეთებელი ხსნარი საშუალო ჯიშის ძაღლებისათვის (10-20კგ)
№ 317-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
Never use in cats: permethrin can be fatal to cats.
 Cat Any weight On the skin - Product label (SPC)
1 pipette
10-20 kg 134 [mg fipronil] 1200 [mg permethrin]
 Dog 10–20 kg On the skin not more often than every 4 weeks Product label (SPC)
268 mg/2400 mg, Spot-on · Cat Any weight Cat Any weight No dose for this species
Never use in cats: permethrin can be fatal to cats.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფიტიქსი 268მგ/2400მგ დასაწვეთებელი ხსნარი დიდი ჯიშის ძაღლებისათვის (20-40კგ)
№ 315-11
Verified on: 15 Oct 2026
268 mg/2400 mg, Spot-on · Dog 20–40 kg Dog 20–40 kg 1 pipette
20-40 kg 268 [mg fipronil] 2400 [mg permethrin]
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფიტიქსი 268მგ/2400მგ დასაწვეთებელი ხსნარი დიდი ჯიშის ძაღლებისათვის (20-40კგ)
№ 315-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Effitix 268 mg/2400 mg, Spot-on

fipronil 268.4 mg + permethrin 2398 mg, spot-on solution for dogs 20-40 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.2/10
Very good
vetman assessment

Effitix

268 mg/2400 mg, fipronil 268.4 mg + permethrin 2398 mg, spot-on solution for dogs 20-40 kg
Assessed clinical scopeDog · Full canine label: flea treatment/prevention and FAD strategy, tick treatment and four-week control, with four-week sand-fly and mosquito repellency when that combined role is clinically required · On the skin
Care settingExact weight-band pipette after weighing and parasite-risk assessment; apply to two to four skin sites, prevent licking, and separate treated dogs from cats until fully dry
vetman score 8.2/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 315-11 · Verified on 15 Oct 2026

A strongly supported four-week flea, tick and vector-repellency option for dogs when the combined role is actually needed. Its value is limited by strict cat-exposure precautions and a more involved application process, not by weak canine efficacy.

Regulatory and scientific credibility9.0/10

All five exact presentations are currently registered in Georgia, with a current regulator-hosted product-line leaflet, a transparent assessment dossier and exact-form evidence.

Clinical efficacy8.5/10

The regulatory dossier and several exact-product controlled or field studies consistently support four-week flea and tick activity plus anti-feeding activity against labelled sand flies and mosquitoes. Some studies are sponsor-linked and bites or attachment are not completely prevented.

Safety and tolerability7.5/10

Correctly selected dogs generally tolerate the label dose well and canine reactions are very rare, but neurologic signs are possible and permethrin exposure can be fatal to cats. Strict species separation, age, weight, illness and reproductive-use restrictions materially shape safe use.

Clinical practicality7.5/10

Monthly weight-band dosing is workable, but application to two to four skin sites, drying time, cat separation, licking prevention and swimming or shampoo restrictions create more handling burden than a simple single-site ectoparasiticide.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Never use on cats or rabbits. Permethrin exposure is extremely poisonous and may be fatal to cats; keep treated dogs away until the site is fully dry and urgently wash and seek veterinary help after accidental exposure.
  • Do not use in sick, febrile or convalescent dogs or in known hypersensitivity to either active substance or an excipient.
  • Use this fixed combination for confirmed or credible flea and/or tick risk when sand-fly or mosquito repellency is also needed; do not add the permethrin component without a coherent clinical purpose.
  • Do not use below 12 weeks of age or 1.5 kg. Weigh accurately and use the exact weight-band pipette; overdose can increase adverse reactions.
  • Very rare canine reactions include application-site pruritus, erythema or alopecia, vomiting, agitation and neurologic signs. Prevent licking; transient hypersalivation may follow oral exposure.
  • Single ticks or bites by sand flies or mosquitoes may still occur, so pathogen transmission cannot be excluded; some Dermacentor or Rhipicephalus present at application may remain alive for 48 hours.
  • Frequent swimming or shampooing may reduce persistence. Keep dogs out of watercourses for two days, minimise human contact for about 12 hours, and use in pregnancy or lactation only after veterinary benefit-risk assessment.
Assessment sources
  1. VMD Effitix leaflet2025
  2. VMD Effitix assessment2018
  3. Effitix European tick field study2016
  4. Effitix sand-fly study2015
  5. Effitix mosquito study2015
  6. Effitix speed-of-kill study2017
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil268.4 mg Permethrin2398 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Virbac · France
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფიტიქსი 268მგ/2400მგ დასაწვეთებელი ხსნარი დიდი ჯიშის ძაღლებისათვის (20-40კგ)
№ 315-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
Never use in cats: permethrin can be fatal to cats.
 Cat Any weight On the skin - Product label (SPC)
1 pipette
20-40 kg 268 [mg fipronil] 2400 [mg permethrin]
 Dog 20–40 kg On the skin not more often than every 4 weeks Product label (SPC)
402 mg/3600 mg, Spot-on · Cat Any weight Cat Any weight No dose for this species
Never use in cats: permethrin can be fatal to cats.
 - Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფიტიქსი 402გ/3600მგ დასაწვეთებელი ხსნარი ძალიან დიდი ჯიშის ძაღლებისათვის (40-60კგ)
№ 314-11
Verified on: 15 Oct 2026
402 mg/3600 mg, Spot-on · Dog 40–60 kg Dog 40–60 kg 1 pipette
40-60 kg 402 [mg fipronil] 3600 [mg permethrin] For dogs > 60 kg the appropriate combination of pipettes should be used.
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფიტიქსი 402გ/3600მგ დასაწვეთებელი ხსნარი ძალიან დიდი ჯიშის ძაღლებისათვის (40-60კგ)
№ 314-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Effitix 402 mg/3600 mg, Spot-on

fipronil 402.6 mg + permethrin 3597 mg, spot-on solution for dogs 40-60 kg
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
8.2/10
Very good
vetman assessment

Effitix

402 mg/3600 mg, fipronil 402.6 mg + permethrin 3597 mg, spot-on solution for dogs 40-60 kg
Assessed clinical scopeDog · Full canine label: flea treatment/prevention and FAD strategy, tick treatment and four-week control, with four-week sand-fly and mosquito repellency when that combined role is clinically required · On the skin
Care settingExact weight-band pipette after weighing and parasite-risk assessment; apply to two to four skin sites, prevent licking, and separate treated dogs from cats until fully dry
vetman score 8.2/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 314-11 · Verified on 15 Oct 2026

A strongly supported four-week flea, tick and vector-repellency option for dogs when the combined role is actually needed. Its value is limited by strict cat-exposure precautions and a more involved application process, not by weak canine efficacy.

Regulatory and scientific credibility9.0/10

All five exact presentations are currently registered in Georgia, with a current regulator-hosted product-line leaflet, a transparent assessment dossier and exact-form evidence.

Clinical efficacy8.5/10

The regulatory dossier and several exact-product controlled or field studies consistently support four-week flea and tick activity plus anti-feeding activity against labelled sand flies and mosquitoes. Some studies are sponsor-linked and bites or attachment are not completely prevented.

Safety and tolerability7.5/10

Correctly selected dogs generally tolerate the label dose well and canine reactions are very rare, but neurologic signs are possible and permethrin exposure can be fatal to cats. Strict species separation, age, weight, illness and reproductive-use restrictions materially shape safe use.

Clinical practicality7.5/10

Monthly weight-band dosing is workable, but application to two to four skin sites, drying time, cat separation, licking prevention and swimming or shampoo restrictions create more handling burden than a simple single-site ectoparasiticide.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Never use on cats or rabbits. Permethrin exposure is extremely poisonous and may be fatal to cats; keep treated dogs away until the site is fully dry and urgently wash and seek veterinary help after accidental exposure.
  • Do not use in sick, febrile or convalescent dogs or in known hypersensitivity to either active substance or an excipient.
  • Use this fixed combination for confirmed or credible flea and/or tick risk when sand-fly or mosquito repellency is also needed; do not add the permethrin component without a coherent clinical purpose.
  • Do not use below 12 weeks of age or 1.5 kg. Weigh accurately and use the exact weight-band pipette; overdose can increase adverse reactions.
  • Very rare canine reactions include application-site pruritus, erythema or alopecia, vomiting, agitation and neurologic signs. Prevent licking; transient hypersalivation may follow oral exposure.
  • Single ticks or bites by sand flies or mosquitoes may still occur, so pathogen transmission cannot be excluded; some Dermacentor or Rhipicephalus present at application may remain alive for 48 hours.
  • Frequent swimming or shampooing may reduce persistence. Keep dogs out of watercourses for two days, minimise human contact for about 12 hours, and use in pregnancy or lactation only after veterinary benefit-risk assessment.
Assessment sources
  1. VMD Effitix leaflet2025
  2. VMD Effitix assessment2018
  3. Effitix European tick field study2016
  4. Effitix sand-fly study2015
  5. Effitix mosquito study2015
  6. Effitix speed-of-kill study2017
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil402.6 mg Permethrin3597 mg
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Virbac · France
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ეფიტიქსი 402გ/3600მგ დასაწვეთებელი ხსნარი ძალიან დიდი ჯიშის ძაღლებისათვის (40-60კგ)
№ 314-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
Never use in cats: permethrin can be fatal to cats.
 Cat Any weight On the skin - Product label (SPC)
1 pipette
40-60 kg 402 [mg fipronil] 3600 [mg permethrin] For dogs > 60 kg the appropriate combination of pipettes should be used.
 Dog 40–60 kg On the skin not more often than every 4 weeks Product label (SPC)
Active substance doses, with sources
Active substance Fipronil
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
6.7 mg/kg Dog Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 67.00 mg / 60.30 mg spot-on solution for dog S - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
7.5–15 mg/kg Dog, Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Spray 0.25% w/v cutaneous spray solution - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
5 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 50.00 mg / 60.00 mg spot-on solution for cat - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
8.3 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Effipro Duo 50 mg/60 mg Spot-on Solution for Cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
Active substance Permethrin
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
50 mg/kg Dog Maintenance On the skin according to the epidemiological situation
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Advantix 40 mg + 200 mg spot-on solution for dogs (<= 4 kg) - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
60 mg/kg Dog Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Effitix 26.8 mg/240 mg spot-on solution for very small dogs - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025

Known Contraindications

  • Critical Fipronil
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Fipronil
    Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
    Sources: VMD SPC · VMD
  • Warning Fipronil (Dog)
    In the absence of available data, the veterinary medicinal product should not be used on puppies less than 8 weeks old and/or weighing less than 2 kg. Puppies and kittens from 2 days of age may be safely treated. Nepoužívat u štěňat do 3 dnů stáří.
    Sources: VMD SPC · VMD
  • Warning Fipronil (Cat)
    In the absence of available data, the veterinary medicinal product should not be used on kittens less than 8 weeks old and/or weighing less than 1 kg. Nepoužívat u koťat do 8 týdnů stáří. Puppies and kittens from 2 days of age may be safely treated.
    Sources: VMD SPC · VMD
  • Caution Fipronil (Cat)
    The potential toxicity of the veterinary medicinal product for kittens of less than 8 weeks of age in contact with a treated queen is not documented. Special care should be taken in this case. Data are not available on treatment of pregnant queens or nursing queens. Přípravek může být podán chovným, březím i laktujícím kočkám.
    Sources: VMD SPC · VMD
  • Critical Permethrin
    Do not use in cases of hypersensitivity to the active substances, or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Permethrin (Cat)
    Do not use on cats. This veterinary medicinal product is extremely poisonous to cats and could be fatal due to the unique physiology of cats which is unable to metabolise certain compounds including permethrin. To prevent cats from being accidentally exposed to the veterinary medicinal product, keep treated dogs away from cats after treatment until the application site is dry. It is important to ensure that cats do not groom the site of application on a dog, which has been treated with this veterinary medicinal product. Seek veterinary advice immediately if this occurs. Do not use on rabbits and cats as adverse reactions and even death can occur In case of accidental dermal exposure, wash the cat with shampoo or soap, and seek veterinary advice rapidly.
    Sources: VMD SPC · VMD
  • Warning Permethrin (Dog)
    In the absence of available data the veterinary medicinal product should not be used on puppies of less than 7 weeks of age or 1.5 kg of weight. The safety of the product has not been established in dogs younger than 12 weeks of age or in dogs weighing less than 1.5 kg.
    Sources: VMD SPC · VMD
  • Caution Permethrin (Dog)
    Can be used during pregnancy and lactation. The safety of the veterinary medicinal product has not been established in dogs during pregnancy, lactation or in animals intended for breeding. Laboratory studies in rabbits and rats with the excipient N-methyl pyrrolidone have shown evidence of foetotoxic effects. Use only according to the benefit-risk assessment by the responsible veterinarian. The safety of the veterinary medicinal product has not been established during pregnancy and lactation in bitches. Use in pregnancy and lactation only in accordance with professional veterinary advice and a benefit/risk assessment.
    Sources: VMD SPC · VMD
  • Caution Permethrin (Dog)
    Can be used during pregnancy and lactation. Use only according to the benefit-risk assessment by the responsible veterinarian.
    Sources: VMD SPC · VMD

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