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Anandin Plus

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Permethrin + Glucaminopropylcarbacridone · AVZ S-P

1 form: ear drops. In force in Georgia: 1 of 1 (veterinary register).

Do not use on cats. Prevent cats from contacting or grooming a treated dog; follow the exact label for the separation period. Species safety: cats →

Forms and doses1 of 1 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Form Species Dose Frequency Georgia
0.5/20 mg/ml ear drops, Ear drops · Cat Cat No dose for this species
DO NOT USE ON CATS. VetMan does not accept post-Soviet manufacturer or domestic-register instructions as sufficient evidence for feline permethrin use. No exact-product feline authorisation from an internationally recognised regulator was verified. The dog dose remains available.
 - Georgia Yes, veterinary
In force until 11 Jun 2030
Veterinary (National Food Agency)
In the register: ანანდინი პლუსი ყურის წვეთები
№ 000877
Verified on: 21 Oct 2026
0.5/20 mg/ml ear drops, Ear drops · Dog Dog 3–5 drops
DOG USE ONLY in VetMan. Instil into each ear, even when only one ear appears affected: 3 drops for small dogs, 4 for medium dogs and 5 for large dogs. Clean first and massage the ear base after dosing. Do not use with a perforated tympanic membrane. Do not use on cats; no exact-product feline authorisation from an internationally recognised regulator was verified.
 · once daily for 3-7 days		 once daily for 3-7 days Georgia Yes, veterinary
In force until 11 Jun 2030
Veterinary (National Food Agency)
In the register: ანანდინი პლუსი ყურის წვეთები
№ 000877
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Anandin Plus 0.5/20 mg/ml ear drops, Ear drops

5 ml for dogs and cats
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Full dog label: ear mite infestation and external otitis, permethrin 0.05% with the claimed immunomodulator glucaminopropylcarbacridone, 3-5 drops per ear once daily for 3-7 days
4.3/10
Weak evidence support
vetman assessment

Anandin Plus

0.5/20 mg/ml ear drops, 5 ml for dogs and cats
Assessed clinical scopeDog · Full dog label: ear mite infestation and external otitis, permethrin 0.05% with the claimed immunomodulator glucaminopropylcarbacridone, 3-5 drops per ear once daily for 3-7 days · Into the ear
Care settingOwner ear treatment after veterinary otoscopy confirms an intact eardrum and the cause of otitis
vetman score 4.3/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 000877 · Verified on 21 Oct 2026

A weak option: a low-dose permethrin ear drop with an unproven immunomodulator and no independent efficacy data. Use an authorised acaricide for ear mites and cytology-guided treatment for otitis.

Regulatory and scientific credibility3.5/10

The exact product is registered in Georgia (000877, valid to 2030) with a current AVZ instruction; glucaminopropylcarbacridone is a Russian 'immunomodulator' with no international authorisation, and the only efficacy data are the manufacturer's.

Clinical efficacy3.0/10

Permethrin has some acaricidal action, but no independent evidence supports 0.05% for 3-7 days against ear mites, and no credible evidence shows that the acridone component helps otitis.

Safety and tolerability5.5/10

At this low concentration permethrin is low risk for dogs; the label excludes a perforated eardrum, safety data for the acridone component are limited, and treated dogs can expose cats in the household.

Clinical practicality6.0/10

Three to five drops per ear once daily for up to a week is easy, but both ears and all in-contact animals need treatment.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Do not use with a perforated eardrum; check by otoscopy first.
  • Contains permethrin: never use on cats, and keep cats from grooming a freshly treated dog's ears.
  • For ear mites, prefer an authorised acaricide with proven efficacy and treat all in-contact animals.
  • For bacterial or yeast otitis, use cytology-guided treatment; the immunomodulator claim is unproven.
  • Treat both ears even if only one looks affected; clean first and massage the ear base after dosing.
Assessment sources
  1. AVZ Anandin Plus ear
  2. Georgia NFA register 20262026
  3. ESCCAP GL32026
  4. UK VMD permethrin cat safety2026
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Cat use on the manufacturer label (ear mites and external otitis); VetMan sets no feline dose because the product contains permethrin
2.9/10
Poor / unconvincing
vetman assessment

Anandin Plus

0.5/20 mg/ml ear drops, 5 ml for dogs and cats
Assessed clinical scopeCat · Cat use on the manufacturer label (ear mites and external otitis); VetMan sets no feline dose because the product contains permethrin · Into the ear
Care settingNot recommended for cats; use an acaricide authorised for cats instead
vetman score 2.9/10 Poor / unconvincing
Evidence confidence: Low Georgia: Yes, veterinary · № 000877 · Verified on 21 Oct 2026

Poor for cats: a permethrin product without credible feline authorisation or proven benefit. Do not use it on cats; choose an acaricide authorised for cats.

Regulatory and scientific credibility3.0/10

The product carries a feline label in Georgia (000877), but no internationally recognised regulator authorises it for cats, and VetMan does not accept post-Soviet instructions as enough evidence for permethrin use in cats.

Clinical efficacy2.5/10

No independent evidence supports 0.05% permethrin against ear mites in cats, and the immunomodulator claim is unproven.

Safety and tolerability2.0/10

Cats metabolise permethrin poorly and can develop tremor, seizures and death; even a low ear dose adds risk through grooming and repeated application, with no proven benefit.

Clinical practicality5.0/10

The drops are easy to instil, but VetMan shows no feline dose and authorised feline acaricides are readily available.

Full-course cost-effectiveness-

No verified current Georgian price or patient-adjusted course cost was found; foreign prices were not substituted.

Important safety and use flags

  • Do not use on cats: permethrin can cause tremor, seizures and death in cats.
  • If a cat is treated by mistake, wash off what is possible and watch for twitching, tremor or seizures; treat as an emergency.
  • Use an acaricide authorised for cats against ear mites and treat all in-contact animals.
  • No credible evidence supports the immunomodulator component.
  • Dog dosing for this product remains available in VetMan.
Assessment sources
  1. AVZ Anandin Plus ear
  2. Georgia NFA register 20262026
  3. UK VMD permethrin cat safety2026
  4. ESCCAP GL32026
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Permethrin0.5 mg/ml Glucaminopropylcarbacridone20 mg/ml
Formulation Type
Ear drops
Administration route
Into the ear
Manufacturer
AVZ S-P · Russia
Manufacturer (register)
AVZ S-P Ltd, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1414, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
In force until 11 Jun 2030
Veterinary (National Food Agency)
In the register: ანანდინი პლუსი ყურის წვეთები
№ 000877
Verified on: 21 Oct 2026
Controlled in Georgia
Unknown
DoseSpeciesWeightRouteFrequencySource
No dose for this species
DO NOT USE ON CATS. VetMan does not accept post-Soviet manufacturer or domestic-register instructions as sufficient evidence for feline permethrin use. No exact-product feline authorisation from an internationally recognised regulator was verified. The dog dose remains available.
 Cat Any weight Into the ear no authorised feline dose
UK VMD permethrin cat safety
Guideline or consensus statement
Recommendations agreed by a panel of veterinary specialists after reviewing the evidence. They guide practice and do not authorise a product.
Permethrin: do not put your cat at risk
GOV.UK safety guidance, 2026
3–5 drops
DOG USE ONLY in VetMan. Instil into each ear, even when only one ear appears affected: 3 drops for small dogs, 4 for medium dogs and 5 for large dogs. Clean first and massage the ear base after dosing. Do not use with a perforated tympanic membrane. Do not use on cats; no exact-product feline authorisation from an internationally recognised regulator was verified.
 Dog Any weight Into the ear once daily for 3-7 days
AVZ Anandin Plus ear
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Anandin Plus ear drops - current official product instruction
AVZ official veterinary product instruction
Active substance doses, with sources
Active substance Permethrin
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
50 mg/kg Dog Maintenance On the skin according to the epidemiological situation
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Advantix 40 mg + 200 mg spot-on solution for dogs (<= 4 kg) - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
60 mg/kg Dog Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Effitix 26.8 mg/240 mg spot-on solution for very small dogs - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025

Glucaminopropylcarbacridone: No dose supported by a publicly verifiable source yet

Known Contraindications

  • Critical Permethrin
    Do not use in cases of hypersensitivity to the active substances, or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Permethrin (Cat)
    Do not use on cats. This veterinary medicinal product is extremely poisonous to cats and could be fatal due to the unique physiology of cats which is unable to metabolise certain compounds including permethrin. To prevent cats from being accidentally exposed to the veterinary medicinal product, keep treated dogs away from cats after treatment until the application site is dry. It is important to ensure that cats do not groom the site of application on a dog, which has been treated with this veterinary medicinal product. Seek veterinary advice immediately if this occurs. Do not use on rabbits and cats as adverse reactions and even death can occur In case of accidental dermal exposure, wash the cat with shampoo or soap, and seek veterinary advice rapidly.
    Sources: VMD SPC · VMD
  • Warning Permethrin (Dog)
    In the absence of available data the veterinary medicinal product should not be used on puppies of less than 7 weeks of age or 1.5 kg of weight. The safety of the product has not been established in dogs younger than 12 weeks of age or in dogs weighing less than 1.5 kg.
    Sources: VMD SPC · VMD
  • Caution Permethrin (Dog)
    Can be used during pregnancy and lactation. The safety of the veterinary medicinal product has not been established in dogs during pregnancy, lactation or in animals intended for breeding. Laboratory studies in rabbits and rats with the excipient N-methyl pyrrolidone have shown evidence of foetotoxic effects. Use only according to the benefit-risk assessment by the responsible veterinarian. The safety of the veterinary medicinal product has not been established during pregnancy and lactation in bitches. Use in pregnancy and lactation only in accordance with professional veterinary advice and a benefit/risk assessment.
    Sources: VMD SPC · VMD
  • Caution Permethrin (Dog)
    Can be used during pregnancy and lactation. Use only according to the benefit-risk assessment by the responsible veterinarian.
    Sources: VMD SPC · VMD

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For veterinary professionals only. It does not replace clinical judgement or the product label; check the dose in the official label (SPC). vetman is not liable for harm caused by using this information.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 21 Oct 2026

All of this shows in vetman as you prescribe

The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

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