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Frontline Spray

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Fipronil · Boehringer Ingelheim

2 forms: topical (unspecified). In force in Georgia: 2 of 2 (veterinary register).

Forms and doses2 of 2 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Dose Frequency Georgia
0.25%, Topical (unspecified) · Cat Cat 3–6 ml/kg
apply 3 to 6 ml per kg bodyweight, (7.5 to 15mg of active ingredient per kg bodyweight) The 100ml pack contains approximately 8 treatments for a short haired medium sized cat (4kg). Data are not available on treatment of pregnant queens or nursing queens.
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინი სპრეი
№ 84-11
Verified on: 15 Oct 2026
0.25%, Topical (unspecified) · Dog Dog 3–6 ml/kg
apply 3 to 6 ml per kg bodyweight, (7.5 to 15mg of active ingredient per kg bodyweight) i.e. 6 to 12 pump applications per kg bodyweight of the 100ml presentation In the absence of safety studies, the minimum treatment interval is 4 weeks. Puppies and kittens from 2 days of age may be safely treated.
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინი სპრეი
№ 84-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Frontline Spray 0.25%, Topical (unspecified)

fipronil 2.5 mg/ml, cutaneous spray 100 ml (0.5 ml per pump) for dogs and cats
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Full labelled canine scope: treatment and prevention of flea and tick infestations, control of species-specific biting lice, and use within a veterinarian-diagnosed flea-allergy-dermatitis strategy
8.2/10
Very good
vetman assessment

Frontline Spray

0.25%, fipronil 2.5 mg/ml, cutaneous spray 100 ml (0.5 ml per pump) for dogs and cats
Assessed clinical scopeDog · Full labelled canine scope: treatment and prevention of flea and tick infestations, control of species-specific biting lice, and use within a veterinarian-diagnosed flea-allergy-dermatitis strategy · On the skin
Care settingWhole-coat treatment after accurate weighing, with the exact pump output and coat length used to calculate dose; environmental flea control added when indicated
vetman score 8.2/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 84-11 · Verified on 15 Oct 2026

A mature, directly studied and locally registered whole-coat fipronil option with broad labelled ectoparasite coverage. Its main trade-off is demanding dose-by-coat application and greater handler exposure rather than weak efficacy.

Regulatory and scientific credibility9.0/10

Both exact pump presentations are currently registered in Georgia and the same 0.25% product remains authorised by the UK VMD, with an official SPC and a regulatory history dating to 1994.

Clinical efficacy8.5/10

Product-specific field and controlled studies support labelled flea and species-specific biting-louse control in dogs and cats, while the current label supports ticks and residual activity. Outcome still depends on complete coat-to-skin coverage, dose accuracy and environmental challenge.

Safety and tolerability8.0/10

Systemic absorption is negligible and labelled-dose tolerability is generally favourable, including puppies from 2 days of age. Whole-coat alcohol exposure, licking, rare skin or neurologic reactions, flammability and rabbit/aquatic toxicity still require strict precautions.

Clinical practicality6.5/10

Dose is weight- and coat-length dependent and requires full coat wetting: 6-12 pump actions/kg with the 100 ml bottle or 2-4/kg with the 250/500 ml bottle, plus gloves, ventilation, fire precautions and natural drying. This is materially more laborious than a pipette.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Never use on rabbits; serious reactions and death can occur. Do not use on sick, febrile or convalescent animals.
  • The hydro-alcoholic spray is highly flammable. Apply outdoors or in a well-ventilated room, away from flame and heat; do not inhale it, and keep the animal away from heat until the coat is completely dry.
  • Weigh accurately, dampen the entire coat down to the skin and prevent licking or mutual grooming until dry. Avoid eyes and broken skin; head application should be made via a gloved hand.
  • Do not use simultaneously with another flea product applied directly to the animal. Treat in-contact animals with an appropriate product and manage bedding and the environment when infestation is established.
  • Single ticks may still attach and infection transmission cannot be completely excluded. The product is not a repellent and is not for direct environmental treatment.
  • Fipronil is hazardous to aquatic organisms. Keep treated dogs out of watercourses for 2 days and prevent product or containers from contaminating water.
Assessment sources
  1. VMD SPC 20262026
  2. Frontline Spray flea field trials1995
  3. Frontline biting-lice trial2002
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Full labelled feline scope: treatment and prevention of flea and tick infestations, control of species-specific biting lice, and use within a veterinarian-diagnosed flea-allergy-dermatitis strategy
8.0/10
Very good
vetman assessment

Frontline Spray

0.25%, fipronil 2.5 mg/ml, cutaneous spray 100 ml (0.5 ml per pump) for dogs and cats
Assessed clinical scopeCat · Full labelled feline scope: treatment and prevention of flea and tick infestations, control of species-specific biting lice, and use within a veterinarian-diagnosed flea-allergy-dermatitis strategy · On the skin
Care settingWhole-coat treatment after accurate weighing, with the exact pump output and coat length used to calculate dose; environmental flea control added when indicated
vetman score 8.0/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 84-11 · Verified on 15 Oct 2026

A mature, directly studied and locally registered whole-coat fipronil option with broad labelled ectoparasite coverage. It is useful even from a very young labelled age, but application is demanding and pregnancy/lactation data in queens are absent.

Regulatory and scientific credibility9.0/10

Both exact pump presentations are currently registered in Georgia and the same 0.25% product remains authorised by the UK VMD, with an official SPC and a regulatory history dating to 1994.

Clinical efficacy8.5/10

Product-specific field and controlled studies support labelled flea and species-specific biting-louse control in dogs and cats, while the current label supports ticks and residual activity. Outcome still depends on complete coat-to-skin coverage, dose accuracy and environmental challenge.

Safety and tolerability7.5/10

Systemic absorption is low and labelled-dose tolerability is generally favourable, including kittens from 2 days of age. Whole-coat alcohol exposure, licking, rare skin or neurologic reactions, flammability and rabbit/aquatic toxicity require strict precautions; data are unavailable for pregnant or nursing queens.

Clinical practicality6.5/10

Dose is weight- and coat-length dependent and requires full coat wetting: 6-12 pump actions/kg with the 100 ml bottle or 2-4/kg with the 250/500 ml bottle, plus gloves, ventilation, fire precautions and natural drying. This is materially more laborious than a pipette.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Never use on rabbits; serious reactions and death can occur. Do not use on sick, febrile or convalescent animals.
  • The hydro-alcoholic spray is highly flammable. Apply outdoors or in a well-ventilated room, away from flame and heat; do not inhale it, and keep the animal away from heat until the coat is completely dry.
  • Weigh accurately, dampen the entire coat down to the skin and prevent licking or mutual grooming until dry. Avoid eyes and broken skin; head application should be made via a gloved hand.
  • Do not use simultaneously with another flea product applied directly to the animal. Treat in-contact animals with an appropriate product and manage bedding and the environment when infestation is established.
  • Single ticks may still attach and infection transmission cannot be completely excluded. The product is not a repellent and is not for direct environmental treatment.
  • Fipronil is hazardous to aquatic organisms. Keep treated dogs out of watercourses for 2 days and prevent product or containers from contaminating water.
  • Data are unavailable for treatment of pregnant or nursing queens; do not infer reproductive safety from the canine label.
Assessment sources
  1. VMD SPC 20262026
  2. Frontline Spray flea field trials1995
  3. Frontline Spray feline lice trials2004
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil2.5 mg/ml
Formulation Type
Topical (unspecified)
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინი სპრეი
№ 84-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ EPA 65331-1
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
3–6 ml/kg
apply 3 to 6 ml per kg bodyweight, (7.5 to 15mg of active ingredient per kg bodyweight) The 100ml pack contains approximately 8 treatments for a short haired medium sized cat (4kg). Data are not available on treatment of pregnant queens or nursing queens.
 Cat Any weight On the skin not more often than every 4 weeks Product label (SPC)
3–6 ml/kg
apply 3 to 6 ml per kg bodyweight, (7.5 to 15mg of active ingredient per kg bodyweight) i.e. 6 to 12 pump applications per kg bodyweight of the 100ml presentation In the absence of safety studies, the minimum treatment interval is 4 weeks. Puppies and kittens from 2 days of age may be safely treated.
 Dog Any weight On the skin not more often than every 4 weeks Product label (SPC)
0.25%, Topical (unspecified) · Cat Cat 3–6 ml/kg
Apply 3–6 mL/kg, equivalent to 7.5–15 mg fipronil/kg. With the 250 or 500 mL bottle, use 2–4 spray pumps/kg. The minimum retreatment interval is 4 weeks.
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინი სპრეი
№ 121-11
Verified on: 15 Oct 2026
0.25%, Topical (unspecified) · Dog Dog 3–6 ml/kg
apply 3 to 6 ml per kg bodyweight, (7.5 to 15mg of active ingredient per kg bodyweight) i.e.... 2 to 4 pump applications of the 250ml and 500ml presentations. The 250ml pack contains approximately 4 treatments for a short haired medium sized dog (20kg).
 · not more often than every 4 weeks		 not more often than every 4 weeks Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინი სპრეი
№ 121-11
Verified on: 15 Oct 2026
Details: pack, label wording, sources, registration

Frontline Spray 0.25%, Topical (unspecified)

fipronil 2.5 mg/ml, cutaneous spray 250 ml or 500 ml (1.5 ml per pump) for dogs and cats
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog Full labelled canine scope: treatment and prevention of flea and tick infestations, control of species-specific biting lice, and use within a veterinarian-diagnosed flea-allergy-dermatitis strategy
8.2/10
Very good
vetman assessment

Frontline Spray

0.25%, fipronil 2.5 mg/ml, cutaneous spray 250 ml or 500 ml (1.5 ml per pump) for dogs and cats
Assessed clinical scopeDog · Full labelled canine scope: treatment and prevention of flea and tick infestations, control of species-specific biting lice, and use within a veterinarian-diagnosed flea-allergy-dermatitis strategy · On the skin
Care settingWhole-coat treatment after accurate weighing, with the exact pump output and coat length used to calculate dose; environmental flea control added when indicated
vetman score 8.2/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 121-11 · Verified on 15 Oct 2026

A mature, directly studied and locally registered whole-coat fipronil option with broad labelled ectoparasite coverage. Its main trade-off is demanding dose-by-coat application and greater handler exposure rather than weak efficacy.

Regulatory and scientific credibility9.0/10

Both exact pump presentations are currently registered in Georgia and the same 0.25% product remains authorised by the UK VMD, with an official SPC and a regulatory history dating to 1994.

Clinical efficacy8.5/10

Product-specific field and controlled studies support labelled flea and species-specific biting-louse control in dogs and cats, while the current label supports ticks and residual activity. Outcome still depends on complete coat-to-skin coverage, dose accuracy and environmental challenge.

Safety and tolerability8.0/10

Systemic absorption is negligible and labelled-dose tolerability is generally favourable, including puppies from 2 days of age. Whole-coat alcohol exposure, licking, rare skin or neurologic reactions, flammability and rabbit/aquatic toxicity still require strict precautions.

Clinical practicality6.5/10

Dose is weight- and coat-length dependent and requires full coat wetting: 6-12 pump actions/kg with the 100 ml bottle or 2-4/kg with the 250/500 ml bottle, plus gloves, ventilation, fire precautions and natural drying. This is materially more laborious than a pipette.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Never use on rabbits; serious reactions and death can occur. Do not use on sick, febrile or convalescent animals.
  • The hydro-alcoholic spray is highly flammable. Apply outdoors or in a well-ventilated room, away from flame and heat; do not inhale it, and keep the animal away from heat until the coat is completely dry.
  • Weigh accurately, dampen the entire coat down to the skin and prevent licking or mutual grooming until dry. Avoid eyes and broken skin; head application should be made via a gloved hand.
  • Do not use simultaneously with another flea product applied directly to the animal. Treat in-contact animals with an appropriate product and manage bedding and the environment when infestation is established.
  • Single ticks may still attach and infection transmission cannot be completely excluded. The product is not a repellent and is not for direct environmental treatment.
  • Fipronil is hazardous to aquatic organisms. Keep treated dogs out of watercourses for 2 days and prevent product or containers from contaminating water.
Assessment sources
  1. VMD SPC 20262026
  2. Frontline Spray flea field trials1995
  3. Frontline biting-lice trial2002
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Cat Full labelled feline scope: treatment and prevention of flea and tick infestations, control of species-specific biting lice, and use within a veterinarian-diagnosed flea-allergy-dermatitis strategy
8.0/10
Very good
vetman assessment

Frontline Spray

0.25%, fipronil 2.5 mg/ml, cutaneous spray 250 ml or 500 ml (1.5 ml per pump) for dogs and cats
Assessed clinical scopeCat · Full labelled feline scope: treatment and prevention of flea and tick infestations, control of species-specific biting lice, and use within a veterinarian-diagnosed flea-allergy-dermatitis strategy · On the skin
Care settingWhole-coat treatment after accurate weighing, with the exact pump output and coat length used to calculate dose; environmental flea control added when indicated
vetman score 8.0/10 Very good
Evidence confidence: High Georgia: Yes, veterinary · № 121-11 · Verified on 15 Oct 2026

A mature, directly studied and locally registered whole-coat fipronil option with broad labelled ectoparasite coverage. It is useful even from a very young labelled age, but application is demanding and pregnancy/lactation data in queens are absent.

Regulatory and scientific credibility9.0/10

Both exact pump presentations are currently registered in Georgia and the same 0.25% product remains authorised by the UK VMD, with an official SPC and a regulatory history dating to 1994.

Clinical efficacy8.5/10

Product-specific field and controlled studies support labelled flea and species-specific biting-louse control in dogs and cats, while the current label supports ticks and residual activity. Outcome still depends on complete coat-to-skin coverage, dose accuracy and environmental challenge.

Safety and tolerability7.5/10

Systemic absorption is low and labelled-dose tolerability is generally favourable, including kittens from 2 days of age. Whole-coat alcohol exposure, licking, rare skin or neurologic reactions, flammability and rabbit/aquatic toxicity require strict precautions; data are unavailable for pregnant or nursing queens.

Clinical practicality6.5/10

Dose is weight- and coat-length dependent and requires full coat wetting: 6-12 pump actions/kg with the 100 ml bottle or 2-4/kg with the 250/500 ml bottle, plus gloves, ventilation, fire precautions and natural drying. This is materially more laborious than a pipette.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • Never use on rabbits; serious reactions and death can occur. Do not use on sick, febrile or convalescent animals.
  • The hydro-alcoholic spray is highly flammable. Apply outdoors or in a well-ventilated room, away from flame and heat; do not inhale it, and keep the animal away from heat until the coat is completely dry.
  • Weigh accurately, dampen the entire coat down to the skin and prevent licking or mutual grooming until dry. Avoid eyes and broken skin; head application should be made via a gloved hand.
  • Do not use simultaneously with another flea product applied directly to the animal. Treat in-contact animals with an appropriate product and manage bedding and the environment when infestation is established.
  • Single ticks may still attach and infection transmission cannot be completely excluded. The product is not a repellent and is not for direct environmental treatment.
  • Fipronil is hazardous to aquatic organisms. Keep treated dogs out of watercourses for 2 days and prevent product or containers from contaminating water.
  • Data are unavailable for treatment of pregnant or nursing queens; do not infer reproductive safety from the canine label.
Assessment sources
  1. VMD SPC 20262026
  2. Frontline Spray flea field trials1995
  3. Frontline Spray feline lice trials2004
Assessed: 21 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil2.5 mg/ml
Formulation Type
Topical (unspecified)
Administration route
On the skin
Manufacturer
Boehringer Ingelheim · Germany
Manufacturer (register)
Boehringer Ingelheim Animal Health France SCS, France
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 615, 19 Oct 2026.
Source: NFA veterinary medicines register ↗
Registration
Georgia Yes, veterinary
Veterinary (National Food Agency)
In the register: ფრონტლაინი სპრეი
№ 121-11
Verified on: 15 Oct 2026
 EU Yes, veterinary
Verified on: 15 Oct 2026
 UK Yes, veterinary
Verified on: 15 Oct 2026
 US Yes, veterinary
№ EPA 65331-1
Verified on: 15 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
3–6 ml/kg
Apply 3–6 mL/kg, equivalent to 7.5–15 mg fipronil/kg. With the 250 or 500 mL bottle, use 2–4 spray pumps/kg. The minimum retreatment interval is 4 weeks.
 Cat Any weight On the skin not more often than every 4 weeks Product label (SPC)
3–6 ml/kg
apply 3 to 6 ml per kg bodyweight, (7.5 to 15mg of active ingredient per kg bodyweight) i.e.... 2 to 4 pump applications of the 250ml and 500ml presentations. The 250ml pack contains approximately 4 treatments for a short haired medium sized dog (20kg).
 Dog Any weight On the skin not more often than every 4 weeks Product label (SPC)
Active substance doses, with sources
Active substance Fipronil
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
6.7 mg/kg Dog Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 67.00 mg / 60.30 mg spot-on solution for dog S - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
7.5–15 mg/kg Dog, Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Spray 0.25% w/v cutaneous spray solution - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
5 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 50.00 mg / 60.00 mg spot-on solution for cat - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
8.3 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Effipro Duo 50 mg/60 mg Spot-on Solution for Cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025

Known Contraindications

  • Critical
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical
    Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
    Sources: VMD SPC · VMD
  • Warning (Dog)
    In the absence of available data, the veterinary medicinal product should not be used on puppies less than 8 weeks old and/or weighing less than 2 kg. Puppies and kittens from 2 days of age may be safely treated. Nepoužívat u štěňat do 3 dnů stáří.
    Sources: VMD SPC · VMD
  • Warning (Cat)
    In the absence of available data, the veterinary medicinal product should not be used on kittens less than 8 weeks old and/or weighing less than 1 kg. Nepoužívat u koťat do 8 týdnů stáří. Puppies and kittens from 2 days of age may be safely treated.
    Sources: VMD SPC · VMD
  • Caution (Cat)
    The potential toxicity of the veterinary medicinal product for kittens of less than 8 weeks of age in contact with a treated queen is not documented. Special care should be taken in this case. Data are not available on treatment of pregnant queens or nursing queens. Přípravek může být podán chovným, březím i laktujícím kočkám.
    Sources: VMD SPC · VMD

Products are connected by name, active ingredients, or therapeutic group. They are not direct substitutes for one another.

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Same active ingredients 2

Same therapeutic group 78

Professional reference for veterinary professionals. Not advertising and not a substitute for the product label/SPC.

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This reference is still growing. Missing a product? Let us know. · Report an error or request an addition · Updated: 16 Oct 2026

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The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.

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