Register
Medicines reference
Product

Chistotel Maximum

Fipronil + Permethrin · JSC NPF Ekoprom, Ekoprom

2 forms: solution, spot-on. In force in Georgia: 2 of 2 (veterinary register).

Do not use on cats. Prevent cats from contacting or grooming a treated dog; follow the exact label for the separation period. Species safety: cats →

Forms and doses2 of 2 in force in Georgia

The dose from the product's label, by species and weight. Check the label of the pack you use.

Choose species and weight; the matching row will be highlighted.
Form Species Weight Dose Frequency Georgia
47.5/9.5 mg/ml, Spot-on · Dog up to 2 kg Dog up to 2 kg 0.5 ml
Apply to dry intact skin inaccessible to licking. Do not use in infectious or convalescent animals, during pregnancy or lactation, or in puppies under 3 months. Do not combine with other insectoacaricides. Do not wash, pet or allow contact with small children for 48 hours after treatment.
· By indication, no more often than once monthly
By indication, no more often than once monthly Georgia Yes, veterinary
In force until 30 Mar 2031
Veterinary (National Food Agency)
In the register: ჩისტოტელ მაქსიმუმი 47.5/9.5 მგ/მლ, 4 × 1 მლ ძაღლისთვის
№ 001232
Verified on: 23 Oct 2026
47.5/9.5 mg/ml, Spot-on · Dog 2–10 kg Dog 2–10 kg 1 ml
Apply to dry intact skin inaccessible to licking. Do not use in infectious or convalescent animals, during pregnancy or lactation, or in puppies under 3 months. Do not combine with other insectoacaricides. Do not wash, pet or allow contact with small children for 48 hours after treatment.
· By indication, no more often than once monthly
By indication, no more often than once monthly Georgia Yes, veterinary
In force until 30 Mar 2031
Veterinary (National Food Agency)
In the register: ჩისტოტელ მაქსიმუმი 47.5/9.5 მგ/მლ, 4 × 1 მლ ძაღლისთვის
№ 001232
Verified on: 23 Oct 2026
47.5/9.5 mg/ml, Spot-on · Dog 10–20 kg Dog 10–20 kg 2 ml
Apply to dry intact skin inaccessible to licking. Do not use in infectious or convalescent animals, during pregnancy or lactation, or in puppies under 3 months. Do not combine with other insectoacaricides. Do not wash, pet or allow contact with small children for 48 hours after treatment.
· By indication, no more often than once monthly
By indication, no more often than once monthly Georgia Yes, veterinary
In force until 30 Mar 2031
Veterinary (National Food Agency)
In the register: ჩისტოტელ მაქსიმუმი 47.5/9.5 მგ/მლ, 4 × 1 მლ ძაღლისთვის
№ 001232
Verified on: 23 Oct 2026
47.5/9.5 mg/ml, Spot-on · Dog 20–30 kg Dog 20–30 kg 3 ml
Apply to dry intact skin inaccessible to licking. Do not use in infectious or convalescent animals, during pregnancy or lactation, or in puppies under 3 months. Do not combine with other insectoacaricides. Do not wash, pet or allow contact with small children for 48 hours after treatment.
· By indication, no more often than once monthly
By indication, no more often than once monthly Georgia Yes, veterinary
In force until 30 Mar 2031
Veterinary (National Food Agency)
In the register: ჩისტოტელ მაქსიმუმი 47.5/9.5 მგ/მლ, 4 × 1 მლ ძაღლისთვის
№ 001232
Verified on: 23 Oct 2026
47.5/9.5 mg/ml, Spot-on · Dog 30–40 kg Dog 30–40 kg 4 ml
Apply to dry intact skin inaccessible to licking. Do not use in infectious or convalescent animals, during pregnancy or lactation, or in puppies under 3 months. Do not combine with other insectoacaricides. Do not wash, pet or allow contact with small children for 48 hours after treatment.
· By indication, no more often than once monthly
By indication, no more often than once monthly Georgia Yes, veterinary
In force until 30 Mar 2031
Veterinary (National Food Agency)
In the register: ჩისტოტელ მაქსიმუმი 47.5/9.5 მგ/მლ, 4 × 1 მლ ძაღლისთვის
№ 001232
Verified on: 23 Oct 2026
47.5/9.5 mg/ml, Spot-on · Dog 40–50 kg Dog 40–50 kg 5 ml
Apply to dry intact skin inaccessible to licking. This dose requires more than one 4 x 1 ml carton. Do not use in infectious or convalescent animals, during pregnancy or lactation, or in puppies under 3 months. Do not combine with other insectoacaricides. Do not wash, pet or allow contact with small children for 48 hours after treatment.
· By indication, no more often than once monthly
By indication, no more often than once monthly Georgia Yes, veterinary
In force until 30 Mar 2031
Veterinary (National Food Agency)
In the register: ჩისტოტელ მაქსიმუმი 47.5/9.5 მგ/მლ, 4 × 1 მლ ძაღლისთვის
№ 001232
Verified on: 23 Oct 2026
47.5/9.5 mg/ml, Spot-on · Dog over 50 kg Dog over 50 kg 0.1 ml/kg
Apply 0.1 ml/kg to dry intact skin inaccessible to licking. This dose requires more than one 4 x 1 ml carton. Do not use in infectious or convalescent animals, during pregnancy or lactation, or in puppies under 3 months. Do not combine with other insectoacaricides. Do not wash, pet or allow contact with small children for 48 hours after treatment.
· By indication, no more often than once monthly
By indication, no more often than once monthly Georgia Yes, veterinary
In force until 30 Mar 2031
Veterinary (National Food Agency)
In the register: ჩისტოტელ მაქსიმუმი 47.5/9.5 მგ/მლ, 4 × 1 მლ ძაღლისთვის
№ 001232
Verified on: 23 Oct 2026
Details: pack, label wording, sources, registration

Chistotel Maximum 47.5/9.5 mg/ml, Spot-on

spot-on drops 4 x 1 ml for dogs
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
4.9/10
Weak evidence support
vetman assessment

Chistotel Maximum

47.5/9.5 mg/ml, spot-on drops 4 x 1 ml for dogs
Assessed clinical scopeDog · Complete dog label: fleas, sucking and biting lice, ixodid ticks, otodectosis, canine sarcoptic mange and prevention of ectoparasite attack across the labelled skin, ear and attached-tick regimens · On the skin
Care settingOwner-applied dog-only spot-on after accurate weighing and veterinarian/product selection; ear and mange regimens require diagnostic veterinary supervision
vetman score 4.9/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 001232 · Verified on 23 Oct 2026

A locally authorised dog spot-on with a plausible fipronil ectoparasite core, but no exact outcome programme and a very low permethrin exposure relative to regulated fipronil-permethrin controls. Broad ear/mange claims, severe cat-contact risk and pack insufficiency above 40 kg make the complete-label practical value weak.

Regulatory and scientific credibility6.5/10

The exact four-pipette dog pack has current Georgian authorisation through 2031, an approved manufacturer instruction and a current Russian umbrella registration. Exact identity is verifiable, but there is no EU/GB/US authorisation or public exact-product regulator assessment; the umbrella feline wording is not accepted as feline evidence.

Clinical efficacy4.0/10

Fipronil supports a plausible flea/tick/lice core, but no exact-product outcomes support the two-month insect, mite, ear or mange breadth. At the label rule, permethrin is about 0.95 mg/kg versus roughly 60-120 mg/kg in authorised comparators, so their repellency/acaricidal trial results cannot validate Chistotel.

Safety and tolerability3.5/10

Dog irritation, salivation/lacrimation and ingestion-related neurologic toxicity are material, and repeated bilateral ear-canal use lacks a tympanic/ototoxicity boundary. Permethrin creates potentially fatal household-cat risk. Exact quantified dog target-animal, reproductive and repeated-course safety data are absent.

Clinical practicality6.0/10

Monthly skin dosing and clear weight bands are workable, but the 4 ml carton is insufficient for one dose above 40 kg and a 0.5 ml small-dog dose requires partial use of a 1 ml tube. Multi-site large-dog application, 48-hour contact/water controls and complex ear/mange repeats add burden.

Full-course cost-effectiveness-

Current Georgian per-treatment price was unavailable; price is excluded from the denominator.

Important safety and use flags

  • Complete dog-scope boundary: this score covers skin prevention/treatment for fleas, lice and ixodid ticks, bilateral ear drops for otodectosis, repeated canine sarcoptic-mange treatment and direct attached-tick application. It does not transfer the umbrella instruction to cats or include feline notoedrosis.
  • Evidence/exposure conflict: the label rule supplies about 4.75 mg/kg fipronil and 0.95 mg/kg permethrin. Authorised fipronil-permethrin controls use about 6.7-13.4 and 60-120 mg/kg respectively; their quantified one-month repellency/kill cannot validate this 63-126-fold lower permethrin exposure.
  • Exact skin dose: under 2 kg 0.5 ml; 2-10 kg 1 ml; 10-20 kg 2 ml; 20-30 kg 3 ml; 30-40 kg 4 ml; 40-50 kg 5 ml; over 50 kg 0.1 ml/kg across 3-4 sites. Apply only to dry intact skin inaccessible to licking; do not round down because the carton is short.
  • Pack practicality: the exact carton contains four 1 ml tubes. It covers one label dose only through 40 kg; 40-50 kg needs 5 ml and over 50 kg needs more than one carton. The 0.5 ml dose partially uses a tube without validated reclosure/storage—measure accurately and discard remainder safely.
  • Dog only—cat emergency: never use this presentation on a cat despite the umbrella manufacturer instruction. Permethrin exposure or grooming a treated dog may be fatal; separate household cats for at least 48 hours and seek emergency veterinary toxicology care after any cat contact/licking.
  • Ear boundary: diagnose otodectosis and examine both canals/tympanic membranes before instilling 1-3 drops bilaterally. Do not use in an ulcerated canal, ruptured/unknown tympanum or nonspecific otitis; repeated 3-5-day dosing lacks an exact public ototoxicity dossier.
  • Mange/tick boundary: confirm canine sarcoptic mange and use 2-4 treatments 7-10 days apart until clinical recovery plus two negative acarologic checks. One drop on an attached tick is not whole-patient prevention; remove it mechanically after 20 minutes if still attached.
  • Do not use under 3 months, during pregnancy/lactation, infectious disease or convalescence, on damaged/wet skin, or with another insectoacaricide. Prevent licking; stop, wash with mild detergent/water and reassess for salivation, lacrimation, dermatitis, vomiting, weakness, ataxia, tremor or seizure.
  • Flea/environment control: treat every suitable household animal with its own species-safe product and manage bedding/environment. Repeat general application only when indicated and no more often than monthly; investigate bathing, reinfestation, adherence and resistance before stacking products.
  • Handler/water control: wear gloves, wash hands, prevent petting and small-child contact, and do not bathe or allow swimming for 48 hours. Fipronil/permethrin are hazardous to aquatic organisms; keep from watercourses and dispose of opened tubes, remainder and packaging safely.
Assessment sources
Assessed: 23 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Fipronil47.5 mg/ml Permethrin9.5 mg/ml
Formulation Type
Spot-on
Administration route
On the skin
Manufacturer
Manufacturer (register)
JSC SPC EKOPROM, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 1666, 19 Oct 2026.
Registration
Georgia Yes, veterinary
In force until 30 Mar 2031
Veterinary (National Food Agency)
In the register: ჩისტოტელ მაქსიმუმი 47.5/9.5 მგ/მლ, 4 × 1 მლ ძაღლისთვის
№ 001232
Verified on: 23 Oct 2026
EU No
UK No
US No
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
Information not fully verified Dog-only complete label: fleas, sucking/biting lice, ixodid ticks, otodectosis and canine sarcoptic mange. Apply the exact weight-band volume to dry intact skin inaccessible to licking; repeat general treatment only when indicated and no more often than monthly. The carton contains 4 ml, so one labelled dose above 40 kg requires more than one carton. Exact-product controlled outcomes were not found.
DoseSpeciesWeightRouteFrequencySource
0.5 ml
Apply to dry intact skin inaccessible to licking. Do not use in infectious or convalescent animals, during pregnancy or lactation, or in puppies under 3 months. Do not combine with other insectoacaricides. Do not wash, pet or allow contact with small children for 48 hours after treatment.
Dog up to 2 kg On the skin By indication, no more often than once monthly
Ekoprom Chistotel Maximum drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Chistotel Maximum drops - official manufacturer-hosted approved instruction
Ekoprom official product instruction, 2019
1 ml
Apply to dry intact skin inaccessible to licking. Do not use in infectious or convalescent animals, during pregnancy or lactation, or in puppies under 3 months. Do not combine with other insectoacaricides. Do not wash, pet or allow contact with small children for 48 hours after treatment.
Dog 2–10 kg On the skin By indication, no more often than once monthly
Ekoprom Chistotel Maximum drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Chistotel Maximum drops - official manufacturer-hosted approved instruction
Ekoprom official product instruction, 2019
2 ml
Apply to dry intact skin inaccessible to licking. Do not use in infectious or convalescent animals, during pregnancy or lactation, or in puppies under 3 months. Do not combine with other insectoacaricides. Do not wash, pet or allow contact with small children for 48 hours after treatment.
Dog 10–20 kg On the skin By indication, no more often than once monthly
Ekoprom Chistotel Maximum drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Chistotel Maximum drops - official manufacturer-hosted approved instruction
Ekoprom official product instruction, 2019
3 ml
Apply to dry intact skin inaccessible to licking. Do not use in infectious or convalescent animals, during pregnancy or lactation, or in puppies under 3 months. Do not combine with other insectoacaricides. Do not wash, pet or allow contact with small children for 48 hours after treatment.
Dog 20–30 kg On the skin By indication, no more often than once monthly
Ekoprom Chistotel Maximum drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Chistotel Maximum drops - official manufacturer-hosted approved instruction
Ekoprom official product instruction, 2019
4 ml
Apply to dry intact skin inaccessible to licking. Do not use in infectious or convalescent animals, during pregnancy or lactation, or in puppies under 3 months. Do not combine with other insectoacaricides. Do not wash, pet or allow contact with small children for 48 hours after treatment.
Dog 30–40 kg On the skin By indication, no more often than once monthly
Ekoprom Chistotel Maximum drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Chistotel Maximum drops - official manufacturer-hosted approved instruction
Ekoprom official product instruction, 2019
5 ml
Apply to dry intact skin inaccessible to licking. This dose requires more than one 4 x 1 ml carton. Do not use in infectious or convalescent animals, during pregnancy or lactation, or in puppies under 3 months. Do not combine with other insectoacaricides. Do not wash, pet or allow contact with small children for 48 hours after treatment.
Dog 40–50 kg On the skin By indication, no more often than once monthly
Ekoprom Chistotel Maximum drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Chistotel Maximum drops - official manufacturer-hosted approved instruction
Ekoprom official product instruction, 2019
0.1 ml/kg
Apply 0.1 ml/kg to dry intact skin inaccessible to licking. This dose requires more than one 4 x 1 ml carton. Do not use in infectious or convalescent animals, during pregnancy or lactation, or in puppies under 3 months. Do not combine with other insectoacaricides. Do not wash, pet or allow contact with small children for 48 hours after treatment.
Dog over 50 kg On the skin By indication, no more often than once monthly
Ekoprom Chistotel Maximum drops
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Chistotel Maximum drops - official manufacturer-hosted approved instruction
Ekoprom official product instruction, 2019
0.4 %, Solution · Cat Any weight Cat Any weight No dose for this species
DO NOT USE ON CATS. VetMan does not accept post-Soviet manufacturer or domestic-register instructions as sufficient evidence for feline permethrin use. No exact-product feline authorisation from an internationally recognised regulator was verified. The dog dose remains available.
- Georgia Yes, veterinary
In force until 10 Dec 2027
Veterinary (National Food Agency)
In the register: ჩისტოტელი მაქსიმუმი შამპუნი
№ 002583
Verified on: 21 Oct 2026
0.4 %, Solution · Dog Any weight Dog Any weight 0.5–1 ml/kg
DOG/PUPPY USE ONLY in VetMan. Wet the coat, apply and lather while avoiding eyes and licking, leave for 5-7 minutes, then rinse completely. Do not use in pregnancy/lactation, weakened, emaciated, infectious or convalescent animals, or with another insectoacaricide. Do not use on cats or kittens; no exact-product feline authorisation from an internationally recognised regulator was verified.
· single application; repeat according to entomological indication
single application; repeat according to entomological indication Georgia Yes, veterinary
In force until 10 Dec 2027
Veterinary (National Food Agency)
In the register: ჩისტოტელი მაქსიმუმი შამპუნი
№ 002583
Verified on: 21 Oct 2026
Details: pack, label wording, sources, registration

Chistotel Maximum 0.4 %, Solution

permethrin 0.4% shampoo, 180 ml for puppies and kittens
vetman assessment
vetman’s 10-point assessment brings together a product’s regulatory credibility, clinical efficacy, safety and practicality. Cost-effectiveness is assessed only when reliable data are available. It is informational and does not replace a veterinarian’s clinical judgment for an individual patient.
Dog
5.1/10
Weak evidence support
vetman assessment

Chistotel Maximum

permethrin 0.4% shampoo, 180 ml for puppies and kittens
Assessed clinical scopeDog · Label-concordant rinse-off treatment of susceptible flea, louse and chewing-louse infestations in dogs; not a persistent whole-house flea-control programme · On the skin
Care settingHome or clinic bathing after veterinary confirmation of the ectoparasite and patient suitability; exact weight-based volume, contact time, complete rinsing and environmental control are required.
vetman score 5.1/10 Weak evidence support
Evidence confidence: Low Georgia: Yes, veterinary · № 002583 · Verified on 21 Oct 2026

A weak juvenile-dog rinse-off option with a clear 0.5-1 ml/kg and 5-7 minute instruction, but no exact-product trial and a serious historical strength conflict in the Georgian source. Do not extend the kitten claim into VetMan without recognised-regulator exact-product evidence.

Regulatory and scientific credibility4.5/10

The exact 0.4%, 180 ml juvenile presentation is actively registered in Georgia and has a detailed current manufacturer instruction. The Georgian source historically recorded a 40% strength while the exact instruction states 0.4%; that 100-fold conflict lowers source confidence, and no recognised-regulator dossier or independent exact-product trial was found.

Clinical efficacy5.0/10

Permethrin is an established contact insecticide and current authorised dog shampoos support a rinse-off role against fleas. The exact instruction also claims lice and chewing lice, but no controlled exact-product outcome study was found. A shampoo treats parasites present during bathing and cannot by itself control the environmental flea life cycle or provide long-lasting protection.

Safety and tolerability6.0/10

The rinse-off 0.4% canine regimen is usable from eight weeks according to the exact instruction, but no independent margin-of-safety study was found. It excludes pregnancy/lactation and weakened, emaciated, infectious or convalescent animals. Feline exposure remains a serious hard stop despite the source label naming kittens.

Clinical practicality5.0/10

Apply 0.5-1 ml/kg to the wetted coat, lather, prevent licking and eye exposure, wait 5-7 minutes, rinse thoroughly, dry and comb. It is feasible but requires full-body bathing and restraint; repeat treatment still needs a parasite and environmental plan rather than automatic shampooing.

Full-course cost-effectiveness-

Price was not assessed and is excluded from the overall score.

Important safety and use flags

  • DO NOT USE ON CATS OR KITTENS. VetMan found no exact-product feline authorisation from an internationally recognised regulator. Keep cats away from the concentrate, bath water, wet lather, towels and the treated dog until the coat has been completely rinsed and dried; suspected exposure requires immediate veterinary advice.
  • Confirm the ectoparasite and burden before treatment. A rinse-off shampoo is not a substitute for a persistent flea programme, and repeated empirical use without examining the animal and environment can miss reinfestation, another parasite or dermatologic disease.
  • For a dog at least eight weeks old, weigh and apply 0.5-1 ml/kg to the wetted coat, lather evenly, maintain contact for 5-7 minutes, then rinse completely, dry and comb.
  • Do not use below eight weeks of age. Do not transfer this threshold to another permethrin product; concentration, cis:trans ratio, excipients and rinse-off instructions are formulation-specific.
  • Do not use during pregnancy or lactation, or in sick, weakened, emaciated, infectious or convalescent animals where excluded by the exact label. Stabilise and diagnose the patient before ectoparasiticide exposure.
  • Prevent licking and contact with the eyes, mouth or other mucosa throughout bathing. Rinse immediately after accidental mucosal exposure; salivation, vomiting, tremor, twitching, ataxia, hyperaesthesia or seizure requires urgent decontamination and veterinary assessment.
  • Do not combine with another insecticide or acaricide unless compatibility and timing are explicitly established. Apparent failure should trigger confirmation of dose, contact time, rinsing, parasite identity and environmental control rather than interval shortening or product stacking.
  • Treat bedding and the household environment when fleas are present and ensure every in-contact animal receives a species-appropriate product. Shampoo removes or kills parasites on the animal at treatment but cannot eliminate environmental eggs, larvae and pupae or guarantee durable protection.
  • Permethrin is hazardous to aquatic organisms and the exact labels warn of toxicity to fish, with some also naming bees. Keep concentrate and rinse water out of drains, ponds and watercourses, use gloves when appropriate, wash hands after treatment and dispose of residue and packaging safely.
Assessment sources
Assessed: 22 Oct 2026The overall score uses 25/25/25/15/10 weights. An unassessed price is excluded and the remaining weights are proportionally renormalised.
Composition / strength
Permethrin0.4 %
Formulation Type
Solution
Administration route
On the skin
Manufacturer
Ekoprom · Russia
Manufacturer (register)
JSC SPC EKOPROM, Russia
Manufacturer and country as in the veterinary medicines register (National Food Agency), row 516, 19 Oct 2026.
Registration
Georgia Yes, veterinary
In force until 10 Dec 2027
Veterinary (National Food Agency)
In the register: ჩისტოტელი მაქსიმუმი შამპუნი
№ 002583
Verified on: 21 Oct 2026
Controlled in Georgia
No
Checked against the narcotics law, Annex 1, lists I-IV, and Order No. 22/n.
Verified on: 16 Oct 2026
DoseSpeciesWeightRouteFrequencySource
No dose for this species
DO NOT USE ON CATS. VetMan does not accept post-Soviet manufacturer or domestic-register instructions as sufficient evidence for feline permethrin use. No exact-product feline authorisation from an internationally recognised regulator was verified. The dog dose remains available.
Cat Any weight On the skin no authorised feline dose
UK VMD permethrin cat safety
Guideline or consensus statement
Recommendations agreed by a panel of veterinary specialists after reviewing the evidence. They guide practice and do not authorise a product.
Permethrin: do not put your cat at risk
GOV.UK safety guidance, 2026
0.5–1 ml/kg
DOG/PUPPY USE ONLY in VetMan. Wet the coat, apply and lather while avoiding eyes and licking, leave for 5-7 minutes, then rinse completely. Do not use in pregnancy/lactation, weakened, emaciated, infectious or convalescent animals, or with another insectoacaricide. Do not use on cats or kittens; no exact-product feline authorisation from an internationally recognised regulator was verified.
Dog Any weight On the skin single application; repeat according to entomological indication
Ekoprom Chistotel Maximum
Manufacturer material
Information published by the maker or a seller, such as a datasheet or product page. A medicines regulator has not necessarily reviewed it.
Chistotel Maximum shampoo for puppies and kittens - official instruction
Official manufacturer instruction, 2026
Active substance doses, with sources
Active substance Fipronil
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
6.7 mg/kg Dog Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 67.00 mg / 60.30 mg spot-on solution for dog S - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
7.5–15 mg/kg Dog, Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Spray 0.25% w/v cutaneous spray solution - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
5 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Frontline Combo 50.00 mg / 60.00 mg spot-on solution for cat - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
8.3 mg/kg Cat Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Effipro Duo 50 mg/60 mg Spot-on Solution for Cats - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025
Active substance Permethrin
Dose calculatorCalculates the active-substance amount; it is not a prescription.
PatientSpecies and weight will be filled in automatically in other calculators.
Selected dose
Dose Species Indication Route Frequency Source
50 mg/kg Dog Maintenance On the skin according to the epidemiological situation
VMD SPC 2026
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Advantix 40 mg + 200 mg spot-on solution for dogs (<= 4 kg) - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2026
60 mg/kg Dog Maintenance On the skin not more often than once every 4 weeks
VMD SPC 2025
Official product label (SPC), VMD, UK
Approved by the UK Veterinary Medicines Directorate (VMD) as part of the product's authorisation. It applies to that product as authorised there.
Effitix 26.8 mg/240 mg spot-on solution for very small dogs - Summary of Product Characteristics
UK Veterinary Medicines Directorate, 2025

Known Contraindications

  • Critical Fipronil
    Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Fipronil
    Do not use on sick (e.g. systemic diseases, fever) or convalescent animals.
    Sources: VMD SPC · VMD
  • Warning Fipronil (Dog)
    In the absence of available data, the veterinary medicinal product should not be used on puppies less than 8 weeks old and/or weighing less than 2 kg. Puppies and kittens from 2 days of age may be safely treated. Nepoužívat u štěňat do 3 dnů stáří.
    Sources: VMD SPC · VMD
  • Warning Fipronil (Cat)
    In the absence of available data, the veterinary medicinal product should not be used on kittens less than 8 weeks old and/or weighing less than 1 kg. Nepoužívat u koťat do 8 týdnů stáří. Puppies and kittens from 2 days of age may be safely treated.
    Sources: VMD SPC · VMD
  • Caution Fipronil (Cat)
    The potential toxicity of the veterinary medicinal product for kittens of less than 8 weeks of age in contact with a treated queen is not documented. Special care should be taken in this case. Data are not available on treatment of pregnant queens or nursing queens. Přípravek může být podán chovným, březím i laktujícím kočkám.
    Sources: VMD SPC · VMD
  • Critical Permethrin
    Do not use in cases of hypersensitivity to the active substances, or to any of the excipients.
    Sources: VMD SPC · VMD
  • Critical Permethrin (Cat)
    Do not use on cats. This veterinary medicinal product is extremely poisonous to cats and could be fatal due to the unique physiology of cats which is unable to metabolise certain compounds including permethrin. To prevent cats from being accidentally exposed to the veterinary medicinal product, keep treated dogs away from cats after treatment until the application site is dry. It is important to ensure that cats do not groom the site of application on a dog, which has been treated with this veterinary medicinal product. Seek veterinary advice immediately if this occurs. Do not use on rabbits and cats as adverse reactions and even death can occur In case of accidental dermal exposure, wash the cat with shampoo or soap, and seek veterinary advice rapidly.
    Sources: VMD SPC · VMD
  • Warning Permethrin (Dog)
    In the absence of available data the veterinary medicinal product should not be used on puppies of less than 7 weeks of age or 1.5 kg of weight. The safety of the product has not been established in dogs younger than 12 weeks of age or in dogs weighing less than 1.5 kg.
    Sources: VMD SPC · VMD
  • Caution Permethrin (Dog)
    Can be used during pregnancy and lactation. The safety of the veterinary medicinal product has not been established in dogs during pregnancy, lactation or in animals intended for breeding. Laboratory studies in rabbits and rats with the excipient N-methyl pyrrolidone have shown evidence of foetotoxic effects. Use only according to the benefit-risk assessment by the responsible veterinarian. The safety of the veterinary medicinal product has not been established during pregnancy and lactation in bitches. Use in pregnancy and lactation only in accordance with professional veterinary advice and a benefit/risk assessment.
    Sources: VMD SPC · VMD
  • Caution Permethrin (Dog)
    Can be used during pregnancy and lactation. Use only according to the benefit-risk assessment by the responsible veterinarian.
    Sources: VMD SPC · VMD

All of this shows in vetman as you prescribe

The dose for the patient's weight, registration in Georgia and controlled status, right on the prescription.